Amino acid dipepetide frequency for Hypnocyclicus thermotrophus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.977AlaAla: 2.977 ± 0.087
0.407AlaCys: 0.407 ± 0.026
2.242AlaAsp: 2.242 ± 0.057
3.132AlaGlu: 3.132 ± 0.082
2.115AlaPhe: 2.115 ± 0.061
3.386AlaGly: 3.386 ± 0.092
0.687AlaHis: 0.687 ± 0.034
5.406AlaIle: 5.406 ± 0.097
5.143AlaLys: 5.143 ± 0.095
4.692AlaLeu: 4.692 ± 0.105
1.215AlaMet: 1.215 ± 0.048
2.627AlaAsn: 2.627 ± 0.06
1.082AlaPro: 1.082 ± 0.041
1.145AlaGln: 1.145 ± 0.045
1.612AlaArg: 1.612 ± 0.049
2.543AlaSer: 2.543 ± 0.073
2.555AlaThr: 2.555 ± 0.071
3.05AlaVal: 3.05 ± 0.078
0.265AlaTrp: 0.265 ± 0.019
1.989AlaTyr: 1.989 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.291CysAla: 0.291 ± 0.025
0.069CysCys: 0.069 ± 0.011
0.326CysAsp: 0.326 ± 0.022
0.438CysGlu: 0.438 ± 0.028
0.288CysPhe: 0.288 ± 0.021
0.578CysGly: 0.578 ± 0.042
0.119CysHis: 0.119 ± 0.013
0.555CysIle: 0.555 ± 0.034
0.556CysLys: 0.556 ± 0.028
0.382CysLeu: 0.382 ± 0.024
0.115CysMet: 0.115 ± 0.013
0.419CysAsn: 0.419 ± 0.029
0.318CysPro: 0.318 ± 0.028
0.14CysGln: 0.14 ± 0.015
0.227CysArg: 0.227 ± 0.02
0.391CysSer: 0.391 ± 0.027
0.285CysThr: 0.285 ± 0.022
0.35CysVal: 0.35 ± 0.021
0.022CysTrp: 0.022 ± 0.006
0.258CysTyr: 0.258 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.196AspAla: 2.196 ± 0.066
0.294AspCys: 0.294 ± 0.021
2.336AspAsp: 2.336 ± 0.065
4.288AspGlu: 4.288 ± 0.081
3.04AspPhe: 3.04 ± 0.058
2.585AspGly: 2.585 ± 0.061
0.479AspHis: 0.479 ± 0.028
7.432AspIle: 7.432 ± 0.109
5.698AspLys: 5.698 ± 0.103
4.595AspLeu: 4.595 ± 0.088
1.345AspMet: 1.345 ± 0.052
3.568AspAsn: 3.568 ± 0.081
1.069AspPro: 1.069 ± 0.046
0.561AspGln: 0.561 ± 0.03
1.628AspArg: 1.628 ± 0.049
2.621AspSer: 2.621 ± 0.068
2.448AspThr: 2.448 ± 0.063
2.697AspVal: 2.697 ± 0.072
0.355AspTrp: 0.355 ± 0.027
2.813AspTyr: 2.813 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
3.69GluAla: 3.69 ± 0.076
0.388GluCys: 0.388 ± 0.028
3.456GluAsp: 3.456 ± 0.076
7.141GluGlu: 7.141 ± 0.144
3.726GluPhe: 3.726 ± 0.083
3.414GluGly: 3.414 ± 0.093
0.918GluHis: 0.918 ± 0.035
10.038GluIle: 10.038 ± 0.143
11.327GluLys: 11.327 ± 0.17
7.971GluLeu: 7.971 ± 0.123
1.773GluMet: 1.773 ± 0.055
7.269GluAsn: 7.269 ± 0.129
1.179GluPro: 1.179 ± 0.045
1.47GluGln: 1.47 ± 0.05
2.363GluArg: 2.363 ± 0.063
2.918GluSer: 2.918 ± 0.073
3.147GluThr: 3.147 ± 0.078
4.44GluVal: 4.44 ± 0.089
0.452GluTrp: 0.452 ± 0.031
3.767GluTyr: 3.767 ± 0.08
0.0GluXaa: 0.0 ± 0.0
Phe
2.112PheAla: 2.112 ± 0.06
0.35PheCys: 0.35 ± 0.026
2.836PheAsp: 2.836 ± 0.07
3.523PheGlu: 3.523 ± 0.065
2.625PhePhe: 2.625 ± 0.078
2.889PheGly: 2.889 ± 0.071
0.541PheHis: 0.541 ± 0.029
5.702PheIle: 5.702 ± 0.125
4.438PheLys: 4.438 ± 0.089
5.103PheLeu: 5.103 ± 0.111
0.993PheMet: 0.993 ± 0.038
3.657PheAsn: 3.657 ± 0.091
1.196PhePro: 1.196 ± 0.046
0.881PheGln: 0.881 ± 0.038
1.297PheArg: 1.297 ± 0.052
3.42PheSer: 3.42 ± 0.066
2.272PheThr: 2.272 ± 0.059
2.32PheVal: 2.32 ± 0.054
0.337PheTrp: 0.337 ± 0.025
2.406PheTyr: 2.406 ± 0.084
0.0PheXaa: 0.0 ± 0.0
Gly
3.332GlyAla: 3.332 ± 0.096
0.449GlyCys: 0.449 ± 0.034
2.885GlyAsp: 2.885 ± 0.063
4.106GlyGlu: 4.106 ± 0.077
2.809GlyPhe: 2.809 ± 0.071
3.642GlyGly: 3.642 ± 0.089
0.88GlyHis: 0.88 ± 0.036
6.704GlyIle: 6.704 ± 0.117
5.537GlyLys: 5.537 ± 0.099
4.668GlyLeu: 4.668 ± 0.091
1.427GlyMet: 1.427 ± 0.057
3.093GlyAsn: 3.093 ± 0.086
1.067GlyPro: 1.067 ± 0.045
1.111GlyGln: 1.111 ± 0.044
1.859GlyArg: 1.859 ± 0.06
2.807GlySer: 2.807 ± 0.077
2.879GlyThr: 2.879 ± 0.07
3.763GlyVal: 3.763 ± 0.096
0.398GlyTrp: 0.398 ± 0.028
2.774GlyTyr: 2.774 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.558HisAla: 0.558 ± 0.029
0.113HisCys: 0.113 ± 0.015
0.581HisAsp: 0.581 ± 0.031
0.774HisGlu: 0.774 ± 0.033
0.684HisPhe: 0.684 ± 0.031
0.824HisGly: 0.824 ± 0.04
0.264HisHis: 0.264 ± 0.02
1.355HisIle: 1.355 ± 0.048
1.111HisLys: 1.111 ± 0.04
1.108HisLeu: 1.108 ± 0.044
0.255HisMet: 0.255 ± 0.017
0.83HisAsn: 0.83 ± 0.038
0.546HisPro: 0.546 ± 0.026
0.277HisGln: 0.277 ± 0.022
0.462HisArg: 0.462 ± 0.024
0.807HisSer: 0.807 ± 0.034
0.647HisThr: 0.647 ± 0.03
0.534HisVal: 0.534 ± 0.032
0.079HisTrp: 0.079 ± 0.01
0.568HisTyr: 0.568 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.753IleAla: 5.753 ± 0.107
0.646IleCys: 0.646 ± 0.033
6.862IleAsp: 6.862 ± 0.115
9.64IleGlu: 9.64 ± 0.152
5.977IlePhe: 5.977 ± 0.131
6.169IleGly: 6.169 ± 0.117
1.221IleHis: 1.221 ± 0.043
12.636IleIle: 12.636 ± 0.209
12.682IleLys: 12.682 ± 0.177
11.084IleLeu: 11.084 ± 0.157
2.019IleMet: 2.019 ± 0.055
8.583IleAsn: 8.583 ± 0.136
3.144IlePro: 3.144 ± 0.075
2.171IleGln: 2.171 ± 0.058
3.0IleArg: 3.0 ± 0.071
7.336IleSer: 7.336 ± 0.122
5.345IleThr: 5.345 ± 0.092
5.822IleVal: 5.822 ± 0.107
0.532IleTrp: 0.532 ± 0.031
4.683IleTyr: 4.683 ± 0.099
0.0IleXaa: 0.0 ± 0.0
Lys
4.396LysAla: 4.396 ± 0.085
0.498LysCys: 0.498 ± 0.034
5.847LysAsp: 5.847 ± 0.092
11.566LysGlu: 11.566 ± 0.184
4.21LysPhe: 4.21 ± 0.09
4.835LysGly: 4.835 ± 0.107
1.214LysHis: 1.214 ± 0.045
13.389LysIle: 13.389 ± 0.178
13.012LysLys: 13.012 ± 0.192
9.68LysLeu: 9.68 ± 0.136
2.499LysMet: 2.499 ± 0.054
10.43LysAsn: 10.43 ± 0.176
1.899LysPro: 1.899 ± 0.058
2.259LysGln: 2.259 ± 0.06
3.108LysArg: 3.108 ± 0.077
5.073LysSer: 5.073 ± 0.091
4.723LysThr: 4.723 ± 0.075
5.474LysVal: 5.474 ± 0.096
0.607LysTrp: 0.607 ± 0.03
6.039LysTyr: 6.039 ± 0.122
0.0LysXaa: 0.0 ± 0.0
Leu
4.875LeuAla: 4.875 ± 0.096
0.467LeuCys: 0.467 ± 0.029
5.318LeuAsp: 5.318 ± 0.094
8.226LeuGlu: 8.226 ± 0.125
4.225LeuPhe: 4.225 ± 0.086
5.34LeuGly: 5.34 ± 0.093
1.09LeuHis: 1.09 ± 0.044
9.31LeuIle: 9.31 ± 0.139
11.014LeuLys: 11.014 ± 0.145
8.281LeuLeu: 8.281 ± 0.123
1.852LeuMet: 1.852 ± 0.061
7.211LeuAsn: 7.211 ± 0.136
2.505LeuPro: 2.505 ± 0.073
1.889LeuGln: 1.889 ± 0.054
2.661LeuArg: 2.661 ± 0.077
5.901LeuSer: 5.901 ± 0.098
4.195LeuThr: 4.195 ± 0.095
4.522LeuVal: 4.522 ± 0.094
0.441LeuTrp: 0.441 ± 0.029
3.38LeuTyr: 3.38 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
1.231MetAla: 1.231 ± 0.045
0.131MetCys: 0.131 ± 0.016
1.045MetAsp: 1.045 ± 0.037
1.491MetGlu: 1.491 ± 0.046
0.979MetPhe: 0.979 ± 0.037
1.434MetGly: 1.434 ± 0.046
0.271MetHis: 0.271 ± 0.022
2.016MetIle: 2.016 ± 0.057
2.519MetLys: 2.519 ± 0.063
1.943MetLeu: 1.943 ± 0.052
0.487MetMet: 0.487 ± 0.025
1.385MetAsn: 1.385 ± 0.045
0.692MetPro: 0.692 ± 0.03
0.513MetGln: 0.513 ± 0.031
0.736MetArg: 0.736 ± 0.038
1.291MetSer: 1.291 ± 0.039
0.939MetThr: 0.939 ± 0.04
1.133MetVal: 1.133 ± 0.046
0.128MetTrp: 0.128 ± 0.015
0.851MetTyr: 0.851 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.636AsnAla: 2.636 ± 0.065
0.452AsnCys: 0.452 ± 0.032
3.404AsnAsp: 3.404 ± 0.068
5.355AsnGlu: 5.355 ± 0.104
3.828AsnPhe: 3.828 ± 0.084
3.912AsnGly: 3.912 ± 0.09
0.783AsnHis: 0.783 ± 0.035
10.491AsnIle: 10.491 ± 0.176
8.845AsnLys: 8.845 ± 0.176
6.765AsnLeu: 6.765 ± 0.126
1.512AsnMet: 1.512 ± 0.039
6.67AsnAsn: 6.67 ± 0.177
1.987AsnPro: 1.987 ± 0.053
1.461AsnGln: 1.461 ± 0.046
2.148AsnArg: 2.148 ± 0.05
4.259AsnSer: 4.259 ± 0.093
3.099AsnThr: 3.099 ± 0.086
3.208AsnVal: 3.208 ± 0.069
0.446AsnTrp: 0.446 ± 0.028
3.831AsnTyr: 3.831 ± 0.094
0.0AsnXaa: 0.0 ± 0.0
Pro
1.208ProAla: 1.208 ± 0.046
0.165ProCys: 0.165 ± 0.016
1.194ProAsp: 1.194 ± 0.043
1.96ProGlu: 1.96 ± 0.061
1.321ProPhe: 1.321 ± 0.045
1.439ProGly: 1.439 ± 0.049
0.428ProHis: 0.428 ± 0.026
2.582ProIle: 2.582 ± 0.068
2.236ProLys: 2.236 ± 0.056
2.257ProLeu: 2.257 ± 0.066
0.525ProMet: 0.525 ± 0.027
1.558ProAsn: 1.558 ± 0.048
0.514ProPro: 0.514 ± 0.024
0.584ProGln: 0.584 ± 0.036
0.692ProArg: 0.692 ± 0.034
1.294ProSer: 1.294 ± 0.039
1.231ProThr: 1.231 ± 0.045
1.506ProVal: 1.506 ± 0.049
0.23ProTrp: 0.23 ± 0.018
1.13ProTyr: 1.13 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
1.088GlnAla: 1.088 ± 0.043
0.088GlnCys: 0.088 ± 0.013
0.963GlnAsp: 0.963 ± 0.039
1.701GlnGlu: 1.701 ± 0.06
0.818GlnPhe: 0.818 ± 0.035
1.142GlnGly: 1.142 ± 0.045
0.236GlnHis: 0.236 ± 0.019
2.194GlnIle: 2.194 ± 0.06
2.282GlnLys: 2.282 ± 0.071
1.834GlnLeu: 1.834 ± 0.06
0.486GlnMet: 0.486 ± 0.026
1.705GlnAsn: 1.705 ± 0.053
0.446GlnPro: 0.446 ± 0.026
0.423GlnGln: 0.423 ± 0.025
0.656GlnArg: 0.656 ± 0.034
1.006GlnSer: 1.006 ± 0.039
1.066GlnThr: 1.066 ± 0.04
1.081GlnVal: 1.081 ± 0.045
0.143GlnTrp: 0.143 ± 0.015
0.812GlnTyr: 0.812 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
1.647ArgAla: 1.647 ± 0.06
0.201ArgCys: 0.201 ± 0.018
1.677ArgAsp: 1.677 ± 0.052
2.751ArgGlu: 2.751 ± 0.069
1.303ArgPhe: 1.303 ± 0.036
1.705ArgGly: 1.705 ± 0.054
0.374ArgHis: 0.374 ± 0.023
3.11ArgIle: 3.11 ± 0.073
3.299ArgLys: 3.299 ± 0.08
2.516ArgLeu: 2.516 ± 0.061
0.659ArgMet: 0.659 ± 0.034
1.837ArgAsn: 1.837 ± 0.055
0.696ArgPro: 0.696 ± 0.032
0.662ArgGln: 0.662 ± 0.034
1.044ArgArg: 1.044 ± 0.042
1.178ArgSer: 1.178 ± 0.045
1.303ArgThr: 1.303 ± 0.047
1.989ArgVal: 1.989 ± 0.056
0.2ArgTrp: 0.2 ± 0.018
1.424ArgTyr: 1.424 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
2.57SerAla: 2.57 ± 0.071
0.365SerCys: 0.365 ± 0.023
2.745SerAsp: 2.745 ± 0.074
3.688SerGlu: 3.688 ± 0.088
3.131SerPhe: 3.131 ± 0.075
3.412SerGly: 3.412 ± 0.077
0.787SerHis: 0.787 ± 0.028
6.381SerIle: 6.381 ± 0.102
5.907SerLys: 5.907 ± 0.089
5.3SerLeu: 5.3 ± 0.091
1.075SerMet: 1.075 ± 0.037
3.881SerAsn: 3.881 ± 0.091
1.318SerPro: 1.318 ± 0.047
1.328SerGln: 1.328 ± 0.046
1.661SerArg: 1.661 ± 0.047
3.193SerSer: 3.193 ± 0.082
2.691SerThr: 2.691 ± 0.072
2.754SerVal: 2.754 ± 0.073
0.353SerTrp: 0.353 ± 0.025
2.512SerTyr: 2.512 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
2.634ThrAla: 2.634 ± 0.069
0.276ThrCys: 0.276 ± 0.023
2.242ThrAsp: 2.242 ± 0.062
3.162ThrGlu: 3.162 ± 0.074
2.217ThrPhe: 2.217 ± 0.068
3.287ThrGly: 3.287 ± 0.07
0.735ThrHis: 0.735 ± 0.033
4.99ThrIle: 4.99 ± 0.095
4.529ThrLys: 4.529 ± 0.076
4.604ThrLeu: 4.604 ± 0.085
0.903ThrMet: 0.903 ± 0.042
2.88ThrAsn: 2.88 ± 0.072
1.598ThrPro: 1.598 ± 0.048
1.032ThrGln: 1.032 ± 0.037
1.279ThrArg: 1.279 ± 0.046
2.578ThrSer: 2.578 ± 0.063
2.622ThrThr: 2.622 ± 0.079
2.598ThrVal: 2.598 ± 0.073
0.271ThrTrp: 0.271 ± 0.022
1.889ThrTyr: 1.889 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
3.014ValAla: 3.014 ± 0.079
0.392ValCys: 0.392 ± 0.025
3.152ValAsp: 3.152 ± 0.072
4.188ValGlu: 4.188 ± 0.096
2.539ValPhe: 2.539 ± 0.072
3.223ValGly: 3.223 ± 0.078
0.669ValHis: 0.669 ± 0.033
5.497ValIle: 5.497 ± 0.093
5.352ValLys: 5.352 ± 0.097
4.814ValLeu: 4.814 ± 0.101
1.143ValMet: 1.143 ± 0.041
3.074ValAsn: 3.074 ± 0.072
1.391ValPro: 1.391 ± 0.044
1.051ValGln: 1.051 ± 0.041
1.528ValArg: 1.528 ± 0.048
3.226ValSer: 3.226 ± 0.078
2.516ValThr: 2.516 ± 0.073
3.484ValVal: 3.484 ± 0.089
0.347ValTrp: 0.347 ± 0.023
2.32ValTyr: 2.32 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.319TrpAla: 0.319 ± 0.029
0.049TrpCys: 0.049 ± 0.009
0.377TrpAsp: 0.377 ± 0.027
0.453TrpGlu: 0.453 ± 0.029
0.297TrpPhe: 0.297 ± 0.025
0.44TrpGly: 0.44 ± 0.028
0.103TrpHis: 0.103 ± 0.013
0.581TrpIle: 0.581 ± 0.03
0.483TrpLys: 0.483 ± 0.029
0.513TrpLeu: 0.513 ± 0.025
0.149TrpMet: 0.149 ± 0.014
0.458TrpAsn: 0.458 ± 0.029
0.136TrpPro: 0.136 ± 0.016
0.189TrpGln: 0.189 ± 0.016
0.197TrpArg: 0.197 ± 0.016
0.343TrpSer: 0.343 ± 0.027
0.231TrpThr: 0.231 ± 0.022
0.292TrpVal: 0.292 ± 0.019
0.085TrpTrp: 0.085 ± 0.013
0.273TrpTyr: 0.273 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.743TyrAla: 1.743 ± 0.053
0.326TyrCys: 0.326 ± 0.022
2.557TyrAsp: 2.557 ± 0.071
3.263TyrGlu: 3.263 ± 0.069
2.767TyrPhe: 2.767 ± 0.08
2.531TyrGly: 2.531 ± 0.069
0.578TyrHis: 0.578 ± 0.03
4.935TyrIle: 4.935 ± 0.1
4.787TyrLys: 4.787 ± 0.108
4.593TyrLeu: 4.593 ± 0.091
0.786TyrMet: 0.786 ± 0.032
3.958TyrAsn: 3.958 ± 0.101
1.272TyrPro: 1.272 ± 0.051
1.026TyrGln: 1.026 ± 0.039
1.418TyrArg: 1.418 ± 0.041
2.867TyrSer: 2.867 ± 0.072
2.132TyrThr: 2.132 ± 0.061
1.905TyrVal: 1.905 ± 0.06
0.276TyrTrp: 0.276 ± 0.018
2.393TyrTyr: 2.393 ± 0.082
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2014 proteins (670777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski