Amino acid dipepetide frequency for Gordonia phage DinoDaryn

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.085AlaAla: 17.085 ± 1.65
0.851AlaCys: 0.851 ± 0.313
8.365AlaAsp: 8.365 ± 0.831
9.287AlaGlu: 9.287 ± 1.029
3.757AlaPhe: 3.757 ± 0.54
14.816AlaGly: 14.816 ± 1.574
2.339AlaHis: 2.339 ± 0.39
4.112AlaIle: 4.112 ± 0.612
6.238AlaLys: 6.238 ± 0.891
9.712AlaLeu: 9.712 ± 0.931
2.907AlaMet: 2.907 ± 0.471
3.474AlaAsn: 3.474 ± 0.472
4.395AlaPro: 4.395 ± 0.587
3.615AlaGln: 3.615 ± 0.462
9.145AlaArg: 9.145 ± 0.839
5.742AlaSer: 5.742 ± 0.656
6.947AlaThr: 6.947 ± 0.575
8.365AlaVal: 8.365 ± 1.047
2.127AlaTrp: 2.127 ± 0.278
2.907AlaTyr: 2.907 ± 0.413
0.0AlaXaa: 0.0 ± 0.0
Cys
0.78CysAla: 0.78 ± 0.264
0.071CysCys: 0.071 ± 0.055
0.567CysAsp: 0.567 ± 0.223
0.496CysGlu: 0.496 ± 0.158
0.071CysPhe: 0.071 ± 0.062
1.347CysGly: 1.347 ± 0.4
0.284CysHis: 0.284 ± 0.125
0.284CysIle: 0.284 ± 0.115
0.354CysLys: 0.354 ± 0.182
0.354CysLeu: 0.354 ± 0.16
0.142CysMet: 0.142 ± 0.104
0.354CysAsn: 0.354 ± 0.155
0.354CysPro: 0.354 ± 0.178
0.213CysGln: 0.213 ± 0.113
0.709CysArg: 0.709 ± 0.256
0.567CysSer: 0.567 ± 0.19
0.071CysThr: 0.071 ± 0.055
0.496CysVal: 0.496 ± 0.18
0.284CysTrp: 0.284 ± 0.146
0.213CysTyr: 0.213 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
9.145AspAla: 9.145 ± 1.024
0.922AspCys: 0.922 ± 0.238
4.537AspAsp: 4.537 ± 0.581
6.451AspGlu: 6.451 ± 0.948
1.772AspPhe: 1.772 ± 0.352
6.238AspGly: 6.238 ± 0.66
1.276AspHis: 1.276 ± 0.331
1.205AspIle: 1.205 ± 0.229
1.56AspLys: 1.56 ± 0.349
5.175AspLeu: 5.175 ± 0.749
1.418AspMet: 1.418 ± 0.352
1.063AspAsn: 1.063 ± 0.235
4.254AspPro: 4.254 ± 0.444
3.119AspGln: 3.119 ± 0.447
6.168AspArg: 6.168 ± 0.635
3.615AspSer: 3.615 ± 0.416
2.907AspThr: 2.907 ± 0.431
5.955AspVal: 5.955 ± 0.653
0.992AspTrp: 0.992 ± 0.245
1.489AspTyr: 1.489 ± 0.3
0.0AspXaa: 0.0 ± 0.0
Glu
8.082GluAla: 8.082 ± 0.771
0.567GluCys: 0.567 ± 0.234
3.97GluAsp: 3.97 ± 0.65
2.481GluGlu: 2.481 ± 0.458
2.339GluPhe: 2.339 ± 0.428
5.459GluGly: 5.459 ± 0.642
1.772GluHis: 1.772 ± 0.337
1.489GluIle: 1.489 ± 0.326
1.843GluLys: 1.843 ± 0.284
6.806GluLeu: 6.806 ± 0.773
1.489GluMet: 1.489 ± 0.346
1.631GluAsn: 1.631 ± 0.314
3.048GluPro: 3.048 ± 0.453
2.41GluGln: 2.41 ± 0.514
5.671GluArg: 5.671 ± 0.6
4.041GluSer: 4.041 ± 0.683
3.403GluThr: 3.403 ± 0.473
5.742GluVal: 5.742 ± 0.814
1.843GluTrp: 1.843 ± 0.41
1.914GluTyr: 1.914 ± 0.396
0.0GluXaa: 0.0 ± 0.0
Phe
4.183PheAla: 4.183 ± 0.62
0.213PheCys: 0.213 ± 0.133
1.56PheAsp: 1.56 ± 0.297
3.048PheGlu: 3.048 ± 0.483
0.567PhePhe: 0.567 ± 0.182
2.552PheGly: 2.552 ± 0.459
0.567PheHis: 0.567 ± 0.22
0.78PheIle: 0.78 ± 0.2
0.922PheLys: 0.922 ± 0.25
1.631PheLeu: 1.631 ± 0.361
0.992PheMet: 0.992 ± 0.255
0.496PheAsn: 0.496 ± 0.179
0.78PhePro: 0.78 ± 0.298
1.063PheGln: 1.063 ± 0.317
2.765PheArg: 2.765 ± 0.402
1.701PheSer: 1.701 ± 0.313
2.552PheThr: 2.552 ± 0.453
2.127PheVal: 2.127 ± 0.467
0.425PheTrp: 0.425 ± 0.172
0.425PheTyr: 0.425 ± 0.183
0.0PheXaa: 0.0 ± 0.0
Gly
9.287GlyAla: 9.287 ± 1.136
0.567GlyCys: 0.567 ± 0.17
7.869GlyAsp: 7.869 ± 0.755
5.955GlyGlu: 5.955 ± 0.54
2.977GlyPhe: 2.977 ± 0.524
10.988GlyGly: 10.988 ± 1.34
1.701GlyHis: 1.701 ± 0.367
3.403GlyIle: 3.403 ± 0.456
4.608GlyLys: 4.608 ± 0.569
5.671GlyLeu: 5.671 ± 0.651
2.977GlyMet: 2.977 ± 0.427
2.694GlyAsn: 2.694 ± 0.496
4.395GlyPro: 4.395 ± 0.629
3.545GlyGln: 3.545 ± 0.567
6.877GlyArg: 6.877 ± 0.609
5.246GlySer: 5.246 ± 0.624
4.821GlyThr: 4.821 ± 0.494
7.16GlyVal: 7.16 ± 1.106
2.056GlyTrp: 2.056 ± 0.507
2.481GlyTyr: 2.481 ± 0.499
0.0GlyXaa: 0.0 ± 0.0
His
2.481HisAla: 2.481 ± 0.521
0.142HisCys: 0.142 ± 0.079
1.347HisAsp: 1.347 ± 0.408
1.063HisGlu: 1.063 ± 0.324
0.567HisPhe: 0.567 ± 0.178
1.985HisGly: 1.985 ± 0.419
0.425HisHis: 0.425 ± 0.185
0.567HisIle: 0.567 ± 0.215
0.638HisLys: 0.638 ± 0.206
1.276HisLeu: 1.276 ± 0.258
0.284HisMet: 0.284 ± 0.122
0.567HisAsn: 0.567 ± 0.193
0.922HisPro: 0.922 ± 0.334
0.638HisGln: 0.638 ± 0.184
1.205HisArg: 1.205 ± 0.301
0.851HisSer: 0.851 ± 0.215
0.992HisThr: 0.992 ± 0.279
2.269HisVal: 2.269 ± 0.478
0.638HisTrp: 0.638 ± 0.205
0.496HisTyr: 0.496 ± 0.17
0.0HisXaa: 0.0 ± 0.0
Ile
5.671IleAla: 5.671 ± 0.648
0.213IleCys: 0.213 ± 0.109
2.339IleAsp: 2.339 ± 0.304
3.545IleGlu: 3.545 ± 0.588
0.567IlePhe: 0.567 ± 0.158
3.19IleGly: 3.19 ± 0.462
0.567IleHis: 0.567 ± 0.174
0.992IleIle: 0.992 ± 0.273
0.354IleLys: 0.354 ± 0.138
2.127IleLeu: 2.127 ± 0.447
0.709IleMet: 0.709 ± 0.219
0.354IleAsn: 0.354 ± 0.168
2.765IlePro: 2.765 ± 0.414
1.276IleGln: 1.276 ± 0.326
1.914IleArg: 1.914 ± 0.404
1.56IleSer: 1.56 ± 0.333
2.056IleThr: 2.056 ± 0.4
2.552IleVal: 2.552 ± 0.364
0.284IleTrp: 0.284 ± 0.174
0.567IleTyr: 0.567 ± 0.214
0.0IleXaa: 0.0 ± 0.0
Lys
4.821LysAla: 4.821 ± 0.74
0.354LysCys: 0.354 ± 0.171
2.056LysAsp: 2.056 ± 0.392
0.922LysGlu: 0.922 ± 0.314
1.205LysPhe: 1.205 ± 0.366
3.474LysGly: 3.474 ± 0.494
0.567LysHis: 0.567 ± 0.197
0.851LysIle: 0.851 ± 0.26
0.567LysLys: 0.567 ± 0.235
3.19LysLeu: 3.19 ± 0.455
0.496LysMet: 0.496 ± 0.189
0.992LysAsn: 0.992 ± 0.274
2.269LysPro: 2.269 ± 0.402
0.78LysGln: 0.78 ± 0.273
4.183LysArg: 4.183 ± 0.685
2.269LysSer: 2.269 ± 0.429
1.56LysThr: 1.56 ± 0.346
3.261LysVal: 3.261 ± 0.491
0.567LysTrp: 0.567 ± 0.241
0.922LysTyr: 0.922 ± 0.268
0.0LysXaa: 0.0 ± 0.0
Leu
10.846LeuAla: 10.846 ± 0.977
0.922LeuCys: 0.922 ± 0.252
6.522LeuAsp: 6.522 ± 0.749
3.474LeuGlu: 3.474 ± 0.477
1.914LeuPhe: 1.914 ± 0.399
6.593LeuGly: 6.593 ± 0.735
1.347LeuHis: 1.347 ± 0.334
2.623LeuIle: 2.623 ± 0.34
2.907LeuLys: 2.907 ± 0.508
4.183LeuLeu: 4.183 ± 0.574
1.843LeuMet: 1.843 ± 0.391
1.914LeuAsn: 1.914 ± 0.42
3.757LeuPro: 3.757 ± 0.498
1.418LeuGln: 1.418 ± 0.309
5.955LeuArg: 5.955 ± 0.839
5.033LeuSer: 5.033 ± 0.521
4.962LeuThr: 4.962 ± 0.631
4.821LeuVal: 4.821 ± 0.625
1.489LeuTrp: 1.489 ± 0.313
2.41LeuTyr: 2.41 ± 0.453
0.0LeuXaa: 0.0 ± 0.0
Met
3.048MetAla: 3.048 ± 0.542
0.142MetCys: 0.142 ± 0.095
1.347MetAsp: 1.347 ± 0.313
0.78MetGlu: 0.78 ± 0.276
0.567MetPhe: 0.567 ± 0.163
1.56MetGly: 1.56 ± 0.291
0.425MetHis: 0.425 ± 0.137
0.922MetIle: 0.922 ± 0.277
0.851MetLys: 0.851 ± 0.269
1.56MetLeu: 1.56 ± 0.382
0.496MetMet: 0.496 ± 0.156
1.347MetAsn: 1.347 ± 0.269
0.922MetPro: 0.922 ± 0.25
0.638MetGln: 0.638 ± 0.178
1.914MetArg: 1.914 ± 0.323
1.701MetSer: 1.701 ± 0.316
1.631MetThr: 1.631 ± 0.335
1.914MetVal: 1.914 ± 0.406
0.78MetTrp: 0.78 ± 0.23
0.425MetTyr: 0.425 ± 0.16
0.0MetXaa: 0.0 ± 0.0
Asn
2.694AsnAla: 2.694 ± 0.444
0.071AsnCys: 0.071 ± 0.078
1.56AsnAsp: 1.56 ± 0.329
1.701AsnGlu: 1.701 ± 0.318
0.992AsnPhe: 0.992 ± 0.256
3.757AsnGly: 3.757 ± 0.518
0.638AsnHis: 0.638 ± 0.225
0.922AsnIle: 0.922 ± 0.316
0.638AsnLys: 0.638 ± 0.223
1.914AsnLeu: 1.914 ± 0.417
0.638AsnMet: 0.638 ± 0.181
0.354AsnAsn: 0.354 ± 0.156
2.694AsnPro: 2.694 ± 0.431
0.851AsnGln: 0.851 ± 0.26
1.985AsnArg: 1.985 ± 0.391
1.205AsnSer: 1.205 ± 0.307
1.701AsnThr: 1.701 ± 0.436
2.339AsnVal: 2.339 ± 0.331
0.284AsnTrp: 0.284 ± 0.15
0.638AsnTyr: 0.638 ± 0.204
0.0AsnXaa: 0.0 ± 0.0
Pro
7.018ProAla: 7.018 ± 0.921
0.496ProCys: 0.496 ± 0.208
3.828ProAsp: 3.828 ± 0.558
4.041ProGlu: 4.041 ± 0.521
1.489ProPhe: 1.489 ± 0.311
4.112ProGly: 4.112 ± 0.476
1.205ProHis: 1.205 ± 0.292
2.552ProIle: 2.552 ± 0.443
1.56ProLys: 1.56 ± 0.399
2.836ProLeu: 2.836 ± 0.452
1.063ProMet: 1.063 ± 0.28
1.134ProAsn: 1.134 ± 0.321
1.631ProPro: 1.631 ± 0.408
1.418ProGln: 1.418 ± 0.317
2.765ProArg: 2.765 ± 0.497
1.631ProSer: 1.631 ± 0.331
2.339ProThr: 2.339 ± 0.303
4.254ProVal: 4.254 ± 0.455
1.134ProTrp: 1.134 ± 0.264
1.134ProTyr: 1.134 ± 0.251
0.0ProXaa: 0.0 ± 0.0
Gln
3.403GlnAla: 3.403 ± 0.454
0.071GlnCys: 0.071 ± 0.076
1.489GlnAsp: 1.489 ± 0.417
0.78GlnGlu: 0.78 ± 0.197
0.851GlnPhe: 0.851 ± 0.267
2.198GlnGly: 2.198 ± 0.32
0.496GlnHis: 0.496 ± 0.156
0.992GlnIle: 0.992 ± 0.222
0.78GlnLys: 0.78 ± 0.264
3.403GlnLeu: 3.403 ± 0.468
0.638GlnMet: 0.638 ± 0.236
0.992GlnAsn: 0.992 ± 0.223
1.631GlnPro: 1.631 ± 0.363
1.347GlnGln: 1.347 ± 0.339
3.19GlnArg: 3.19 ± 0.516
2.056GlnSer: 2.056 ± 0.428
1.985GlnThr: 1.985 ± 0.396
2.269GlnVal: 2.269 ± 0.394
0.78GlnTrp: 0.78 ± 0.196
0.922GlnTyr: 0.922 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
10.067ArgAla: 10.067 ± 1.089
0.638ArgCys: 0.638 ± 0.279
5.317ArgAsp: 5.317 ± 0.712
5.884ArgGlu: 5.884 ± 0.751
2.907ArgPhe: 2.907 ± 0.374
6.309ArgGly: 6.309 ± 0.772
1.701ArgHis: 1.701 ± 0.355
3.686ArgIle: 3.686 ± 0.482
3.19ArgLys: 3.19 ± 0.496
5.459ArgLeu: 5.459 ± 0.633
1.772ArgMet: 1.772 ± 0.355
2.552ArgAsn: 2.552 ± 0.423
3.332ArgPro: 3.332 ± 0.611
1.56ArgGln: 1.56 ± 0.354
7.585ArgArg: 7.585 ± 0.958
2.977ArgSer: 2.977 ± 0.46
4.395ArgThr: 4.395 ± 0.465
6.593ArgVal: 6.593 ± 0.725
1.134ArgTrp: 1.134 ± 0.299
2.339ArgTyr: 2.339 ± 0.471
0.0ArgXaa: 0.0 ± 0.0
Ser
7.444SerAla: 7.444 ± 0.997
0.496SerCys: 0.496 ± 0.156
4.75SerAsp: 4.75 ± 0.581
3.19SerGlu: 3.19 ± 0.463
1.134SerPhe: 1.134 ± 0.28
5.246SerGly: 5.246 ± 0.7
0.638SerHis: 0.638 ± 0.225
1.914SerIle: 1.914 ± 0.332
1.418SerLys: 1.418 ± 0.358
4.254SerLeu: 4.254 ± 0.595
1.063SerMet: 1.063 ± 0.245
1.701SerAsn: 1.701 ± 0.313
1.914SerPro: 1.914 ± 0.365
1.276SerGln: 1.276 ± 0.212
3.332SerArg: 3.332 ± 0.593
2.907SerSer: 2.907 ± 0.462
2.623SerThr: 2.623 ± 0.522
4.324SerVal: 4.324 ± 0.532
1.347SerTrp: 1.347 ± 0.416
0.992SerTyr: 0.992 ± 0.333
0.0SerXaa: 0.0 ± 0.0
Thr
6.168ThrAla: 6.168 ± 0.564
0.425ThrCys: 0.425 ± 0.184
3.474ThrAsp: 3.474 ± 0.473
3.332ThrGlu: 3.332 ± 0.488
2.056ThrPhe: 2.056 ± 0.347
4.395ThrGly: 4.395 ± 0.552
0.922ThrHis: 0.922 ± 0.256
2.694ThrIle: 2.694 ± 0.438
1.56ThrLys: 1.56 ± 0.28
4.537ThrLeu: 4.537 ± 0.454
1.134ThrMet: 1.134 ± 0.306
2.056ThrAsn: 2.056 ± 0.508
3.403ThrPro: 3.403 ± 0.528
1.063ThrGln: 1.063 ± 0.275
3.686ThrArg: 3.686 ± 0.473
2.056ThrSer: 2.056 ± 0.387
3.615ThrThr: 3.615 ± 0.76
6.38ThrVal: 6.38 ± 0.601
1.347ThrTrp: 1.347 ± 0.303
1.772ThrTyr: 1.772 ± 0.411
0.0ThrXaa: 0.0 ± 0.0
Val
9.783ValAla: 9.783 ± 0.663
0.425ValCys: 0.425 ± 0.174
5.246ValAsp: 5.246 ± 0.62
6.522ValGlu: 6.522 ± 0.714
2.127ValPhe: 2.127 ± 0.451
6.38ValGly: 6.38 ± 0.822
1.631ValHis: 1.631 ± 0.373
2.623ValIle: 2.623 ± 0.438
3.686ValLys: 3.686 ± 0.761
6.735ValLeu: 6.735 ± 0.836
1.914ValMet: 1.914 ± 0.264
2.41ValAsn: 2.41 ± 0.45
3.615ValPro: 3.615 ± 0.541
2.198ValGln: 2.198 ± 0.379
5.6ValArg: 5.6 ± 0.673
4.324ValSer: 4.324 ± 0.514
5.175ValThr: 5.175 ± 0.701
7.373ValVal: 7.373 ± 0.793
1.843ValTrp: 1.843 ± 0.366
1.914ValTyr: 1.914 ± 0.419
0.0ValXaa: 0.0 ± 0.0
Trp
1.772TrpAla: 1.772 ± 0.347
0.142TrpCys: 0.142 ± 0.091
1.56TrpAsp: 1.56 ± 0.309
1.418TrpGlu: 1.418 ± 0.34
0.496TrpPhe: 0.496 ± 0.162
1.631TrpGly: 1.631 ± 0.419
0.425TrpHis: 0.425 ± 0.182
0.567TrpIle: 0.567 ± 0.188
0.851TrpLys: 0.851 ± 0.257
2.339TrpLeu: 2.339 ± 0.338
0.284TrpMet: 0.284 ± 0.145
0.638TrpAsn: 0.638 ± 0.241
0.78TrpPro: 0.78 ± 0.271
0.922TrpGln: 0.922 ± 0.256
1.985TrpArg: 1.985 ± 0.459
1.205TrpSer: 1.205 ± 0.304
1.631TrpThr: 1.631 ± 0.348
0.922TrpVal: 0.922 ± 0.243
0.213TrpTrp: 0.213 ± 0.117
0.496TrpTyr: 0.496 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.41TyrAla: 2.41 ± 0.414
0.284TyrCys: 0.284 ± 0.148
1.56TyrAsp: 1.56 ± 0.35
1.631TyrGlu: 1.631 ± 0.288
0.992TyrPhe: 0.992 ± 0.251
3.048TyrGly: 3.048 ± 0.386
0.425TyrHis: 0.425 ± 0.178
0.425TyrIle: 0.425 ± 0.176
0.78TyrLys: 0.78 ± 0.27
1.772TyrLeu: 1.772 ± 0.352
0.638TyrMet: 0.638 ± 0.22
0.851TyrAsn: 0.851 ± 0.199
0.78TyrPro: 0.78 ± 0.242
0.922TyrGln: 0.922 ± 0.189
2.836TyrArg: 2.836 ± 0.467
1.276TyrSer: 1.276 ± 0.316
0.709TyrThr: 0.709 ± 0.187
2.41TyrVal: 2.41 ± 0.483
0.709TyrTrp: 0.709 ± 0.214
0.567TyrTyr: 0.567 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 82 proteins (14107 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski