Amino acid dipepetide frequency for Flavobacterium kingsejongi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.034AlaAla: 6.034 ± 0.116
0.557AlaCys: 0.557 ± 0.021
3.63AlaAsp: 3.63 ± 0.062
4.256AlaGlu: 4.256 ± 0.088
3.497AlaPhe: 3.497 ± 0.066
4.819AlaGly: 4.819 ± 0.091
1.236AlaHis: 1.236 ± 0.037
5.922AlaIle: 5.922 ± 0.081
4.79AlaLys: 4.79 ± 0.081
7.236AlaLeu: 7.236 ± 0.098
1.645AlaMet: 1.645 ± 0.041
3.576AlaAsn: 3.576 ± 0.091
2.463AlaPro: 2.463 ± 0.067
2.808AlaGln: 2.808 ± 0.053
2.053AlaArg: 2.053 ± 0.045
4.265AlaSer: 4.265 ± 0.074
5.071AlaThr: 5.071 ± 0.146
4.976AlaVal: 4.976 ± 0.077
0.604AlaTrp: 0.604 ± 0.026
2.794AlaTyr: 2.794 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.518CysAla: 0.518 ± 0.032
0.116CysCys: 0.116 ± 0.009
0.416CysAsp: 0.416 ± 0.022
0.465CysGlu: 0.465 ± 0.036
0.402CysPhe: 0.402 ± 0.023
0.605CysGly: 0.605 ± 0.025
0.189CysHis: 0.189 ± 0.014
0.608CysIle: 0.608 ± 0.024
0.416CysLys: 0.416 ± 0.02
0.653CysLeu: 0.653 ± 0.026
0.14CysMet: 0.14 ± 0.01
0.419CysAsn: 0.419 ± 0.023
0.304CysPro: 0.304 ± 0.021
0.234CysGln: 0.234 ± 0.013
0.237CysArg: 0.237 ± 0.014
0.579CysSer: 0.579 ± 0.03
0.551CysThr: 0.551 ± 0.036
0.445CysVal: 0.445 ± 0.024
0.06CysTrp: 0.06 ± 0.007
0.311CysTyr: 0.311 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.982AspAla: 3.982 ± 0.074
0.407AspCys: 0.407 ± 0.019
2.49AspAsp: 2.49 ± 0.057
3.124AspGlu: 3.124 ± 0.069
3.506AspPhe: 3.506 ± 0.059
3.481AspGly: 3.481 ± 0.062
0.964AspHis: 0.964 ± 0.031
3.877AspIle: 3.877 ± 0.067
3.825AspLys: 3.825 ± 0.079
4.903AspLeu: 4.903 ± 0.09
1.032AspMet: 1.032 ± 0.033
2.832AspAsn: 2.832 ± 0.05
1.893AspPro: 1.893 ± 0.058
1.571AspGln: 1.571 ± 0.036
1.944AspArg: 1.944 ± 0.047
2.982AspSer: 2.982 ± 0.055
3.106AspThr: 3.106 ± 0.053
3.15AspVal: 3.15 ± 0.062
0.671AspTrp: 0.671 ± 0.026
2.823AspTyr: 2.823 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.591GluAla: 4.591 ± 0.085
0.32GluCys: 0.32 ± 0.018
3.034GluAsp: 3.034 ± 0.064
4.175GluGlu: 4.175 ± 0.092
2.695GluPhe: 2.695 ± 0.049
3.505GluGly: 3.505 ± 0.079
1.108GluHis: 1.108 ± 0.033
5.102GluIle: 5.102 ± 0.083
5.721GluLys: 5.721 ± 0.093
5.732GluLeu: 5.732 ± 0.094
1.518GluMet: 1.518 ± 0.035
4.284GluAsn: 4.284 ± 0.065
1.484GluPro: 1.484 ± 0.039
2.378GluGln: 2.378 ± 0.054
2.377GluArg: 2.377 ± 0.053
3.165GluSer: 3.165 ± 0.053
3.534GluThr: 3.534 ± 0.063
3.917GluVal: 3.917 ± 0.069
0.664GluTrp: 0.664 ± 0.024
2.477GluTyr: 2.477 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.153PheAla: 3.153 ± 0.054
0.518PheCys: 0.518 ± 0.031
3.04PheAsp: 3.04 ± 0.055
3.294PheGlu: 3.294 ± 0.05
2.608PhePhe: 2.608 ± 0.055
3.547PheGly: 3.547 ± 0.072
0.873PheHis: 0.873 ± 0.033
3.586PheIle: 3.586 ± 0.067
3.19PheLys: 3.19 ± 0.064
4.531PheLeu: 4.531 ± 0.083
1.112PheMet: 1.112 ± 0.031
2.718PheAsn: 2.718 ± 0.048
1.755PhePro: 1.755 ± 0.041
1.623PheGln: 1.623 ± 0.038
1.858PheArg: 1.858 ± 0.04
3.839PheSer: 3.839 ± 0.071
3.349PheThr: 3.349 ± 0.072
2.896PheVal: 2.896 ± 0.056
0.534PheTrp: 0.534 ± 0.025
2.168PheTyr: 2.168 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.408GlyAla: 4.408 ± 0.086
0.663GlyCys: 0.663 ± 0.043
3.063GlyAsp: 3.063 ± 0.058
3.255GlyGlu: 3.255 ± 0.065
3.411GlyPhe: 3.411 ± 0.066
4.495GlyGly: 4.495 ± 0.112
1.149GlyHis: 1.149 ± 0.033
5.668GlyIle: 5.668 ± 0.069
4.963GlyLys: 4.963 ± 0.077
5.658GlyLeu: 5.658 ± 0.077
1.7GlyMet: 1.7 ± 0.041
3.847GlyAsn: 3.847 ± 0.07
1.399GlyPro: 1.399 ± 0.05
2.096GlyGln: 2.096 ± 0.045
2.059GlyArg: 2.059 ± 0.048
4.132GlySer: 4.132 ± 0.076
4.912GlyThr: 4.912 ± 0.15
4.122GlyVal: 4.122 ± 0.063
0.748GlyTrp: 0.748 ± 0.024
2.939GlyTyr: 2.939 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.028HisAla: 1.028 ± 0.029
0.177HisCys: 0.177 ± 0.012
0.841HisAsp: 0.841 ± 0.028
1.01HisGlu: 1.01 ± 0.032
1.224HisPhe: 1.224 ± 0.034
0.994HisGly: 0.994 ± 0.031
0.48HisHis: 0.48 ± 0.023
1.286HisIle: 1.286 ± 0.034
1.222HisLys: 1.222 ± 0.034
1.767HisLeu: 1.767 ± 0.042
0.315HisMet: 0.315 ± 0.017
1.041HisAsn: 1.041 ± 0.044
0.914HisPro: 0.914 ± 0.03
0.72HisGln: 0.72 ± 0.027
0.649HisArg: 0.649 ± 0.021
1.08HisSer: 1.08 ± 0.035
1.126HisThr: 1.126 ± 0.033
0.844HisVal: 0.844 ± 0.027
0.201HisTrp: 0.201 ± 0.013
1.016HisTyr: 1.016 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.32IleAla: 6.32 ± 0.08
0.631IleCys: 0.631 ± 0.022
4.287IleAsp: 4.287 ± 0.069
4.759IleGlu: 4.759 ± 0.085
3.301IlePhe: 3.301 ± 0.049
5.055IleGly: 5.055 ± 0.074
1.396IleHis: 1.396 ± 0.035
5.925IleIle: 5.925 ± 0.092
4.967IleLys: 4.967 ± 0.076
6.829IleLeu: 6.829 ± 0.095
1.458IleMet: 1.458 ± 0.039
4.144IleAsn: 4.144 ± 0.061
3.379IlePro: 3.379 ± 0.056
2.868IleGln: 2.868 ± 0.055
3.041IleArg: 3.041 ± 0.051
5.157IleSer: 5.157 ± 0.081
5.487IleThr: 5.487 ± 0.096
5.07IleVal: 5.07 ± 0.073
0.661IleTrp: 0.661 ± 0.023
2.746IleTyr: 2.746 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.189LysAla: 5.189 ± 0.091
0.313LysCys: 0.313 ± 0.015
4.006LysAsp: 4.006 ± 0.085
5.54LysGlu: 5.54 ± 0.089
2.688LysPhe: 2.688 ± 0.053
4.256LysGly: 4.256 ± 0.073
1.157LysHis: 1.157 ± 0.037
6.149LysIle: 6.149 ± 0.093
6.586LysLys: 6.586 ± 0.104
5.928LysLeu: 5.928 ± 0.084
2.174LysMet: 2.174 ± 0.041
4.995LysAsn: 4.995 ± 0.088
2.326LysPro: 2.326 ± 0.056
2.505LysGln: 2.505 ± 0.056
2.554LysArg: 2.554 ± 0.051
4.282LysSer: 4.282 ± 0.076
4.504LysThr: 4.504 ± 0.082
4.33LysVal: 4.33 ± 0.076
0.699LysTrp: 0.699 ± 0.023
2.8LysTyr: 2.8 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.147LeuAla: 6.147 ± 0.083
0.725LeuCys: 0.725 ± 0.028
4.709LeuAsp: 4.709 ± 0.075
5.857LeuGlu: 5.857 ± 0.092
4.92LeuPhe: 4.92 ± 0.082
5.578LeuGly: 5.578 ± 0.075
1.751LeuHis: 1.751 ± 0.038
6.484LeuIle: 6.484 ± 0.094
7.099LeuLys: 7.099 ± 0.105
9.449LeuLeu: 9.449 ± 0.136
2.118LeuMet: 2.118 ± 0.04
5.052LeuAsn: 5.052 ± 0.075
3.824LeuPro: 3.824 ± 0.054
3.88LeuGln: 3.88 ± 0.076
3.202LeuArg: 3.202 ± 0.055
6.59LeuSer: 6.59 ± 0.082
5.435LeuThr: 5.435 ± 0.131
5.274LeuVal: 5.274 ± 0.075
0.819LeuTrp: 0.819 ± 0.031
3.439LeuTyr: 3.439 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
1.748MetAla: 1.748 ± 0.041
0.124MetCys: 0.124 ± 0.011
1.234MetAsp: 1.234 ± 0.032
1.474MetGlu: 1.474 ± 0.039
0.778MetPhe: 0.778 ± 0.029
1.389MetGly: 1.389 ± 0.033
0.421MetHis: 0.421 ± 0.019
1.643MetIle: 1.643 ± 0.039
2.229MetLys: 2.229 ± 0.049
1.971MetLeu: 1.971 ± 0.04
0.602MetMet: 0.602 ± 0.026
1.278MetAsn: 1.278 ± 0.033
0.875MetPro: 0.875 ± 0.029
0.863MetGln: 0.863 ± 0.029
0.831MetArg: 0.831 ± 0.03
1.382MetSer: 1.382 ± 0.04
1.293MetThr: 1.293 ± 0.037
1.417MetVal: 1.417 ± 0.04
0.172MetTrp: 0.172 ± 0.013
0.69MetTyr: 0.69 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.183AsnAla: 4.183 ± 0.07
0.453AsnCys: 0.453 ± 0.025
2.971AsnAsp: 2.971 ± 0.057
3.262AsnGlu: 3.262 ± 0.075
2.836AsnPhe: 2.836 ± 0.054
4.2AsnGly: 4.2 ± 0.094
1.022AsnHis: 1.022 ± 0.034
4.268AsnIle: 4.268 ± 0.08
3.589AsnLys: 3.589 ± 0.064
5.003AsnLeu: 5.003 ± 0.075
1.171AsnMet: 1.171 ± 0.034
3.517AsnAsn: 3.517 ± 0.074
2.95AsnPro: 2.95 ± 0.06
2.119AsnGln: 2.119 ± 0.049
2.134AsnArg: 2.134 ± 0.048
3.579AsnSer: 3.579 ± 0.066
3.815AsnThr: 3.815 ± 0.079
3.337AsnVal: 3.337 ± 0.068
0.67AsnTrp: 0.67 ± 0.024
2.836AsnTyr: 2.836 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.685ProAla: 2.685 ± 0.08
0.202ProCys: 0.202 ± 0.014
2.179ProAsp: 2.179 ± 0.054
3.16ProGlu: 3.16 ± 0.055
1.925ProPhe: 1.925 ± 0.04
2.319ProGly: 2.319 ± 0.062
0.574ProHis: 0.574 ± 0.024
2.607ProIle: 2.607 ± 0.047
2.47ProLys: 2.47 ± 0.06
3.131ProLeu: 3.131 ± 0.058
0.797ProMet: 0.797 ± 0.024
2.237ProAsn: 2.237 ± 0.049
0.896ProPro: 0.896 ± 0.036
1.251ProGln: 1.251 ± 0.034
0.863ProArg: 0.863 ± 0.028
2.03ProSer: 2.03 ± 0.046
2.373ProThr: 2.373 ± 0.114
2.961ProVal: 2.961 ± 0.061
0.293ProTrp: 0.293 ± 0.015
1.462ProTyr: 1.462 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.313GlnAla: 2.313 ± 0.054
0.228GlnCys: 0.228 ± 0.018
1.756GlnAsp: 1.756 ± 0.038
2.384GlnGlu: 2.384 ± 0.05
1.761GlnPhe: 1.761 ± 0.048
1.815GlnGly: 1.815 ± 0.04
0.766GlnHis: 0.766 ± 0.029
2.581GlnIle: 2.581 ± 0.045
3.145GlnLys: 3.145 ± 0.053
3.956GlnLeu: 3.956 ± 0.08
0.813GlnMet: 0.813 ± 0.024
2.26GlnAsn: 2.26 ± 0.043
1.253GlnPro: 1.253 ± 0.034
1.796GlnGln: 1.796 ± 0.042
1.26GlnArg: 1.26 ± 0.04
2.132GlnSer: 2.132 ± 0.052
2.024GlnThr: 2.024 ± 0.049
2.069GlnVal: 2.069 ± 0.044
0.458GlnTrp: 0.458 ± 0.021
1.613GlnTyr: 1.613 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.018ArgAla: 2.018 ± 0.049
0.184ArgCys: 0.184 ± 0.012
1.784ArgAsp: 1.784 ± 0.04
2.241ArgGlu: 2.241 ± 0.047
1.863ArgPhe: 1.863 ± 0.038
1.836ArgGly: 1.836 ± 0.042
0.616ArgHis: 0.616 ± 0.024
3.009ArgIle: 3.009 ± 0.054
3.02ArgLys: 3.02 ± 0.054
3.218ArgLeu: 3.218 ± 0.061
1.033ArgMet: 1.033 ± 0.03
2.23ArgAsn: 2.23 ± 0.039
1.138ArgPro: 1.138 ± 0.036
1.209ArgGln: 1.209 ± 0.037
1.222ArgArg: 1.222 ± 0.036
1.999ArgSer: 1.999 ± 0.051
1.87ArgThr: 1.87 ± 0.044
2.03ArgVal: 2.03 ± 0.047
0.388ArgTrp: 0.388 ± 0.016
1.643ArgTyr: 1.643 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.088SerAla: 4.088 ± 0.063
0.653SerCys: 0.653 ± 0.03
3.386SerAsp: 3.386 ± 0.062
3.606SerGlu: 3.606 ± 0.062
3.531SerPhe: 3.531 ± 0.068
5.054SerGly: 5.054 ± 0.092
1.094SerHis: 1.094 ± 0.034
4.752SerIle: 4.752 ± 0.075
4.277SerLys: 4.277 ± 0.075
5.722SerLeu: 5.722 ± 0.07
1.265SerMet: 1.265 ± 0.037
3.355SerAsn: 3.355 ± 0.062
2.194SerPro: 2.194 ± 0.056
2.129SerGln: 2.129 ± 0.04
2.243SerArg: 2.243 ± 0.044
3.804SerSer: 3.804 ± 0.074
3.59SerThr: 3.59 ± 0.072
4.055SerVal: 4.055 ± 0.072
0.703SerTrp: 0.703 ± 0.029
2.803SerTyr: 2.803 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.58ThrAla: 5.58 ± 0.168
0.392ThrCys: 0.392 ± 0.023
3.517ThrAsp: 3.517 ± 0.071
3.562ThrGlu: 3.562 ± 0.057
2.961ThrPhe: 2.961 ± 0.052
4.822ThrGly: 4.822 ± 0.126
1.055ThrHis: 1.055 ± 0.046
5.573ThrIle: 5.573 ± 0.098
3.634ThrLys: 3.634 ± 0.058
5.945ThrLeu: 5.945 ± 0.094
1.079ThrMet: 1.079 ± 0.033
3.406ThrAsn: 3.406 ± 0.098
3.101ThrPro: 3.101 ± 0.097
2.186ThrGln: 2.186 ± 0.052
1.775ThrArg: 1.775 ± 0.044
3.485ThrSer: 3.485 ± 0.076
4.765ThrThr: 4.765 ± 0.165
4.972ThrVal: 4.972 ± 0.161
0.567ThrTrp: 0.567 ± 0.035
2.558ThrTyr: 2.558 ± 0.075
0.0ThrXaa: 0.0 ± 0.0
Val
4.944ValAla: 4.944 ± 0.08
0.536ValCys: 0.536 ± 0.027
3.115ValAsp: 3.115 ± 0.066
3.365ValGlu: 3.365 ± 0.059
3.358ValPhe: 3.358 ± 0.059
3.638ValGly: 3.638 ± 0.064
1.064ValHis: 1.064 ± 0.03
4.899ValIle: 4.899 ± 0.073
4.135ValLys: 4.135 ± 0.07
6.126ValLeu: 6.126 ± 0.079
1.373ValMet: 1.373 ± 0.037
3.405ValAsn: 3.405 ± 0.124
2.48ValPro: 2.48 ± 0.053
2.122ValGln: 2.122 ± 0.043
2.141ValArg: 2.141 ± 0.052
4.334ValSer: 4.334 ± 0.073
4.571ValThr: 4.571 ± 0.145
4.359ValVal: 4.359 ± 0.084
0.579ValTrp: 0.579 ± 0.023
2.451ValTyr: 2.451 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.614TrpAla: 0.614 ± 0.026
0.094TrpCys: 0.094 ± 0.009
0.536TrpAsp: 0.536 ± 0.022
0.654TrpGlu: 0.654 ± 0.023
0.515TrpPhe: 0.515 ± 0.02
0.619TrpGly: 0.619 ± 0.023
0.206TrpHis: 0.206 ± 0.011
0.781TrpIle: 0.781 ± 0.026
0.802TrpLys: 0.802 ± 0.027
0.896TrpLeu: 0.896 ± 0.03
0.317TrpMet: 0.317 ± 0.017
0.705TrpAsn: 0.705 ± 0.03
0.201TrpPro: 0.201 ± 0.016
0.441TrpGln: 0.441 ± 0.019
0.331TrpArg: 0.331 ± 0.016
0.621TrpSer: 0.621 ± 0.025
0.562TrpThr: 0.562 ± 0.026
0.561TrpVal: 0.561 ± 0.022
0.135TrpTrp: 0.135 ± 0.013
0.475TrpTyr: 0.475 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.69TyrAla: 2.69 ± 0.052
0.376TyrCys: 0.376 ± 0.019
2.571TyrAsp: 2.571 ± 0.059
2.339TyrGlu: 2.339 ± 0.042
2.412TyrPhe: 2.412 ± 0.045
2.656TyrGly: 2.656 ± 0.049
0.816TyrHis: 0.816 ± 0.026
2.763TyrIle: 2.763 ± 0.05
2.901TyrLys: 2.901 ± 0.061
3.698TyrLeu: 3.698 ± 0.065
0.747TyrMet: 0.747 ± 0.025
2.616TyrAsn: 2.616 ± 0.055
1.585TyrPro: 1.585 ± 0.039
1.585TyrGln: 1.585 ± 0.04
1.779TyrArg: 1.779 ± 0.041
2.866TyrSer: 2.866 ± 0.055
2.995TyrThr: 2.995 ± 0.077
2.208TyrVal: 2.208 ± 0.049
0.441TyrTrp: 0.441 ± 0.019
2.102TyrTyr: 2.102 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3535 proteins (1176805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski