Amino acid dipepetide frequency for Agrobacterium phage Atu_ph08

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.926AlaAla: 18.926 ± 1.59
0.901AlaCys: 0.901 ± 0.305
7.528AlaAsp: 7.528 ± 0.759
8.058AlaGlu: 8.058 ± 1.058
4.029AlaPhe: 4.029 ± 0.423
9.596AlaGly: 9.596 ± 1.283
2.121AlaHis: 2.121 ± 0.382
6.362AlaIle: 6.362 ± 0.759
8.111AlaLys: 8.111 ± 0.822
8.853AlaLeu: 8.853 ± 0.568
4.294AlaMet: 4.294 ± 0.386
3.658AlaAsn: 3.658 ± 0.492
5.195AlaPro: 5.195 ± 0.562
5.46AlaGln: 5.46 ± 0.621
7.263AlaArg: 7.263 ± 0.73
5.672AlaSer: 5.672 ± 0.543
5.832AlaThr: 5.832 ± 0.482
6.362AlaVal: 6.362 ± 0.627
1.962AlaTrp: 1.962 ± 0.348
2.121AlaTyr: 2.121 ± 0.292
0.0AlaXaa: 0.0 ± 0.0
Cys
0.689CysAla: 0.689 ± 0.281
0.053CysCys: 0.053 ± 0.054
0.636CysAsp: 0.636 ± 0.22
0.424CysGlu: 0.424 ± 0.2
0.212CysPhe: 0.212 ± 0.127
0.901CysGly: 0.901 ± 0.301
0.212CysHis: 0.212 ± 0.142
0.636CysIle: 0.636 ± 0.225
0.159CysLys: 0.159 ± 0.132
0.636CysLeu: 0.636 ± 0.267
0.212CysMet: 0.212 ± 0.128
0.053CysAsn: 0.053 ± 0.063
0.318CysPro: 0.318 ± 0.144
0.0CysGln: 0.0 ± 0.0
0.636CysArg: 0.636 ± 0.215
0.371CysSer: 0.371 ± 0.17
0.53CysThr: 0.53 ± 0.193
0.477CysVal: 0.477 ± 0.166
0.159CysTrp: 0.159 ± 0.09
0.371CysTyr: 0.371 ± 0.218
0.0CysXaa: 0.0 ± 0.0
Asp
8.747AspAla: 8.747 ± 0.768
0.371AspCys: 0.371 ± 0.159
5.354AspAsp: 5.354 ± 0.662
5.301AspGlu: 5.301 ± 0.646
1.962AspPhe: 1.962 ± 0.261
5.195AspGly: 5.195 ± 0.52
1.325AspHis: 1.325 ± 0.26
3.446AspIle: 3.446 ± 0.337
3.075AspLys: 3.075 ± 0.34
5.142AspLeu: 5.142 ± 0.527
1.59AspMet: 1.59 ± 0.298
2.333AspAsn: 2.333 ± 0.336
4.135AspPro: 4.135 ± 0.474
2.227AspGln: 2.227 ± 0.486
3.87AspArg: 3.87 ± 0.574
1.855AspSer: 1.855 ± 0.379
2.863AspThr: 2.863 ± 0.333
3.87AspVal: 3.87 ± 0.404
1.325AspTrp: 1.325 ± 0.252
1.272AspTyr: 1.272 ± 0.256
0.0AspXaa: 0.0 ± 0.0
Glu
9.33GluAla: 9.33 ± 0.927
0.583GluCys: 0.583 ± 0.238
3.128GluAsp: 3.128 ± 0.405
3.605GluGlu: 3.605 ± 0.541
1.962GluPhe: 1.962 ± 0.333
4.506GluGly: 4.506 ± 0.493
1.431GluHis: 1.431 ± 0.298
3.181GluIle: 3.181 ± 0.489
4.294GluLys: 4.294 ± 0.515
5.407GluLeu: 5.407 ± 0.51
2.015GluMet: 2.015 ± 0.312
2.28GluAsn: 2.28 ± 0.33
3.128GluPro: 3.128 ± 0.355
3.128GluGln: 3.128 ± 0.452
4.93GluArg: 4.93 ± 0.495
2.704GluSer: 2.704 ± 0.315
4.294GluThr: 4.294 ± 0.431
3.764GluVal: 3.764 ± 0.398
1.219GluTrp: 1.219 ± 0.361
1.59GluTyr: 1.59 ± 0.341
0.0GluXaa: 0.0 ± 0.0
Phe
3.552PheAla: 3.552 ± 0.439
0.106PheCys: 0.106 ± 0.092
2.863PheAsp: 2.863 ± 0.399
1.696PheGlu: 1.696 ± 0.244
0.901PhePhe: 0.901 ± 0.213
2.651PheGly: 2.651 ± 0.421
0.636PheHis: 0.636 ± 0.135
1.908PheIle: 1.908 ± 0.365
1.484PheLys: 1.484 ± 0.253
2.227PheLeu: 2.227 ± 0.423
1.007PheMet: 1.007 ± 0.268
1.007PheAsn: 1.007 ± 0.251
1.431PhePro: 1.431 ± 0.274
1.113PheGln: 1.113 ± 0.216
1.855PheArg: 1.855 ± 0.256
1.908PheSer: 1.908 ± 0.346
1.643PheThr: 1.643 ± 0.271
2.28PheVal: 2.28 ± 0.361
0.318PheTrp: 0.318 ± 0.149
0.795PheTyr: 0.795 ± 0.218
0.0PheXaa: 0.0 ± 0.0
Gly
8.164GlyAla: 8.164 ± 0.595
0.689GlyCys: 0.689 ± 0.255
4.824GlyAsp: 4.824 ± 0.422
4.4GlyGlu: 4.4 ± 0.515
2.121GlyPhe: 2.121 ± 0.316
5.885GlyGly: 5.885 ± 0.73
1.06GlyHis: 1.06 ± 0.256
3.87GlyIle: 3.87 ± 0.49
5.195GlyLys: 5.195 ± 0.703
5.991GlyLeu: 5.991 ± 0.509
2.545GlyMet: 2.545 ± 0.358
2.863GlyAsn: 2.863 ± 0.444
2.545GlyPro: 2.545 ± 0.348
3.075GlyGln: 3.075 ± 0.757
5.46GlyArg: 5.46 ± 0.561
4.665GlySer: 4.665 ± 0.582
4.718GlyThr: 4.718 ± 0.654
5.885GlyVal: 5.885 ± 0.585
1.219GlyTrp: 1.219 ± 0.275
2.492GlyTyr: 2.492 ± 0.36
0.0GlyXaa: 0.0 ± 0.0
His
1.855HisAla: 1.855 ± 0.311
0.265HisCys: 0.265 ± 0.124
1.431HisAsp: 1.431 ± 0.248
1.325HisGlu: 1.325 ± 0.266
0.954HisPhe: 0.954 ± 0.265
1.802HisGly: 1.802 ± 0.417
0.53HisHis: 0.53 ± 0.194
1.166HisIle: 1.166 ± 0.228
0.424HisLys: 0.424 ± 0.145
1.696HisLeu: 1.696 ± 0.307
0.318HisMet: 0.318 ± 0.133
1.007HisAsn: 1.007 ± 0.22
1.007HisPro: 1.007 ± 0.205
0.742HisGln: 0.742 ± 0.201
1.378HisArg: 1.378 ± 0.224
1.272HisSer: 1.272 ± 0.29
0.742HisThr: 0.742 ± 0.257
1.484HisVal: 1.484 ± 0.335
0.318HisTrp: 0.318 ± 0.139
0.901HisTyr: 0.901 ± 0.193
0.0HisXaa: 0.0 ± 0.0
Ile
5.566IleAla: 5.566 ± 0.43
0.53IleCys: 0.53 ± 0.229
4.612IleAsp: 4.612 ± 0.41
3.87IleGlu: 3.87 ± 0.466
1.643IlePhe: 1.643 ± 0.272
4.718IleGly: 4.718 ± 0.44
0.742IleHis: 0.742 ± 0.22
1.855IleIle: 1.855 ± 0.405
2.174IleLys: 2.174 ± 0.328
3.393IleLeu: 3.393 ± 0.579
0.742IleMet: 0.742 ± 0.244
1.908IleAsn: 1.908 ± 0.335
1.908IlePro: 1.908 ± 0.295
1.802IleGln: 1.802 ± 0.307
3.234IleArg: 3.234 ± 0.43
2.28IleSer: 2.28 ± 0.277
3.181IleThr: 3.181 ± 0.388
3.34IleVal: 3.34 ± 0.395
1.113IleTrp: 1.113 ± 0.279
1.113IleTyr: 1.113 ± 0.302
0.0IleXaa: 0.0 ± 0.0
Lys
7.263LysAla: 7.263 ± 0.685
0.159LysCys: 0.159 ± 0.118
3.181LysAsp: 3.181 ± 0.393
3.711LysGlu: 3.711 ± 0.431
1.378LysPhe: 1.378 ± 0.307
4.082LysGly: 4.082 ± 0.587
0.901LysHis: 0.901 ± 0.246
2.81LysIle: 2.81 ± 0.546
3.499LysLys: 3.499 ± 0.591
4.559LysLeu: 4.559 ± 0.527
1.431LysMet: 1.431 ± 0.324
1.59LysAsn: 1.59 ± 0.275
2.386LysPro: 2.386 ± 0.353
2.439LysGln: 2.439 ± 0.338
4.559LysArg: 4.559 ± 0.518
2.969LysSer: 2.969 ± 0.317
3.075LysThr: 3.075 ± 0.347
2.757LysVal: 2.757 ± 0.433
1.166LysTrp: 1.166 ± 0.255
0.901LysTyr: 0.901 ± 0.195
0.0LysXaa: 0.0 ± 0.0
Leu
8.853LeuAla: 8.853 ± 0.692
0.689LeuCys: 0.689 ± 0.235
4.771LeuAsp: 4.771 ± 0.49
6.627LeuGlu: 6.627 ± 0.721
2.386LeuPhe: 2.386 ± 0.429
5.725LeuGly: 5.725 ± 0.626
2.068LeuHis: 2.068 ± 0.42
3.34LeuIle: 3.34 ± 0.473
3.605LeuLys: 3.605 ± 0.33
4.506LeuLeu: 4.506 ± 0.561
1.749LeuMet: 1.749 ± 0.286
3.287LeuAsn: 3.287 ± 0.422
4.082LeuPro: 4.082 ± 0.519
2.81LeuGln: 2.81 ± 0.347
5.301LeuArg: 5.301 ± 0.414
4.771LeuSer: 4.771 ± 0.512
4.347LeuThr: 4.347 ± 0.504
4.135LeuVal: 4.135 ± 0.448
0.901LeuTrp: 0.901 ± 0.241
1.855LeuTyr: 1.855 ± 0.445
0.0LeuXaa: 0.0 ± 0.0
Met
3.128MetAla: 3.128 ± 0.451
0.159MetCys: 0.159 ± 0.111
0.901MetAsp: 0.901 ± 0.228
1.007MetGlu: 1.007 ± 0.233
0.636MetPhe: 0.636 ± 0.17
1.855MetGly: 1.855 ± 0.324
0.424MetHis: 0.424 ± 0.129
1.272MetIle: 1.272 ± 0.253
1.431MetLys: 1.431 ± 0.233
2.333MetLeu: 2.333 ± 0.341
0.689MetMet: 0.689 ± 0.17
0.742MetAsn: 0.742 ± 0.184
1.272MetPro: 1.272 ± 0.227
0.954MetGln: 0.954 ± 0.24
1.59MetArg: 1.59 ± 0.275
2.333MetSer: 2.333 ± 0.395
2.333MetThr: 2.333 ± 0.418
1.325MetVal: 1.325 ± 0.349
0.212MetTrp: 0.212 ± 0.125
0.424MetTyr: 0.424 ± 0.116
0.0MetXaa: 0.0 ± 0.0
Asn
4.294AsnAla: 4.294 ± 0.438
0.477AsnCys: 0.477 ± 0.195
2.174AsnAsp: 2.174 ± 0.273
2.439AsnGlu: 2.439 ± 0.356
1.166AsnPhe: 1.166 ± 0.258
2.704AsnGly: 2.704 ± 0.431
0.848AsnHis: 0.848 ± 0.228
1.431AsnIle: 1.431 ± 0.309
1.962AsnLys: 1.962 ± 0.341
2.015AsnLeu: 2.015 ± 0.332
0.901AsnMet: 0.901 ± 0.281
1.537AsnAsn: 1.537 ± 0.381
2.545AsnPro: 2.545 ± 0.315
0.689AsnGln: 0.689 ± 0.181
2.545AsnArg: 2.545 ± 0.34
1.802AsnSer: 1.802 ± 0.286
1.749AsnThr: 1.749 ± 0.301
2.439AsnVal: 2.439 ± 0.369
0.477AsnTrp: 0.477 ± 0.173
0.689AsnTyr: 0.689 ± 0.226
0.0AsnXaa: 0.0 ± 0.0
Pro
7.528ProAla: 7.528 ± 0.777
0.424ProCys: 0.424 ± 0.208
3.817ProAsp: 3.817 ± 0.385
3.764ProGlu: 3.764 ± 0.428
1.166ProPhe: 1.166 ± 0.204
3.34ProGly: 3.34 ± 0.45
0.742ProHis: 0.742 ± 0.314
2.121ProIle: 2.121 ± 0.343
2.333ProLys: 2.333 ± 0.374
3.605ProLeu: 3.605 ± 0.397
0.954ProMet: 0.954 ± 0.206
2.174ProAsn: 2.174 ± 0.342
2.227ProPro: 2.227 ± 0.442
1.537ProGln: 1.537 ± 0.313
2.651ProArg: 2.651 ± 0.404
2.651ProSer: 2.651 ± 0.32
2.81ProThr: 2.81 ± 0.336
3.658ProVal: 3.658 ± 0.483
0.901ProTrp: 0.901 ± 0.206
1.219ProTyr: 1.219 ± 0.348
0.0ProXaa: 0.0 ± 0.0
Gln
4.559GlnAla: 4.559 ± 0.633
0.265GlnCys: 0.265 ± 0.145
2.015GlnAsp: 2.015 ± 0.324
2.068GlnGlu: 2.068 ± 0.371
1.325GlnPhe: 1.325 ± 0.285
2.757GlnGly: 2.757 ± 0.377
1.06GlnHis: 1.06 ± 0.235
1.749GlnIle: 1.749 ± 0.283
2.28GlnLys: 2.28 ± 0.296
3.075GlnLeu: 3.075 ± 0.43
0.689GlnMet: 0.689 ± 0.194
1.007GlnAsn: 1.007 ± 0.2
1.962GlnPro: 1.962 ± 0.277
2.704GlnGln: 2.704 ± 0.594
3.658GlnArg: 3.658 ± 0.456
2.492GlnSer: 2.492 ± 0.281
2.015GlnThr: 2.015 ± 0.266
1.962GlnVal: 1.962 ± 0.324
0.795GlnTrp: 0.795 ± 0.189
0.795GlnTyr: 0.795 ± 0.158
0.0GlnXaa: 0.0 ± 0.0
Arg
6.998ArgAla: 6.998 ± 0.596
0.795ArgCys: 0.795 ± 0.353
4.082ArgAsp: 4.082 ± 0.496
4.559ArgGlu: 4.559 ± 0.595
2.598ArgPhe: 2.598 ± 0.342
4.188ArgGly: 4.188 ± 0.424
1.643ArgHis: 1.643 ± 0.346
3.605ArgIle: 3.605 ± 0.402
4.559ArgLys: 4.559 ± 0.509
6.362ArgLeu: 6.362 ± 0.585
1.378ArgMet: 1.378 ± 0.253
2.333ArgAsn: 2.333 ± 0.352
3.764ArgPro: 3.764 ± 0.507
2.651ArgGln: 2.651 ± 0.368
5.407ArgArg: 5.407 ± 0.556
3.128ArgSer: 3.128 ± 0.371
3.393ArgThr: 3.393 ± 0.402
3.658ArgVal: 3.658 ± 0.409
1.272ArgTrp: 1.272 ± 0.348
2.333ArgTyr: 2.333 ± 0.381
0.0ArgXaa: 0.0 ± 0.0
Ser
5.089SerAla: 5.089 ± 0.561
0.265SerCys: 0.265 ± 0.131
3.499SerAsp: 3.499 ± 0.421
3.552SerGlu: 3.552 ± 0.422
1.431SerPhe: 1.431 ± 0.277
5.46SerGly: 5.46 ± 0.508
1.431SerHis: 1.431 ± 0.27
2.386SerIle: 2.386 ± 0.347
2.386SerLys: 2.386 ± 0.329
3.499SerLeu: 3.499 ± 0.499
1.007SerMet: 1.007 ± 0.223
1.431SerAsn: 1.431 ± 0.312
2.863SerPro: 2.863 ± 0.342
2.068SerGln: 2.068 ± 0.308
3.393SerArg: 3.393 ± 0.477
3.075SerSer: 3.075 ± 0.575
3.075SerThr: 3.075 ± 0.405
4.188SerVal: 4.188 ± 0.55
0.848SerTrp: 0.848 ± 0.165
1.166SerTyr: 1.166 ± 0.224
0.0SerXaa: 0.0 ± 0.0
Thr
6.945ThrAla: 6.945 ± 0.623
0.212ThrCys: 0.212 ± 0.115
3.552ThrAsp: 3.552 ± 0.421
3.446ThrGlu: 3.446 ± 0.481
1.59ThrPhe: 1.59 ± 0.301
4.559ThrGly: 4.559 ± 0.645
1.113ThrHis: 1.113 ± 0.293
3.128ThrIle: 3.128 ± 0.437
2.969ThrLys: 2.969 ± 0.432
3.923ThrLeu: 3.923 ± 0.363
1.166ThrMet: 1.166 ± 0.187
2.121ThrAsn: 2.121 ± 0.346
3.128ThrPro: 3.128 ± 0.373
1.749ThrGln: 1.749 ± 0.294
2.81ThrArg: 2.81 ± 0.345
2.757ThrSer: 2.757 ± 0.434
2.704ThrThr: 2.704 ± 0.289
5.301ThrVal: 5.301 ± 0.596
1.007ThrTrp: 1.007 ± 0.236
1.113ThrTyr: 1.113 ± 0.345
0.0ThrXaa: 0.0 ± 0.0
Val
7.475ValAla: 7.475 ± 0.725
0.583ValCys: 0.583 ± 0.253
4.506ValAsp: 4.506 ± 0.593
4.612ValGlu: 4.612 ± 0.471
1.908ValPhe: 1.908 ± 0.227
4.029ValGly: 4.029 ± 0.496
0.901ValHis: 0.901 ± 0.246
3.923ValIle: 3.923 ± 0.536
3.499ValLys: 3.499 ± 0.41
4.188ValLeu: 4.188 ± 0.542
1.537ValMet: 1.537 ± 0.287
2.333ValAsn: 2.333 ± 0.405
3.552ValPro: 3.552 ± 0.479
2.068ValGln: 2.068 ± 0.294
4.082ValArg: 4.082 ± 0.456
3.446ValSer: 3.446 ± 0.438
4.135ValThr: 4.135 ± 0.515
3.817ValVal: 3.817 ± 0.454
1.484ValTrp: 1.484 ± 0.269
0.795ValTyr: 0.795 ± 0.231
0.0ValXaa: 0.0 ± 0.0
Trp
1.962TrpAla: 1.962 ± 0.4
0.106TrpCys: 0.106 ± 0.079
1.219TrpAsp: 1.219 ± 0.229
0.636TrpGlu: 0.636 ± 0.197
0.636TrpPhe: 0.636 ± 0.171
1.219TrpGly: 1.219 ± 0.278
0.636TrpHis: 0.636 ± 0.216
0.742TrpIle: 0.742 ± 0.284
0.742TrpLys: 0.742 ± 0.21
2.651TrpLeu: 2.651 ± 0.458
0.212TrpMet: 0.212 ± 0.098
0.583TrpAsn: 0.583 ± 0.149
0.795TrpPro: 0.795 ± 0.26
0.795TrpGln: 0.795 ± 0.172
1.643TrpArg: 1.643 ± 0.289
0.689TrpSer: 0.689 ± 0.228
0.742TrpThr: 0.742 ± 0.241
0.901TrpVal: 0.901 ± 0.221
0.477TrpTrp: 0.477 ± 0.145
0.318TrpTyr: 0.318 ± 0.102
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.378TyrAla: 1.378 ± 0.288
0.053TyrCys: 0.053 ± 0.056
1.166TyrAsp: 1.166 ± 0.199
1.378TyrGlu: 1.378 ± 0.232
1.378TyrPhe: 1.378 ± 0.3
2.492TyrGly: 2.492 ± 0.395
0.795TyrHis: 0.795 ± 0.211
0.848TyrIle: 0.848 ± 0.149
0.636TyrLys: 0.636 ± 0.176
1.749TyrLeu: 1.749 ± 0.274
0.53TyrMet: 0.53 ± 0.156
0.636TyrAsn: 0.636 ± 0.155
1.378TyrPro: 1.378 ± 0.293
1.219TyrGln: 1.219 ± 0.324
2.439TyrArg: 2.439 ± 0.333
1.272TyrSer: 1.272 ± 0.26
1.113TyrThr: 1.113 ± 0.207
1.272TyrVal: 1.272 ± 0.405
0.53TyrTrp: 0.53 ± 0.173
0.53TyrTyr: 0.53 ± 0.173
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (18864 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski