Amino acid dipepetide frequency for Candidatus Mancarchaeum acidiphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.212AlaAla: 4.212 ± 0.16
0.415AlaCys: 0.415 ± 0.045
3.025AlaAsp: 3.025 ± 0.112
3.848AlaGlu: 3.848 ± 0.122
2.932AlaPhe: 2.932 ± 0.12
4.096AlaGly: 4.096 ± 0.114
0.768AlaHis: 0.768 ± 0.049
5.957AlaIle: 5.957 ± 0.168
5.185AlaLys: 5.185 ± 0.177
5.939AlaLeu: 5.939 ± 0.17
1.648AlaMet: 1.648 ± 0.082
3.357AlaAsn: 3.357 ± 0.124
1.796AlaPro: 1.796 ± 0.09
1.345AlaGln: 1.345 ± 0.072
2.218AlaArg: 2.218 ± 0.097
4.915AlaSer: 4.915 ± 0.162
2.86AlaThr: 2.86 ± 0.122
4.529AlaVal: 4.529 ± 0.148
0.35AlaTrp: 0.35 ± 0.038
2.95AlaTyr: 2.95 ± 0.096
0.0AlaXaa: 0.0 ± 0.0
Cys
0.357CysAla: 0.357 ± 0.039
0.05CysCys: 0.05 ± 0.014
0.379CysAsp: 0.379 ± 0.04
0.433CysGlu: 0.433 ± 0.046
0.202CysPhe: 0.202 ± 0.026
0.746CysGly: 0.746 ± 0.063
0.123CysHis: 0.123 ± 0.02
0.436CysIle: 0.436 ± 0.041
0.487CysLys: 0.487 ± 0.046
0.393CysLeu: 0.393 ± 0.034
0.133CysMet: 0.133 ± 0.022
0.429CysAsn: 0.429 ± 0.043
0.343CysPro: 0.343 ± 0.044
0.126CysGln: 0.126 ± 0.023
0.307CysArg: 0.307 ± 0.032
0.617CysSer: 0.617 ± 0.05
0.436CysThr: 0.436 ± 0.041
0.382CysVal: 0.382 ± 0.031
0.043CysTrp: 0.043 ± 0.013
0.328CysTyr: 0.328 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
3.177AspAla: 3.177 ± 0.116
0.364AspCys: 0.364 ± 0.036
2.755AspAsp: 2.755 ± 0.141
3.729AspGlu: 3.729 ± 0.145
2.542AspPhe: 2.542 ± 0.116
2.896AspGly: 2.896 ± 0.104
0.555AspHis: 0.555 ± 0.046
5.272AspIle: 5.272 ± 0.168
4.774AspLys: 4.774 ± 0.168
5.315AspLeu: 5.315 ± 0.173
1.504AspMet: 1.504 ± 0.081
2.888AspAsn: 2.888 ± 0.114
1.861AspPro: 1.861 ± 0.076
1.01AspGln: 1.01 ± 0.063
2.052AspArg: 2.052 ± 0.095
4.428AspSer: 4.428 ± 0.133
2.272AspThr: 2.272 ± 0.093
3.217AspVal: 3.217 ± 0.116
0.361AspTrp: 0.361 ± 0.042
2.899AspTyr: 2.899 ± 0.113
0.0AspXaa: 0.0 ± 0.0
Glu
3.851GluAla: 3.851 ± 0.134
0.382GluCys: 0.382 ± 0.033
3.491GluAsp: 3.491 ± 0.136
4.497GluGlu: 4.497 ± 0.181
2.86GluPhe: 2.86 ± 0.104
3.869GluGly: 3.869 ± 0.126
0.883GluHis: 0.883 ± 0.056
5.496GluIle: 5.496 ± 0.155
6.491GluLys: 6.491 ± 0.213
6.065GluLeu: 6.065 ± 0.15
1.677GluMet: 1.677 ± 0.083
3.657GluAsn: 3.657 ± 0.125
1.554GluPro: 1.554 ± 0.072
1.363GluGln: 1.363 ± 0.082
2.607GluArg: 2.607 ± 0.11
4.865GluSer: 4.865 ± 0.148
2.549GluThr: 2.549 ± 0.109
3.833GluVal: 3.833 ± 0.133
0.498GluTrp: 0.498 ± 0.046
2.751GluTyr: 2.751 ± 0.108
0.0GluXaa: 0.0 ± 0.0
Phe
2.906PheAla: 2.906 ± 0.131
0.263PheCys: 0.263 ± 0.034
2.683PheAsp: 2.683 ± 0.118
2.333PheGlu: 2.333 ± 0.098
1.731PhePhe: 1.731 ± 0.098
3.498PheGly: 3.498 ± 0.127
0.501PheHis: 0.501 ± 0.045
3.938PheIle: 3.938 ± 0.138
3.076PheLys: 3.076 ± 0.111
3.592PheLeu: 3.592 ± 0.145
1.085PheMet: 1.085 ± 0.067
2.701PheAsn: 2.701 ± 0.104
1.399PhePro: 1.399 ± 0.07
0.689PheGln: 0.689 ± 0.051
1.561PheArg: 1.561 ± 0.076
3.804PheSer: 3.804 ± 0.136
2.438PheThr: 2.438 ± 0.103
2.885PheVal: 2.885 ± 0.107
0.343PheTrp: 0.343 ± 0.034
2.088PheTyr: 2.088 ± 0.094
0.0PheXaa: 0.0 ± 0.0
Gly
3.451GlyAla: 3.451 ± 0.116
0.451GlyCys: 0.451 ± 0.055
2.921GlyAsp: 2.921 ± 0.101
3.224GlyGlu: 3.224 ± 0.103
3.303GlyPhe: 3.303 ± 0.132
4.298GlyGly: 4.298 ± 0.177
0.811GlyHis: 0.811 ± 0.054
7.212GlyIle: 7.212 ± 0.197
5.773GlyLys: 5.773 ± 0.165
5.445GlyLeu: 5.445 ± 0.153
2.023GlyMet: 2.023 ± 0.089
3.693GlyAsn: 3.693 ± 0.137
1.619GlyPro: 1.619 ± 0.086
1.309GlyGln: 1.309 ± 0.069
2.625GlyArg: 2.625 ± 0.117
5.532GlySer: 5.532 ± 0.188
3.588GlyThr: 3.588 ± 0.168
4.06GlyVal: 4.06 ± 0.135
0.858GlyTrp: 0.858 ± 0.086
3.426GlyTyr: 3.426 ± 0.138
0.0GlyXaa: 0.0 ± 0.0
His
0.757HisAla: 0.757 ± 0.044
0.141HisCys: 0.141 ± 0.025
0.602HisAsp: 0.602 ± 0.046
0.7HisGlu: 0.7 ± 0.054
0.588HisPhe: 0.588 ± 0.048
0.797HisGly: 0.797 ± 0.066
0.292HisHis: 0.292 ± 0.034
1.331HisIle: 1.331 ± 0.066
1.046HisLys: 1.046 ± 0.065
1.255HisLeu: 1.255 ± 0.062
0.411HisMet: 0.411 ± 0.043
0.811HisAsn: 0.811 ± 0.056
0.645HisPro: 0.645 ± 0.045
0.249HisGln: 0.249 ± 0.03
0.62HisArg: 0.62 ± 0.053
1.259HisSer: 1.259 ± 0.074
0.674HisThr: 0.674 ± 0.049
0.775HisVal: 0.775 ± 0.055
0.159HisTrp: 0.159 ± 0.026
0.671HisTyr: 0.671 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
6.487IleAla: 6.487 ± 0.215
0.548IleCys: 0.548 ± 0.049
5.207IleAsp: 5.207 ± 0.16
5.593IleGlu: 5.593 ± 0.181
3.599IlePhe: 3.599 ± 0.148
6.0IleGly: 6.0 ± 0.168
1.01IleHis: 1.01 ± 0.063
7.966IleIle: 7.966 ± 0.239
7.904IleLys: 7.904 ± 0.213
7.468IleLeu: 7.468 ± 0.221
2.059IleMet: 2.059 ± 0.105
5.78IleAsn: 5.78 ± 0.162
3.209IlePro: 3.209 ± 0.11
1.471IleGln: 1.471 ± 0.076
3.101IleArg: 3.101 ± 0.118
8.287IleSer: 8.287 ± 0.181
4.367IleThr: 4.367 ± 0.145
5.07IleVal: 5.07 ± 0.182
0.53IleTrp: 0.53 ± 0.047
3.995IleTyr: 3.995 ± 0.134
0.0IleXaa: 0.0 ± 0.0
Lys
5.175LysAla: 5.175 ± 0.152
0.627LysCys: 0.627 ± 0.06
5.315LysAsp: 5.315 ± 0.17
7.245LysGlu: 7.245 ± 0.228
3.642LysPhe: 3.642 ± 0.126
5.625LysGly: 5.625 ± 0.176
1.208LysHis: 1.208 ± 0.083
6.761LysIle: 6.761 ± 0.18
7.144LysLys: 7.144 ± 0.23
7.486LysLeu: 7.486 ± 0.183
2.286LysMet: 2.286 ± 0.089
4.554LysAsn: 4.554 ± 0.132
2.82LysPro: 2.82 ± 0.109
1.738LysGln: 1.738 ± 0.09
3.559LysArg: 3.559 ± 0.144
6.668LysSer: 6.668 ± 0.186
3.487LysThr: 3.487 ± 0.112
5.312LysVal: 5.312 ± 0.161
0.584LysTrp: 0.584 ± 0.046
3.678LysTyr: 3.678 ± 0.134
0.0LysXaa: 0.0 ± 0.0
Leu
5.351LeuAla: 5.351 ± 0.155
0.483LeuCys: 0.483 ± 0.045
5.002LeuAsp: 5.002 ± 0.167
5.323LeuGlu: 5.323 ± 0.164
3.952LeuPhe: 3.952 ± 0.17
5.946LeuGly: 5.946 ± 0.164
1.424LeuHis: 1.424 ± 0.067
7.353LeuIle: 7.353 ± 0.218
7.749LeuLys: 7.749 ± 0.218
8.301LeuLeu: 8.301 ± 0.231
2.308LeuMet: 2.308 ± 0.102
5.708LeuAsn: 5.708 ± 0.147
3.538LeuPro: 3.538 ± 0.132
2.048LeuGln: 2.048 ± 0.085
3.058LeuArg: 3.058 ± 0.122
8.081LeuSer: 8.081 ± 0.195
4.215LeuThr: 4.215 ± 0.131
5.542LeuVal: 5.542 ± 0.151
0.649LeuTrp: 0.649 ± 0.053
3.992LeuTyr: 3.992 ± 0.116
0.0LeuXaa: 0.0 ± 0.0
Met
1.911MetAla: 1.911 ± 0.088
0.108MetCys: 0.108 ± 0.02
1.641MetAsp: 1.641 ± 0.081
1.821MetGlu: 1.821 ± 0.08
1.042MetPhe: 1.042 ± 0.064
1.464MetGly: 1.464 ± 0.085
0.584MetHis: 0.584 ± 0.053
1.962MetIle: 1.962 ± 0.085
2.07MetLys: 2.07 ± 0.09
2.528MetLeu: 2.528 ± 0.097
0.746MetMet: 0.746 ± 0.056
1.45MetAsn: 1.45 ± 0.081
1.172MetPro: 1.172 ± 0.069
0.862MetGln: 0.862 ± 0.058
0.829MetArg: 0.829 ± 0.065
1.976MetSer: 1.976 ± 0.089
1.06MetThr: 1.06 ± 0.061
1.803MetVal: 1.803 ± 0.084
0.105MetTrp: 0.105 ± 0.019
0.948MetTyr: 0.948 ± 0.046
0.0MetXaa: 0.0 ± 0.0
Asn
3.819AsnAla: 3.819 ± 0.127
0.415AsnCys: 0.415 ± 0.038
2.802AsnAsp: 2.802 ± 0.11
3.959AsnGlu: 3.959 ± 0.112
2.6AsnPhe: 2.6 ± 0.086
4.089AsnGly: 4.089 ± 0.146
0.75AsnHis: 0.75 ± 0.047
5.045AsnIle: 5.045 ± 0.128
4.836AsnLys: 4.836 ± 0.175
5.193AsnLeu: 5.193 ± 0.169
1.543AsnMet: 1.543 ± 0.078
3.206AsnAsn: 3.206 ± 0.171
2.348AsnPro: 2.348 ± 0.107
1.244AsnGln: 1.244 ± 0.067
2.066AsnArg: 2.066 ± 0.097
5.29AsnSer: 5.29 ± 0.222
2.726AsnThr: 2.726 ± 0.129
3.437AsnVal: 3.437 ± 0.125
0.415AsnTrp: 0.415 ± 0.048
3.116AsnTyr: 3.116 ± 0.146
0.0AsnXaa: 0.0 ± 0.0
Pro
1.929ProAla: 1.929 ± 0.082
0.13ProCys: 0.13 ± 0.021
1.893ProAsp: 1.893 ± 0.092
2.683ProGlu: 2.683 ± 0.109
1.608ProPhe: 1.608 ± 0.088
2.146ProGly: 2.146 ± 0.12
0.494ProHis: 0.494 ± 0.046
2.939ProIle: 2.939 ± 0.106
2.91ProLys: 2.91 ± 0.1
2.86ProLeu: 2.86 ± 0.103
0.851ProMet: 0.851 ± 0.053
2.027ProAsn: 2.027 ± 0.092
1.183ProPro: 1.183 ± 0.082
0.822ProGln: 0.822 ± 0.056
0.981ProArg: 0.981 ± 0.063
3.015ProSer: 3.015 ± 0.153
1.807ProThr: 1.807 ± 0.105
2.254ProVal: 2.254 ± 0.09
0.307ProTrp: 0.307 ± 0.036
1.695ProTyr: 1.695 ± 0.087
0.0ProXaa: 0.0 ± 0.0
Gln
1.446GlnAla: 1.446 ± 0.077
0.141GlnCys: 0.141 ± 0.024
0.992GlnAsp: 0.992 ± 0.062
1.338GlnGlu: 1.338 ± 0.069
0.984GlnPhe: 0.984 ± 0.068
1.219GlnGly: 1.219 ± 0.061
0.35GlnHis: 0.35 ± 0.037
1.868GlnIle: 1.868 ± 0.077
1.713GlnLys: 1.713 ± 0.087
1.991GlnLeu: 1.991 ± 0.093
0.671GlnMet: 0.671 ± 0.051
1.295GlnAsn: 1.295 ± 0.076
0.772GlnPro: 0.772 ± 0.06
0.685GlnGln: 0.685 ± 0.059
0.905GlnArg: 0.905 ± 0.066
1.835GlnSer: 1.835 ± 0.087
0.916GlnThr: 0.916 ± 0.058
1.316GlnVal: 1.316 ± 0.075
0.155GlnTrp: 0.155 ± 0.023
0.941GlnTyr: 0.941 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
2.055ArgAla: 2.055 ± 0.099
0.303ArgCys: 0.303 ± 0.038
2.005ArgAsp: 2.005 ± 0.1
2.402ArgGlu: 2.402 ± 0.098
1.713ArgPhe: 1.713 ± 0.074
2.077ArgGly: 2.077 ± 0.104
0.602ArgHis: 0.602 ± 0.045
3.393ArgIle: 3.393 ± 0.12
3.404ArgLys: 3.404 ± 0.151
3.437ArgLeu: 3.437 ± 0.144
1.111ArgMet: 1.111 ± 0.065
1.991ArgAsn: 1.991 ± 0.087
1.071ArgPro: 1.071 ± 0.078
0.966ArgGln: 0.966 ± 0.057
1.843ArgArg: 1.843 ± 0.089
2.737ArgSer: 2.737 ± 0.097
1.572ArgThr: 1.572 ± 0.066
2.236ArgVal: 2.236 ± 0.098
0.278ArgTrp: 0.278 ± 0.034
1.886ArgTyr: 1.886 ± 0.094
0.0ArgXaa: 0.0 ± 0.0
Ser
4.944SerAla: 4.944 ± 0.173
0.599SerCys: 0.599 ± 0.059
4.529SerAsp: 4.529 ± 0.152
5.11SerGlu: 5.11 ± 0.122
3.563SerPhe: 3.563 ± 0.132
5.845SerGly: 5.845 ± 0.248
1.14SerHis: 1.14 ± 0.056
8.225SerIle: 8.225 ± 0.163
7.457SerLys: 7.457 ± 0.186
7.248SerLeu: 7.248 ± 0.196
2.077SerMet: 2.077 ± 0.091
5.211SerAsn: 5.211 ± 0.192
2.625SerPro: 2.625 ± 0.142
2.001SerGln: 2.001 ± 0.099
3.076SerArg: 3.076 ± 0.119
7.428SerSer: 7.428 ± 0.352
4.237SerThr: 4.237 ± 0.218
4.713SerVal: 4.713 ± 0.175
0.508SerTrp: 0.508 ± 0.042
4.035SerTyr: 4.035 ± 0.149
0.0SerXaa: 0.0 ± 0.0
Thr
3.354ThrAla: 3.354 ± 0.121
0.4ThrCys: 0.4 ± 0.052
2.697ThrAsp: 2.697 ± 0.097
2.661ThrGlu: 2.661 ± 0.129
1.958ThrPhe: 1.958 ± 0.09
3.534ThrGly: 3.534 ± 0.174
0.66ThrHis: 0.66 ± 0.046
4.19ThrIle: 4.19 ± 0.135
3.429ThrLys: 3.429 ± 0.115
4.486ThrLeu: 4.486 ± 0.133
1.19ThrMet: 1.19 ± 0.068
2.618ThrAsn: 2.618 ± 0.12
2.001ThrPro: 2.001 ± 0.092
1.125ThrGln: 1.125 ± 0.064
1.486ThrArg: 1.486 ± 0.072
3.819ThrSer: 3.819 ± 0.225
2.679ThrThr: 2.679 ± 0.137
2.939ThrVal: 2.939 ± 0.125
0.299ThrTrp: 0.299 ± 0.036
2.315ThrTyr: 2.315 ± 0.129
0.0ThrXaa: 0.0 ± 0.0
Val
4.071ValAla: 4.071 ± 0.139
0.422ValCys: 0.422 ± 0.042
3.206ValAsp: 3.206 ± 0.125
3.419ValGlu: 3.419 ± 0.118
2.564ValPhe: 2.564 ± 0.102
3.714ValGly: 3.714 ± 0.135
0.858ValHis: 0.858 ± 0.056
5.643ValIle: 5.643 ± 0.164
5.02ValLys: 5.02 ± 0.15
5.669ValLeu: 5.669 ± 0.177
1.457ValMet: 1.457 ± 0.077
3.84ValAsn: 3.84 ± 0.143
2.398ValPro: 2.398 ± 0.108
1.226ValGln: 1.226 ± 0.065
2.081ValArg: 2.081 ± 0.1
5.167ValSer: 5.167 ± 0.154
3.047ValThr: 3.047 ± 0.108
3.812ValVal: 3.812 ± 0.151
0.462ValTrp: 0.462 ± 0.037
2.878ValTyr: 2.878 ± 0.113
0.0ValXaa: 0.0 ± 0.0
Trp
0.411TrpAla: 0.411 ± 0.041
0.097TrpCys: 0.097 ± 0.02
0.346TrpAsp: 0.346 ± 0.041
0.404TrpGlu: 0.404 ± 0.038
0.278TrpPhe: 0.278 ± 0.036
0.386TrpGly: 0.386 ± 0.036
0.169TrpHis: 0.169 ± 0.024
0.685TrpIle: 0.685 ± 0.05
0.519TrpLys: 0.519 ± 0.039
0.707TrpLeu: 0.707 ± 0.057
0.198TrpMet: 0.198 ± 0.025
0.458TrpAsn: 0.458 ± 0.044
0.263TrpPro: 0.263 ± 0.034
0.256TrpGln: 0.256 ± 0.03
0.281TrpArg: 0.281 ± 0.036
0.48TrpSer: 0.48 ± 0.043
0.415TrpThr: 0.415 ± 0.065
0.404TrpVal: 0.404 ± 0.045
0.123TrpTrp: 0.123 ± 0.024
0.523TrpTyr: 0.523 ± 0.062
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.679TyrAla: 2.679 ± 0.1
0.411TyrCys: 0.411 ± 0.044
2.38TyrAsp: 2.38 ± 0.117
2.521TyrGlu: 2.521 ± 0.115
1.854TyrPhe: 1.854 ± 0.099
3.375TyrGly: 3.375 ± 0.126
0.599TyrHis: 0.599 ± 0.044
3.981TyrIle: 3.981 ± 0.118
3.927TyrLys: 3.927 ± 0.148
4.648TyrLeu: 4.648 ± 0.146
1.1TyrMet: 1.1 ± 0.062
3.224TyrAsn: 3.224 ± 0.14
1.915TyrPro: 1.915 ± 0.102
0.999TyrGln: 0.999 ± 0.063
1.825TyrArg: 1.825 ± 0.082
4.371TyrSer: 4.371 ± 0.148
2.495TyrThr: 2.495 ± 0.157
2.434TyrVal: 2.434 ± 0.123
0.379TyrTrp: 0.379 ± 0.04
2.272TyrTyr: 2.272 ± 0.114
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 944 proteins (277313 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski