Amino acid dipepetide frequency for Clostridium indicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.399AlaAla: 7.399 ± 0.086	1.082AlaCys: 1.082 ± 0.023	4.324AlaAsp: 4.324 ± 0.062	4.886AlaGlu: 4.886 ± 0.072	2.964AlaPhe: 2.964 ± 0.049	6.32AlaGly: 6.32 ± 0.066	1.011AlaHis: 1.011 ± 0.025	4.726AlaIle: 4.726 ± 0.054	4.287AlaLys: 4.287 ± 0.059	6.582AlaLeu: 6.582 ± 0.061	2.247AlaMet: 2.247 ± 0.04	2.393AlaAsn: 2.393 ± 0.038	1.953AlaPro: 1.953 ± 0.038	2.065AlaGln: 2.065 ± 0.035	2.869AlaArg: 2.869 ± 0.042	4.088AlaSer: 4.088 ± 0.05	2.874AlaThr: 2.874 ± 0.059	6.342AlaVal: 6.342 ± 0.058	0.626AlaTrp: 0.626 ± 0.021	2.586AlaTyr: 2.586 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.027	0.285CysCys: 0.285 ± 0.012	0.801CysAsp: 0.801 ± 0.021	0.858CysGlu: 0.858 ± 0.029	0.66CysPhe: 0.66 ± 0.019	1.335CysGly: 1.335 ± 0.031	0.287CysHis: 0.287 ± 0.013	1.094CysIle: 1.094 ± 0.027	0.769CysLys: 0.769 ± 0.024	1.202CysLeu: 1.202 ± 0.027	0.454CysMet: 0.454 ± 0.015	0.59CysAsn: 0.59 ± 0.02	0.62CysPro: 0.62 ± 0.026	0.407CysGln: 0.407 ± 0.015	0.816CysArg: 0.816 ± 0.025	1.0CysSer: 1.0 ± 0.023	0.735CysThr: 0.735 ± 0.021	0.893CysVal: 0.893 ± 0.021	0.133CysTrp: 0.133 ± 0.009	0.574CysTyr: 0.574 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.372AspAla: 3.372 ± 0.058	0.856AspCys: 0.856 ± 0.024	2.653AspAsp: 2.653 ± 0.047	4.174AspGlu: 4.174 ± 0.053	2.614AspPhe: 2.614 ± 0.04	4.328AspGly: 4.328 ± 0.064	0.978AspHis: 0.978 ± 0.025	4.413AspIle: 4.413 ± 0.051	3.486AspLys: 3.486 ± 0.05	4.8AspLeu: 4.8 ± 0.05	1.826AspMet: 1.826 ± 0.033	2.268AspAsn: 2.268 ± 0.038	1.917AspPro: 1.917 ± 0.038	1.724AspGln: 1.724 ± 0.034	2.509AspArg: 2.509 ± 0.04	3.324AspSer: 3.324 ± 0.048	2.958AspThr: 2.958 ± 0.042	3.261AspVal: 3.261 ± 0.044	0.63AspTrp: 0.63 ± 0.02	2.823AspTyr: 2.823 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.224GluAla: 5.224 ± 0.066	0.757GluCys: 0.757 ± 0.023	3.901GluAsp: 3.901 ± 0.047	6.652GluGlu: 6.652 ± 0.074	2.652GluPhe: 2.652 ± 0.042	4.269GluGly: 4.269 ± 0.054	1.233GluHis: 1.233 ± 0.028	5.61GluIle: 5.61 ± 0.063	6.184GluLys: 6.184 ± 0.071	6.689GluLeu: 6.689 ± 0.068	2.21GluMet: 2.21 ± 0.04	3.883GluAsn: 3.883 ± 0.047	1.928GluPro: 1.928 ± 0.037	2.683GluGln: 2.683 ± 0.041	3.233GluArg: 3.233 ± 0.049	3.773GluSer: 3.773 ± 0.05	3.848GluThr: 3.848 ± 0.061	4.202GluVal: 4.202 ± 0.055	0.644GluTrp: 0.644 ± 0.02	3.021GluTyr: 3.021 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.828PheAla: 2.828 ± 0.045	0.705PheCys: 0.705 ± 0.02	2.515PheAsp: 2.515 ± 0.039	2.688PheGlu: 2.688 ± 0.043	2.008PhePhe: 2.008 ± 0.039	3.02PheGly: 3.02 ± 0.047	0.955PheHis: 0.955 ± 0.024	3.147PheIle: 3.147 ± 0.049	2.366PheLys: 2.366 ± 0.039	4.233PheLeu: 4.233 ± 0.058	1.253PheMet: 1.253 ± 0.03	1.757PheAsn: 1.757 ± 0.036	1.411PhePro: 1.411 ± 0.029	1.429PheGln: 1.429 ± 0.029	1.64PheArg: 1.64 ± 0.035	3.061PheSer: 3.061 ± 0.049	2.565PheThr: 2.565 ± 0.043	2.609PheVal: 2.609 ± 0.036	0.446PheTrp: 0.446 ± 0.017	1.857PheTyr: 1.857 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.809GlyAla: 4.809 ± 0.07	1.217GlyCys: 1.217 ± 0.031	3.606GlyAsp: 3.606 ± 0.052	4.74GlyGlu: 4.74 ± 0.057	3.392GlyPhe: 3.392 ± 0.05	4.998GlyGly: 4.998 ± 0.082	1.215GlyHis: 1.215 ± 0.024	6.492GlyIle: 6.492 ± 0.073	5.349GlyLys: 5.349 ± 0.054	6.087GlyLeu: 6.087 ± 0.059	2.373GlyMet: 2.373 ± 0.037	3.311GlyAsn: 3.311 ± 0.051	1.507GlyPro: 1.507 ± 0.05	2.084GlyGln: 2.084 ± 0.033	3.057GlyArg: 3.057 ± 0.045	4.392GlySer: 4.392 ± 0.063	4.293GlyThr: 4.293 ± 0.058	4.711GlyVal: 4.711 ± 0.058	0.76GlyTrp: 0.76 ± 0.024	3.26GlyTyr: 3.26 ± 0.053	0.001GlyXaa: 0.001 ± 0.001
His	1.051HisAla: 1.051 ± 0.022	0.3HisCys: 0.3 ± 0.013	0.858HisAsp: 0.858 ± 0.025	1.069HisGlu: 1.069 ± 0.027	0.84HisPhe: 0.84 ± 0.019	1.304HisGly: 1.304 ± 0.025	0.417HisHis: 0.417 ± 0.016	1.391HisIle: 1.391 ± 0.03	0.949HisLys: 0.949 ± 0.021	1.557HisLeu: 1.557 ± 0.028	0.543HisMet: 0.543 ± 0.018	0.756HisAsn: 0.756 ± 0.021	0.772HisPro: 0.772 ± 0.022	0.54HisGln: 0.54 ± 0.017	0.739HisArg: 0.739 ± 0.02	1.042HisSer: 1.042 ± 0.026	0.987HisThr: 0.987 ± 0.022	1.032HisVal: 1.032 ± 0.023	0.184HisTrp: 0.184 ± 0.011	0.814HisTyr: 0.814 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.486IleAla: 5.486 ± 0.056	1.285IleCys: 1.285 ± 0.027	4.025IleAsp: 4.025 ± 0.054	4.665IleGlu: 4.665 ± 0.06	2.996IlePhe: 2.996 ± 0.053	5.092IleGly: 5.092 ± 0.062	1.389IleHis: 1.389 ± 0.03	5.567IleIle: 5.567 ± 0.075	4.633IleLys: 4.633 ± 0.05	7.36IleLeu: 7.36 ± 0.092	2.134IleMet: 2.134 ± 0.04	3.298IleAsn: 3.298 ± 0.046	3.336IlePro: 3.336 ± 0.044	2.35IleGln: 2.35 ± 0.036	3.789IleArg: 3.789 ± 0.046	5.349IleSer: 5.349 ± 0.068	4.552IleThr: 4.552 ± 0.057	4.484IleVal: 4.484 ± 0.054	0.72IleTrp: 0.72 ± 0.021	2.844IleTyr: 2.844 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.878LysAla: 4.878 ± 0.066	0.619LysCys: 0.619 ± 0.021	3.999LysAsp: 3.999 ± 0.055	6.666LysGlu: 6.666 ± 0.075	1.915LysPhe: 1.915 ± 0.036	4.26LysGly: 4.26 ± 0.052	0.962LysHis: 0.962 ± 0.024	4.834LysIle: 4.834 ± 0.055	6.034LysLys: 6.034 ± 0.068	5.441LysLeu: 5.441 ± 0.056	2.028LysMet: 2.028 ± 0.037	3.836LysAsn: 3.836 ± 0.05	2.158LysPro: 2.158 ± 0.04	2.472LysGln: 2.472 ± 0.038	3.16LysArg: 3.16 ± 0.046	3.804LysSer: 3.804 ± 0.047	3.944LysThr: 3.944 ± 0.053	3.895LysVal: 3.895 ± 0.051	0.63LysTrp: 0.63 ± 0.019	2.652LysTyr: 2.652 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.517LeuAla: 6.517 ± 0.078	1.47LeuCys: 1.47 ± 0.027	4.782LeuAsp: 4.782 ± 0.055	6.146LeuGlu: 6.146 ± 0.066	4.177LeuPhe: 4.177 ± 0.06	5.839LeuGly: 5.839 ± 0.066	1.512LeuHis: 1.512 ± 0.032	6.508LeuIle: 6.508 ± 0.07	6.937LeuLys: 6.937 ± 0.065	8.895LeuLeu: 8.895 ± 0.097	2.67LeuMet: 2.67 ± 0.038	4.432LeuAsn: 4.432 ± 0.05	3.607LeuPro: 3.607 ± 0.05	2.557LeuGln: 2.557 ± 0.039	3.633LeuArg: 3.633 ± 0.051	6.888LeuSer: 6.888 ± 0.067	5.342LeuThr: 5.342 ± 0.063	5.295LeuVal: 5.295 ± 0.058	0.831LeuTrp: 0.831 ± 0.026	3.461LeuTyr: 3.461 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.439MetAla: 2.439 ± 0.038	0.309MetCys: 0.309 ± 0.013	1.797MetAsp: 1.797 ± 0.029	2.674MetGlu: 2.674 ± 0.038	0.984MetPhe: 0.984 ± 0.023	2.112MetGly: 2.112 ± 0.038	0.393MetHis: 0.393 ± 0.015	2.27MetIle: 2.27 ± 0.039	2.589MetLys: 2.589 ± 0.041	2.56MetLeu: 2.56 ± 0.042	0.954MetMet: 0.954 ± 0.024	1.716MetAsn: 1.716 ± 0.029	1.128MetPro: 1.128 ± 0.028	0.939MetGln: 0.939 ± 0.024	1.191MetArg: 1.191 ± 0.023	1.778MetSer: 1.778 ± 0.034	1.717MetThr: 1.717 ± 0.032	2.044MetVal: 2.044 ± 0.034	0.219MetTrp: 0.219 ± 0.012	0.831MetTyr: 0.831 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.957AsnAla: 2.957 ± 0.04	0.66AsnCys: 0.66 ± 0.022	2.22AsnAsp: 2.22 ± 0.037	2.85AsnGlu: 2.85 ± 0.042	1.679AsnPhe: 1.679 ± 0.033	3.723AsnGly: 3.723 ± 0.055	0.903AsnHis: 0.903 ± 0.021	3.377AsnIle: 3.377 ± 0.05	2.724AsnLys: 2.724 ± 0.042	3.947AsnLeu: 3.947 ± 0.048	1.367AsnMet: 1.367 ± 0.032	2.088AsnAsn: 2.088 ± 0.044	2.153AsnPro: 2.153 ± 0.039	1.817AsnGln: 1.817 ± 0.043	2.328AsnArg: 2.328 ± 0.036	2.768AsnSer: 2.768 ± 0.041	2.487AsnThr: 2.487 ± 0.038	2.692AsnVal: 2.692 ± 0.043	0.478AsnTrp: 0.478 ± 0.014	2.041AsnTyr: 2.041 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.574ProAla: 2.574 ± 0.045	0.507ProCys: 0.507 ± 0.025	2.524ProAsp: 2.524 ± 0.033	3.129ProGlu: 3.129 ± 0.049	1.648ProPhe: 1.648 ± 0.034	2.545ProGly: 2.545 ± 0.044	0.594ProHis: 0.594 ± 0.021	2.031ProIle: 2.031 ± 0.036	1.83ProLys: 1.83 ± 0.034	2.874ProLeu: 2.874 ± 0.041	0.915ProMet: 0.915 ± 0.028	1.192ProAsn: 1.192 ± 0.031	0.885ProPro: 0.885 ± 0.025	1.09ProGln: 1.09 ± 0.026	1.061ProArg: 1.061 ± 0.025	1.953ProSer: 1.953 ± 0.039	1.507ProThr: 1.507 ± 0.046	3.376ProVal: 3.376 ± 0.055	0.345ProTrp: 0.345 ± 0.015	1.538ProTyr: 1.538 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.438GlnAla: 2.438 ± 0.045	0.373GlnCys: 0.373 ± 0.015	1.519GlnAsp: 1.519 ± 0.029	2.487GlnGlu: 2.487 ± 0.037	1.28GlnPhe: 1.28 ± 0.03	2.014GlnGly: 2.014 ± 0.035	0.431GlnHis: 0.431 ± 0.015	2.719GlnIle: 2.719 ± 0.042	2.566GlnLys: 2.566 ± 0.038	2.969GlnLeu: 2.969 ± 0.037	1.205GlnMet: 1.205 ± 0.029	1.607GlnAsn: 1.607 ± 0.034	0.936GlnPro: 0.936 ± 0.022	1.072GlnGln: 1.072 ± 0.026	1.336GlnArg: 1.336 ± 0.033	1.945GlnSer: 1.945 ± 0.037	1.821GlnThr: 1.821 ± 0.032	1.901GlnVal: 1.901 ± 0.035	0.361GlnTrp: 0.361 ± 0.014	1.468GlnTyr: 1.468 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.435ArgAla: 2.435 ± 0.033	0.588ArgCys: 0.588 ± 0.018	2.25ArgAsp: 2.25 ± 0.033	3.605ArgGlu: 3.605 ± 0.055	2.025ArgPhe: 2.025 ± 0.035	2.372ArgGly: 2.372 ± 0.031	0.787ArgHis: 0.787 ± 0.022	3.701ArgIle: 3.701 ± 0.048	3.35ArgLys: 3.35 ± 0.047	4.274ArgLeu: 4.274 ± 0.054	1.482ArgMet: 1.482 ± 0.029	2.216ArgAsn: 2.216 ± 0.038	1.282ArgPro: 1.282 ± 0.03	1.707ArgGln: 1.707 ± 0.033	2.067ArgArg: 2.067 ± 0.044	2.33ArgSer: 2.33 ± 0.039	2.245ArgThr: 2.245 ± 0.041	2.546ArgVal: 2.546 ± 0.044	0.417ArgTrp: 0.417 ± 0.017	1.999ArgTyr: 1.999 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.378SerAla: 4.378 ± 0.061	0.91SerCys: 0.91 ± 0.027	3.532SerAsp: 3.532 ± 0.044	3.943SerGlu: 3.943 ± 0.054	3.068SerPhe: 3.068 ± 0.043	5.404SerGly: 5.404 ± 0.063	1.1SerHis: 1.1 ± 0.026	4.598SerIle: 4.598 ± 0.057	3.552SerLys: 3.552 ± 0.043	5.756SerLeu: 5.756 ± 0.064	2.055SerMet: 2.055 ± 0.038	2.449SerAsn: 2.449 ± 0.039	1.994SerPro: 1.994 ± 0.037	2.162SerGln: 2.162 ± 0.039	2.916SerArg: 2.916 ± 0.042	4.067SerSer: 4.067 ± 0.059	2.907SerThr: 2.907 ± 0.046	4.534SerVal: 4.534 ± 0.054	0.619SerTrp: 0.619 ± 0.022	2.661SerTyr: 2.661 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.742ThrAla: 4.742 ± 0.068	0.627ThrCys: 0.627 ± 0.021	3.191ThrAsp: 3.191 ± 0.057	3.667ThrGlu: 3.667 ± 0.05	2.165ThrPhe: 2.165 ± 0.036	5.111ThrGly: 5.111 ± 0.088	0.858ThrHis: 0.858 ± 0.021	4.02ThrIle: 4.02 ± 0.051	2.904ThrLys: 2.904 ± 0.045	4.793ThrLeu: 4.793 ± 0.059	1.489ThrMet: 1.489 ± 0.03	2.075ThrAsn: 2.075 ± 0.041	2.198ThrPro: 2.198 ± 0.045	1.554ThrGln: 1.554 ± 0.029	2.073ThrArg: 2.073 ± 0.037	3.101ThrSer: 3.101 ± 0.047	2.806ThrThr: 2.806 ± 0.048	4.465ThrVal: 4.465 ± 0.069	0.514ThrTrp: 0.514 ± 0.018	2.124ThrTyr: 2.124 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.116ValAla: 4.116 ± 0.054	1.096ValCys: 1.096 ± 0.026	3.327ValAsp: 3.327 ± 0.046	4.063ValGlu: 4.063 ± 0.057	3.089ValPhe: 3.089 ± 0.046	3.829ValGly: 3.829 ± 0.051	1.027ValHis: 1.027 ± 0.024	5.313ValIle: 5.313 ± 0.064	4.537ValLys: 4.537 ± 0.05	6.493ValLeu: 6.493 ± 0.072	2.055ValMet: 2.055 ± 0.042	2.986ValAsn: 2.986 ± 0.044	2.539ValPro: 2.539 ± 0.038	1.74ValGln: 1.74 ± 0.033	2.784ValArg: 2.784 ± 0.041	4.792ValSer: 4.792 ± 0.054	4.16ValThr: 4.16 ± 0.068	4.331ValVal: 4.331 ± 0.059	0.635ValTrp: 0.635 ± 0.019	2.61ValTyr: 2.61 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.532TrpAla: 0.532 ± 0.019	0.158TrpCys: 0.158 ± 0.01	0.572TrpAsp: 0.572 ± 0.017	0.66TrpGlu: 0.66 ± 0.02	0.451TrpPhe: 0.451 ± 0.018	0.711TrpGly: 0.711 ± 0.02	0.184TrpHis: 0.184 ± 0.011	0.689TrpIle: 0.689 ± 0.021	0.766TrpLys: 0.766 ± 0.021	0.922TrpLeu: 0.922 ± 0.022	0.277TrpMet: 0.277 ± 0.012	0.587TrpAsn: 0.587 ± 0.019	0.228TrpPro: 0.228 ± 0.011	0.378TrpGln: 0.378 ± 0.014	0.396TrpArg: 0.396 ± 0.017	0.591TrpSer: 0.591 ± 0.021	0.474TrpThr: 0.474 ± 0.017	0.546TrpVal: 0.546 ± 0.019	0.128TrpTrp: 0.128 ± 0.009	0.466TrpTyr: 0.466 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.504TyrAla: 2.504 ± 0.041	0.653TyrCys: 0.653 ± 0.021	2.519TyrAsp: 2.519 ± 0.043	2.976TyrGlu: 2.976 ± 0.044	1.887TyrPhe: 1.887 ± 0.037	3.067TyrGly: 3.067 ± 0.042	0.911TyrHis: 0.911 ± 0.021	2.856TyrIle: 2.856 ± 0.043	2.376TyrLys: 2.376 ± 0.034	4.064TyrLeu: 4.064 ± 0.055	1.105TyrMet: 1.105 ± 0.024	1.82TyrAsn: 1.82 ± 0.034	1.563TyrPro: 1.563 ± 0.035	1.676TyrGln: 1.676 ± 0.036	2.08TyrArg: 2.08 ± 0.029	2.556TyrSer: 2.556 ± 0.043	2.257TyrThr: 2.257 ± 0.045	2.363TyrVal: 2.363 ± 0.032	0.398TyrTrp: 0.398 ± 0.017	1.983TyrTyr: 1.983 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5501 proteins (1752169 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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