Amino acid dipepetide frequency for Strongyloides venezuelensis (Threadworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.366AlaAla: 2.366 ± 0.032	0.792AlaCys: 0.792 ± 0.014	1.891AlaAsp: 1.891 ± 0.02	2.358AlaGlu: 2.358 ± 0.031	2.144AlaPhe: 2.144 ± 0.021	1.925AlaGly: 1.925 ± 0.022	0.773AlaHis: 0.773 ± 0.012	3.397AlaIle: 3.397 ± 0.027	3.11AlaLys: 3.11 ± 0.025	3.954AlaLeu: 3.954 ± 0.036	0.99AlaMet: 0.99 ± 0.013	2.236AlaAsn: 2.236 ± 0.02	1.582AlaPro: 1.582 ± 0.023	1.275AlaGln: 1.275 ± 0.018	1.685AlaArg: 1.685 ± 0.021	3.2AlaSer: 3.2 ± 0.03	2.292AlaThr: 2.292 ± 0.029	2.451AlaVal: 2.451 ± 0.022	0.338AlaTrp: 0.338 ± 0.008	1.511AlaTyr: 1.511 ± 0.015	0.002AlaXaa: 0.002 ± 0.0
Cys	0.742CysAla: 0.742 ± 0.013	0.521CysCys: 0.521 ± 0.013	1.192CysAsp: 1.192 ± 0.021	1.203CysGlu: 1.203 ± 0.02	1.02CysPhe: 1.02 ± 0.015	1.265CysGly: 1.265 ± 0.019	0.492CysHis: 0.492 ± 0.01	1.551CysIle: 1.551 ± 0.02	1.584CysLys: 1.584 ± 0.019	1.89CysLeu: 1.89 ± 0.019	0.444CysMet: 0.444 ± 0.008	1.373CysAsn: 1.373 ± 0.019	0.942CysPro: 0.942 ± 0.02	0.821CysGln: 0.821 ± 0.017	0.882CysArg: 0.882 ± 0.013	1.695CysSer: 1.695 ± 0.018	1.056CysThr: 1.056 ± 0.015	1.051CysVal: 1.051 ± 0.016	0.175CysTrp: 0.175 ± 0.005	0.901CysTyr: 0.901 ± 0.012	0.001CysXaa: 0.001 ± 0.0
Asp	1.992AspAla: 1.992 ± 0.024	1.116AspCys: 1.116 ± 0.018	4.026AspAsp: 4.026 ± 0.033	4.432AspGlu: 4.432 ± 0.036	2.728AspPhe: 2.728 ± 0.023	2.9AspGly: 2.9 ± 0.029	0.946AspHis: 0.946 ± 0.012	4.835AspIle: 4.835 ± 0.041	4.532AspLys: 4.532 ± 0.033	4.345AspLeu: 4.345 ± 0.03	1.249AspMet: 1.249 ± 0.013	4.065AspAsn: 4.065 ± 0.026	1.761AspPro: 1.761 ± 0.016	1.417AspGln: 1.417 ± 0.017	1.972AspArg: 1.972 ± 0.018	4.164AspSer: 4.164 ± 0.027	2.571AspThr: 2.571 ± 0.021	3.279AspVal: 3.279 ± 0.029	0.468AspTrp: 0.468 ± 0.009	2.313AspTyr: 2.313 ± 0.021	0.003AspXaa: 0.003 ± 0.001
Glu	2.783GluAla: 2.783 ± 0.033	1.351GluCys: 1.351 ± 0.018	3.866GluAsp: 3.866 ± 0.029	5.74GluGlu: 5.74 ± 0.055	2.616GluPhe: 2.616 ± 0.022	2.693GluGly: 2.693 ± 0.027	1.214GluHis: 1.214 ± 0.016	5.469GluIle: 5.469 ± 0.036	6.619GluLys: 6.619 ± 0.047	5.058GluLeu: 5.058 ± 0.04	1.685GluMet: 1.685 ± 0.018	5.206GluAsn: 5.206 ± 0.035	1.591GluPro: 1.591 ± 0.018	1.867GluGln: 1.867 ± 0.022	2.894GluArg: 2.894 ± 0.026	4.475GluSer: 4.475 ± 0.031	3.349GluThr: 3.349 ± 0.045	3.427GluVal: 3.427 ± 0.031	0.613GluTrp: 0.613 ± 0.012	2.558GluTyr: 2.558 ± 0.022	0.004GluXaa: 0.004 ± 0.001
Phe	2.004PheAla: 2.004 ± 0.019	1.087PheCys: 1.087 ± 0.014	2.908PheAsp: 2.908 ± 0.022	2.872PheGlu: 2.872 ± 0.024	2.684PhePhe: 2.684 ± 0.027	2.695PheGly: 2.695 ± 0.026	1.031PheHis: 1.031 ± 0.013	4.101PheIle: 4.101 ± 0.034	3.626PheLys: 3.626 ± 0.027	4.64PheLeu: 4.64 ± 0.039	1.122PheMet: 1.122 ± 0.014	3.381PheAsn: 3.381 ± 0.03	1.736PhePro: 1.736 ± 0.019	1.554PheGln: 1.554 ± 0.016	1.739PheArg: 1.739 ± 0.019	4.022PheSer: 4.022 ± 0.031	2.659PheThr: 2.659 ± 0.022	2.801PheVal: 2.801 ± 0.018	0.464PheTrp: 0.464 ± 0.01	2.208PheTyr: 2.208 ± 0.019	0.003PheXaa: 0.003 ± 0.001
Gly	2.02GlyAla: 2.02 ± 0.023	1.009GlyCys: 1.009 ± 0.018	2.549GlyAsp: 2.549 ± 0.022	2.846GlyGlu: 2.846 ± 0.028	2.311GlyPhe: 2.311 ± 0.022	2.869GlyGly: 2.869 ± 0.042	0.993GlyHis: 0.993 ± 0.013	3.896GlyIle: 3.896 ± 0.028	4.055GlyLys: 4.055 ± 0.027	3.645GlyLeu: 3.645 ± 0.031	1.151GlyMet: 1.151 ± 0.019	3.341GlyAsn: 3.341 ± 0.026	1.524GlyPro: 1.524 ± 0.032	1.454GlyGln: 1.454 ± 0.02	2.199GlyArg: 2.199 ± 0.022	3.718GlySer: 3.718 ± 0.033	2.666GlyThr: 2.666 ± 0.024	2.679GlyVal: 2.679 ± 0.024	0.429GlyTrp: 0.429 ± 0.009	2.162GlyTyr: 2.162 ± 0.023	0.003GlyXaa: 0.003 ± 0.001
His	0.76HisAla: 0.76 ± 0.012	0.475HisCys: 0.475 ± 0.008	1.024HisAsp: 1.024 ± 0.015	1.185HisGlu: 1.185 ± 0.014	1.121HisPhe: 1.121 ± 0.013	1.066HisGly: 1.066 ± 0.016	0.632HisHis: 0.632 ± 0.013	1.582HisIle: 1.582 ± 0.015	1.405HisLys: 1.405 ± 0.016	1.952HisLeu: 1.952 ± 0.02	0.462HisMet: 0.462 ± 0.009	1.232HisAsn: 1.232 ± 0.014	0.889HisPro: 0.889 ± 0.012	0.77HisGln: 0.77 ± 0.011	0.91HisArg: 0.91 ± 0.012	1.666HisSer: 1.666 ± 0.019	0.987HisThr: 0.987 ± 0.012	1.119HisVal: 1.119 ± 0.014	0.205HisTrp: 0.205 ± 0.007	0.941HisTyr: 0.941 ± 0.013	0.001HisXaa: 0.001 ± 0.0
Ile	3.33IleAla: 3.33 ± 0.022	1.721IleCys: 1.721 ± 0.022	4.542IleAsp: 4.542 ± 0.032	5.111IleGlu: 5.111 ± 0.037	4.397IlePhe: 4.397 ± 0.035	3.67IleGly: 3.67 ± 0.024	1.717IleHis: 1.717 ± 0.016	6.62IleIle: 6.62 ± 0.045	6.562IleLys: 6.562 ± 0.037	7.36IleLeu: 7.36 ± 0.041	1.671IleMet: 1.671 ± 0.016	5.756IleAsn: 5.756 ± 0.036	3.64IlePro: 3.64 ± 0.027	2.604IleGln: 2.604 ± 0.022	3.079IleArg: 3.079 ± 0.025	6.743IleSer: 6.743 ± 0.036	4.462IleThr: 4.462 ± 0.028	4.46IleVal: 4.46 ± 0.03	0.685IleTrp: 0.685 ± 0.011	3.15IleTyr: 3.15 ± 0.026	0.005IleXaa: 0.005 ± 0.001
Lys	3.142LysAla: 3.142 ± 0.025	1.818LysCys: 1.818 ± 0.021	4.628LysAsp: 4.628 ± 0.034	6.267LysGlu: 6.267 ± 0.049	3.616LysPhe: 3.616 ± 0.027	3.171LysGly: 3.171 ± 0.026	1.7LysHis: 1.7 ± 0.019	7.007LysIle: 7.007 ± 0.043	8.757LysLys: 8.757 ± 0.068	6.98LysLeu: 6.98 ± 0.045	2.037LysMet: 2.037 ± 0.017	7.052LysAsn: 7.052 ± 0.041	2.687LysPro: 2.687 ± 0.03	2.571LysGln: 2.571 ± 0.019	3.924LysArg: 3.924 ± 0.03	6.01LysSer: 6.01 ± 0.039	4.384LysThr: 4.384 ± 0.03	4.33LysVal: 4.33 ± 0.031	0.742LysTrp: 0.742 ± 0.012	3.609LysTyr: 3.609 ± 0.024	0.005LysXaa: 0.005 ± 0.001
Leu	3.791LeuAla: 3.791 ± 0.029	1.725LeuCys: 1.725 ± 0.018	4.295LeuAsp: 4.295 ± 0.03	5.401LeuGlu: 5.401 ± 0.046	4.379LeuPhe: 4.379 ± 0.033	3.636LeuGly: 3.636 ± 0.029	1.886LeuHis: 1.886 ± 0.019	6.515LeuIle: 6.515 ± 0.037	7.638LeuLys: 7.638 ± 0.041	8.359LeuLeu: 8.359 ± 0.048	1.982LeuMet: 1.982 ± 0.02	5.864LeuAsn: 5.864 ± 0.036	3.873LeuPro: 3.873 ± 0.03	3.261LeuGln: 3.261 ± 0.03	3.847LeuArg: 3.847 ± 0.029	7.604LeuSer: 7.604 ± 0.039	4.995LeuThr: 4.995 ± 0.033	4.221LeuVal: 4.221 ± 0.032	0.736LeuTrp: 0.736 ± 0.011	3.286LeuTyr: 3.286 ± 0.026	0.007LeuXaa: 0.007 ± 0.001
Met	1.174MetAla: 1.174 ± 0.014	0.392MetCys: 0.392 ± 0.007	1.32MetAsp: 1.32 ± 0.016	1.639MetGlu: 1.639 ± 0.017	1.07MetPhe: 1.07 ± 0.014	1.013MetGly: 1.013 ± 0.017	0.404MetHis: 0.404 ± 0.008	1.745MetIle: 1.745 ± 0.015	2.063MetLys: 2.063 ± 0.017	1.967MetLeu: 1.967 ± 0.021	0.587MetMet: 0.587 ± 0.01	1.606MetAsn: 1.606 ± 0.019	0.891MetPro: 0.891 ± 0.014	0.584MetGln: 0.584 ± 0.011	0.898MetArg: 0.898 ± 0.011	1.854MetSer: 1.854 ± 0.019	1.293MetThr: 1.293 ± 0.015	1.246MetVal: 1.246 ± 0.014	0.187MetTrp: 0.187 ± 0.006	0.832MetTyr: 0.832 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	2.53AsnAla: 2.53 ± 0.021	1.486AsnCys: 1.486 ± 0.018	4.628AsnAsp: 4.628 ± 0.03	5.036AsnGlu: 5.036 ± 0.032	3.638AsnPhe: 3.638 ± 0.028	3.798AsnGly: 3.798 ± 0.033	1.378AsnHis: 1.378 ± 0.014	6.39AsnIle: 6.39 ± 0.042	5.43AsnLys: 5.43 ± 0.038	5.837AsnLeu: 5.837 ± 0.035	1.559AsnMet: 1.559 ± 0.017	6.321AsnAsn: 6.321 ± 0.052	2.395AsnPro: 2.395 ± 0.023	2.246AsnGln: 2.246 ± 0.024	2.453AsnArg: 2.453 ± 0.021	5.688AsnSer: 5.688 ± 0.039	3.59AsnThr: 3.59 ± 0.025	4.211AsnVal: 4.211 ± 0.027	0.567AsnTrp: 0.567 ± 0.009	3.046AsnTyr: 3.046 ± 0.026	0.005AsnXaa: 0.005 ± 0.001
Pro	1.367ProAla: 1.367 ± 0.02	0.635ProCys: 0.635 ± 0.013	1.83ProAsp: 1.83 ± 0.019	2.412ProGlu: 2.412 ± 0.028	1.854ProPhe: 1.854 ± 0.019	1.94ProGly: 1.94 ± 0.054	0.752ProHis: 0.752 ± 0.013	3.019ProIle: 3.019 ± 0.026	3.039ProLys: 3.039 ± 0.029	3.291ProLeu: 3.291 ± 0.027	0.766ProMet: 0.766 ± 0.011	2.457ProAsn: 2.457 ± 0.025	2.266ProPro: 2.266 ± 0.033	1.469ProGln: 1.469 ± 0.02	1.462ProArg: 1.462 ± 0.017	3.518ProSer: 3.518 ± 0.031	2.463ProThr: 2.463 ± 0.033	2.056ProVal: 2.056 ± 0.021	0.31ProTrp: 0.31 ± 0.008	1.579ProTyr: 1.579 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	1.283GlnAla: 1.283 ± 0.019	0.713GlnCys: 0.713 ± 0.016	1.328GlnAsp: 1.328 ± 0.017	1.895GlnGlu: 1.895 ± 0.021	1.561GlnPhe: 1.561 ± 0.016	1.31GlnGly: 1.31 ± 0.017	0.713GlnHis: 0.713 ± 0.011	2.562GlnIle: 2.562 ± 0.022	2.839GlnLys: 2.839 ± 0.022	3.175GlnLeu: 3.175 ± 0.025	0.894GlnMet: 0.894 ± 0.012	2.503GlnAsn: 2.503 ± 0.024	1.288GlnPro: 1.288 ± 0.019	1.768GlnGln: 1.768 ± 0.035	1.599GlnArg: 1.599 ± 0.018	2.481GlnSer: 2.481 ± 0.022	1.757GlnThr: 1.757 ± 0.017	1.556GlnVal: 1.556 ± 0.018	0.319GlnTrp: 0.319 ± 0.007	1.37GlnTyr: 1.37 ± 0.015	0.002GlnXaa: 0.002 ± 0.001
Arg	1.562ArgAla: 1.562 ± 0.019	0.888ArgCys: 0.888 ± 0.015	2.067ArgAsp: 2.067 ± 0.02	2.574ArgGlu: 2.574 ± 0.026	1.921ArgPhe: 1.921 ± 0.019	1.872ArgGly: 1.872 ± 0.021	0.972ArgHis: 0.972 ± 0.012	3.163ArgIle: 3.163 ± 0.024	4.021ArgLys: 4.021 ± 0.03	3.585ArgLeu: 3.585 ± 0.027	1.002ArgMet: 1.002 ± 0.014	3.087ArgAsn: 3.087 ± 0.026	1.458ArgPro: 1.458 ± 0.017	1.512ArgGln: 1.512 ± 0.017	2.681ArgArg: 2.681 ± 0.025	3.096ArgSer: 3.096 ± 0.029	2.012ArgThr: 2.012 ± 0.019	1.995ArgVal: 1.995 ± 0.019	0.392ArgTrp: 0.392 ± 0.009	1.716ArgTyr: 1.716 ± 0.017	0.003ArgXaa: 0.003 ± 0.001
Ser	2.828SerAla: 2.828 ± 0.027	1.624SerCys: 1.624 ± 0.023	4.315SerAsp: 4.315 ± 0.034	4.63SerGlu: 4.63 ± 0.044	4.025SerPhe: 4.025 ± 0.028	3.866SerGly: 3.866 ± 0.031	1.571SerHis: 1.571 ± 0.016	6.504SerIle: 6.504 ± 0.038	6.523SerLys: 6.523 ± 0.043	7.285SerLeu: 7.285 ± 0.035	1.709SerMet: 1.709 ± 0.017	5.928SerAsn: 5.928 ± 0.037	3.223SerPro: 3.223 ± 0.033	2.78SerGln: 2.78 ± 0.025	3.258SerArg: 3.258 ± 0.022	8.203SerSer: 8.203 ± 0.063	5.134SerThr: 5.134 ± 0.04	4.026SerVal: 4.026 ± 0.028	0.644SerTrp: 0.644 ± 0.01	3.027SerTyr: 3.027 ± 0.025	0.003SerXaa: 0.003 ± 0.001
Thr	2.267ThrAla: 2.267 ± 0.023	1.154ThrCys: 1.154 ± 0.021	2.585ThrAsp: 2.585 ± 0.022	3.087ThrGlu: 3.087 ± 0.05	2.987ThrPhe: 2.987 ± 0.024	2.639ThrGly: 2.639 ± 0.027	0.994ThrHis: 0.994 ± 0.014	4.883ThrIle: 4.883 ± 0.034	4.206ThrLys: 4.206 ± 0.031	4.911ThrLeu: 4.911 ± 0.028	1.131ThrMet: 1.131 ± 0.013	3.777ThrAsn: 3.777 ± 0.026	2.627ThrPro: 2.627 ± 0.029	1.619ThrGln: 1.619 ± 0.018	1.937ThrArg: 1.937 ± 0.017	5.02ThrSer: 5.02 ± 0.032	4.496ThrThr: 4.496 ± 0.066	3.044ThrVal: 3.044 ± 0.024	0.439ThrTrp: 0.439 ± 0.008	1.978ThrTyr: 1.978 ± 0.017	0.002ThrXaa: 0.002 ± 0.001
Val	2.429ValAla: 2.429 ± 0.025	1.106ValCys: 1.106 ± 0.017	3.228ValAsp: 3.228 ± 0.03	3.503ValGlu: 3.503 ± 0.029	2.611ValPhe: 2.611 ± 0.022	2.584ValGly: 2.584 ± 0.022	1.038ValHis: 1.038 ± 0.013	4.275ValIle: 4.275 ± 0.03	4.523ValLys: 4.523 ± 0.035	4.58ValLeu: 4.58 ± 0.035	1.207ValMet: 1.207 ± 0.015	3.573ValAsn: 3.573 ± 0.024	2.305ValPro: 2.305 ± 0.023	1.604ValGln: 1.604 ± 0.015	2.046ValArg: 2.046 ± 0.019	4.216ValSer: 4.216 ± 0.029	3.12ValThr: 3.12 ± 0.022	3.365ValVal: 3.365 ± 0.029	0.498ValTrp: 0.498 ± 0.01	2.046ValTyr: 2.046 ± 0.019	0.003ValXaa: 0.003 ± 0.001
Trp	0.344TrpAla: 0.344 ± 0.009	0.182TrpCys: 0.182 ± 0.006	0.459TrpAsp: 0.459 ± 0.008	0.499TrpGlu: 0.499 ± 0.011	0.414TrpPhe: 0.414 ± 0.008	0.385TrpGly: 0.385 ± 0.008	0.193TrpHis: 0.193 ± 0.005	0.733TrpIle: 0.733 ± 0.012	0.852TrpLys: 0.852 ± 0.012	0.792TrpLeu: 0.792 ± 0.014	0.243TrpMet: 0.243 ± 0.006	0.622TrpAsn: 0.622 ± 0.012	0.277TrpPro: 0.277 ± 0.007	0.28TrpGln: 0.28 ± 0.007	0.448TrpArg: 0.448 ± 0.008	0.654TrpSer: 0.654 ± 0.012	0.44TrpThr: 0.44 ± 0.009	0.425TrpVal: 0.425 ± 0.008	0.106TrpTrp: 0.106 ± 0.004	0.378TrpTyr: 0.378 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.557TyrAla: 1.557 ± 0.017	1.002TyrCys: 1.002 ± 0.011	2.429TyrAsp: 2.429 ± 0.018	2.387TyrGlu: 2.387 ± 0.02	2.24TyrPhe: 2.24 ± 0.022	2.224TyrGly: 2.224 ± 0.021	0.982TyrHis: 0.982 ± 0.013	3.03TyrIle: 3.03 ± 0.023	3.047TyrLys: 3.047 ± 0.025	3.692TyrLeu: 3.692 ± 0.029	0.873TyrMet: 0.873 ± 0.01	2.85TyrAsn: 2.85 ± 0.024	1.527TyrPro: 1.527 ± 0.019	1.458TyrGln: 1.458 ± 0.015	1.663TyrArg: 1.663 ± 0.02	3.074TyrSer: 3.074 ± 0.026	2.055TyrThr: 2.055 ± 0.018	2.115TyrVal: 2.115 ± 0.02	0.408TyrTrp: 0.408 ± 0.008	1.997TyrTyr: 1.997 ± 0.023	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.002XaaGlu: 0.002 ± 0.0	0.003XaaPhe: 0.003 ± 0.001	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.005XaaIle: 0.005 ± 0.001	0.005XaaLys: 0.005 ± 0.001	0.005XaaLeu: 0.005 ± 0.001	0.004XaaMet: 0.004 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.003XaaPro: 0.003 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.0	0.005XaaSer: 0.005 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.003XaaTyr: 0.003 ± 0.001	0.352XaaXaa: 0.352 ± 0.045

Statistics based on 16626 proteins (6663319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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