Amino acid dipepetide frequency for Flexivirga caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.937AlaAla: 19.937 ± 0.182	1.018AlaCys: 1.018 ± 0.027	8.219AlaAsp: 8.219 ± 0.091	7.15AlaGlu: 7.15 ± 0.1	3.296AlaPhe: 3.296 ± 0.061	12.449AlaGly: 12.449 ± 0.106	2.825AlaHis: 2.825 ± 0.045	5.451AlaIle: 5.451 ± 0.074	2.944AlaLys: 2.944 ± 0.064	12.964AlaLeu: 12.964 ± 0.118	2.743AlaMet: 2.743 ± 0.047	2.185AlaAsn: 2.185 ± 0.046	6.045AlaPro: 6.045 ± 0.071	4.379AlaGln: 4.379 ± 0.068	9.109AlaArg: 9.109 ± 0.095	6.458AlaSer: 6.458 ± 0.087	7.797AlaThr: 7.797 ± 0.089	11.082AlaVal: 11.082 ± 0.104	1.75AlaTrp: 1.75 ± 0.041	2.513AlaTyr: 2.513 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.079CysAla: 1.079 ± 0.028	0.125CysCys: 0.125 ± 0.012	0.503CysAsp: 0.503 ± 0.023	0.344CysGlu: 0.344 ± 0.018	0.26CysPhe: 0.26 ± 0.016	0.934CysGly: 0.934 ± 0.031	0.191CysHis: 0.191 ± 0.011	0.271CysIle: 0.271 ± 0.016	0.114CysLys: 0.114 ± 0.01	0.694CysLeu: 0.694 ± 0.025	0.14CysMet: 0.14 ± 0.01	0.153CysAsn: 0.153 ± 0.011	0.455CysPro: 0.455 ± 0.022	0.192CysGln: 0.192 ± 0.011	0.601CysArg: 0.601 ± 0.026	0.494CysSer: 0.494 ± 0.023	0.505CysThr: 0.505 ± 0.019	0.667CysVal: 0.667 ± 0.022	0.166CysTrp: 0.166 ± 0.013	0.175CysTyr: 0.175 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.846AspAla: 7.846 ± 0.083	0.398AspCys: 0.398 ± 0.02	4.196AspAsp: 4.196 ± 0.073	4.155AspGlu: 4.155 ± 0.071	1.762AspPhe: 1.762 ± 0.031	5.865AspGly: 5.865 ± 0.081	1.439AspHis: 1.439 ± 0.032	2.133AspIle: 2.133 ± 0.045	1.242AspLys: 1.242 ± 0.038	6.465AspLeu: 6.465 ± 0.089	0.866AspMet: 0.866 ± 0.025	1.154AspAsn: 1.154 ± 0.031	4.126AspPro: 4.126 ± 0.056	1.878AspGln: 1.878 ± 0.038	4.83AspArg: 4.83 ± 0.066	2.721AspSer: 2.721 ± 0.043	2.944AspThr: 2.944 ± 0.054	5.247AspVal: 5.247 ± 0.067	1.039AspTrp: 1.039 ± 0.031	1.292AspTyr: 1.292 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	5.876GluAla: 5.876 ± 0.087	0.36GluCys: 0.36 ± 0.017	2.413GluAsp: 2.413 ± 0.049	2.545GluGlu: 2.545 ± 0.054	1.59GluPhe: 1.59 ± 0.036	3.327GluGly: 3.327 ± 0.068	1.657GluHis: 1.657 ± 0.039	2.421GluIle: 2.421 ± 0.037	1.116GluLys: 1.116 ± 0.035	6.364GluLeu: 6.364 ± 0.08	0.913GluMet: 0.913 ± 0.026	0.913GluAsn: 0.913 ± 0.028	2.825GluPro: 2.825 ± 0.056	2.472GluGln: 2.472 ± 0.052	4.858GluArg: 4.858 ± 0.074	2.716GluSer: 2.716 ± 0.052	2.771GluThr: 2.771 ± 0.046	4.461GluVal: 4.461 ± 0.069	0.751GluTrp: 0.751 ± 0.028	0.809GluTyr: 0.809 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.02PheAla: 4.02 ± 0.067	0.251PheCys: 0.251 ± 0.016	2.092PheAsp: 2.092 ± 0.043	1.527PheGlu: 1.527 ± 0.041	0.964PhePhe: 0.964 ± 0.032	3.34PheGly: 3.34 ± 0.059	0.664PheHis: 0.664 ± 0.025	0.949PheIle: 0.949 ± 0.032	0.466PheLys: 0.466 ± 0.02	2.507PheLeu: 2.507 ± 0.055	0.44PheMet: 0.44 ± 0.019	0.596PheAsn: 0.596 ± 0.025	1.309PhePro: 1.309 ± 0.032	0.675PheGln: 0.675 ± 0.023	1.736PheArg: 1.736 ± 0.038	1.551PheSer: 1.551 ± 0.036	1.946PheThr: 1.946 ± 0.039	2.707PheVal: 2.707 ± 0.051	0.424PheTrp: 0.424 ± 0.02	0.645PheTyr: 0.645 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.28GlyAla: 10.28 ± 0.11	0.827GlyCys: 0.827 ± 0.026	5.063GlyAsp: 5.063 ± 0.061	4.489GlyGlu: 4.489 ± 0.061	2.996GlyPhe: 2.996 ± 0.056	7.925GlyGly: 7.925 ± 0.084	2.218GlyHis: 2.218 ± 0.045	4.081GlyIle: 4.081 ± 0.057	2.517GlyLys: 2.517 ± 0.052	8.809GlyLeu: 8.809 ± 0.09	2.294GlyMet: 2.294 ± 0.045	1.883GlyAsn: 1.883 ± 0.044	4.023GlyPro: 4.023 ± 0.05	2.795GlyGln: 2.795 ± 0.053	6.714GlyArg: 6.714 ± 0.082	5.663GlySer: 5.663 ± 0.08	5.549GlyThr: 5.549 ± 0.079	7.824GlyVal: 7.824 ± 0.076	1.735GlyTrp: 1.735 ± 0.042	2.271GlyTyr: 2.271 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.682HisAla: 2.682 ± 0.049	0.218HisCys: 0.218 ± 0.014	1.594HisAsp: 1.594 ± 0.037	1.307HisGlu: 1.307 ± 0.035	0.689HisPhe: 0.689 ± 0.024	2.384HisGly: 2.384 ± 0.043	0.721HisHis: 0.721 ± 0.031	0.758HisIle: 0.758 ± 0.026	0.343HisLys: 0.343 ± 0.016	2.478HisLeu: 2.478 ± 0.046	0.318HisMet: 0.318 ± 0.017	0.411HisAsn: 0.411 ± 0.019	1.705HisPro: 1.705 ± 0.035	0.705HisGln: 0.705 ± 0.024	2.024HisArg: 2.024 ± 0.043	1.119HisSer: 1.119 ± 0.029	1.36HisThr: 1.36 ± 0.03	1.928HisVal: 1.928 ± 0.04	0.399HisTrp: 0.399 ± 0.014	0.481HisTyr: 0.481 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.993IleAla: 5.993 ± 0.077	0.403IleCys: 0.403 ± 0.016	3.079IleAsp: 3.079 ± 0.05	2.443IleGlu: 2.443 ± 0.054	1.139IlePhe: 1.139 ± 0.033	4.417IleGly: 4.417 ± 0.07	0.769IleHis: 0.769 ± 0.027	1.416IleIle: 1.416 ± 0.042	0.789IleLys: 0.789 ± 0.029	3.034IleLeu: 3.034 ± 0.055	0.576IleMet: 0.576 ± 0.024	0.902IleAsn: 0.902 ± 0.031	2.232IlePro: 2.232 ± 0.045	0.938IleGln: 0.938 ± 0.026	2.675IleArg: 2.675 ± 0.05	2.263IleSer: 2.263 ± 0.048	2.62IleThr: 2.62 ± 0.044	3.853IleVal: 3.853 ± 0.073	0.456IleTrp: 0.456 ± 0.024	0.698IleTyr: 0.698 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.514LysAla: 2.514 ± 0.054	0.108LysCys: 0.108 ± 0.012	1.142LysAsp: 1.142 ± 0.035	1.0LysGlu: 1.0 ± 0.029	0.596LysPhe: 0.596 ± 0.023	1.65LysGly: 1.65 ± 0.043	0.499LysHis: 0.499 ± 0.02	0.913LysIle: 0.913 ± 0.032	0.749LysLys: 0.749 ± 0.041	2.09LysLeu: 2.09 ± 0.041	0.384LysMet: 0.384 ± 0.018	0.514LysAsn: 0.514 ± 0.023	1.292LysPro: 1.292 ± 0.032	0.823LysGln: 0.823 ± 0.028	1.447LysArg: 1.447 ± 0.037	1.314LysSer: 1.314 ± 0.037	1.3LysThr: 1.3 ± 0.04	1.89LysVal: 1.89 ± 0.049	0.261LysTrp: 0.261 ± 0.014	0.524LysTyr: 0.524 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.301LeuAla: 14.301 ± 0.13	0.777LeuCys: 0.777 ± 0.025	6.541LeuAsp: 6.541 ± 0.083	4.355LeuGlu: 4.355 ± 0.078	2.5LeuPhe: 2.5 ± 0.053	8.893LeuGly: 8.893 ± 0.106	2.383LeuHis: 2.383 ± 0.046	4.032LeuIle: 4.032 ± 0.067	1.733LeuLys: 1.733 ± 0.045	10.629LeuLeu: 10.629 ± 0.124	1.685LeuMet: 1.685 ± 0.042	1.696LeuAsn: 1.696 ± 0.039	5.882LeuPro: 5.882 ± 0.074	2.999LeuGln: 2.999 ± 0.049	8.323LeuArg: 8.323 ± 0.099	5.465LeuSer: 5.465 ± 0.064	6.661LeuThr: 6.661 ± 0.081	9.285LeuVal: 9.285 ± 0.107	1.243LeuTrp: 1.243 ± 0.031	1.598LeuTyr: 1.598 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.279MetAla: 2.279 ± 0.045	0.171MetCys: 0.171 ± 0.012	0.836MetAsp: 0.836 ± 0.027	0.677MetGlu: 0.677 ± 0.026	0.538MetPhe: 0.538 ± 0.023	1.31MetGly: 1.31 ± 0.035	0.41MetHis: 0.41 ± 0.017	0.816MetIle: 0.816 ± 0.024	0.47MetLys: 0.47 ± 0.023	1.948MetLeu: 1.948 ± 0.039	0.337MetMet: 0.337 ± 0.018	0.438MetAsn: 0.438 ± 0.021	1.296MetPro: 1.296 ± 0.03	0.628MetGln: 0.628 ± 0.024	1.509MetArg: 1.509 ± 0.035	1.47MetSer: 1.47 ± 0.038	1.938MetThr: 1.938 ± 0.04	1.485MetVal: 1.485 ± 0.037	0.232MetTrp: 0.232 ± 0.014	0.31MetTyr: 0.31 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.313AsnAla: 2.313 ± 0.046	0.155AsnCys: 0.155 ± 0.013	1.134AsnAsp: 1.134 ± 0.033	0.802AsnGlu: 0.802 ± 0.026	0.565AsnPhe: 0.565 ± 0.021	1.746AsnGly: 1.746 ± 0.043	0.404AsnHis: 0.404 ± 0.018	0.738AsnIle: 0.738 ± 0.025	0.451AsnLys: 0.451 ± 0.019	1.928AsnLeu: 1.928 ± 0.036	0.308AsnMet: 0.308 ± 0.016	0.453AsnAsn: 0.453 ± 0.02	1.534AsnPro: 1.534 ± 0.035	0.574AsnGln: 0.574 ± 0.022	1.164AsnArg: 1.164 ± 0.029	1.091AsnSer: 1.091 ± 0.038	1.126AsnThr: 1.126 ± 0.036	1.577AsnVal: 1.577 ± 0.035	0.316AsnTrp: 0.316 ± 0.017	0.478AsnTyr: 0.478 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.477ProAla: 7.477 ± 0.096	0.313ProCys: 0.313 ± 0.016	4.165ProAsp: 4.165 ± 0.063	3.354ProGlu: 3.354 ± 0.054	1.457ProPhe: 1.457 ± 0.037	5.575ProGly: 5.575 ± 0.077	1.278ProHis: 1.278 ± 0.032	1.971ProIle: 1.971 ± 0.037	1.169ProLys: 1.169 ± 0.037	4.574ProLeu: 4.574 ± 0.063	1.077ProMet: 1.077 ± 0.033	0.976ProAsn: 0.976 ± 0.031	2.757ProPro: 2.757 ± 0.056	1.903ProGln: 1.903 ± 0.04	3.431ProArg: 3.431 ± 0.058	3.185ProSer: 3.185 ± 0.063	3.46ProThr: 3.46 ± 0.054	5.121ProVal: 5.121 ± 0.064	0.956ProTrp: 0.956 ± 0.027	1.157ProTyr: 1.157 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.783GlnAla: 3.783 ± 0.062	0.21GlnCys: 0.21 ± 0.015	1.506GlnAsp: 1.506 ± 0.036	1.418GlnGlu: 1.418 ± 0.033	0.887GlnPhe: 0.887 ± 0.028	2.156GlnGly: 2.156 ± 0.047	0.961GlnHis: 0.961 ± 0.029	1.478GlnIle: 1.478 ± 0.031	0.521GlnLys: 0.521 ± 0.02	4.102GlnLeu: 4.102 ± 0.058	0.561GlnMet: 0.561 ± 0.022	0.518GlnAsn: 0.518 ± 0.021	1.988GlnPro: 1.988 ± 0.046	1.66GlnGln: 1.66 ± 0.045	2.882GlnArg: 2.882 ± 0.059	1.595GlnSer: 1.595 ± 0.038	1.669GlnThr: 1.669 ± 0.034	3.188GlnVal: 3.188 ± 0.06	0.61GlnTrp: 0.61 ± 0.024	0.548GlnTyr: 0.548 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.136ArgAla: 9.136 ± 0.105	0.617ArgCys: 0.617 ± 0.022	4.558ArgAsp: 4.558 ± 0.073	4.21ArgGlu: 4.21 ± 0.068	2.254ArgPhe: 2.254 ± 0.049	5.436ArgGly: 5.436 ± 0.068	2.004ArgHis: 2.004 ± 0.042	3.309ArgIle: 3.309 ± 0.052	1.585ArgLys: 1.585 ± 0.041	7.984ArgLeu: 7.984 ± 0.098	1.859ArgMet: 1.859 ± 0.037	1.363ArgAsn: 1.363 ± 0.032	4.18ArgPro: 4.18 ± 0.058	2.5ArgGln: 2.5 ± 0.048	7.073ArgArg: 7.073 ± 0.101	4.526ArgSer: 4.526 ± 0.077	4.591ArgThr: 4.591 ± 0.066	5.915ArgVal: 5.915 ± 0.082	1.4ArgTrp: 1.4 ± 0.038	1.576ArgTyr: 1.576 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.165SerAla: 7.165 ± 0.082	0.41SerCys: 0.41 ± 0.019	2.956SerAsp: 2.956 ± 0.051	2.374SerGlu: 2.374 ± 0.052	1.771SerPhe: 1.771 ± 0.041	6.109SerGly: 6.109 ± 0.081	1.134SerHis: 1.134 ± 0.031	2.224SerIle: 2.224 ± 0.049	1.187SerLys: 1.187 ± 0.033	5.153SerLeu: 5.153 ± 0.064	1.345SerMet: 1.345 ± 0.031	1.082SerAsn: 1.082 ± 0.031	3.1SerPro: 3.1 ± 0.054	1.576SerGln: 1.576 ± 0.039	4.028SerArg: 4.028 ± 0.054	3.567SerSer: 3.567 ± 0.076	3.588SerThr: 3.588 ± 0.056	4.724SerVal: 4.724 ± 0.061	1.006SerTrp: 1.006 ± 0.033	1.447SerTyr: 1.447 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.948ThrAla: 7.948 ± 0.091	0.521ThrCys: 0.521 ± 0.023	3.772ThrAsp: 3.772 ± 0.059	2.903ThrGlu: 2.903 ± 0.05	1.805ThrPhe: 1.805 ± 0.044	6.208ThrGly: 6.208 ± 0.074	1.331ThrHis: 1.331 ± 0.035	2.507ThrIle: 2.507 ± 0.053	1.334ThrLys: 1.334 ± 0.036	5.571ThrLeu: 5.571 ± 0.073	1.17ThrMet: 1.17 ± 0.032	1.17ThrAsn: 1.17 ± 0.036	3.885ThrPro: 3.885 ± 0.062	1.703ThrGln: 1.703 ± 0.038	4.072ThrArg: 4.072 ± 0.065	3.664ThrSer: 3.664 ± 0.053	4.203ThrThr: 4.203 ± 0.077	5.831ThrVal: 5.831 ± 0.076	0.986ThrTrp: 0.986 ± 0.027	1.336ThrTyr: 1.336 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	11.535ValAla: 11.535 ± 0.101	0.808ValCys: 0.808 ± 0.026	5.442ValAsp: 5.442 ± 0.066	4.568ValGlu: 4.568 ± 0.075	2.501ValPhe: 2.501 ± 0.053	7.162ValGly: 7.162 ± 0.097	1.942ValHis: 1.942 ± 0.038	4.019ValIle: 4.019 ± 0.059	1.604ValLys: 1.604 ± 0.043	9.527ValLeu: 9.527 ± 0.103	1.584ValMet: 1.584 ± 0.035	1.664ValAsn: 1.664 ± 0.035	4.752ValPro: 4.752 ± 0.061	2.573ValGln: 2.573 ± 0.042	6.625ValArg: 6.625 ± 0.087	4.981ValSer: 4.981 ± 0.066	5.865ValThr: 5.865 ± 0.086	8.944ValVal: 8.944 ± 0.108	1.203ValTrp: 1.203 ± 0.032	1.359ValTyr: 1.359 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.657TrpAla: 1.657 ± 0.037	0.197TrpCys: 0.197 ± 0.013	0.825TrpAsp: 0.825 ± 0.029	0.588TrpGlu: 0.588 ± 0.021	0.537TrpPhe: 0.537 ± 0.022	1.061TrpGly: 1.061 ± 0.028	0.422TrpHis: 0.422 ± 0.019	0.646TrpIle: 0.646 ± 0.024	0.321TrpLys: 0.321 ± 0.015	1.953TrpLeu: 1.953 ± 0.047	0.299TrpMet: 0.299 ± 0.015	0.367TrpAsn: 0.367 ± 0.017	0.858TrpPro: 0.858 ± 0.023	0.62TrpGln: 0.62 ± 0.021	1.374TrpArg: 1.374 ± 0.031	1.084TrpSer: 1.084 ± 0.031	0.982TrpThr: 0.982 ± 0.031	1.169TrpVal: 1.169 ± 0.031	0.428TrpTrp: 0.428 ± 0.02	0.277TrpTyr: 0.277 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.038	0.177TyrCys: 0.177 ± 0.013	1.562TyrAsp: 1.562 ± 0.038	0.946TyrGlu: 0.946 ± 0.031	0.701TyrPhe: 0.701 ± 0.026	2.012TyrGly: 2.012 ± 0.041	0.377TyrHis: 0.377 ± 0.018	0.561TyrIle: 0.561 ± 0.022	0.354TyrLys: 0.354 ± 0.018	2.206TyrLeu: 2.206 ± 0.043	0.197TyrMet: 0.197 ± 0.013	0.419TyrAsn: 0.419 ± 0.019	1.114TyrPro: 1.114 ± 0.032	0.647TyrGln: 0.647 ± 0.019	1.598TyrArg: 1.598 ± 0.037	1.018TyrSer: 1.018 ± 0.032	1.045TyrThr: 1.045 ± 0.029	1.758TyrVal: 1.758 ± 0.04	0.305TyrTrp: 0.305 ± 0.014	0.474TyrTyr: 0.474 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3842 proteins (1225569 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---