Amino acid dipepetide frequency for Rhodobacteraceae bacterium TG-679

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.153AlaAla: 21.153 ± 0.26	1.243AlaCys: 1.243 ± 0.036	8.113AlaAsp: 8.113 ± 0.076	7.887AlaGlu: 7.887 ± 0.092	4.567AlaPhe: 4.567 ± 0.063	11.794AlaGly: 11.794 ± 0.117	2.504AlaHis: 2.504 ± 0.045	5.472AlaIle: 5.472 ± 0.067	2.699AlaLys: 2.699 ± 0.06	15.598AlaLeu: 15.598 ± 0.144	3.798AlaMet: 3.798 ± 0.059	2.56AlaAsn: 2.56 ± 0.049	7.367AlaPro: 7.367 ± 0.101	4.812AlaGln: 4.812 ± 0.073	10.758AlaArg: 10.758 ± 0.131	5.562AlaSer: 5.562 ± 0.067	6.416AlaThr: 6.416 ± 0.083	9.435AlaVal: 9.435 ± 0.096	1.529AlaTrp: 1.529 ± 0.04	2.418AlaTyr: 2.418 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.261CysAla: 1.261 ± 0.034	0.113CysCys: 0.113 ± 0.011	0.577CysAsp: 0.577 ± 0.026	0.413CysGlu: 0.413 ± 0.02	0.329CysPhe: 0.329 ± 0.015	0.984CysGly: 0.984 ± 0.03	0.278CysHis: 0.278 ± 0.021	0.383CysIle: 0.383 ± 0.018	0.188CysLys: 0.188 ± 0.012	0.903CysLeu: 0.903 ± 0.029	0.174CysMet: 0.174 ± 0.011	0.201CysAsn: 0.201 ± 0.012	0.564CysPro: 0.564 ± 0.022	0.209CysGln: 0.209 ± 0.013	0.637CysArg: 0.637 ± 0.022	0.416CysSer: 0.416 ± 0.018	0.478CysThr: 0.478 ± 0.021	0.634CysVal: 0.634 ± 0.028	0.123CysTrp: 0.123 ± 0.01	0.181CysTyr: 0.181 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.451AspAla: 8.451 ± 0.101	0.541AspCys: 0.541 ± 0.022	3.462AspAsp: 3.462 ± 0.077	3.209AspGlu: 3.209 ± 0.059	2.323AspPhe: 2.323 ± 0.052	6.53AspGly: 6.53 ± 0.13	1.247AspHis: 1.247 ± 0.036	2.96AspIle: 2.96 ± 0.043	1.257AspLys: 1.257 ± 0.041	6.846AspLeu: 6.846 ± 0.087	1.704AspMet: 1.704 ± 0.033	1.198AspAsn: 1.198 ± 0.031	4.287AspPro: 4.287 ± 0.067	1.519AspGln: 1.519 ± 0.04	5.044AspArg: 5.044 ± 0.07	2.301AspSer: 2.301 ± 0.057	3.547AspThr: 3.547 ± 0.091	4.301AspVal: 4.301 ± 0.059	1.235AspTrp: 1.235 ± 0.029	1.438AspTyr: 1.438 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.61GluAla: 7.61 ± 0.099	0.35GluCys: 0.35 ± 0.018	3.135GluAsp: 3.135 ± 0.053	2.58GluGlu: 2.58 ± 0.061	1.6GluPhe: 1.6 ± 0.038	4.374GluGly: 4.374 ± 0.066	1.025GluHis: 1.025 ± 0.032	3.144GluIle: 3.144 ± 0.047	1.625GluLys: 1.625 ± 0.043	4.636GluLeu: 4.636 ± 0.071	1.62GluMet: 1.62 ± 0.037	1.434GluAsn: 1.434 ± 0.038	2.307GluPro: 2.307 ± 0.051	1.705GluGln: 1.705 ± 0.04	3.913GluArg: 3.913 ± 0.065	1.948GluSer: 1.948 ± 0.047	3.502GluThr: 3.502 ± 0.061	3.972GluVal: 3.972 ± 0.064	0.573GluTrp: 0.573 ± 0.021	0.848GluTyr: 0.848 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.652PheAla: 4.652 ± 0.067	0.413PheCys: 0.413 ± 0.018	2.912PheAsp: 2.912 ± 0.056	2.054PheGlu: 2.054 ± 0.042	1.438PhePhe: 1.438 ± 0.039	3.765PheGly: 3.765 ± 0.056	0.732PheHis: 0.732 ± 0.026	1.42PheIle: 1.42 ± 0.034	0.716PheLys: 0.716 ± 0.026	3.338PheLeu: 3.338 ± 0.063	0.794PheMet: 0.794 ± 0.026	0.954PheAsn: 0.954 ± 0.034	1.6PhePro: 1.6 ± 0.033	0.92PheGln: 0.92 ± 0.027	2.263PheArg: 2.263 ± 0.044	2.005PheSer: 2.005 ± 0.046	2.168PheThr: 2.168 ± 0.047	2.718PheVal: 2.718 ± 0.055	0.531PheTrp: 0.531 ± 0.02	0.792PheTyr: 0.792 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.728GlyAla: 11.728 ± 0.109	0.906GlyCys: 0.906 ± 0.028	5.043GlyAsp: 5.043 ± 0.092	4.201GlyGlu: 4.201 ± 0.062	3.709GlyPhe: 3.709 ± 0.061	8.375GlyGly: 8.375 ± 0.124	2.044GlyHis: 2.044 ± 0.045	4.414GlyIle: 4.414 ± 0.067	2.567GlyLys: 2.567 ± 0.045	10.117GlyLeu: 10.117 ± 0.115	2.614GlyMet: 2.614 ± 0.059	2.017GlyAsn: 2.017 ± 0.059	4.422GlyPro: 4.422 ± 0.061	3.083GlyGln: 3.083 ± 0.057	6.602GlyArg: 6.602 ± 0.074	4.455GlySer: 4.455 ± 0.086	5.402GlyThr: 5.402 ± 0.084	6.68GlyVal: 6.68 ± 0.077	1.594GlyTrp: 1.594 ± 0.038	2.177GlyTyr: 2.177 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.505HisAla: 2.505 ± 0.052	0.231HisCys: 0.231 ± 0.014	1.395HisAsp: 1.395 ± 0.034	0.951HisGlu: 0.951 ± 0.029	0.755HisPhe: 0.755 ± 0.024	2.023HisGly: 2.023 ± 0.049	0.482HisHis: 0.482 ± 0.024	0.789HisIle: 0.789 ± 0.024	0.437HisLys: 0.437 ± 0.017	2.031HisLeu: 2.031 ± 0.038	0.52HisMet: 0.52 ± 0.022	0.38HisAsn: 0.38 ± 0.018	1.365HisPro: 1.365 ± 0.035	0.469HisGln: 0.469 ± 0.021	1.353HisArg: 1.353 ± 0.036	0.802HisSer: 0.802 ± 0.026	0.848HisThr: 0.848 ± 0.028	1.654HisVal: 1.654 ± 0.038	0.325HisTrp: 0.325 ± 0.016	0.485HisTyr: 0.485 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.011IleAla: 7.011 ± 0.079	0.488IleCys: 0.488 ± 0.02	3.526IleAsp: 3.526 ± 0.052	2.881IleGlu: 2.881 ± 0.051	1.529IlePhe: 1.529 ± 0.042	4.772IleGly: 4.772 ± 0.062	0.759IleHis: 0.759 ± 0.029	1.739IleIle: 1.739 ± 0.049	0.994IleLys: 0.994 ± 0.036	4.12IleLeu: 4.12 ± 0.072	0.913IleMet: 0.913 ± 0.028	1.174IleAsn: 1.174 ± 0.03	2.146IlePro: 2.146 ± 0.05	0.91IleGln: 0.91 ± 0.033	2.924IleArg: 2.924 ± 0.055	2.401IleSer: 2.401 ± 0.049	2.729IleThr: 2.729 ± 0.051	3.699IleVal: 3.699 ± 0.063	0.608IleTrp: 0.608 ± 0.023	1.013IleTyr: 1.013 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.197LysAla: 3.197 ± 0.067	0.149LysCys: 0.149 ± 0.012	1.288LysAsp: 1.288 ± 0.046	0.986LysGlu: 0.986 ± 0.035	0.673LysPhe: 0.673 ± 0.024	2.059LysGly: 2.059 ± 0.047	0.424LysHis: 0.424 ± 0.02	1.267LysIle: 1.267 ± 0.034	0.785LysLys: 0.785 ± 0.036	2.44LysLeu: 2.44 ± 0.051	0.678LysMet: 0.678 ± 0.022	0.547LysAsn: 0.547 ± 0.024	1.447LysPro: 1.447 ± 0.036	0.641LysGln: 0.641 ± 0.026	1.739LysArg: 1.739 ± 0.041	1.356LysSer: 1.356 ± 0.036	1.554LysThr: 1.554 ± 0.04	1.851LysVal: 1.851 ± 0.048	0.286LysTrp: 0.286 ± 0.015	0.495LysTyr: 0.495 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.533LeuAla: 14.533 ± 0.145	1.041LeuCys: 1.041 ± 0.032	6.725LeuAsp: 6.725 ± 0.087	5.037LeuGlu: 5.037 ± 0.065	3.417LeuPhe: 3.417 ± 0.059	8.951LeuGly: 8.951 ± 0.102	2.023LeuHis: 2.023 ± 0.042	4.535LeuIle: 4.535 ± 0.082	2.606LeuLys: 2.606 ± 0.053	9.288LeuLeu: 9.288 ± 0.124	2.549LeuMet: 2.549 ± 0.051	2.428LeuAsn: 2.428 ± 0.049	6.047LeuPro: 6.047 ± 0.076	2.556LeuGln: 2.556 ± 0.046	7.947LeuArg: 7.947 ± 0.108	6.551LeuSer: 6.551 ± 0.08	5.932LeuThr: 5.932 ± 0.071	7.412LeuVal: 7.412 ± 0.089	1.241LeuTrp: 1.241 ± 0.033	1.762LeuTyr: 1.762 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.48MetAla: 3.48 ± 0.055	0.196MetCys: 0.196 ± 0.012	1.416MetAsp: 1.416 ± 0.033	1.137MetGlu: 1.137 ± 0.029	0.722MetPhe: 0.722 ± 0.026	2.222MetGly: 2.222 ± 0.052	0.456MetHis: 0.456 ± 0.019	1.391MetIle: 1.391 ± 0.037	0.811MetLys: 0.811 ± 0.027	2.499MetLeu: 2.499 ± 0.05	0.655MetMet: 0.655 ± 0.023	0.733MetAsn: 0.733 ± 0.023	1.568MetPro: 1.568 ± 0.041	0.903MetGln: 0.903 ± 0.024	1.802MetArg: 1.802 ± 0.039	1.546MetSer: 1.546 ± 0.04	2.127MetThr: 2.127 ± 0.041	1.805MetVal: 1.805 ± 0.041	0.234MetTrp: 0.234 ± 0.014	0.322MetTyr: 0.322 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.953AsnAla: 2.953 ± 0.053	0.213AsnCys: 0.213 ± 0.013	1.41AsnAsp: 1.41 ± 0.05	0.997AsnGlu: 0.997 ± 0.031	0.823AsnPhe: 0.823 ± 0.028	2.268AsnGly: 2.268 ± 0.077	0.418AsnHis: 0.418 ± 0.018	1.159AsnIle: 1.159 ± 0.038	0.453AsnLys: 0.453 ± 0.021	2.228AsnLeu: 2.228 ± 0.046	0.568AsnMet: 0.568 ± 0.022	0.556AsnAsn: 0.556 ± 0.023	1.686AsnPro: 1.686 ± 0.041	0.593AsnGln: 0.593 ± 0.027	1.646AsnArg: 1.646 ± 0.041	0.971AsnSer: 0.971 ± 0.033	1.327AsnThr: 1.327 ± 0.048	1.729AsnVal: 1.729 ± 0.041	0.368AsnTrp: 0.368 ± 0.019	0.58AsnTyr: 0.58 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.886ProAla: 6.886 ± 0.094	0.409ProCys: 0.409 ± 0.018	4.807ProAsp: 4.807 ± 0.071	3.839ProGlu: 3.839 ± 0.054	1.97ProPhe: 1.97 ± 0.042	5.614ProGly: 5.614 ± 0.076	1.079ProHis: 1.079 ± 0.031	1.971ProIle: 1.971 ± 0.046	1.275ProLys: 1.275 ± 0.036	5.124ProLeu: 5.124 ± 0.069	1.327ProMet: 1.327 ± 0.036	1.182ProAsn: 1.182 ± 0.033	2.909ProPro: 2.909 ± 0.06	1.685ProGln: 1.685 ± 0.039	3.357ProArg: 3.357 ± 0.062	2.591ProSer: 2.591 ± 0.049	2.526ProThr: 2.526 ± 0.042	4.809ProVal: 4.809 ± 0.064	0.678ProTrp: 0.678 ± 0.026	1.052ProTyr: 1.052 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.165GlnAla: 4.165 ± 0.062	0.189GlnCys: 0.189 ± 0.014	1.726GlnAsp: 1.726 ± 0.044	1.269GlnGlu: 1.269 ± 0.035	0.945GlnPhe: 0.945 ± 0.031	2.564GlnGly: 2.564 ± 0.044	0.518GlnHis: 0.518 ± 0.021	1.761GlnIle: 1.761 ± 0.041	0.795GlnLys: 0.795 ± 0.027	2.488GlnLeu: 2.488 ± 0.048	0.947GlnMet: 0.947 ± 0.028	0.791GlnAsn: 0.791 ± 0.028	1.624GlnPro: 1.624 ± 0.034	1.02GlnGln: 1.02 ± 0.038	2.152GlnArg: 2.152 ± 0.048	1.601GlnSer: 1.601 ± 0.041	1.8GlnThr: 1.8 ± 0.038	2.381GlnVal: 2.381 ± 0.046	0.357GlnTrp: 0.357 ± 0.017	0.491GlnTyr: 0.491 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.707ArgAla: 9.707 ± 0.121	0.547ArgCys: 0.547 ± 0.023	4.779ArgAsp: 4.779 ± 0.066	3.686ArgGlu: 3.686 ± 0.057	2.831ArgPhe: 2.831 ± 0.051	5.459ArgGly: 5.459 ± 0.078	1.627ArgHis: 1.627 ± 0.044	3.899ArgIle: 3.899 ± 0.06	1.992ArgLys: 1.992 ± 0.045	8.086ArgLeu: 8.086 ± 0.103	1.982ArgMet: 1.982 ± 0.043	1.665ArgAsn: 1.665 ± 0.035	3.777ArgPro: 3.777 ± 0.064	2.193ArgGln: 2.193 ± 0.044	5.962ArgArg: 5.962 ± 0.096	3.43ArgSer: 3.43 ± 0.054	3.493ArgThr: 3.493 ± 0.059	5.172ArgVal: 5.172 ± 0.074	0.897ArgTrp: 0.897 ± 0.027	1.464ArgTyr: 1.464 ± 0.038	0.001ArgXaa: 0.001 ± 0.001
Ser	5.983SerAla: 5.983 ± 0.082	0.422SerCys: 0.422 ± 0.022	3.163SerAsp: 3.163 ± 0.057	2.493SerGlu: 2.493 ± 0.051	2.178SerPhe: 2.178 ± 0.051	5.646SerGly: 5.646 ± 0.089	0.958SerHis: 0.958 ± 0.028	2.164SerIle: 2.164 ± 0.043	1.078SerLys: 1.078 ± 0.036	4.737SerLeu: 4.737 ± 0.072	1.203SerMet: 1.203 ± 0.032	1.156SerAsn: 1.156 ± 0.033	2.458SerPro: 2.458 ± 0.044	1.39SerGln: 1.39 ± 0.038	3.28SerArg: 3.28 ± 0.049	2.327SerSer: 2.327 ± 0.057	2.316SerThr: 2.316 ± 0.045	3.954SerVal: 3.954 ± 0.059	0.598SerTrp: 0.598 ± 0.021	1.171SerTyr: 1.171 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.123ThrAla: 7.123 ± 0.093	0.525ThrCys: 0.525 ± 0.022	3.553ThrAsp: 3.553 ± 0.08	2.791ThrGlu: 2.791 ± 0.04	1.957ThrPhe: 1.957 ± 0.046	6.05ThrGly: 6.05 ± 0.085	1.047ThrHis: 1.047 ± 0.031	2.458ThrIle: 2.458 ± 0.059	1.061ThrLys: 1.061 ± 0.033	6.389ThrLeu: 6.389 ± 0.086	1.207ThrMet: 1.207 ± 0.031	1.161ThrAsn: 1.161 ± 0.035	3.62ThrPro: 3.62 ± 0.056	1.576ThrGln: 1.576 ± 0.043	3.834ThrArg: 3.834 ± 0.056	2.503ThrSer: 2.503 ± 0.053	2.712ThrThr: 2.712 ± 0.059	4.66ThrVal: 4.66 ± 0.08	0.64ThrTrp: 0.64 ± 0.023	1.108ThrTyr: 1.108 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.556ValAla: 9.556 ± 0.1	0.711ValCys: 0.711 ± 0.023	4.098ValAsp: 4.098 ± 0.065	3.848ValGlu: 3.848 ± 0.059	3.071ValPhe: 3.071 ± 0.054	5.797ValGly: 5.797 ± 0.075	1.373ValHis: 1.373 ± 0.036	4.058ValIle: 4.058 ± 0.076	1.743ValLys: 1.743 ± 0.048	8.099ValLeu: 8.099 ± 0.091	2.024ValMet: 2.024 ± 0.046	1.872ValAsn: 1.872 ± 0.065	4.193ValPro: 4.193 ± 0.062	2.248ValGln: 2.248 ± 0.044	4.762ValArg: 4.762 ± 0.07	4.144ValSer: 4.144 ± 0.063	5.21ValThr: 5.21 ± 0.096	5.728ValVal: 5.728 ± 0.083	0.977ValTrp: 0.977 ± 0.031	1.36ValTyr: 1.36 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.395TrpAla: 1.395 ± 0.034	0.147TrpCys: 0.147 ± 0.013	0.752TrpAsp: 0.752 ± 0.024	0.588TrpGlu: 0.588 ± 0.024	0.534TrpPhe: 0.534 ± 0.024	1.004TrpGly: 1.004 ± 0.03	0.351TrpHis: 0.351 ± 0.019	0.592TrpIle: 0.592 ± 0.025	0.347TrpLys: 0.347 ± 0.016	1.559TrpLeu: 1.559 ± 0.037	0.347TrpMet: 0.347 ± 0.016	0.401TrpAsn: 0.401 ± 0.018	0.716TrpPro: 0.716 ± 0.026	0.588TrpGln: 0.588 ± 0.023	1.131TrpArg: 1.131 ± 0.032	0.737TrpSer: 0.737 ± 0.022	0.798TrpThr: 0.798 ± 0.025	0.844TrpVal: 0.844 ± 0.026	0.201TrpTrp: 0.201 ± 0.012	0.264TrpTyr: 0.264 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.333TyrAla: 2.333 ± 0.048	0.207TyrCys: 0.207 ± 0.014	1.52TyrAsp: 1.52 ± 0.043	1.055TyrGlu: 1.055 ± 0.033	0.814TyrPhe: 0.814 ± 0.023	1.901TyrGly: 1.901 ± 0.039	0.456TyrHis: 0.456 ± 0.021	0.757TyrIle: 0.757 ± 0.024	0.435TyrLys: 0.435 ± 0.02	2.058TyrLeu: 2.058 ± 0.047	0.401TyrMet: 0.401 ± 0.017	0.534TyrAsn: 0.534 ± 0.021	0.989TyrPro: 0.989 ± 0.029	0.564TyrGln: 0.564 ± 0.022	1.542TyrArg: 1.542 ± 0.036	1.028TyrSer: 1.028 ± 0.028	1.089TyrThr: 1.089 ± 0.03	1.435TyrVal: 1.435 ± 0.038	0.302TyrTrp: 0.302 ± 0.015	0.523TyrTyr: 0.523 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3860 proteins (1231217 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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