Amino acid dipepetide frequency for Paenibacillus antri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.088AlaAla: 13.088 ± 0.137	0.827AlaCys: 0.827 ± 0.02	5.438AlaAsp: 5.438 ± 0.064	7.18AlaGlu: 7.18 ± 0.076	4.427AlaPhe: 4.427 ± 0.045	8.295AlaGly: 8.295 ± 0.088	1.536AlaHis: 1.536 ± 0.028	5.287AlaIle: 5.287 ± 0.056	4.447AlaLys: 4.447 ± 0.056	10.602AlaLeu: 10.602 ± 0.094	2.727AlaMet: 2.727 ± 0.039	3.053AlaAsn: 3.053 ± 0.05	4.096AlaPro: 4.096 ± 0.06	2.404AlaGln: 2.404 ± 0.039	5.057AlaArg: 5.057 ± 0.064	6.276AlaSer: 6.276 ± 0.06	4.677AlaThr: 4.677 ± 0.064	7.936AlaVal: 7.936 ± 0.071	1.347AlaTrp: 1.347 ± 0.03	3.311AlaTyr: 3.311 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.669CysAla: 0.669 ± 0.019	0.1CysCys: 0.1 ± 0.008	0.414CysAsp: 0.414 ± 0.015	0.42CysGlu: 0.42 ± 0.015	0.314CysPhe: 0.314 ± 0.016	0.751CysGly: 0.751 ± 0.02	0.157CysHis: 0.157 ± 0.009	0.395CysIle: 0.395 ± 0.014	0.254CysLys: 0.254 ± 0.012	0.642CysLeu: 0.642 ± 0.017	0.183CysMet: 0.183 ± 0.009	0.227CysAsn: 0.227 ± 0.01	0.348CysPro: 0.348 ± 0.014	0.128CysGln: 0.128 ± 0.009	0.511CysArg: 0.511 ± 0.015	0.464CysSer: 0.464 ± 0.016	0.349CysThr: 0.349 ± 0.013	0.498CysVal: 0.498 ± 0.017	0.085CysTrp: 0.085 ± 0.007	0.247CysTyr: 0.247 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.031AspAla: 6.031 ± 0.069	0.375AspCys: 0.375 ± 0.016	2.95AspAsp: 2.95 ± 0.037	4.008AspGlu: 4.008 ± 0.046	2.255AspPhe: 2.255 ± 0.035	5.194AspGly: 5.194 ± 0.064	0.979AspHis: 0.979 ± 0.022	3.185AspIle: 3.185 ± 0.041	1.899AspLys: 1.899 ± 0.034	4.536AspLeu: 4.536 ± 0.048	1.182AspMet: 1.182 ± 0.023	1.477AspAsn: 1.477 ± 0.03	2.916AspPro: 2.916 ± 0.039	1.261AspGln: 1.261 ± 0.028	3.939AspArg: 3.939 ± 0.05	2.292AspSer: 2.292 ± 0.034	2.265AspThr: 2.265 ± 0.034	4.473AspVal: 4.473 ± 0.047	0.928AspTrp: 0.928 ± 0.022	1.907AspTyr: 1.907 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.089GluAla: 8.089 ± 0.075	0.356GluCys: 0.356 ± 0.015	3.117GluAsp: 3.117 ± 0.043	5.296GluGlu: 5.296 ± 0.057	2.11GluPhe: 2.11 ± 0.031	5.086GluGly: 5.086 ± 0.054	1.418GluHis: 1.418 ± 0.022	3.379GluIle: 3.379 ± 0.049	3.338GluLys: 3.338 ± 0.048	7.094GluLeu: 7.094 ± 0.065	1.786GluMet: 1.786 ± 0.031	1.929GluAsn: 1.929 ± 0.036	2.993GluPro: 2.993 ± 0.045	2.681GluGln: 2.681 ± 0.039	6.07GluArg: 6.07 ± 0.062	3.545GluSer: 3.545 ± 0.041	3.977GluThr: 3.977 ± 0.05	3.965GluVal: 3.965 ± 0.042	1.099GluTrp: 1.099 ± 0.025	1.991GluTyr: 1.991 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.365PheAla: 4.365 ± 0.049	0.323PheCys: 0.323 ± 0.012	2.563PheAsp: 2.563 ± 0.031	2.738PheGlu: 2.738 ± 0.038	1.844PhePhe: 1.844 ± 0.034	3.633PheGly: 3.633 ± 0.044	0.91PheHis: 0.91 ± 0.022	2.088PheIle: 2.088 ± 0.032	1.519PheLys: 1.519 ± 0.035	4.108PheLeu: 4.108 ± 0.06	0.983PheMet: 0.983 ± 0.023	1.216PheAsn: 1.216 ± 0.026	1.765PhePro: 1.765 ± 0.031	1.282PheGln: 1.282 ± 0.025	2.742PheArg: 2.742 ± 0.038	2.445PheSer: 2.445 ± 0.034	2.092PheThr: 2.092 ± 0.037	3.454PheVal: 3.454 ± 0.045	0.562PheTrp: 0.562 ± 0.016	1.428PheTyr: 1.428 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	8.031GlyAla: 8.031 ± 0.083	0.727GlyCys: 0.727 ± 0.018	4.196GlyAsp: 4.196 ± 0.051	5.32GlyGlu: 5.32 ± 0.053	3.468GlyPhe: 3.468 ± 0.044	6.864GlyGly: 6.864 ± 0.083	1.397GlyHis: 1.397 ± 0.026	4.865GlyIle: 4.865 ± 0.056	3.957GlyLys: 3.957 ± 0.051	7.296GlyLeu: 7.296 ± 0.071	2.385GlyMet: 2.385 ± 0.036	2.511GlyAsn: 2.511 ± 0.046	2.456GlyPro: 2.456 ± 0.042	2.095GlyGln: 2.095 ± 0.031	4.776GlyArg: 4.776 ± 0.054	4.494GlySer: 4.494 ± 0.068	4.663GlyThr: 4.663 ± 0.056	6.235GlyVal: 6.235 ± 0.055	1.347GlyTrp: 1.347 ± 0.029	2.917GlyTyr: 2.917 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.757HisAla: 1.757 ± 0.031	0.187HisCys: 0.187 ± 0.01	0.969HisAsp: 0.969 ± 0.024	1.133HisGlu: 1.133 ± 0.024	0.903HisPhe: 0.903 ± 0.022	1.609HisGly: 1.609 ± 0.029	0.515HisHis: 0.515 ± 0.019	1.103HisIle: 1.103 ± 0.026	0.64HisLys: 0.64 ± 0.018	1.881HisLeu: 1.881 ± 0.034	0.489HisMet: 0.489 ± 0.015	0.532HisAsn: 0.532 ± 0.016	1.319HisPro: 1.319 ± 0.023	0.549HisGln: 0.549 ± 0.017	1.383HisArg: 1.383 ± 0.027	0.959HisSer: 0.959 ± 0.022	0.945HisThr: 0.945 ± 0.025	1.384HisVal: 1.384 ± 0.025	0.356HisTrp: 0.356 ± 0.012	0.815HisTyr: 0.815 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.98IleAla: 5.98 ± 0.063	0.419IleCys: 0.419 ± 0.015	3.63IleAsp: 3.63 ± 0.047	3.941IleGlu: 3.941 ± 0.05	1.834IlePhe: 1.834 ± 0.03	4.909IleGly: 4.909 ± 0.058	1.148IleHis: 1.148 ± 0.023	2.329IleIle: 2.329 ± 0.045	1.802IleLys: 1.802 ± 0.036	4.394IleLeu: 4.394 ± 0.051	1.159IleMet: 1.159 ± 0.026	1.541IleAsn: 1.541 ± 0.03	2.724IlePro: 2.724 ± 0.036	1.707IleGln: 1.707 ± 0.026	4.029IleArg: 4.029 ± 0.052	2.896IleSer: 2.896 ± 0.043	2.545IleThr: 2.545 ± 0.035	5.272IleVal: 5.272 ± 0.062	0.612IleTrp: 0.612 ± 0.018	1.699IleTyr: 1.699 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.925LysAla: 3.925 ± 0.04	0.185LysCys: 0.185 ± 0.01	2.333LysAsp: 2.333 ± 0.039	3.374LysGlu: 3.374 ± 0.042	1.287LysPhe: 1.287 ± 0.024	2.811LysGly: 2.811 ± 0.039	1.012LysHis: 1.012 ± 0.021	2.191LysIle: 2.191 ± 0.04	2.345LysLys: 2.345 ± 0.041	4.53LysLeu: 4.53 ± 0.049	1.209LysMet: 1.209 ± 0.029	1.378LysAsn: 1.378 ± 0.029	2.142LysPro: 2.142 ± 0.039	1.63LysGln: 1.63 ± 0.029	3.005LysArg: 3.005 ± 0.043	2.303LysSer: 2.303 ± 0.034	2.485LysThr: 2.485 ± 0.038	2.739LysVal: 2.739 ± 0.04	0.551LysTrp: 0.551 ± 0.014	1.504LysTyr: 1.504 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	9.728LeuAla: 9.728 ± 0.086	0.707LeuCys: 0.707 ± 0.022	5.016LeuAsp: 5.016 ± 0.045	6.384LeuGlu: 6.384 ± 0.063	4.51LeuPhe: 4.51 ± 0.059	6.953LeuGly: 6.953 ± 0.064	2.016LeuHis: 2.016 ± 0.034	4.981LeuIle: 4.981 ± 0.065	4.123LeuLys: 4.123 ± 0.056	10.711LeuLeu: 10.711 ± 0.118	2.273LeuMet: 2.273 ± 0.035	2.995LeuAsn: 2.995 ± 0.042	4.941LeuPro: 4.941 ± 0.049	3.509LeuGln: 3.509 ± 0.042	6.529LeuArg: 6.529 ± 0.066	6.357LeuSer: 6.357 ± 0.055	5.456LeuThr: 5.456 ± 0.058	6.466LeuVal: 6.466 ± 0.062	1.195LeuTrp: 1.195 ± 0.029	3.293LeuTyr: 3.293 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.203MetAla: 2.203 ± 0.034	0.157MetCys: 0.157 ± 0.009	1.337MetAsp: 1.337 ± 0.024	1.741MetGlu: 1.741 ± 0.029	1.015MetPhe: 1.015 ± 0.023	1.581MetGly: 1.581 ± 0.029	0.482MetHis: 0.482 ± 0.014	1.598MetIle: 1.598 ± 0.03	1.691MetLys: 1.691 ± 0.032	2.648MetLeu: 2.648 ± 0.041	0.733MetMet: 0.733 ± 0.018	1.282MetAsn: 1.282 ± 0.023	1.139MetPro: 1.139 ± 0.023	0.852MetGln: 0.852 ± 0.021	1.594MetArg: 1.594 ± 0.03	1.596MetSer: 1.596 ± 0.023	1.742MetThr: 1.742 ± 0.026	1.444MetVal: 1.444 ± 0.027	0.263MetTrp: 0.263 ± 0.011	0.809MetTyr: 0.809 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.184AsnAla: 3.184 ± 0.043	0.19AsnCys: 0.19 ± 0.011	1.811AsnAsp: 1.811 ± 0.035	2.291AsnGlu: 2.291 ± 0.036	1.128AsnPhe: 1.128 ± 0.024	3.258AsnGly: 3.258 ± 0.043	0.649AsnHis: 0.649 ± 0.02	1.649AsnIle: 1.649 ± 0.032	1.215AsnLys: 1.215 ± 0.025	2.61AsnLeu: 2.61 ± 0.034	0.738AsnMet: 0.738 ± 0.02	1.063AsnAsn: 1.063 ± 0.033	1.772AsnPro: 1.772 ± 0.03	0.94AsnGln: 0.94 ± 0.02	2.079AsnArg: 2.079 ± 0.035	1.42AsnSer: 1.42 ± 0.027	1.518AsnThr: 1.518 ± 0.033	2.702AsnVal: 2.702 ± 0.039	0.415AsnTrp: 0.415 ± 0.015	1.137AsnTyr: 1.137 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.497ProAla: 4.497 ± 0.062	0.257ProCys: 0.257 ± 0.013	2.961ProAsp: 2.961 ± 0.04	3.896ProGlu: 3.896 ± 0.04	2.05ProPhe: 2.05 ± 0.032	3.57ProGly: 3.57 ± 0.049	0.963ProHis: 0.963 ± 0.021	2.591ProIle: 2.591 ± 0.032	1.781ProLys: 1.781 ± 0.028	4.179ProLeu: 4.179 ± 0.047	1.158ProMet: 1.158 ± 0.024	1.677ProAsn: 1.677 ± 0.033	1.839ProPro: 1.839 ± 0.033	1.171ProGln: 1.171 ± 0.029	1.926ProArg: 1.926 ± 0.028	2.827ProSer: 2.827 ± 0.036	2.336ProThr: 2.336 ± 0.036	3.355ProVal: 3.355 ± 0.045	0.641ProTrp: 0.641 ± 0.019	1.657ProTyr: 1.657 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.086GlnAla: 3.086 ± 0.039	0.158GlnCys: 0.158 ± 0.01	1.358GlnAsp: 1.358 ± 0.026	1.941GlnGlu: 1.941 ± 0.036	1.188GlnPhe: 1.188 ± 0.026	2.232GlnGly: 2.232 ± 0.039	0.546GlnHis: 0.546 ± 0.016	1.573GlnIle: 1.573 ± 0.029	1.233GlnLys: 1.233 ± 0.026	3.098GlnLeu: 3.098 ± 0.039	0.819GlnMet: 0.819 ± 0.019	0.855GlnAsn: 0.855 ± 0.02	1.369GlnPro: 1.369 ± 0.03	1.173GlnGln: 1.173 ± 0.032	1.916GlnArg: 1.916 ± 0.033	1.743GlnSer: 1.743 ± 0.031	1.652GlnThr: 1.652 ± 0.032	1.936GlnVal: 1.936 ± 0.032	0.479GlnTrp: 0.479 ± 0.017	1.08GlnTyr: 1.08 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	5.135ArgAla: 5.135 ± 0.067	0.465ArgCys: 0.465 ± 0.017	3.214ArgAsp: 3.214 ± 0.04	4.669ArgGlu: 4.669 ± 0.055	3.014ArgPhe: 3.014 ± 0.041	4.189ArgGly: 4.189 ± 0.054	1.311ArgHis: 1.311 ± 0.026	4.105ArgIle: 4.105 ± 0.052	3.07ArgLys: 3.07 ± 0.041	7.046ArgLeu: 7.046 ± 0.071	2.045ArgMet: 2.045 ± 0.036	2.124ArgAsn: 2.124 ± 0.037	2.495ArgPro: 2.495 ± 0.041	1.914ArgGln: 1.914 ± 0.03	4.563ArgArg: 4.563 ± 0.066	3.777ArgSer: 3.777 ± 0.045	3.536ArgThr: 3.536 ± 0.04	4.13ArgVal: 4.13 ± 0.054	1.073ArgTrp: 1.073 ± 0.021	2.301ArgTyr: 2.301 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.487SerAla: 5.487 ± 0.058	0.381SerCys: 0.381 ± 0.014	2.987SerAsp: 2.987 ± 0.039	3.596SerGlu: 3.596 ± 0.052	2.861SerPhe: 2.861 ± 0.047	5.294SerGly: 5.294 ± 0.054	1.03SerHis: 1.03 ± 0.024	3.531SerIle: 3.531 ± 0.047	2.342SerLys: 2.342 ± 0.033	5.651SerLeu: 5.651 ± 0.058	1.6SerMet: 1.6 ± 0.029	1.771SerAsn: 1.771 ± 0.033	2.578SerPro: 2.578 ± 0.037	1.425SerGln: 1.425 ± 0.025	3.228SerArg: 3.228 ± 0.039	3.361SerSer: 3.361 ± 0.06	2.718SerThr: 2.718 ± 0.043	4.45SerVal: 4.45 ± 0.048	0.806SerTrp: 0.806 ± 0.021	2.012SerTyr: 2.012 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.18ThrAla: 5.18 ± 0.061	0.309ThrCys: 0.309 ± 0.012	2.777ThrAsp: 2.777 ± 0.038	3.252ThrGlu: 3.252 ± 0.039	2.497ThrPhe: 2.497 ± 0.04	4.398ThrGly: 4.398 ± 0.06	0.961ThrHis: 0.961 ± 0.02	3.527ThrIle: 3.527 ± 0.042	2.144ThrLys: 2.144 ± 0.036	5.465ThrLeu: 5.465 ± 0.055	1.407ThrMet: 1.407 ± 0.025	1.767ThrAsn: 1.767 ± 0.035	2.691ThrPro: 2.691 ± 0.041	1.235ThrGln: 1.235 ± 0.024	2.412ThrArg: 2.412 ± 0.034	2.819ThrSer: 2.819 ± 0.041	2.857ThrThr: 2.857 ± 0.048	4.618ThrVal: 4.618 ± 0.061	0.664ThrTrp: 0.664 ± 0.018	1.933ThrTyr: 1.933 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.012ValAla: 7.012 ± 0.065	0.653ValCys: 0.653 ± 0.018	4.163ValAsp: 4.163 ± 0.051	4.914ValGlu: 4.914 ± 0.048	3.063ValPhe: 3.063 ± 0.04	5.495ValGly: 5.495 ± 0.066	1.43ValHis: 1.43 ± 0.027	3.622ValIle: 3.622 ± 0.044	3.11ValLys: 3.11 ± 0.049	6.985ValLeu: 6.985 ± 0.072	1.725ValMet: 1.725 ± 0.032	2.483ValAsn: 2.483 ± 0.032	3.69ValPro: 3.69 ± 0.048	2.165ValGln: 2.165 ± 0.034	5.035ValArg: 5.035 ± 0.055	4.845ValSer: 4.845 ± 0.053	4.539ValThr: 4.539 ± 0.068	6.376ValVal: 6.376 ± 0.068	1.067ValTrp: 1.067 ± 0.026	2.63ValTyr: 2.63 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.102TrpAla: 1.102 ± 0.025	0.115TrpCys: 0.115 ± 0.008	0.758TrpAsp: 0.758 ± 0.018	0.82TrpGlu: 0.82 ± 0.019	0.682TrpPhe: 0.682 ± 0.019	0.953TrpGly: 0.953 ± 0.022	0.306TrpHis: 0.306 ± 0.013	0.862TrpIle: 0.862 ± 0.021	0.739TrpLys: 0.739 ± 0.018	1.497TrpLeu: 1.497 ± 0.03	0.483TrpMet: 0.483 ± 0.015	0.715TrpAsn: 0.715 ± 0.018	0.48TrpPro: 0.48 ± 0.016	0.4TrpGln: 0.4 ± 0.015	0.853TrpArg: 0.853 ± 0.02	0.921TrpSer: 0.921 ± 0.024	0.926TrpThr: 0.926 ± 0.026	0.944TrpVal: 0.944 ± 0.021	0.218TrpTrp: 0.218 ± 0.011	0.467TrpTyr: 0.467 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.461TyrAla: 3.461 ± 0.043	0.267TyrCys: 0.267 ± 0.011	2.061TyrAsp: 2.061 ± 0.037	2.404TyrGlu: 2.404 ± 0.037	1.609TyrPhe: 1.609 ± 0.033	2.924TyrGly: 2.924 ± 0.042	0.662TyrHis: 0.662 ± 0.018	1.712TyrIle: 1.712 ± 0.03	1.292TyrLys: 1.292 ± 0.029	3.169TyrLeu: 3.169 ± 0.047	0.821TyrMet: 0.821 ± 0.022	1.175TyrAsn: 1.175 ± 0.03	1.58TyrPro: 1.58 ± 0.027	0.912TyrGln: 0.912 ± 0.026	2.524TyrArg: 2.524 ± 0.032	1.769TyrSer: 1.769 ± 0.035	1.637TyrThr: 1.637 ± 0.027	2.626TyrVal: 2.626 ± 0.035	0.534TyrTrp: 0.534 ± 0.017	1.301TyrTyr: 1.301 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6188 proteins (2117431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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