Amino acid dipepetide frequency for Nocardia panacis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.831AlaAla: 22.831 ± 0.175	1.006AlaCys: 1.006 ± 0.024	8.591AlaAsp: 8.591 ± 0.076	9.223AlaGlu: 9.223 ± 0.093	3.344AlaPhe: 3.344 ± 0.045	12.17AlaGly: 12.17 ± 0.072	2.94AlaHis: 2.94 ± 0.034	5.227AlaIle: 5.227 ± 0.056	2.81AlaLys: 2.81 ± 0.047	14.137AlaLeu: 14.137 ± 0.103	2.743AlaMet: 2.743 ± 0.036	2.541AlaAsn: 2.541 ± 0.039	6.768AlaPro: 6.768 ± 0.075	4.105AlaGln: 4.105 ± 0.053	10.169AlaArg: 10.169 ± 0.089	5.114AlaSer: 5.114 ± 0.051	7.298AlaThr: 7.298 ± 0.064	11.684AlaVal: 11.684 ± 0.105	1.611AlaTrp: 1.611 ± 0.032	2.394AlaTyr: 2.394 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.169CysAla: 1.169 ± 0.03	0.097CysCys: 0.097 ± 0.007	0.482CysAsp: 0.482 ± 0.016	0.406CysGlu: 0.406 ± 0.014	0.225CysPhe: 0.225 ± 0.011	0.994CysGly: 0.994 ± 0.025	0.179CysHis: 0.179 ± 0.01	0.173CysIle: 0.173 ± 0.009	0.11CysLys: 0.11 ± 0.008	0.749CysLeu: 0.749 ± 0.021	0.098CysMet: 0.098 ± 0.007	0.124CysAsn: 0.124 ± 0.01	0.464CysPro: 0.464 ± 0.015	0.182CysGln: 0.182 ± 0.008	0.618CysArg: 0.618 ± 0.019	0.418CysSer: 0.418 ± 0.015	0.456CysThr: 0.456 ± 0.015	0.61CysVal: 0.61 ± 0.019	0.129CysTrp: 0.129 ± 0.008	0.171CysTyr: 0.171 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.345AspAla: 7.345 ± 0.058	0.441AspCys: 0.441 ± 0.017	3.105AspAsp: 3.105 ± 0.038	3.387AspGlu: 3.387 ± 0.044	1.772AspPhe: 1.772 ± 0.03	5.323AspGly: 5.323 ± 0.052	1.415AspHis: 1.415 ± 0.026	2.688AspIle: 2.688 ± 0.036	1.163AspLys: 1.163 ± 0.026	6.503AspLeu: 6.503 ± 0.07	0.904AspMet: 0.904 ± 0.022	1.193AspAsn: 1.193 ± 0.027	4.785AspPro: 4.785 ± 0.051	1.758AspGln: 1.758 ± 0.031	5.33AspArg: 5.33 ± 0.064	3.004AspSer: 3.004 ± 0.036	3.258AspThr: 3.258 ± 0.043	3.72AspVal: 3.72 ± 0.048	0.97AspTrp: 0.97 ± 0.021	1.422AspTyr: 1.422 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.89GluAla: 5.89 ± 0.065	0.388GluCys: 0.388 ± 0.015	2.285GluAsp: 2.285 ± 0.036	2.347GluGlu: 2.347 ± 0.043	2.182GluPhe: 2.182 ± 0.035	3.227GluGly: 3.227 ± 0.054	1.593GluHis: 1.593 ± 0.033	2.976GluIle: 2.976 ± 0.04	1.12GluLys: 1.12 ± 0.032	7.362GluLeu: 7.362 ± 0.082	1.076GluMet: 1.076 ± 0.024	1.052GluAsn: 1.052 ± 0.025	3.112GluPro: 3.112 ± 0.047	2.456GluGln: 2.456 ± 0.037	5.117GluArg: 5.117 ± 0.059	3.176GluSer: 3.176 ± 0.046	2.79GluThr: 2.79 ± 0.032	4.655GluVal: 4.655 ± 0.063	0.841GluTrp: 0.841 ± 0.024	1.255GluTyr: 1.255 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.283PheAla: 4.283 ± 0.051	0.267PheCys: 0.267 ± 0.011	2.522PheAsp: 2.522 ± 0.044	1.596PheGlu: 1.596 ± 0.035	0.882PhePhe: 0.882 ± 0.021	3.58PheGly: 3.58 ± 0.046	0.673PheHis: 0.673 ± 0.018	0.883PheIle: 0.883 ± 0.023	0.443PheLys: 0.443 ± 0.016	2.587PheLeu: 2.587 ± 0.043	0.404PheMet: 0.404 ± 0.014	0.585PheAsn: 0.585 ± 0.016	1.45PhePro: 1.45 ± 0.025	0.727PheGln: 0.727 ± 0.021	1.883PheArg: 1.883 ± 0.029	1.404PheSer: 1.404 ± 0.027	2.021PheThr: 2.021 ± 0.036	2.425PheVal: 2.425 ± 0.035	0.408PheTrp: 0.408 ± 0.016	0.624PheTyr: 0.624 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	11.165GlyAla: 11.165 ± 0.087	0.809GlyCys: 0.809 ± 0.026	4.482GlyAsp: 4.482 ± 0.051	4.527GlyGlu: 4.527 ± 0.063	3.027GlyPhe: 3.027 ± 0.043	7.678GlyGly: 7.678 ± 0.089	2.057GlyHis: 2.057 ± 0.034	4.308GlyIle: 4.308 ± 0.052	2.272GlyLys: 2.272 ± 0.036	8.822GlyLeu: 8.822 ± 0.069	1.998GlyMet: 1.998 ± 0.032	1.846GlyAsn: 1.846 ± 0.033	4.644GlyPro: 4.644 ± 0.051	2.431GlyGln: 2.431 ± 0.038	6.988GlyArg: 6.988 ± 0.06	5.043GlySer: 5.043 ± 0.058	5.146GlyThr: 5.146 ± 0.053	7.369GlyVal: 7.369 ± 0.066	1.609GlyTrp: 1.609 ± 0.029	2.399GlyTyr: 2.399 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.576HisAla: 2.576 ± 0.034	0.231HisCys: 0.231 ± 0.012	1.261HisAsp: 1.261 ± 0.026	1.159HisGlu: 1.159 ± 0.027	0.684HisPhe: 0.684 ± 0.016	2.153HisGly: 2.153 ± 0.032	0.698HisHis: 0.698 ± 0.02	0.871HisIle: 0.871 ± 0.022	0.305HisLys: 0.305 ± 0.011	2.331HisLeu: 2.331 ± 0.033	0.349HisMet: 0.349 ± 0.013	0.474HisAsn: 0.474 ± 0.016	1.782HisPro: 1.782 ± 0.03	0.606HisGln: 0.606 ± 0.016	2.188HisArg: 2.188 ± 0.036	1.103HisSer: 1.103 ± 0.025	1.33HisThr: 1.33 ± 0.024	1.375HisVal: 1.375 ± 0.029	0.384HisTrp: 0.384 ± 0.012	0.535HisTyr: 0.535 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.755IleAla: 6.755 ± 0.058	0.335IleCys: 0.335 ± 0.013	3.417IleAsp: 3.417 ± 0.048	2.794IleGlu: 2.794 ± 0.037	1.027IlePhe: 1.027 ± 0.027	4.733IleGly: 4.733 ± 0.05	0.765IleHis: 0.765 ± 0.02	1.323IleIle: 1.323 ± 0.03	0.748IleLys: 0.748 ± 0.019	3.245IleLeu: 3.245 ± 0.046	0.581IleMet: 0.581 ± 0.017	0.91IleAsn: 0.91 ± 0.023	2.516IlePro: 2.516 ± 0.037	0.906IleGln: 0.906 ± 0.02	2.947IleArg: 2.947 ± 0.038	2.15IleSer: 2.15 ± 0.037	2.661IleThr: 2.661 ± 0.043	3.47IleVal: 3.47 ± 0.046	0.486IleTrp: 0.486 ± 0.016	0.749IleTyr: 0.749 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.313LysAla: 2.313 ± 0.04	0.113LysCys: 0.113 ± 0.008	0.95LysAsp: 0.95 ± 0.023	0.835LysGlu: 0.835 ± 0.02	0.599LysPhe: 0.599 ± 0.017	1.42LysGly: 1.42 ± 0.032	0.402LysHis: 0.402 ± 0.015	0.887LysIle: 0.887 ± 0.023	0.554LysLys: 0.554 ± 0.022	2.02LysLeu: 2.02 ± 0.035	0.411LysMet: 0.411 ± 0.014	0.458LysAsn: 0.458 ± 0.015	1.336LysPro: 1.336 ± 0.031	0.715LysGln: 0.715 ± 0.019	1.343LysArg: 1.343 ± 0.026	1.271LysSer: 1.271 ± 0.025	1.206LysThr: 1.206 ± 0.028	1.693LysVal: 1.693 ± 0.032	0.278LysTrp: 0.278 ± 0.012	0.475LysTyr: 0.475 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.296LeuAla: 15.296 ± 0.111	0.854LeuCys: 0.854 ± 0.022	6.868LeuAsp: 6.868 ± 0.07	4.736LeuGlu: 4.736 ± 0.05	2.808LeuPhe: 2.808 ± 0.042	9.224LeuGly: 9.224 ± 0.074	2.133LeuHis: 2.133 ± 0.029	4.304LeuIle: 4.304 ± 0.048	1.384LeuLys: 1.384 ± 0.028	10.651LeuLeu: 10.651 ± 0.099	1.539LeuMet: 1.539 ± 0.033	1.94LeuAsn: 1.94 ± 0.034	6.239LeuPro: 6.239 ± 0.067	2.096LeuGln: 2.096 ± 0.032	9.226LeuArg: 9.226 ± 0.086	5.52LeuSer: 5.52 ± 0.059	6.656LeuThr: 6.656 ± 0.066	8.464LeuVal: 8.464 ± 0.07	1.211LeuTrp: 1.211 ± 0.028	1.696LeuTyr: 1.696 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.337MetAla: 2.337 ± 0.034	0.146MetCys: 0.146 ± 0.008	0.9MetAsp: 0.9 ± 0.02	0.632MetGlu: 0.632 ± 0.021	0.588MetPhe: 0.588 ± 0.018	1.336MetGly: 1.336 ± 0.027	0.374MetHis: 0.374 ± 0.013	0.899MetIle: 0.899 ± 0.022	0.368MetLys: 0.368 ± 0.013	1.867MetLeu: 1.867 ± 0.03	0.325MetMet: 0.325 ± 0.013	0.471MetAsn: 0.471 ± 0.016	1.141MetPro: 1.141 ± 0.023	0.46MetGln: 0.46 ± 0.015	1.639MetArg: 1.639 ± 0.027	1.406MetSer: 1.406 ± 0.027	1.562MetThr: 1.562 ± 0.03	1.598MetVal: 1.598 ± 0.029	0.234MetTrp: 0.234 ± 0.01	0.338MetTyr: 0.338 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.473AsnAla: 2.473 ± 0.036	0.168AsnCys: 0.168 ± 0.01	0.999AsnAsp: 0.999 ± 0.024	0.9AsnGlu: 0.9 ± 0.023	0.589AsnPhe: 0.589 ± 0.018	1.982AsnGly: 1.982 ± 0.036	0.429AsnHis: 0.429 ± 0.015	0.899AsnIle: 0.899 ± 0.023	0.428AsnLys: 0.428 ± 0.016	1.923AsnLeu: 1.923 ± 0.029	0.391AsnMet: 0.391 ± 0.015	0.506AsnAsn: 0.506 ± 0.018	1.706AsnPro: 1.706 ± 0.035	0.601AsnGln: 0.601 ± 0.019	1.553AsnArg: 1.553 ± 0.026	1.199AsnSer: 1.199 ± 0.024	1.285AsnThr: 1.285 ± 0.026	1.393AsnVal: 1.393 ± 0.029	0.347AsnTrp: 0.347 ± 0.012	0.508AsnTyr: 0.508 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.71ProAla: 7.71 ± 0.08	0.327ProCys: 0.327 ± 0.013	4.361ProAsp: 4.361 ± 0.048	4.276ProGlu: 4.276 ± 0.057	1.579ProPhe: 1.579 ± 0.026	5.484ProGly: 5.484 ± 0.061	1.283ProHis: 1.283 ± 0.029	2.384ProIle: 2.384 ± 0.036	1.284ProLys: 1.284 ± 0.03	5.136ProLeu: 5.136 ± 0.059	1.055ProMet: 1.055 ± 0.025	1.396ProAsn: 1.396 ± 0.031	3.232ProPro: 3.232 ± 0.056	1.887ProGln: 1.887 ± 0.04	3.782ProArg: 3.782 ± 0.047	2.817ProSer: 2.817 ± 0.042	3.676ProThr: 3.676 ± 0.046	5.037ProVal: 5.037 ± 0.06	0.855ProTrp: 0.855 ± 0.02	1.103ProTyr: 1.103 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.579GlnAla: 3.579 ± 0.042	0.185GlnCys: 0.185 ± 0.011	1.162GlnAsp: 1.162 ± 0.025	1.147GlnGlu: 1.147 ± 0.026	0.859GlnPhe: 0.859 ± 0.022	1.95GlnGly: 1.95 ± 0.037	0.701GlnHis: 0.701 ± 0.018	1.363GlnIle: 1.363 ± 0.023	0.494GlnLys: 0.494 ± 0.018	3.354GlnLeu: 3.354 ± 0.043	0.6GlnMet: 0.6 ± 0.017	0.541GlnAsn: 0.541 ± 0.018	1.8GlnPro: 1.8 ± 0.038	1.346GlnGln: 1.346 ± 0.036	2.726GlnArg: 2.726 ± 0.039	1.342GlnSer: 1.342 ± 0.026	1.481GlnThr: 1.481 ± 0.024	2.643GlnVal: 2.643 ± 0.041	0.577GlnTrp: 0.577 ± 0.016	0.615GlnTyr: 0.615 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.247ArgAla: 10.247 ± 0.089	0.601ArgCys: 0.601 ± 0.02	4.509ArgAsp: 4.509 ± 0.057	4.62ArgGlu: 4.62 ± 0.06	2.606ArgPhe: 2.606 ± 0.034	5.648ArgGly: 5.648 ± 0.052	1.957ArgHis: 1.957 ± 0.032	4.182ArgIle: 4.182 ± 0.041	1.612ArgLys: 1.612 ± 0.029	8.386ArgLeu: 8.386 ± 0.07	1.994ArgMet: 1.994 ± 0.029	1.629ArgAsn: 1.629 ± 0.028	4.448ArgPro: 4.448 ± 0.05	2.291ArgGln: 2.291 ± 0.035	7.34ArgArg: 7.34 ± 0.082	4.024ArgSer: 4.024 ± 0.038	5.225ArgThr: 5.225 ± 0.054	6.142ArgVal: 6.142 ± 0.053	1.394ArgTrp: 1.394 ± 0.024	2.001ArgTyr: 2.001 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.002SerAla: 7.002 ± 0.064	0.381SerCys: 0.381 ± 0.015	2.843SerAsp: 2.843 ± 0.041	2.589SerGlu: 2.589 ± 0.045	1.506SerPhe: 1.506 ± 0.028	6.013SerGly: 6.013 ± 0.061	0.984SerHis: 0.984 ± 0.021	2.065SerIle: 2.065 ± 0.03	1.024SerLys: 1.024 ± 0.026	4.403SerLeu: 4.403 ± 0.045	1.196SerMet: 1.196 ± 0.029	1.032SerAsn: 1.032 ± 0.022	2.762SerPro: 2.762 ± 0.037	1.222SerGln: 1.222 ± 0.027	3.623SerArg: 3.623 ± 0.05	2.673SerSer: 2.673 ± 0.046	3.183SerThr: 3.183 ± 0.039	4.286SerVal: 4.286 ± 0.046	0.834SerTrp: 0.834 ± 0.02	1.135SerTyr: 1.135 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.366ThrAla: 8.366 ± 0.076	0.416ThrCys: 0.416 ± 0.016	3.616ThrAsp: 3.616 ± 0.041	3.563ThrGlu: 3.563 ± 0.039	1.657ThrPhe: 1.657 ± 0.026	5.946ThrGly: 5.946 ± 0.064	1.231ThrHis: 1.231 ± 0.026	2.385ThrIle: 2.385 ± 0.035	1.231ThrLys: 1.231 ± 0.024	5.749ThrLeu: 5.749 ± 0.053	1.118ThrMet: 1.118 ± 0.022	1.125ThrAsn: 1.125 ± 0.021	3.788ThrPro: 3.788 ± 0.043	1.401ThrGln: 1.401 ± 0.029	4.015ThrArg: 4.015 ± 0.042	2.817ThrSer: 2.817 ± 0.038	3.598ThrThr: 3.598 ± 0.054	5.729ThrVal: 5.729 ± 0.06	0.804ThrTrp: 0.804 ± 0.022	1.255ThrTyr: 1.255 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	11.367ValAla: 11.367 ± 0.096	0.729ValCys: 0.729 ± 0.021	5.155ValAsp: 5.155 ± 0.05	4.47ValGlu: 4.47 ± 0.054	2.484ValPhe: 2.484 ± 0.035	6.768ValGly: 6.768 ± 0.062	1.75ValHis: 1.75 ± 0.032	3.414ValIle: 3.414 ± 0.045	1.328ValLys: 1.328 ± 0.03	9.393ValLeu: 9.393 ± 0.081	1.26ValMet: 1.26 ± 0.029	1.654ValAsn: 1.654 ± 0.029	4.687ValPro: 4.687 ± 0.053	1.993ValGln: 1.993 ± 0.033	6.924ValArg: 6.924 ± 0.068	4.152ValSer: 4.152 ± 0.048	4.879ValThr: 4.879 ± 0.056	7.745ValVal: 7.745 ± 0.077	1.004ValTrp: 1.004 ± 0.022	1.487ValTyr: 1.487 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.525TrpAla: 1.525 ± 0.032	0.155TrpCys: 0.155 ± 0.01	0.751TrpAsp: 0.751 ± 0.022	0.685TrpGlu: 0.685 ± 0.017	0.518TrpPhe: 0.518 ± 0.014	0.97TrpGly: 0.97 ± 0.023	0.374TrpHis: 0.374 ± 0.013	0.604TrpIle: 0.604 ± 0.018	0.287TrpLys: 0.287 ± 0.011	1.722TrpLeu: 1.722 ± 0.032	0.307TrpMet: 0.307 ± 0.012	0.387TrpAsn: 0.387 ± 0.016	0.77TrpPro: 0.77 ± 0.023	0.605TrpGln: 0.605 ± 0.017	1.362TrpArg: 1.362 ± 0.028	0.996TrpSer: 0.996 ± 0.021	0.905TrpThr: 0.905 ± 0.024	1.103TrpVal: 1.103 ± 0.025	0.329TrpTrp: 0.329 ± 0.013	0.323TrpTyr: 0.323 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.477TyrAla: 2.477 ± 0.041	0.202TyrCys: 0.202 ± 0.01	1.228TyrAsp: 1.228 ± 0.03	1.01TyrGlu: 1.01 ± 0.023	0.709TyrPhe: 0.709 ± 0.021	2.022TyrGly: 2.022 ± 0.035	0.458TyrHis: 0.458 ± 0.015	0.683TyrIle: 0.683 ± 0.019	0.315TyrLys: 0.315 ± 0.013	2.507TyrLeu: 2.507 ± 0.036	0.272TyrMet: 0.272 ± 0.012	0.414TyrAsn: 0.414 ± 0.014	1.236TyrPro: 1.236 ± 0.027	0.676TyrGln: 0.676 ± 0.018	2.083TyrArg: 2.083 ± 0.029	1.124TyrSer: 1.124 ± 0.02	1.193TyrThr: 1.193 ± 0.026	1.503TyrVal: 1.503 ± 0.031	0.374TyrTrp: 0.374 ± 0.014	0.483TyrTyr: 0.483 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6591 proteins (2131699 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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