Amino acid dipepetide frequency for Acetobacter aceti NBRC 14818

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.845AlaAla: 13.845 ± 0.184	1.334AlaCys: 1.334 ± 0.039	5.887AlaAsp: 5.887 ± 0.089	6.421AlaGlu: 6.421 ± 0.113	3.966AlaPhe: 3.966 ± 0.069	9.765AlaGly: 9.765 ± 0.15	2.355AlaHis: 2.355 ± 0.05	5.551AlaIle: 5.551 ± 0.076	3.25AlaLys: 3.25 ± 0.069	12.583AlaLeu: 12.583 ± 0.135	3.097AlaMet: 3.097 ± 0.047	2.571AlaAsn: 2.571 ± 0.059	5.412AlaPro: 5.412 ± 0.079	3.837AlaGln: 3.837 ± 0.07	7.691AlaArg: 7.691 ± 0.11	6.83AlaSer: 6.83 ± 0.106	6.072AlaThr: 6.072 ± 0.093	7.883AlaVal: 7.883 ± 0.1	1.45AlaTrp: 1.45 ± 0.04	2.247AlaTyr: 2.247 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.066CysAla: 1.066 ± 0.033	0.166CysCys: 0.166 ± 0.013	0.594CysAsp: 0.594 ± 0.025	0.486CysGlu: 0.486 ± 0.023	0.373CysPhe: 0.373 ± 0.019	1.095CysGly: 1.095 ± 0.034	0.291CysHis: 0.291 ± 0.02	0.515CysIle: 0.515 ± 0.024	0.215CysLys: 0.215 ± 0.015	1.019CysLeu: 1.019 ± 0.032	0.225CysMet: 0.225 ± 0.015	0.242CysAsn: 0.242 ± 0.015	0.556CysPro: 0.556 ± 0.025	0.278CysGln: 0.278 ± 0.016	0.711CysArg: 0.711 ± 0.027	0.634CysSer: 0.634 ± 0.023	0.56CysThr: 0.56 ± 0.024	0.835CysVal: 0.835 ± 0.03	0.126CysTrp: 0.126 ± 0.012	0.242CysTyr: 0.242 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.212AspAla: 6.212 ± 0.088	0.545AspCys: 0.545 ± 0.024	2.966AspAsp: 2.966 ± 0.061	3.236AspGlu: 3.236 ± 0.067	2.022AspPhe: 2.022 ± 0.045	4.756AspGly: 4.756 ± 0.076	1.297AspHis: 1.297 ± 0.038	3.128AspIle: 3.128 ± 0.056	1.491AspLys: 1.491 ± 0.041	5.79AspLeu: 5.79 ± 0.085	1.512AspMet: 1.512 ± 0.037	1.425AspAsn: 1.425 ± 0.041	3.235AspPro: 3.235 ± 0.052	1.735AspGln: 1.735 ± 0.048	4.0AspArg: 4.0 ± 0.06	2.523AspSer: 2.523 ± 0.052	2.9AspThr: 2.9 ± 0.051	4.215AspVal: 4.215 ± 0.069	0.901AspTrp: 0.901 ± 0.03	1.366AspTyr: 1.366 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.991GluAla: 6.991 ± 0.114	0.439GluCys: 0.439 ± 0.024	2.801GluAsp: 2.801 ± 0.057	3.342GluGlu: 3.342 ± 0.077	1.553GluPhe: 1.553 ± 0.045	4.138GluGly: 4.138 ± 0.074	1.319GluHis: 1.319 ± 0.035	3.259GluIle: 3.259 ± 0.067	2.641GluLys: 2.641 ± 0.061	4.649GluLeu: 4.649 ± 0.071	1.448GluMet: 1.448 ± 0.041	1.906GluAsn: 1.906 ± 0.049	2.446GluPro: 2.446 ± 0.056	2.31GluGln: 2.31 ± 0.055	4.371GluArg: 4.371 ± 0.086	2.573GluSer: 2.573 ± 0.048	3.777GluThr: 3.777 ± 0.068	3.411GluVal: 3.411 ± 0.061	0.751GluTrp: 0.751 ± 0.03	0.97GluTyr: 0.97 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.748PheAla: 3.748 ± 0.064	0.496PheCys: 0.496 ± 0.027	2.265PheAsp: 2.265 ± 0.045	1.838PheGlu: 1.838 ± 0.042	1.501PhePhe: 1.501 ± 0.044	3.435PheGly: 3.435 ± 0.058	0.866PheHis: 0.866 ± 0.029	1.657PheIle: 1.657 ± 0.041	0.83PheLys: 0.83 ± 0.028	3.718PheLeu: 3.718 ± 0.069	0.928PheMet: 0.928 ± 0.032	1.055PheAsn: 1.055 ± 0.038	1.833PhePro: 1.833 ± 0.044	1.013PheGln: 1.013 ± 0.033	2.401PheArg: 2.401 ± 0.048	2.816PheSer: 2.816 ± 0.052	2.031PheThr: 2.031 ± 0.045	2.668PheVal: 2.668 ± 0.052	0.524PheTrp: 0.524 ± 0.024	0.893PheTyr: 0.893 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.098GlyAla: 8.098 ± 0.115	0.977GlyCys: 0.977 ± 0.028	4.066GlyAsp: 4.066 ± 0.068	4.286GlyGlu: 4.286 ± 0.081	3.404GlyPhe: 3.404 ± 0.058	7.115GlyGly: 7.115 ± 0.137	2.027GlyHis: 2.027 ± 0.046	4.422GlyIle: 4.422 ± 0.069	3.284GlyLys: 3.284 ± 0.066	8.747GlyLeu: 8.747 ± 0.114	2.479GlyMet: 2.479 ± 0.057	2.344GlyAsn: 2.344 ± 0.06	3.34GlyPro: 3.34 ± 0.062	3.043GlyGln: 3.043 ± 0.058	5.635GlyArg: 5.635 ± 0.084	5.142GlySer: 5.142 ± 0.086	4.803GlyThr: 4.803 ± 0.091	6.188GlyVal: 6.188 ± 0.081	1.485GlyTrp: 1.485 ± 0.045	2.175GlyTyr: 2.175 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.426HisAla: 2.426 ± 0.051	0.256HisCys: 0.256 ± 0.017	1.381HisAsp: 1.381 ± 0.038	1.163HisGlu: 1.163 ± 0.032	0.96HisPhe: 0.96 ± 0.028	1.981HisGly: 1.981 ± 0.05	0.663HisHis: 0.663 ± 0.027	1.193HisIle: 1.193 ± 0.042	0.585HisLys: 0.585 ± 0.024	2.311HisLeu: 2.311 ± 0.057	0.601HisMet: 0.601 ± 0.023	0.63HisAsn: 0.63 ± 0.028	1.469HisPro: 1.469 ± 0.039	0.654HisGln: 0.654 ± 0.023	1.433HisArg: 1.433 ± 0.038	1.216HisSer: 1.216 ± 0.035	1.127HisThr: 1.127 ± 0.036	1.763HisVal: 1.763 ± 0.045	0.389HisTrp: 0.389 ± 0.02	0.61HisTyr: 0.61 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.427IleAla: 6.427 ± 0.089	0.561IleCys: 0.561 ± 0.026	3.155IleAsp: 3.155 ± 0.061	3.19IleGlu: 3.19 ± 0.052	1.702IlePhe: 1.702 ± 0.045	4.77IleGly: 4.77 ± 0.076	0.991IleHis: 0.991 ± 0.031	2.456IleIle: 2.456 ± 0.058	1.348IleLys: 1.348 ± 0.046	4.965IleLeu: 4.965 ± 0.081	1.176IleMet: 1.176 ± 0.04	1.525IleAsn: 1.525 ± 0.044	2.706IlePro: 2.706 ± 0.056	1.349IleGln: 1.349 ± 0.039	3.521IleArg: 3.521 ± 0.06	3.368IleSer: 3.368 ± 0.062	2.988IleThr: 2.988 ± 0.056	4.063IleVal: 4.063 ± 0.075	0.608IleTrp: 0.608 ± 0.023	1.044IleTyr: 1.044 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.026LysAla: 4.026 ± 0.072	0.155LysCys: 0.155 ± 0.012	1.787LysAsp: 1.787 ± 0.046	1.825LysGlu: 1.825 ± 0.048	0.813LysPhe: 0.813 ± 0.03	2.662LysGly: 2.662 ± 0.061	0.669LysHis: 0.669 ± 0.025	1.891LysIle: 1.891 ± 0.052	1.624LysLys: 1.624 ± 0.053	3.028LysLeu: 3.028 ± 0.067	0.776LysMet: 0.776 ± 0.033	1.141LysAsn: 1.141 ± 0.04	1.977LysPro: 1.977 ± 0.042	1.178LysGln: 1.178 ± 0.038	2.254LysArg: 2.254 ± 0.056	1.844LysSer: 1.844 ± 0.052	2.183LysThr: 2.183 ± 0.048	2.167LysVal: 2.167 ± 0.052	0.344LysTrp: 0.344 ± 0.02	0.591LysTyr: 0.591 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.197LeuAla: 12.197 ± 0.141	1.218LeuCys: 1.218 ± 0.036	5.798LeuAsp: 5.798 ± 0.086	5.129LeuGlu: 5.129 ± 0.08	3.804LeuPhe: 3.804 ± 0.071	7.694LeuGly: 7.694 ± 0.103	2.324LeuHis: 2.324 ± 0.053	4.977LeuIle: 4.977 ± 0.077	3.529LeuLys: 3.529 ± 0.072	10.207LeuLeu: 10.207 ± 0.143	2.376LeuMet: 2.376 ± 0.055	2.819LeuAsn: 2.819 ± 0.058	6.442LeuPro: 6.442 ± 0.094	2.958LeuGln: 2.958 ± 0.052	7.019LeuArg: 7.019 ± 0.102	7.511LeuSer: 7.511 ± 0.1	6.196LeuThr: 6.196 ± 0.108	7.107LeuVal: 7.107 ± 0.096	1.324LeuTrp: 1.324 ± 0.038	2.058LeuTyr: 2.058 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.881MetAla: 2.881 ± 0.054	0.182MetCys: 0.182 ± 0.014	1.194MetAsp: 1.194 ± 0.039	1.257MetGlu: 1.257 ± 0.034	0.719MetPhe: 0.719 ± 0.033	1.882MetGly: 1.882 ± 0.05	0.486MetHis: 0.486 ± 0.021	1.406MetIle: 1.406 ± 0.041	1.113MetLys: 1.113 ± 0.037	2.688MetLeu: 2.688 ± 0.056	0.725MetMet: 0.725 ± 0.027	0.86MetAsn: 0.86 ± 0.03	1.568MetPro: 1.568 ± 0.038	0.929MetGln: 0.929 ± 0.031	1.644MetArg: 1.644 ± 0.044	1.711MetSer: 1.711 ± 0.042	2.109MetThr: 2.109 ± 0.047	1.671MetVal: 1.671 ± 0.041	0.191MetTrp: 0.191 ± 0.014	0.298MetTyr: 0.298 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.27AsnAla: 3.27 ± 0.064	0.278AsnCys: 0.278 ± 0.014	1.567AsnAsp: 1.567 ± 0.043	1.397AsnGlu: 1.397 ± 0.039	0.987AsnPhe: 0.987 ± 0.03	2.776AsnGly: 2.776 ± 0.076	0.635AsnHis: 0.635 ± 0.024	1.6AsnIle: 1.6 ± 0.04	0.786AsnLys: 0.786 ± 0.029	2.593AsnLeu: 2.593 ± 0.056	0.65AsnMet: 0.65 ± 0.025	0.839AsnAsn: 0.839 ± 0.034	1.802AsnPro: 1.802 ± 0.043	0.868AsnGln: 0.868 ± 0.036	1.836AsnArg: 1.836 ± 0.041	1.535AsnSer: 1.535 ± 0.047	1.56AsnThr: 1.56 ± 0.052	2.03AsnVal: 2.03 ± 0.047	0.464AsnTrp: 0.464 ± 0.022	0.736AsnTyr: 0.736 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.96ProAla: 5.96 ± 0.098	0.419ProCys: 0.419 ± 0.024	3.946ProAsp: 3.946 ± 0.07	4.029ProGlu: 4.029 ± 0.064	2.045ProPhe: 2.045 ± 0.051	4.297ProGly: 4.297 ± 0.068	1.282ProHis: 1.282 ± 0.036	2.111ProIle: 2.111 ± 0.045	1.526ProLys: 1.526 ± 0.046	5.009ProLeu: 5.009 ± 0.074	1.18ProMet: 1.18 ± 0.032	1.302ProAsn: 1.302 ± 0.035	2.789ProPro: 2.789 ± 0.079	1.781ProGln: 1.781 ± 0.047	2.805ProArg: 2.805 ± 0.057	3.27ProSer: 3.27 ± 0.061	2.845ProThr: 2.845 ± 0.059	4.929ProVal: 4.929 ± 0.075	0.753ProTrp: 0.753 ± 0.032	1.246ProTyr: 1.246 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.106GlnAla: 4.106 ± 0.079	0.23GlnCys: 0.23 ± 0.015	1.759GlnAsp: 1.759 ± 0.042	1.712GlnGlu: 1.712 ± 0.036	1.112GlnPhe: 1.112 ± 0.034	2.377GlnGly: 2.377 ± 0.05	0.709GlnHis: 0.709 ± 0.029	2.077GlnIle: 2.077 ± 0.048	1.42GlnLys: 1.42 ± 0.037	2.719GlnLeu: 2.719 ± 0.054	0.893GlnMet: 0.893 ± 0.031	1.089GlnAsn: 1.089 ± 0.031	1.858GlnPro: 1.858 ± 0.052	1.41GlnGln: 1.41 ± 0.047	2.158GlnArg: 2.158 ± 0.047	2.055GlnSer: 2.055 ± 0.045	2.135GlnThr: 2.135 ± 0.052	2.243GlnVal: 2.243 ± 0.052	0.419GlnTrp: 0.419 ± 0.021	0.691GlnTyr: 0.691 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.601ArgAla: 6.601 ± 0.093	0.571ArgCys: 0.571 ± 0.025	3.611ArgAsp: 3.611 ± 0.076	3.898ArgGlu: 3.898 ± 0.081	2.804ArgPhe: 2.804 ± 0.055	4.224ArgGly: 4.224 ± 0.067	1.877ArgHis: 1.877 ± 0.043	4.013ArgIle: 4.013 ± 0.067	2.642ArgLys: 2.642 ± 0.058	7.738ArgLeu: 7.738 ± 0.096	1.763ArgMet: 1.763 ± 0.041	2.186ArgAsn: 2.186 ± 0.049	3.256ArgPro: 3.256 ± 0.061	2.68ArgGln: 2.68 ± 0.065	5.179ArgArg: 5.179 ± 0.104	3.929ArgSer: 3.929 ± 0.055	3.466ArgThr: 3.466 ± 0.054	4.517ArgVal: 4.517 ± 0.07	0.955ArgTrp: 0.955 ± 0.035	1.851ArgTyr: 1.851 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.461SerAla: 6.461 ± 0.089	0.653SerCys: 0.653 ± 0.027	3.472SerAsp: 3.472 ± 0.063	3.204SerGlu: 3.204 ± 0.06	2.65SerPhe: 2.65 ± 0.05	6.067SerGly: 6.067 ± 0.106	1.409SerHis: 1.409 ± 0.038	2.942SerIle: 2.942 ± 0.052	1.627SerLys: 1.627 ± 0.04	6.579SerLeu: 6.579 ± 0.098	1.535SerMet: 1.535 ± 0.043	1.629SerAsn: 1.629 ± 0.051	3.29SerPro: 3.29 ± 0.064	1.803SerGln: 1.803 ± 0.035	4.042SerArg: 4.042 ± 0.063	4.211SerSer: 4.211 ± 0.099	3.216SerThr: 3.216 ± 0.079	4.842SerVal: 4.842 ± 0.073	0.886SerTrp: 0.886 ± 0.033	1.503SerTyr: 1.503 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.296ThrAla: 6.296 ± 0.123	0.506ThrCys: 0.506 ± 0.024	3.204ThrAsp: 3.204 ± 0.062	2.804ThrGlu: 2.804 ± 0.06	1.955ThrPhe: 1.955 ± 0.045	5.601ThrGly: 5.601 ± 0.084	1.294ThrHis: 1.294 ± 0.036	3.059ThrIle: 3.059 ± 0.062	1.506ThrLys: 1.506 ± 0.043	6.821ThrLeu: 6.821 ± 0.102	1.238ThrMet: 1.238 ± 0.039	1.46ThrAsn: 1.46 ± 0.049	3.788ThrPro: 3.788 ± 0.068	1.852ThrGln: 1.852 ± 0.051	3.428ThrArg: 3.428 ± 0.068	3.422ThrSer: 3.422 ± 0.066	3.278ThrThr: 3.278 ± 0.077	4.586ThrVal: 4.586 ± 0.074	0.758ThrTrp: 0.758 ± 0.028	1.228ThrTyr: 1.228 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.115ValAla: 8.115 ± 0.115	0.784ValCys: 0.784 ± 0.027	3.726ValAsp: 3.726 ± 0.061	4.155ValGlu: 4.155 ± 0.081	2.71ValPhe: 2.71 ± 0.056	5.402ValGly: 5.402 ± 0.068	1.432ValHis: 1.432 ± 0.04	3.954ValIle: 3.954 ± 0.065	2.269ValLys: 2.269 ± 0.057	7.554ValLeu: 7.554 ± 0.098	2.064ValMet: 2.064 ± 0.045	1.942ValAsn: 1.942 ± 0.048	3.958ValPro: 3.958 ± 0.064	2.151ValGln: 2.151 ± 0.046	4.774ValArg: 4.774 ± 0.08	5.216ValSer: 5.216 ± 0.08	4.823ValThr: 4.823 ± 0.083	5.663ValVal: 5.663 ± 0.095	1.032ValTrp: 1.032 ± 0.033	1.414ValTyr: 1.414 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.069TrpAla: 1.069 ± 0.035	0.202TrpCys: 0.202 ± 0.014	0.626TrpAsp: 0.626 ± 0.028	0.599TrpGlu: 0.599 ± 0.027	0.56TrpPhe: 0.56 ± 0.021	0.914TrpGly: 0.914 ± 0.034	0.385TrpHis: 0.385 ± 0.019	0.731TrpIle: 0.731 ± 0.028	0.595TrpLys: 0.595 ± 0.028	1.769TrpLeu: 1.769 ± 0.046	0.377TrpMet: 0.377 ± 0.022	0.552TrpAsn: 0.552 ± 0.022	0.66TrpPro: 0.66 ± 0.028	0.604TrpGln: 0.604 ± 0.026	1.188TrpArg: 1.188 ± 0.036	0.915TrpSer: 0.915 ± 0.031	0.788TrpThr: 0.788 ± 0.032	0.809TrpVal: 0.809 ± 0.029	0.219TrpTrp: 0.219 ± 0.015	0.338TrpTyr: 0.338 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.053	0.257TyrCys: 0.257 ± 0.016	1.45TyrAsp: 1.45 ± 0.044	1.124TyrGlu: 1.124 ± 0.033	0.876TyrPhe: 0.876 ± 0.03	2.11TyrGly: 2.11 ± 0.047	0.5TyrHis: 0.5 ± 0.022	0.971TyrIle: 0.971 ± 0.033	0.654TyrLys: 0.654 ± 0.024	2.2TyrLeu: 2.2 ± 0.049	0.47TyrMet: 0.47 ± 0.024	0.692TyrAsn: 0.692 ± 0.031	1.139TyrPro: 1.139 ± 0.04	0.739TyrGln: 0.739 ± 0.032	1.671TyrArg: 1.671 ± 0.039	1.3TyrSer: 1.3 ± 0.045	1.227TyrThr: 1.227 ± 0.043	1.548TyrVal: 1.548 ± 0.043	0.321TyrTrp: 0.321 ± 0.017	0.656TyrTyr: 0.656 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3146 proteins (1000029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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