Amino acid dipepetide frequency for Pepper virus A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.146AlaAla: 6.146 ± 3.106
0.723AlaCys: 0.723 ± 0.364
2.892AlaAsp: 2.892 ± 1.086
2.892AlaGlu: 2.892 ± 1.921
4.7AlaPhe: 4.7 ± 0.725
2.892AlaGly: 2.892 ± 0.864
0.723AlaHis: 0.723 ± 0.69
4.338AlaIle: 4.338 ± 1.281
5.785AlaLys: 5.785 ± 1.015
6.146AlaLeu: 6.146 ± 0.75
1.446AlaMet: 1.446 ± 0.732
3.254AlaAsn: 3.254 ± 0.977
3.977AlaPro: 3.977 ± 2.026
2.892AlaGln: 2.892 ± 0.925
3.254AlaArg: 3.254 ± 1.0
6.508AlaSer: 6.508 ± 2.064
5.061AlaThr: 5.061 ± 0.909
6.508AlaVal: 6.508 ± 1.649
0.362AlaTrp: 0.362 ± 0.182
1.808AlaTyr: 1.808 ± 0.692
0.0AlaXaa: 0.0 ± 0.0
Cys
1.446CysAla: 1.446 ± 0.728
1.446CysCys: 1.446 ± 1.49
0.362CysAsp: 0.362 ± 0.981
1.085CysGlu: 1.085 ± 0.663
2.169CysPhe: 2.169 ± 1.622
1.808CysGly: 1.808 ± 1.399
0.362CysHis: 0.362 ± 0.981
1.808CysIle: 1.808 ± 0.91
1.808CysLys: 1.808 ± 1.035
2.531CysLeu: 2.531 ± 0.911
0.0CysMet: 0.0 ± 0.0
2.892CysAsn: 2.892 ± 1.044
1.446CysPro: 1.446 ± 0.728
0.723CysGln: 0.723 ± 0.705
1.085CysArg: 1.085 ± 0.623
2.531CysSer: 2.531 ± 0.911
1.085CysThr: 1.085 ± 0.546
2.531CysVal: 2.531 ± 1.565
0.0CysTrp: 0.0 ± 0.0
1.808CysTyr: 1.808 ± 0.759
0.0CysXaa: 0.0 ± 0.0
Asp
3.254AspAla: 3.254 ± 1.235
2.169AspCys: 2.169 ± 1.171
0.723AspAsp: 0.723 ± 0.364
3.615AspGlu: 3.615 ± 1.219
0.723AspPhe: 0.723 ± 0.745
3.977AspGly: 3.977 ± 1.28
2.169AspHis: 2.169 ± 0.556
3.615AspIle: 3.615 ± 0.892
2.531AspLys: 2.531 ± 1.215
6.146AspLeu: 6.146 ± 2.403
0.723AspMet: 0.723 ± 0.364
3.254AspAsn: 3.254 ± 0.725
1.808AspPro: 1.808 ± 1.399
2.531AspGln: 2.531 ± 1.227
2.892AspArg: 2.892 ± 1.456
2.169AspSer: 2.169 ± 0.556
1.808AspThr: 1.808 ± 1.46
3.977AspVal: 3.977 ± 1.628
1.085AspTrp: 1.085 ± 1.008
2.169AspTyr: 2.169 ± 1.246
0.0AspXaa: 0.0 ± 0.0
Glu
2.169GluAla: 2.169 ± 0.723
0.362GluCys: 0.362 ± 0.182
2.531GluAsp: 2.531 ± 0.8
6.508GluGlu: 6.508 ± 1.325
2.531GluPhe: 2.531 ± 1.276
6.508GluGly: 6.508 ± 3.035
2.531GluHis: 2.531 ± 0.837
2.892GluIle: 2.892 ± 0.972
1.808GluLys: 1.808 ± 0.642
8.677GluLeu: 8.677 ± 0.973
1.808GluMet: 1.808 ± 0.642
2.892GluAsn: 2.892 ± 0.972
1.446GluPro: 1.446 ± 0.728
2.169GluGln: 2.169 ± 0.7
3.977GluArg: 3.977 ± 1.616
4.7GluSer: 4.7 ± 1.711
1.446GluThr: 1.446 ± 1.38
5.423GluVal: 5.423 ± 0.844
1.446GluTrp: 1.446 ± 0.728
2.169GluTyr: 2.169 ± 0.7
0.0GluXaa: 0.0 ± 0.0
Phe
2.892PheAla: 2.892 ± 0.649
1.808PheCys: 1.808 ± 0.638
4.7PheAsp: 4.7 ± 0.91
5.061PheGlu: 5.061 ± 1.668
2.169PhePhe: 2.169 ± 0.7
3.615PheGly: 3.615 ± 1.778
1.085PheHis: 1.085 ± 0.546
1.446PheIle: 1.446 ± 0.88
2.169PheLys: 2.169 ± 1.092
4.338PheLeu: 4.338 ± 1.401
0.362PheMet: 0.362 ± 0.67
2.892PheAsn: 2.892 ± 0.958
0.362PhePro: 0.362 ± 0.776
0.723PheGln: 0.723 ± 0.364
1.085PheArg: 1.085 ± 1.243
3.615PheSer: 3.615 ± 0.54
1.808PheThr: 1.808 ± 1.031
3.977PheVal: 3.977 ± 1.609
0.0PheTrp: 0.0 ± 0.0
1.446PheTyr: 1.446 ± 0.88
0.0PheXaa: 0.0 ± 0.0
Gly
4.338GlyAla: 4.338 ± 0.825
1.446GlyCys: 1.446 ± 0.695
2.892GlyAsp: 2.892 ± 1.695
4.338GlyGlu: 4.338 ± 0.825
2.892GlyPhe: 2.892 ± 2.528
3.615GlyGly: 3.615 ± 1.878
1.085GlyHis: 1.085 ± 0.546
2.531GlyIle: 2.531 ± 1.748
4.338GlyLys: 4.338 ± 2.265
7.231GlyLeu: 7.231 ± 0.852
1.446GlyMet: 1.446 ± 0.79
2.169GlyAsn: 2.169 ± 0.556
2.531GlyPro: 2.531 ± 0.453
2.892GlyGln: 2.892 ± 0.925
3.615GlyArg: 3.615 ± 2.661
4.7GlySer: 4.7 ± 1.945
5.061GlyThr: 5.061 ± 1.054
4.7GlyVal: 4.7 ± 0.953
0.362GlyTrp: 0.362 ± 0.182
1.808GlyTyr: 1.808 ± 0.91
0.0GlyXaa: 0.0 ± 0.0
His
2.169HisAla: 2.169 ± 0.858
0.0HisCys: 0.0 ± 0.0
1.085HisAsp: 1.085 ± 1.476
0.723HisGlu: 0.723 ± 0.364
0.0HisPhe: 0.0 ± 0.0
0.362HisGly: 0.362 ± 0.182
0.362HisHis: 0.362 ± 0.182
1.446HisIle: 1.446 ± 0.606
0.723HisLys: 0.723 ± 0.364
4.7HisLeu: 4.7 ± 1.296
0.362HisMet: 0.362 ± 0.182
2.169HisAsn: 2.169 ± 2.069
0.0HisPro: 0.0 ± 0.0
1.085HisGln: 1.085 ± 0.546
2.531HisArg: 2.531 ± 1.515
2.892HisSer: 2.892 ± 0.409
1.808HisThr: 1.808 ± 0.692
1.446HisVal: 1.446 ± 0.606
0.0HisTrp: 0.0 ± 0.0
0.723HisTyr: 0.723 ± 0.364
0.0HisXaa: 0.0 ± 0.0
Ile
4.338IleAla: 4.338 ± 1.927
2.531IleCys: 2.531 ± 0.911
3.254IleAsp: 3.254 ± 1.235
2.892IleGlu: 2.892 ± 1.212
2.531IlePhe: 2.531 ± 0.98
2.892IleGly: 2.892 ± 1.456
0.723IleHis: 0.723 ± 0.364
2.531IleIle: 2.531 ± 1.78
4.338IleLys: 4.338 ± 1.543
3.615IleLeu: 3.615 ± 2.402
1.446IleMet: 1.446 ± 0.606
3.615IleAsn: 3.615 ± 1.935
1.446IlePro: 1.446 ± 1.826
1.446IleGln: 1.446 ± 0.728
3.977IleArg: 3.977 ± 1.616
2.531IleSer: 2.531 ± 0.95
2.892IleThr: 2.892 ± 0.972
2.531IleVal: 2.531 ± 0.837
0.723IleTrp: 0.723 ± 0.913
1.446IleTyr: 1.446 ± 0.606
0.0IleXaa: 0.0 ± 0.0
Lys
3.254LysAla: 3.254 ± 1.293
1.808LysCys: 1.808 ± 0.91
3.615LysAsp: 3.615 ± 0.828
2.531LysGlu: 2.531 ± 1.087
3.615LysPhe: 3.615 ± 1.426
4.338LysGly: 4.338 ± 0.824
1.085LysHis: 1.085 ± 0.546
0.723LysIle: 0.723 ± 0.364
2.892LysLys: 2.892 ± 1.456
7.231LysLeu: 7.231 ± 2.553
1.085LysMet: 1.085 ± 0.576
1.446LysAsn: 1.446 ± 0.728
2.531LysPro: 2.531 ± 0.911
2.169LysGln: 2.169 ± 0.723
3.254LysArg: 3.254 ± 2.128
4.338LysSer: 4.338 ± 1.784
3.977LysThr: 3.977 ± 1.366
5.061LysVal: 5.061 ± 1.674
0.362LysTrp: 0.362 ± 0.182
1.808LysTyr: 1.808 ± 0.91
0.0LysXaa: 0.0 ± 0.0
Leu
5.785LeuAla: 5.785 ± 1.479
4.338LeuCys: 4.338 ± 1.574
6.508LeuAsp: 6.508 ± 1.384
6.869LeuGlu: 6.869 ± 1.516
3.977LeuPhe: 3.977 ± 1.084
7.231LeuGly: 7.231 ± 1.054
2.531LeuHis: 2.531 ± 0.8
5.061LeuIle: 5.061 ± 1.27
6.508LeuLys: 6.508 ± 1.853
8.677LeuLeu: 8.677 ± 2.536
1.446LeuMet: 1.446 ± 0.728
4.338LeuAsn: 4.338 ± 1.401
6.146LeuPro: 6.146 ± 0.979
3.254LeuGln: 3.254 ± 1.293
7.231LeuArg: 7.231 ± 1.591
6.146LeuSer: 6.146 ± 1.143
5.785LeuThr: 5.785 ± 1.803
7.231LeuVal: 7.231 ± 2.596
0.362LeuTrp: 0.362 ± 0.182
3.254LeuTyr: 3.254 ± 0.758
0.0LeuXaa: 0.0 ± 0.0
Met
3.615MetAla: 3.615 ± 1.834
0.723MetCys: 0.723 ± 0.364
1.808MetAsp: 1.808 ± 0.642
1.085MetGlu: 1.085 ± 0.546
0.0MetPhe: 0.0 ± 0.0
1.085MetGly: 1.085 ± 0.623
0.362MetHis: 0.362 ± 0.182
1.085MetIle: 1.085 ± 0.878
1.808MetLys: 1.808 ± 0.918
2.169MetLeu: 2.169 ± 0.556
0.0MetMet: 0.0 ± 0.0
0.362MetAsn: 0.362 ± 0.182
1.085MetPro: 1.085 ± 0.676
1.085MetGln: 1.085 ± 0.546
1.808MetArg: 1.808 ± 0.642
1.085MetSer: 1.085 ± 1.227
0.0MetThr: 0.0 ± 0.0
0.362MetVal: 0.362 ± 0.182
0.0MetTrp: 0.0 ± 0.0
0.362MetTyr: 0.362 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
5.061AsnAla: 5.061 ± 1.562
1.085AsnCys: 1.085 ± 0.663
0.723AsnAsp: 0.723 ± 0.364
3.254AsnGlu: 3.254 ± 1.12
2.169AsnPhe: 2.169 ± 1.092
0.723AsnGly: 0.723 ± 0.364
1.446AsnHis: 1.446 ± 0.816
0.362AsnIle: 0.362 ± 0.182
2.531AsnLys: 2.531 ± 1.276
5.061AsnLeu: 5.061 ± 2.9
1.446AsnMet: 1.446 ± 0.606
2.531AsnAsn: 2.531 ± 1.212
2.531AsnPro: 2.531 ± 1.888
2.169AsnGln: 2.169 ± 0.7
2.531AsnArg: 2.531 ± 1.227
1.085AsnSer: 1.085 ± 0.546
2.892AsnThr: 2.892 ± 0.409
1.085AsnVal: 1.085 ± 0.546
0.723AsnTrp: 0.723 ± 0.69
2.531AsnTyr: 2.531 ± 1.68
0.0AsnXaa: 0.0 ± 0.0
Pro
2.892ProAla: 2.892 ± 0.409
1.446ProCys: 1.446 ± 0.816
4.7ProAsp: 4.7 ± 1.19
4.7ProGlu: 4.7 ± 0.873
1.446ProPhe: 1.446 ± 1.423
3.254ProGly: 3.254 ± 1.709
1.446ProHis: 1.446 ± 0.606
2.531ProIle: 2.531 ± 1.515
0.362ProLys: 0.362 ± 0.182
3.254ProLeu: 3.254 ± 2.487
1.085ProMet: 1.085 ± 0.878
1.085ProAsn: 1.085 ± 1.304
1.808ProPro: 1.808 ± 0.711
1.446ProGln: 1.446 ± 0.606
2.531ProArg: 2.531 ± 0.911
4.338ProSer: 4.338 ± 2.562
2.169ProThr: 2.169 ± 0.641
0.362ProVal: 0.362 ± 0.182
0.723ProTrp: 0.723 ± 0.364
1.446ProTyr: 1.446 ± 0.728
0.0ProXaa: 0.0 ± 0.0
Gln
2.892GlnAla: 2.892 ± 1.119
1.446GlnCys: 1.446 ± 0.728
1.085GlnAsp: 1.085 ± 0.546
2.892GlnGlu: 2.892 ± 0.925
1.085GlnPhe: 1.085 ± 0.546
1.446GlnGly: 1.446 ± 0.625
0.723GlnHis: 0.723 ± 0.364
2.169GlnIle: 2.169 ± 1.326
2.169GlnLys: 2.169 ± 1.246
3.977GlnLeu: 3.977 ± 0.673
0.362GlnMet: 0.362 ± 0.191
1.085GlnAsn: 1.085 ± 1.304
0.723GlnPro: 0.723 ± 0.69
1.085GlnGln: 1.085 ± 0.546
2.169GlnArg: 2.169 ± 0.641
3.254GlnSer: 3.254 ± 0.443
1.808GlnThr: 1.808 ± 0.91
2.892GlnVal: 2.892 ± 2.759
0.362GlnTrp: 0.362 ± 0.182
0.723GlnTyr: 0.723 ± 0.705
0.0GlnXaa: 0.0 ± 0.0
Arg
3.977ArgAla: 3.977 ± 1.664
2.169ArgCys: 2.169 ± 2.739
3.615ArgAsp: 3.615 ± 1.284
2.892ArgGlu: 2.892 ± 1.456
5.785ArgPhe: 5.785 ± 0.661
2.892ArgGly: 2.892 ± 0.958
1.446ArgHis: 1.446 ± 1.125
2.892ArgIle: 2.892 ± 0.409
1.808ArgLys: 1.808 ± 1.035
5.423ArgLeu: 5.423 ± 1.494
1.085ArgMet: 1.085 ± 0.546
2.892ArgAsn: 2.892 ± 1.45
2.892ArgPro: 2.892 ± 2.405
1.808ArgGln: 1.808 ± 0.638
2.892ArgArg: 2.892 ± 2.241
3.615ArgSer: 3.615 ± 1.743
3.254ArgThr: 3.254 ± 1.641
2.531ArgVal: 2.531 ± 2.354
1.085ArgTrp: 1.085 ± 0.623
2.531ArgTyr: 2.531 ± 1.274
0.0ArgXaa: 0.0 ± 0.0
Ser
5.061SerAla: 5.061 ± 1.433
1.446SerCys: 1.446 ± 1.125
5.423SerAsp: 5.423 ± 1.327
4.7SerGlu: 4.7 ± 0.848
3.254SerPhe: 3.254 ± 1.335
5.423SerGly: 5.423 ± 2.286
1.808SerHis: 1.808 ± 2.391
4.338SerIle: 4.338 ± 1.34
4.7SerLys: 4.7 ± 1.711
7.231SerLeu: 7.231 ± 1.156
1.446SerMet: 1.446 ± 0.88
1.446SerAsn: 1.446 ± 0.606
2.169SerPro: 2.169 ± 0.7
1.808SerGln: 1.808 ± 0.91
3.977SerArg: 3.977 ± 0.611
5.061SerSer: 5.061 ± 2.539
4.338SerThr: 4.338 ± 1.402
5.423SerVal: 5.423 ± 0.844
0.362SerTrp: 0.362 ± 0.182
4.7SerTyr: 4.7 ± 2.175
0.0SerXaa: 0.0 ± 0.0
Thr
3.615ThrAla: 3.615 ± 1.277
0.723ThrCys: 0.723 ± 0.745
1.808ThrAsp: 1.808 ± 0.642
2.169ThrGlu: 2.169 ± 0.977
4.338ThrPhe: 4.338 ± 0.865
5.061ThrGly: 5.061 ± 1.429
2.169ThrHis: 2.169 ± 0.556
2.892ThrIle: 2.892 ± 0.925
1.446ThrLys: 1.446 ± 0.816
4.7ThrLeu: 4.7 ± 1.247
1.446ThrMet: 1.446 ± 0.606
2.169ThrAsn: 2.169 ± 0.641
2.892ThrPro: 2.892 ± 1.744
1.446ThrGln: 1.446 ± 1.38
3.254ThrArg: 3.254 ± 1.171
4.338ThrSer: 4.338 ± 1.036
2.531ThrThr: 2.531 ± 2.112
3.254ThrVal: 3.254 ± 1.638
0.362ThrTrp: 0.362 ± 0.793
1.808ThrTyr: 1.808 ± 1.46
0.0ThrXaa: 0.0 ± 0.0
Val
5.785ValAla: 5.785 ± 1.933
2.169ValCys: 2.169 ± 0.977
2.531ValAsp: 2.531 ± 1.276
3.254ValGlu: 3.254 ± 2.373
1.085ValPhe: 1.085 ± 0.663
4.7ValGly: 4.7 ± 1.629
1.446ValHis: 1.446 ± 0.606
5.785ValIle: 5.785 ± 1.68
3.977ValLys: 3.977 ± 1.439
5.785ValLeu: 5.785 ± 2.297
1.085ValMet: 1.085 ± 0.546
1.085ValAsn: 1.085 ± 0.546
3.615ValPro: 3.615 ± 1.732
2.892ValGln: 2.892 ± 1.212
3.254ValArg: 3.254 ± 1.087
7.954ValSer: 7.954 ± 2.981
3.977ValThr: 3.977 ± 1.63
5.785ValVal: 5.785 ± 1.85
1.085ValTrp: 1.085 ± 0.546
1.808ValTyr: 1.808 ± 0.642
0.0ValXaa: 0.0 ± 0.0
Trp
0.362TrpAla: 0.362 ± 0.793
0.362TrpCys: 0.362 ± 0.182
0.362TrpAsp: 0.362 ± 0.182
0.362TrpGlu: 0.362 ± 0.182
0.362TrpPhe: 0.362 ± 0.182
0.362TrpGly: 0.362 ± 0.182
0.362TrpHis: 0.362 ± 0.182
0.0TrpIle: 0.0 ± 0.0
0.723TrpLys: 0.723 ± 0.69
1.446TrpLeu: 1.446 ± 0.728
0.0TrpMet: 0.0 ± 0.0
0.362TrpAsn: 0.362 ± 0.793
1.085TrpPro: 1.085 ± 0.546
0.0TrpGln: 0.0 ± 0.0
0.362TrpArg: 0.362 ± 0.182
1.085TrpSer: 1.085 ± 0.623
0.0TrpThr: 0.0 ± 0.0
1.808TrpVal: 1.808 ± 1.027
0.0TrpTrp: 0.0 ± 0.0
0.362TrpTyr: 0.362 ± 0.182
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.254TyrAla: 3.254 ± 1.384
0.723TyrCys: 0.723 ± 0.69
0.723TyrAsp: 0.723 ± 0.364
2.169TyrGlu: 2.169 ± 1.092
1.085TyrPhe: 1.085 ± 1.184
1.808TyrGly: 1.808 ± 0.711
0.723TyrHis: 0.723 ± 0.705
3.254TyrIle: 3.254 ± 1.335
4.7TyrLys: 4.7 ± 1.175
4.338TyrLeu: 4.338 ± 0.825
1.446TyrMet: 1.446 ± 1.38
0.0TyrAsn: 0.0 ± 0.0
2.531TyrPro: 2.531 ± 1.087
0.723TyrGln: 0.723 ± 1.421
1.808TyrArg: 1.808 ± 0.638
2.169TyrSer: 2.169 ± 0.723
0.723TyrThr: 0.723 ± 0.745
2.169TyrVal: 2.169 ± 0.723
0.362TyrTrp: 0.362 ± 0.182
1.085TyrTyr: 1.085 ± 0.546
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (2767 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski