Amino acid dipepetide frequency for Diaporthe ampelina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.467AlaAla: 11.467 ± 0.078	1.046AlaCys: 1.046 ± 0.018	5.234AlaAsp: 5.234 ± 0.035	5.844AlaGlu: 5.844 ± 0.046	3.373AlaPhe: 3.373 ± 0.032	7.372AlaGly: 7.372 ± 0.047	1.889AlaHis: 1.889 ± 0.023	4.21AlaIle: 4.21 ± 0.031	4.408AlaLys: 4.408 ± 0.035	8.229AlaLeu: 8.229 ± 0.045	2.116AlaMet: 2.116 ± 0.02	3.194AlaAsn: 3.194 ± 0.027	4.887AlaPro: 4.887 ± 0.04	3.71AlaGln: 3.71 ± 0.029	5.419AlaArg: 5.419 ± 0.041	7.263AlaSer: 7.263 ± 0.045	5.674AlaThr: 5.674 ± 0.036	6.291AlaVal: 6.291 ± 0.04	1.306AlaTrp: 1.306 ± 0.018	2.351AlaTyr: 2.351 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.953CysAla: 0.953 ± 0.016	0.199CysCys: 0.199 ± 0.007	0.632CysAsp: 0.632 ± 0.013	0.569CysGlu: 0.569 ± 0.011	0.506CysPhe: 0.506 ± 0.011	0.947CysGly: 0.947 ± 0.014	0.273CysHis: 0.273 ± 0.007	0.616CysIle: 0.616 ± 0.012	0.456CysLys: 0.456 ± 0.01	1.125CysLeu: 1.125 ± 0.017	0.252CysMet: 0.252 ± 0.007	0.403CysAsn: 0.403 ± 0.01	0.58CysPro: 0.58 ± 0.011	0.377CysGln: 0.377 ± 0.01	0.633CysArg: 0.633 ± 0.012	0.767CysSer: 0.767 ± 0.013	0.629CysThr: 0.629 ± 0.014	0.802CysVal: 0.802 ± 0.014	0.188CysTrp: 0.188 ± 0.006	0.326CysTyr: 0.326 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.45AspAla: 5.45 ± 0.04	0.604AspCys: 0.604 ± 0.014	4.894AspAsp: 4.894 ± 0.051	4.915AspGlu: 4.915 ± 0.038	2.368AspPhe: 2.368 ± 0.024	4.895AspGly: 4.895 ± 0.038	1.258AspHis: 1.258 ± 0.017	2.904AspIle: 2.904 ± 0.024	2.726AspLys: 2.726 ± 0.025	5.297AspLeu: 5.297 ± 0.034	1.374AspMet: 1.374 ± 0.016	2.001AspAsn: 2.001 ± 0.022	3.463AspPro: 3.463 ± 0.025	1.955AspGln: 1.955 ± 0.021	3.161AspArg: 3.161 ± 0.03	3.998AspSer: 3.998 ± 0.035	3.011AspThr: 3.011 ± 0.025	4.145AspVal: 4.145 ± 0.032	0.947AspTrp: 0.947 ± 0.016	1.679AspTyr: 1.679 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.159GluAla: 6.159 ± 0.045	0.57GluCys: 0.57 ± 0.013	4.547GluAsp: 4.547 ± 0.039	5.304GluGlu: 5.304 ± 0.052	1.979GluPhe: 1.979 ± 0.022	4.174GluGly: 4.174 ± 0.031	1.375GluHis: 1.375 ± 0.018	2.817GluIle: 2.817 ± 0.027	3.644GluLys: 3.644 ± 0.04	5.364GluLeu: 5.364 ± 0.038	1.481GluMet: 1.481 ± 0.019	2.174GluAsn: 2.174 ± 0.027	2.773GluPro: 2.773 ± 0.03	2.494GluGln: 2.494 ± 0.027	3.849GluArg: 3.849 ± 0.036	3.769GluSer: 3.769 ± 0.027	3.31GluThr: 3.31 ± 0.03	3.832GluVal: 3.832 ± 0.03	0.933GluTrp: 0.933 ± 0.013	1.664GluTyr: 1.664 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.275PheAla: 3.275 ± 0.03	0.521PheCys: 0.521 ± 0.01	2.443PheAsp: 2.443 ± 0.023	2.182PheGlu: 2.182 ± 0.022	1.656PhePhe: 1.656 ± 0.023	3.095PheGly: 3.095 ± 0.034	0.844PheHis: 0.844 ± 0.013	1.737PheIle: 1.737 ± 0.021	1.563PheLys: 1.563 ± 0.02	3.415PheLeu: 3.415 ± 0.031	0.849PheMet: 0.849 ± 0.015	1.479PheAsn: 1.479 ± 0.021	1.872PhePro: 1.872 ± 0.024	1.311PheGln: 1.311 ± 0.018	1.93PheArg: 1.93 ± 0.021	2.83PheSer: 2.83 ± 0.025	2.174PheThr: 2.174 ± 0.019	2.631PheVal: 2.631 ± 0.025	0.678PheTrp: 0.678 ± 0.014	1.157PheTyr: 1.157 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	6.667GlyAla: 6.667 ± 0.038	0.868GlyCys: 0.868 ± 0.015	4.423GlyAsp: 4.423 ± 0.034	4.121GlyGlu: 4.121 ± 0.032	3.05GlyPhe: 3.05 ± 0.027	7.509GlyGly: 7.509 ± 0.071	1.798GlyHis: 1.798 ± 0.022	3.572GlyIle: 3.572 ± 0.031	3.688GlyLys: 3.688 ± 0.031	6.64GlyLeu: 6.64 ± 0.042	1.686GlyMet: 1.686 ± 0.022	2.689GlyAsn: 2.689 ± 0.028	3.591GlyPro: 3.591 ± 0.03	2.81GlyGln: 2.81 ± 0.028	4.43GlyArg: 4.43 ± 0.035	5.967GlySer: 5.967 ± 0.04	4.352GlyThr: 4.352 ± 0.036	5.026GlyVal: 5.026 ± 0.033	1.304GlyTrp: 1.304 ± 0.018	2.216GlyTyr: 2.216 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.837HisAla: 1.837 ± 0.022	0.297HisCys: 0.297 ± 0.008	1.343HisAsp: 1.343 ± 0.016	1.326HisGlu: 1.326 ± 0.02	0.91HisPhe: 0.91 ± 0.016	1.784HisGly: 1.784 ± 0.023	0.752HisHis: 0.752 ± 0.015	1.074HisIle: 1.074 ± 0.015	0.932HisLys: 0.932 ± 0.015	2.039HisLeu: 2.039 ± 0.022	0.49HisMet: 0.49 ± 0.011	0.779HisAsn: 0.779 ± 0.013	1.461HisPro: 1.461 ± 0.016	0.856HisGln: 0.856 ± 0.016	1.361HisArg: 1.361 ± 0.016	1.497HisSer: 1.497 ± 0.02	1.107HisThr: 1.107 ± 0.018	1.495HisVal: 1.495 ± 0.017	0.343HisTrp: 0.343 ± 0.009	0.658HisTyr: 0.658 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.129IleAla: 4.129 ± 0.033	0.651IleCys: 0.651 ± 0.013	2.775IleAsp: 2.775 ± 0.025	2.693IleGlu: 2.693 ± 0.027	1.874IlePhe: 1.874 ± 0.024	3.164IleGly: 3.164 ± 0.029	1.03IleHis: 1.03 ± 0.016	2.334IleIle: 2.334 ± 0.029	2.145IleLys: 2.145 ± 0.025	4.179IleLeu: 4.179 ± 0.033	1.048IleMet: 1.048 ± 0.016	1.728IleAsn: 1.728 ± 0.019	2.683IlePro: 2.683 ± 0.025	1.702IleGln: 1.702 ± 0.022	2.566IleArg: 2.566 ± 0.024	3.299IleSer: 3.299 ± 0.024	2.751IleThr: 2.751 ± 0.027	3.15IleVal: 3.15 ± 0.032	0.705IleTrp: 0.705 ± 0.012	1.337IleTyr: 1.337 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.701LysAla: 4.701 ± 0.036	0.441LysCys: 0.441 ± 0.01	2.941LysAsp: 2.941 ± 0.031	3.343LysGlu: 3.343 ± 0.037	1.481LysPhe: 1.481 ± 0.017	3.19LysGly: 3.19 ± 0.029	1.071LysHis: 1.071 ± 0.017	2.196LysIle: 2.196 ± 0.027	3.407LysLys: 3.407 ± 0.043	4.093LysLeu: 4.093 ± 0.034	1.039LysMet: 1.039 ± 0.016	1.7LysAsn: 1.7 ± 0.022	2.571LysPro: 2.571 ± 0.026	1.85LysGln: 1.85 ± 0.021	3.189LysArg: 3.189 ± 0.029	3.185LysSer: 3.185 ± 0.031	2.898LysThr: 2.898 ± 0.027	3.0LysVal: 3.0 ± 0.026	0.697LysTrp: 0.697 ± 0.013	1.403LysTyr: 1.403 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.57LeuAla: 8.57 ± 0.05	1.109LeuCys: 1.109 ± 0.017	5.401LeuAsp: 5.401 ± 0.037	5.382LeuGlu: 5.382 ± 0.04	3.278LeuPhe: 3.278 ± 0.03	6.475LeuGly: 6.475 ± 0.04	2.014LeuHis: 2.014 ± 0.022	3.66LeuIle: 3.66 ± 0.029	4.159LeuLys: 4.159 ± 0.031	8.009LeuLeu: 8.009 ± 0.056	1.833LeuMet: 1.833 ± 0.02	3.047LeuAsn: 3.047 ± 0.025	4.998LeuPro: 4.998 ± 0.032	3.565LeuGln: 3.565 ± 0.033	5.649LeuArg: 5.649 ± 0.039	6.619LeuSer: 6.619 ± 0.04	4.759LeuThr: 4.759 ± 0.033	5.877LeuVal: 5.877 ± 0.036	1.236LeuTrp: 1.236 ± 0.018	2.357LeuTyr: 2.357 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.436MetAla: 2.436 ± 0.022	0.24MetCys: 0.24 ± 0.007	1.303MetAsp: 1.303 ± 0.017	1.253MetGlu: 1.253 ± 0.02	0.786MetPhe: 0.786 ± 0.015	1.603MetGly: 1.603 ± 0.02	0.466MetHis: 0.466 ± 0.011	0.966MetIle: 0.966 ± 0.017	1.006MetLys: 1.006 ± 0.015	1.891MetLeu: 1.891 ± 0.02	0.588MetMet: 0.588 ± 0.012	0.761MetAsn: 0.761 ± 0.012	1.186MetPro: 1.186 ± 0.017	0.843MetGln: 0.843 ± 0.016	1.311MetArg: 1.311 ± 0.019	1.76MetSer: 1.76 ± 0.02	1.303MetThr: 1.303 ± 0.015	1.401MetVal: 1.401 ± 0.015	0.294MetTrp: 0.294 ± 0.008	0.553MetTyr: 0.553 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.202AsnAla: 3.202 ± 0.029	0.416AsnCys: 0.416 ± 0.01	1.948AsnAsp: 1.948 ± 0.024	1.957AsnGlu: 1.957 ± 0.021	1.439AsnPhe: 1.439 ± 0.018	3.169AsnGly: 3.169 ± 0.029	0.76AsnHis: 0.76 ± 0.012	1.93AsnIle: 1.93 ± 0.019	1.597AsnLys: 1.597 ± 0.02	3.155AsnLeu: 3.155 ± 0.028	0.853AsnMet: 0.853 ± 0.015	1.515AsnAsn: 1.515 ± 0.023	2.235AsnPro: 2.235 ± 0.024	1.199AsnGln: 1.199 ± 0.019	1.722AsnArg: 1.722 ± 0.021	2.478AsnSer: 2.478 ± 0.023	2.093AsnThr: 2.093 ± 0.022	2.416AsnVal: 2.416 ± 0.023	0.564AsnTrp: 0.564 ± 0.011	1.093AsnTyr: 1.093 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.548ProAla: 5.548 ± 0.04	0.449ProCys: 0.449 ± 0.008	3.342ProAsp: 3.342 ± 0.027	3.792ProGlu: 3.792 ± 0.03	1.975ProPhe: 1.975 ± 0.02	4.341ProGly: 4.341 ± 0.033	1.147ProHis: 1.147 ± 0.017	2.188ProIle: 2.188 ± 0.02	2.494ProLys: 2.494 ± 0.029	4.309ProLeu: 4.309 ± 0.029	0.979ProMet: 0.979 ± 0.016	1.949ProAsn: 1.949 ± 0.023	4.104ProPro: 4.104 ± 0.043	2.131ProGln: 2.131 ± 0.025	3.081ProArg: 3.081 ± 0.029	4.784ProSer: 4.784 ± 0.039	3.406ProThr: 3.406 ± 0.027	3.528ProVal: 3.528 ± 0.025	0.749ProTrp: 0.749 ± 0.013	1.465ProTyr: 1.465 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.773GlnAla: 3.773 ± 0.03	0.398GlnCys: 0.398 ± 0.009	2.186GlnAsp: 2.186 ± 0.022	2.289GlnGlu: 2.289 ± 0.027	1.247GlnPhe: 1.247 ± 0.017	2.607GlnGly: 2.607 ± 0.021	0.973GlnHis: 0.973 ± 0.017	1.731GlnIle: 1.731 ± 0.022	1.887GlnLys: 1.887 ± 0.023	3.364GlnLeu: 3.364 ± 0.036	0.862GlnMet: 0.862 ± 0.015	1.412GlnAsn: 1.412 ± 0.02	2.27GlnPro: 2.27 ± 0.024	2.359GlnGln: 2.359 ± 0.049	2.464GlnArg: 2.464 ± 0.027	2.591GlnSer: 2.591 ± 0.025	2.052GlnThr: 2.052 ± 0.021	2.273GlnVal: 2.273 ± 0.021	0.584GlnTrp: 0.584 ± 0.012	1.111GlnTyr: 1.111 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.036ArgAla: 5.036 ± 0.039	0.617ArgCys: 0.617 ± 0.011	3.608ArgAsp: 3.608 ± 0.036	3.804ArgGlu: 3.804 ± 0.037	2.135ArgPhe: 2.135 ± 0.026	3.925ArgGly: 3.925 ± 0.033	1.45ArgHis: 1.45 ± 0.018	2.648ArgIle: 2.648 ± 0.023	3.29ArgLys: 3.29 ± 0.031	5.402ArgLeu: 5.402 ± 0.036	1.297ArgMet: 1.297 ± 0.018	2.09ArgAsn: 2.09 ± 0.023	3.174ArgPro: 3.174 ± 0.031	2.503ArgGln: 2.503 ± 0.027	4.774ArgArg: 4.774 ± 0.046	4.045ArgSer: 4.045 ± 0.034	3.005ArgThr: 3.005 ± 0.024	3.548ArgVal: 3.548 ± 0.03	0.961ArgTrp: 0.961 ± 0.014	1.61ArgTyr: 1.61 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.72SerAla: 6.72 ± 0.042	0.75SerCys: 0.75 ± 0.015	4.028SerAsp: 4.028 ± 0.031	3.763SerGlu: 3.763 ± 0.034	2.802SerPhe: 2.802 ± 0.026	5.78SerGly: 5.78 ± 0.039	1.585SerHis: 1.585 ± 0.019	3.468SerIle: 3.468 ± 0.029	3.489SerLys: 3.489 ± 0.035	6.501SerLeu: 6.501 ± 0.04	1.595SerMet: 1.595 ± 0.019	2.651SerAsn: 2.651 ± 0.029	4.429SerPro: 4.429 ± 0.039	2.804SerGln: 2.804 ± 0.027	4.238SerArg: 4.238 ± 0.036	7.213SerSer: 7.213 ± 0.066	4.78SerThr: 4.78 ± 0.041	4.5SerVal: 4.5 ± 0.031	1.097SerTrp: 1.097 ± 0.016	1.988SerTyr: 1.988 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.654ThrAla: 5.654 ± 0.036	0.68ThrCys: 0.68 ± 0.015	2.964ThrAsp: 2.964 ± 0.029	3.07ThrGlu: 3.07 ± 0.028	2.263ThrPhe: 2.263 ± 0.025	4.512ThrGly: 4.512 ± 0.038	1.178ThrHis: 1.178 ± 0.018	2.841ThrIle: 2.841 ± 0.024	2.544ThrLys: 2.544 ± 0.025	4.938ThrLeu: 4.938 ± 0.036	1.153ThrMet: 1.153 ± 0.015	2.1ThrAsn: 2.1 ± 0.025	3.773ThrPro: 3.773 ± 0.036	1.943ThrGln: 1.943 ± 0.02	2.945ThrArg: 2.945 ± 0.025	4.567ThrSer: 4.567 ± 0.037	3.939ThrThr: 3.939 ± 0.04	3.996ThrVal: 3.996 ± 0.035	0.889ThrTrp: 0.889 ± 0.014	1.647ThrTyr: 1.647 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	6.11ValAla: 6.11 ± 0.043	0.798ValCys: 0.798 ± 0.013	4.224ValAsp: 4.224 ± 0.03	4.13ValGlu: 4.13 ± 0.028	2.7ValPhe: 2.7 ± 0.029	4.634ValGly: 4.634 ± 0.038	1.38ValHis: 1.38 ± 0.018	2.984ValIle: 2.984 ± 0.027	3.038ValLys: 3.038 ± 0.027	6.014ValLeu: 6.014 ± 0.04	1.433ValMet: 1.433 ± 0.015	2.31ValAsn: 2.31 ± 0.022	3.678ValPro: 3.678 ± 0.028	2.405ValGln: 2.405 ± 0.023	3.651ValArg: 3.651 ± 0.034	4.579ValSer: 4.579 ± 0.031	3.787ValThr: 3.787 ± 0.031	5.027ValVal: 5.027 ± 0.037	0.972ValTrp: 0.972 ± 0.016	1.885ValTyr: 1.885 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.315TrpAla: 1.315 ± 0.018	0.192TrpCys: 0.192 ± 0.006	1.038TrpAsp: 1.038 ± 0.015	0.895TrpGlu: 0.895 ± 0.015	0.582TrpPhe: 0.582 ± 0.011	1.032TrpGly: 1.032 ± 0.014	0.356TrpHis: 0.356 ± 0.01	0.716TrpIle: 0.716 ± 0.014	0.776TrpLys: 0.776 ± 0.014	1.406TrpLeu: 1.406 ± 0.019	0.382TrpMet: 0.382 ± 0.009	0.624TrpAsn: 0.624 ± 0.013	0.644TrpPro: 0.644 ± 0.012	0.579TrpGln: 0.579 ± 0.01	0.958TrpArg: 0.958 ± 0.016	1.041TrpSer: 1.041 ± 0.017	0.968TrpThr: 0.968 ± 0.015	0.993TrpVal: 0.993 ± 0.016	0.296TrpTrp: 0.296 ± 0.008	0.439TrpTyr: 0.439 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.281TyrAla: 2.281 ± 0.022	0.387TyrCys: 0.387 ± 0.009	1.77TyrAsp: 1.77 ± 0.021	1.578TyrGlu: 1.578 ± 0.015	1.238TyrPhe: 1.238 ± 0.02	2.197TyrGly: 2.197 ± 0.027	0.741TyrHis: 0.741 ± 0.012	1.35TyrIle: 1.35 ± 0.017	1.152TyrLys: 1.152 ± 0.015	2.624TyrLeu: 2.624 ± 0.025	0.64TyrMet: 0.64 ± 0.011	1.136TyrAsn: 1.136 ± 0.017	1.39TyrPro: 1.39 ± 0.016	1.037TyrGln: 1.037 ± 0.015	1.593TyrArg: 1.593 ± 0.022	1.931TyrSer: 1.931 ± 0.021	1.599TyrThr: 1.599 ± 0.018	1.809TyrVal: 1.809 ± 0.02	0.486TyrTrp: 0.486 ± 0.01	0.97TyrTyr: 0.97 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.035XaaXaa: 0.035 ± 0.023

Statistics based on 10703 proteins (4723684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---