Amino acid dipepetide frequency for Vibrio sp. JCM 19236

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.699AlaAla: 6.699 ± 0.095
0.881AlaCys: 0.881 ± 0.026
4.386AlaAsp: 4.386 ± 0.067
5.619AlaGlu: 5.619 ± 0.074
3.403AlaPhe: 3.403 ± 0.059
5.795AlaGly: 5.795 ± 0.076
1.523AlaHis: 1.523 ± 0.035
5.978AlaIle: 5.978 ± 0.076
4.902AlaLys: 4.902 ± 0.063
9.28AlaLeu: 9.28 ± 0.096
2.81AlaMet: 2.81 ± 0.053
3.527AlaAsn: 3.527 ± 0.054
2.958AlaPro: 2.958 ± 0.052
3.491AlaGln: 3.491 ± 0.054
3.513AlaArg: 3.513 ± 0.058
5.566AlaSer: 5.566 ± 0.072
4.581AlaThr: 4.581 ± 0.064
5.92AlaVal: 5.92 ± 0.061
0.976AlaTrp: 0.976 ± 0.029
2.335AlaTyr: 2.335 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.786CysAla: 0.786 ± 0.026
0.156CysCys: 0.156 ± 0.012
0.578CysAsp: 0.578 ± 0.025
0.621CysGlu: 0.621 ± 0.023
0.432CysPhe: 0.432 ± 0.019
0.878CysGly: 0.878 ± 0.024
0.325CysHis: 0.325 ± 0.019
0.605CysIle: 0.605 ± 0.024
0.424CysLys: 0.424 ± 0.021
0.985CysLeu: 0.985 ± 0.027
0.32CysMet: 0.32 ± 0.016
0.361CysAsn: 0.361 ± 0.017
0.415CysPro: 0.415 ± 0.018
0.414CysGln: 0.414 ± 0.019
0.446CysArg: 0.446 ± 0.021
0.736CysSer: 0.736 ± 0.022
0.502CysThr: 0.502 ± 0.021
0.689CysVal: 0.689 ± 0.026
0.141CysTrp: 0.141 ± 0.01
0.321CysTyr: 0.321 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.564AspAla: 4.564 ± 0.063
0.492AspCys: 0.492 ± 0.018
2.98AspAsp: 2.98 ± 0.063
3.902AspGlu: 3.902 ± 0.057
2.53AspPhe: 2.53 ± 0.043
4.009AspGly: 4.009 ± 0.08
1.033AspHis: 1.033 ± 0.031
3.806AspIle: 3.806 ± 0.057
3.409AspLys: 3.409 ± 0.054
5.396AspLeu: 5.396 ± 0.063
1.44AspMet: 1.44 ± 0.034
2.469AspAsn: 2.469 ± 0.051
2.011AspPro: 2.011 ± 0.047
1.901AspGln: 1.901 ± 0.038
2.177AspArg: 2.177 ± 0.041
3.617AspSer: 3.617 ± 0.063
2.853AspThr: 2.853 ± 0.053
3.916AspVal: 3.916 ± 0.07
0.862AspTrp: 0.862 ± 0.026
2.137AspTyr: 2.137 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.435GluAla: 5.435 ± 0.079
0.584GluCys: 0.584 ± 0.021
3.083GluAsp: 3.083 ± 0.054
4.19GluGlu: 4.19 ± 0.068
2.763GluPhe: 2.763 ± 0.05
3.818GluGly: 3.818 ± 0.054
1.641GluHis: 1.641 ± 0.04
3.815GluIle: 3.815 ± 0.055
3.779GluLys: 3.779 ± 0.052
7.479GluLeu: 7.479 ± 0.09
1.724GluMet: 1.724 ± 0.035
2.734GluAsn: 2.734 ± 0.047
2.174GluPro: 2.174 ± 0.049
3.969GluGln: 3.969 ± 0.058
3.281GluArg: 3.281 ± 0.058
4.026GluSer: 4.026 ± 0.054
3.345GluThr: 3.345 ± 0.045
4.73GluVal: 4.73 ± 0.065
0.831GluTrp: 0.831 ± 0.022
1.969GluTyr: 1.969 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.71PheAla: 3.71 ± 0.059
0.478PheCys: 0.478 ± 0.02
2.927PheAsp: 2.927 ± 0.055
2.906PheGlu: 2.906 ± 0.049
1.679PhePhe: 1.679 ± 0.043
3.399PheGly: 3.399 ± 0.055
0.825PheHis: 0.825 ± 0.023
2.822PheIle: 2.822 ± 0.058
2.067PheLys: 2.067 ± 0.037
3.469PheLeu: 3.469 ± 0.057
1.167PheMet: 1.167 ± 0.033
2.107PheAsn: 2.107 ± 0.043
1.392PhePro: 1.392 ± 0.034
1.271PheGln: 1.271 ± 0.031
1.48PheArg: 1.48 ± 0.033
3.244PheSer: 3.244 ± 0.052
2.498PheThr: 2.498 ± 0.047
3.03PheVal: 3.03 ± 0.049
0.581PheTrp: 0.581 ± 0.018
1.313PheTyr: 1.313 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.467GlyAla: 5.467 ± 0.079
0.878GlyCys: 0.878 ± 0.027
3.846GlyAsp: 3.846 ± 0.069
4.56GlyGlu: 4.56 ± 0.065
3.504GlyPhe: 3.504 ± 0.049
4.924GlyGly: 4.924 ± 0.094
1.449GlyHis: 1.449 ± 0.035
4.832GlyIle: 4.832 ± 0.066
3.976GlyLys: 3.976 ± 0.051
7.046GlyLeu: 7.046 ± 0.072
2.193GlyMet: 2.193 ± 0.042
2.673GlyAsn: 2.673 ± 0.05
1.577GlyPro: 1.577 ± 0.034
2.635GlyGln: 2.635 ± 0.044
2.917GlyArg: 2.917 ± 0.058
4.252GlySer: 4.252 ± 0.068
3.657GlyThr: 3.657 ± 0.079
5.34GlyVal: 5.34 ± 0.069
0.988GlyTrp: 0.988 ± 0.028
2.65GlyTyr: 2.65 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.508HisAla: 1.508 ± 0.033
0.308HisCys: 0.308 ± 0.015
1.063HisAsp: 1.063 ± 0.035
1.08HisGlu: 1.08 ± 0.029
1.053HisPhe: 1.053 ± 0.028
1.553HisGly: 1.553 ± 0.04
0.634HisHis: 0.634 ± 0.024
1.308HisIle: 1.308 ± 0.029
1.086HisLys: 1.086 ± 0.029
2.231HisLeu: 2.231 ± 0.041
0.534HisMet: 0.534 ± 0.021
0.85HisAsn: 0.85 ± 0.024
1.098HisPro: 1.098 ± 0.03
1.106HisGln: 1.106 ± 0.031
1.005HisArg: 1.005 ± 0.031
1.449HisSer: 1.449 ± 0.035
1.073HisThr: 1.073 ± 0.032
1.205HisVal: 1.205 ± 0.034
0.368HisTrp: 0.368 ± 0.017
0.809HisTyr: 0.809 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.226IleAla: 6.226 ± 0.079
0.65IleCys: 0.65 ± 0.023
4.106IleAsp: 4.106 ± 0.064
4.9IleGlu: 4.9 ± 0.069
2.301IlePhe: 2.301 ± 0.047
4.654IleGly: 4.654 ± 0.065
1.19IleHis: 1.19 ± 0.03
3.396IleIle: 3.396 ± 0.063
3.256IleLys: 3.256 ± 0.044
5.286IleLeu: 5.286 ± 0.07
1.358IleMet: 1.358 ± 0.032
2.739IleAsn: 2.739 ± 0.046
2.656IlePro: 2.656 ± 0.049
2.265IleGln: 2.265 ± 0.046
2.586IleArg: 2.586 ± 0.046
4.609IleSer: 4.609 ± 0.064
3.745IleThr: 3.745 ± 0.06
4.046IleVal: 4.046 ± 0.054
0.657IleTrp: 0.657 ± 0.021
1.753IleTyr: 1.753 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.887LysAla: 4.887 ± 0.071
0.317LysCys: 0.317 ± 0.017
2.796LysAsp: 2.796 ± 0.051
3.521LysGlu: 3.521 ± 0.061
1.678LysPhe: 1.678 ± 0.04
3.463LysGly: 3.463 ± 0.055
1.297LysHis: 1.297 ± 0.033
2.859LysIle: 2.859 ± 0.041
2.834LysLys: 2.834 ± 0.051
5.669LysLeu: 5.669 ± 0.069
1.52LysMet: 1.52 ± 0.043
2.032LysAsn: 2.032 ± 0.038
2.433LysPro: 2.433 ± 0.041
3.066LysGln: 3.066 ± 0.054
2.752LysArg: 2.752 ± 0.044
3.321LysSer: 3.321 ± 0.055
2.753LysThr: 2.753 ± 0.046
4.101LysVal: 4.101 ± 0.057
0.602LysTrp: 0.602 ± 0.022
1.466LysTyr: 1.466 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
9.323LeuAla: 9.323 ± 0.087
1.112LeuCys: 1.112 ± 0.029
5.851LeuAsp: 5.851 ± 0.073
6.627LeuGlu: 6.627 ± 0.085
4.346LeuPhe: 4.346 ± 0.075
7.239LeuGly: 7.239 ± 0.087
1.922LeuHis: 1.922 ± 0.04
6.098LeuIle: 6.098 ± 0.076
5.517LeuLys: 5.517 ± 0.057
9.997LeuLeu: 9.997 ± 0.112
2.858LeuMet: 2.858 ± 0.051
4.462LeuAsn: 4.462 ± 0.059
4.498LeuPro: 4.498 ± 0.055
3.455LeuGln: 3.455 ± 0.046
4.148LeuArg: 4.148 ± 0.056
8.036LeuSer: 8.036 ± 0.086
5.936LeuThr: 5.936 ± 0.068
7.422LeuVal: 7.422 ± 0.078
1.049LeuTrp: 1.049 ± 0.031
2.611LeuTyr: 2.611 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.629MetAla: 2.629 ± 0.048
0.284MetCys: 0.284 ± 0.013
1.369MetAsp: 1.369 ± 0.037
1.332MetGlu: 1.332 ± 0.031
1.105MetPhe: 1.105 ± 0.029
1.924MetGly: 1.924 ± 0.039
0.573MetHis: 0.573 ± 0.022
1.538MetIle: 1.538 ± 0.034
1.646MetLys: 1.646 ± 0.036
3.039MetLeu: 3.039 ± 0.052
0.893MetMet: 0.893 ± 0.025
1.184MetAsn: 1.184 ± 0.032
1.371MetPro: 1.371 ± 0.033
1.281MetGln: 1.281 ± 0.032
1.28MetArg: 1.28 ± 0.031
2.11MetSer: 2.11 ± 0.046
1.722MetThr: 1.722 ± 0.036
2.112MetVal: 2.112 ± 0.049
0.284MetTrp: 0.284 ± 0.016
0.672MetTyr: 0.672 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.191AsnAla: 3.191 ± 0.052
0.407AsnCys: 0.407 ± 0.018
2.264AsnAsp: 2.264 ± 0.053
2.406AsnGlu: 2.406 ± 0.044
1.703AsnPhe: 1.703 ± 0.036
2.988AsnGly: 2.988 ± 0.054
0.976AsnHis: 0.976 ± 0.027
2.658AsnIle: 2.658 ± 0.051
2.275AsnLys: 2.275 ± 0.041
4.218AsnLeu: 4.218 ± 0.058
1.048AsnMet: 1.048 ± 0.025
1.88AsnAsn: 1.88 ± 0.04
2.216AsnPro: 2.216 ± 0.041
2.073AsnGln: 2.073 ± 0.038
1.906AsnArg: 1.906 ± 0.039
2.668AsnSer: 2.668 ± 0.052
2.311AsnThr: 2.311 ± 0.046
2.565AsnVal: 2.565 ± 0.05
0.638AsnTrp: 0.638 ± 0.025
1.446AsnTyr: 1.446 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
2.894ProAla: 2.894 ± 0.053
0.338ProCys: 0.338 ± 0.016
2.148ProAsp: 2.148 ± 0.043
3.319ProGlu: 3.319 ± 0.052
1.738ProPhe: 1.738 ± 0.037
2.019ProGly: 2.019 ± 0.039
0.844ProHis: 0.844 ± 0.027
2.479ProIle: 2.479 ± 0.041
2.012ProLys: 2.012 ± 0.043
3.967ProLeu: 3.967 ± 0.056
1.205ProMet: 1.205 ± 0.032
1.665ProAsn: 1.665 ± 0.029
1.039ProPro: 1.039 ± 0.028
1.615ProGln: 1.615 ± 0.035
1.405ProArg: 1.405 ± 0.032
2.637ProSer: 2.637 ± 0.041
2.312ProThr: 2.312 ± 0.044
3.033ProVal: 3.033 ± 0.054
0.489ProTrp: 0.489 ± 0.016
1.237ProTyr: 1.237 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.991GlnAla: 3.991 ± 0.064
0.328GlnCys: 0.328 ± 0.013
2.25GlnAsp: 2.25 ± 0.048
2.626GlnGlu: 2.626 ± 0.044
1.696GlnPhe: 1.696 ± 0.036
3.021GlnGly: 3.021 ± 0.045
0.994GlnHis: 0.994 ± 0.028
2.48GlnIle: 2.48 ± 0.039
2.205GlnLys: 2.205 ± 0.039
4.445GlnLeu: 4.445 ± 0.058
1.259GlnMet: 1.259 ± 0.03
1.667GlnAsn: 1.667 ± 0.036
1.511GlnPro: 1.511 ± 0.034
2.408GlnGln: 2.408 ± 0.052
2.076GlnArg: 2.076 ± 0.043
2.746GlnSer: 2.746 ± 0.049
2.332GlnThr: 2.332 ± 0.046
3.206GlnVal: 3.206 ± 0.047
0.567GlnTrp: 0.567 ± 0.019
1.316GlnTyr: 1.316 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
3.356ArgAla: 3.356 ± 0.061
0.467ArgCys: 0.467 ± 0.021
2.371ArgAsp: 2.371 ± 0.043
2.861ArgGlu: 2.861 ± 0.051
2.255ArgPhe: 2.255 ± 0.043
2.529ArgGly: 2.529 ± 0.045
1.003ArgHis: 1.003 ± 0.026
2.858ArgIle: 2.858 ± 0.044
2.287ArgLys: 2.287 ± 0.042
4.552ArgLeu: 4.552 ± 0.066
1.372ArgMet: 1.372 ± 0.03
1.822ArgAsn: 1.822 ± 0.035
1.515ArgPro: 1.515 ± 0.036
1.834ArgGln: 1.834 ± 0.042
2.178ArgArg: 2.178 ± 0.047
2.7ArgSer: 2.7 ± 0.047
2.148ArgThr: 2.148 ± 0.042
3.188ArgVal: 3.188 ± 0.046
0.586ArgTrp: 0.586 ± 0.024
1.633ArgTyr: 1.633 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
5.366SerAla: 5.366 ± 0.059
0.641SerCys: 0.641 ± 0.026
3.897SerAsp: 3.897 ± 0.061
4.329SerGlu: 4.329 ± 0.062
3.019SerPhe: 3.019 ± 0.058
5.088SerGly: 5.088 ± 0.073
1.533SerHis: 1.533 ± 0.036
4.401SerIle: 4.401 ± 0.057
3.55SerLys: 3.55 ± 0.052
7.281SerLeu: 7.281 ± 0.081
1.99SerMet: 1.99 ± 0.037
2.87SerAsn: 2.87 ± 0.052
2.326SerPro: 2.326 ± 0.038
2.947SerGln: 2.947 ± 0.054
2.924SerArg: 2.924 ± 0.049
4.622SerSer: 4.622 ± 0.067
3.483SerThr: 3.483 ± 0.059
4.868SerVal: 4.868 ± 0.061
0.883SerTrp: 0.883 ± 0.027
2.168SerTyr: 2.168 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.489ThrAla: 4.489 ± 0.057
0.515ThrCys: 0.515 ± 0.022
3.025ThrAsp: 3.025 ± 0.059
3.313ThrGlu: 3.313 ± 0.052
2.231ThrPhe: 2.231 ± 0.048
4.142ThrGly: 4.142 ± 0.058
1.224ThrHis: 1.224 ± 0.033
3.497ThrIle: 3.497 ± 0.065
2.545ThrLys: 2.545 ± 0.053
6.196ThrLeu: 6.196 ± 0.077
1.38ThrMet: 1.38 ± 0.027
2.112ThrAsn: 2.112 ± 0.042
2.677ThrPro: 2.677 ± 0.049
2.442ThrGln: 2.442 ± 0.043
2.174ThrArg: 2.174 ± 0.042
3.549ThrSer: 3.549 ± 0.052
3.097ThrThr: 3.097 ± 0.051
3.976ThrVal: 3.976 ± 0.074
0.682ThrTrp: 0.682 ± 0.023
1.613ThrTyr: 1.613 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
6.479ValAla: 6.479 ± 0.079
0.751ValCys: 0.751 ± 0.022
4.234ValAsp: 4.234 ± 0.07
5.042ValGlu: 5.042 ± 0.063
2.877ValPhe: 2.877 ± 0.053
4.937ValGly: 4.937 ± 0.062
1.238ValHis: 1.238 ± 0.03
4.629ValIle: 4.629 ± 0.059
3.53ValLys: 3.53 ± 0.052
6.908ValLeu: 6.908 ± 0.082
2.092ValMet: 2.092 ± 0.042
2.977ValAsn: 2.977 ± 0.056
2.733ValPro: 2.733 ± 0.057
2.275ValGln: 2.275 ± 0.043
2.921ValArg: 2.921 ± 0.045
5.351ValSer: 5.351 ± 0.071
4.344ValThr: 4.344 ± 0.069
5.575ValVal: 5.575 ± 0.074
0.81ValTrp: 0.81 ± 0.025
1.978ValTyr: 1.978 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.849TrpAla: 0.849 ± 0.029
0.179TrpCys: 0.179 ± 0.01
0.647TrpAsp: 0.647 ± 0.022
0.558TrpGlu: 0.558 ± 0.024
0.598TrpPhe: 0.598 ± 0.023
0.81TrpGly: 0.81 ± 0.024
0.349TrpHis: 0.349 ± 0.016
0.691TrpIle: 0.691 ± 0.023
0.598TrpLys: 0.598 ± 0.022
1.687TrpLeu: 1.687 ± 0.037
0.473TrpMet: 0.473 ± 0.021
0.522TrpAsn: 0.522 ± 0.02
0.45TrpPro: 0.45 ± 0.024
0.771TrpGln: 0.771 ± 0.024
0.637TrpArg: 0.637 ± 0.023
0.777TrpSer: 0.777 ± 0.024
0.604TrpThr: 0.604 ± 0.02
0.86TrpVal: 0.86 ± 0.027
0.226TrpTrp: 0.226 ± 0.012
0.409TrpTyr: 0.409 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.296TyrAla: 2.296 ± 0.044
0.369TyrCys: 0.369 ± 0.018
1.684TyrAsp: 1.684 ± 0.037
1.657TyrGlu: 1.657 ± 0.036
1.454TyrPhe: 1.454 ± 0.031
2.174TyrGly: 2.174 ± 0.042
0.745TyrHis: 0.745 ± 0.024
1.628TyrIle: 1.628 ± 0.034
1.469TyrLys: 1.469 ± 0.035
3.375TyrLeu: 3.375 ± 0.049
0.715TyrMet: 0.715 ± 0.024
1.182TyrAsn: 1.182 ± 0.03
1.346TyrPro: 1.346 ± 0.032
1.907TyrGln: 1.907 ± 0.038
1.707TyrArg: 1.707 ± 0.033
2.17TyrSer: 2.17 ± 0.039
1.585TyrThr: 1.585 ± 0.037
1.899TyrVal: 1.899 ± 0.036
0.474TyrTrp: 0.474 ± 0.018
1.046TyrTyr: 1.046 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6630 proteins (1336432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski