Amino acid dipepetide frequency for Mycobacterium ulcerans str. Harvey

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.241AlaAla: 20.241 ± 0.164	1.431AlaCys: 1.431 ± 0.03	7.256AlaAsp: 7.256 ± 0.07	6.825AlaGlu: 6.825 ± 0.072	3.079AlaPhe: 3.079 ± 0.044	12.086AlaGly: 12.086 ± 0.11	2.876AlaHis: 2.876 ± 0.043	5.631AlaIle: 5.631 ± 0.063	3.19AlaLys: 3.19 ± 0.054	12.298AlaLeu: 12.298 ± 0.1	3.14AlaMet: 3.14 ± 0.039	2.921AlaAsn: 2.921 ± 0.048	6.134AlaPro: 6.134 ± 0.072	4.148AlaGln: 4.148 ± 0.047	9.245AlaArg: 9.245 ± 0.077	6.586AlaSer: 6.586 ± 0.058	8.344AlaThr: 8.344 ± 0.089	10.593AlaVal: 10.593 ± 0.089	1.626AlaTrp: 1.626 ± 0.033	2.053AlaTyr: 2.053 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.562CysAla: 1.562 ± 0.033	0.41CysCys: 0.41 ± 0.015	0.587CysAsp: 0.587 ± 0.016	0.399CysGlu: 0.399 ± 0.015	0.229CysPhe: 0.229 ± 0.012	1.427CysGly: 1.427 ± 0.031	0.228CysHis: 0.228 ± 0.012	0.336CysIle: 0.336 ± 0.015	0.168CysLys: 0.168 ± 0.01	0.712CysLeu: 0.712 ± 0.023	0.457CysMet: 0.457 ± 0.016	0.2CysAsn: 0.2 ± 0.01	0.772CysPro: 0.772 ± 0.023	0.281CysGln: 0.281 ± 0.014	1.462CysArg: 1.462 ± 0.032	1.17CysSer: 1.17 ± 0.03	0.588CysThr: 0.588 ± 0.018	0.768CysVal: 0.768 ± 0.024	0.432CysTrp: 0.432 ± 0.02	0.213CysTyr: 0.213 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.515AspAla: 6.515 ± 0.063	0.471AspCys: 0.471 ± 0.017	3.409AspAsp: 3.409 ± 0.055	3.46AspGlu: 3.46 ± 0.05	1.576AspPhe: 1.576 ± 0.032	5.223AspGly: 5.223 ± 0.064	1.322AspHis: 1.322 ± 0.026	2.285AspIle: 2.285 ± 0.044	1.041AspLys: 1.041 ± 0.028	5.34AspLeu: 5.34 ± 0.063	0.923AspMet: 0.923 ± 0.026	1.32AspAsn: 1.32 ± 0.03	4.009AspPro: 4.009 ± 0.05	1.894AspGln: 1.894 ± 0.033	4.455AspArg: 4.455 ± 0.057	2.724AspSer: 2.724 ± 0.04	2.87AspThr: 2.87 ± 0.048	4.729AspVal: 4.729 ± 0.05	0.849AspTrp: 0.849 ± 0.025	1.282AspTyr: 1.282 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	5.243GluAla: 5.243 ± 0.062	0.386GluCys: 0.386 ± 0.017	2.13GluAsp: 2.13 ± 0.031	2.046GluGlu: 2.046 ± 0.041	1.592GluPhe: 1.592 ± 0.031	2.772GluGly: 2.772 ± 0.045	1.515GluHis: 1.515 ± 0.03	2.393GluIle: 2.393 ± 0.036	1.285GluLys: 1.285 ± 0.031	5.885GluLeu: 5.885 ± 0.072	1.011GluMet: 1.011 ± 0.025	1.062GluAsn: 1.062 ± 0.026	2.622GluPro: 2.622 ± 0.045	1.961GluGln: 1.961 ± 0.037	3.856GluArg: 3.856 ± 0.059	2.408GluSer: 2.408 ± 0.041	2.282GluThr: 2.282 ± 0.037	4.003GluVal: 4.003 ± 0.051	0.597GluTrp: 0.597 ± 0.018	0.904GluTyr: 0.904 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.803PheAla: 3.803 ± 0.053	0.35PheCys: 0.35 ± 0.015	2.232PheAsp: 2.232 ± 0.034	1.495PheGlu: 1.495 ± 0.029	0.965PhePhe: 0.965 ± 0.025	3.319PheGly: 3.319 ± 0.051	0.588PheHis: 0.588 ± 0.018	1.06PheIle: 1.06 ± 0.027	0.448PheLys: 0.448 ± 0.019	2.287PheLeu: 2.287 ± 0.043	0.475PheMet: 0.475 ± 0.018	0.81PheAsn: 0.81 ± 0.039	1.667PhePro: 1.667 ± 0.033	0.628PheGln: 0.628 ± 0.02	1.869PheArg: 1.869 ± 0.033	1.695PheSer: 1.695 ± 0.032	1.844PheThr: 1.844 ± 0.034	2.228PheVal: 2.228 ± 0.041	0.432PheTrp: 0.432 ± 0.017	0.591PheTyr: 0.591 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.231GlyAla: 10.231 ± 0.102	1.17GlyCys: 1.17 ± 0.03	4.472GlyAsp: 4.472 ± 0.061	3.733GlyGlu: 3.733 ± 0.051	3.065GlyPhe: 3.065 ± 0.059	8.358GlyGly: 8.358 ± 0.176	2.212GlyHis: 2.212 ± 0.037	4.014GlyIle: 4.014 ± 0.044	2.116GlyLys: 2.116 ± 0.037	8.213GlyLeu: 8.213 ± 0.083	2.328GlyMet: 2.328 ± 0.036	2.565GlyAsn: 2.565 ± 0.085	4.57GlyPro: 4.57 ± 0.067	3.048GlyGln: 3.048 ± 0.041	6.715GlyArg: 6.715 ± 0.074	6.06GlySer: 6.06 ± 0.067	5.02GlyThr: 5.02 ± 0.066	6.745GlyVal: 6.745 ± 0.062	1.798GlyTrp: 1.798 ± 0.031	2.367GlyTyr: 2.367 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.427HisAla: 2.427 ± 0.043	0.387HisCys: 0.387 ± 0.014	1.323HisAsp: 1.323 ± 0.03	0.971HisGlu: 0.971 ± 0.026	0.666HisPhe: 0.666 ± 0.019	2.193HisGly: 2.193 ± 0.037	0.774HisHis: 0.774 ± 0.024	0.811HisIle: 0.811 ± 0.021	0.334HisLys: 0.334 ± 0.014	2.11HisLeu: 2.11 ± 0.04	0.367HisMet: 0.367 ± 0.016	0.496HisAsn: 0.496 ± 0.017	1.714HisPro: 1.714 ± 0.034	0.777HisGln: 0.777 ± 0.025	2.645HisArg: 2.645 ± 0.046	1.134HisSer: 1.134 ± 0.028	1.525HisThr: 1.525 ± 0.029	1.607HisVal: 1.607 ± 0.028	0.544HisTrp: 0.544 ± 0.018	0.652HisTyr: 0.652 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.999IleAla: 5.999 ± 0.065	0.755IleCys: 0.755 ± 0.025	3.141IleAsp: 3.141 ± 0.044	2.496IleGlu: 2.496 ± 0.036	1.061IlePhe: 1.061 ± 0.027	4.524IleGly: 4.524 ± 0.061	0.776IleHis: 0.776 ± 0.023	1.636IleIle: 1.636 ± 0.036	0.826IleLys: 0.826 ± 0.025	2.76IleLeu: 2.76 ± 0.041	0.739IleMet: 0.739 ± 0.021	1.257IleAsn: 1.257 ± 0.029	2.416IlePro: 2.416 ± 0.04	0.854IleGln: 0.854 ± 0.025	2.994IleArg: 2.994 ± 0.041	2.537IleSer: 2.537 ± 0.036	3.214IleThr: 3.214 ± 0.052	3.329IleVal: 3.329 ± 0.045	0.528IleTrp: 0.528 ± 0.019	0.823IleTyr: 0.823 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.376LysAla: 2.376 ± 0.042	0.154LysCys: 0.154 ± 0.011	0.905LysAsp: 0.905 ± 0.026	0.728LysGlu: 0.728 ± 0.024	0.557LysPhe: 0.557 ± 0.021	1.301LysGly: 1.301 ± 0.031	0.423LysHis: 0.423 ± 0.017	1.136LysIle: 1.136 ± 0.026	0.528LysLys: 0.528 ± 0.022	2.071LysLeu: 2.071 ± 0.037	0.565LysMet: 0.565 ± 0.019	0.513LysAsn: 0.513 ± 0.016	1.453LysPro: 1.453 ± 0.035	0.758LysGln: 0.758 ± 0.021	1.518LysArg: 1.518 ± 0.03	1.641LysSer: 1.641 ± 0.039	1.566LysThr: 1.566 ± 0.032	1.698LysVal: 1.698 ± 0.035	0.297LysTrp: 0.297 ± 0.014	0.411LysTyr: 0.411 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.277LeuAla: 13.277 ± 0.105	0.805LeuCys: 0.805 ± 0.021	6.007LeuAsp: 6.007 ± 0.062	3.855LeuGlu: 3.855 ± 0.057	2.438LeuPhe: 2.438 ± 0.045	8.088LeuGly: 8.088 ± 0.077	2.256LeuHis: 2.256 ± 0.035	4.115LeuIle: 4.115 ± 0.058	1.845LeuLys: 1.845 ± 0.035	9.086LeuLeu: 9.086 ± 0.094	1.897LeuMet: 1.897 ± 0.034	2.462LeuAsn: 2.462 ± 0.043	6.002LeuPro: 6.002 ± 0.06	2.687LeuGln: 2.687 ± 0.04	7.453LeuArg: 7.453 ± 0.077	5.491LeuSer: 5.491 ± 0.059	5.961LeuThr: 5.961 ± 0.057	7.853LeuVal: 7.853 ± 0.062	1.147LeuTrp: 1.147 ± 0.028	1.481LeuTyr: 1.481 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.96MetAla: 2.96 ± 0.044	0.257MetCys: 0.257 ± 0.012	0.859MetAsp: 0.859 ± 0.022	0.683MetGlu: 0.683 ± 0.022	0.703MetPhe: 0.703 ± 0.021	1.709MetGly: 1.709 ± 0.031	0.609MetHis: 0.609 ± 0.018	1.202MetIle: 1.202 ± 0.025	0.433MetLys: 0.433 ± 0.016	2.393MetLeu: 2.393 ± 0.042	0.588MetMet: 0.588 ± 0.02	0.483MetAsn: 0.483 ± 0.016	1.405MetPro: 1.405 ± 0.03	0.581MetGln: 0.581 ± 0.019	1.956MetArg: 1.956 ± 0.032	1.513MetSer: 1.513 ± 0.03	1.903MetThr: 1.903 ± 0.031	1.738MetVal: 1.738 ± 0.035	0.347MetTrp: 0.347 ± 0.016	0.362MetTyr: 0.362 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.944AsnAla: 2.944 ± 0.048	0.242AsnCys: 0.242 ± 0.013	1.108AsnAsp: 1.108 ± 0.03	1.085AsnGlu: 1.085 ± 0.026	0.73AsnPhe: 0.73 ± 0.026	2.571AsnGly: 2.571 ± 0.054	0.561AsnHis: 0.561 ± 0.018	1.155AsnIle: 1.155 ± 0.036	0.415AsnLys: 0.415 ± 0.016	2.263AsnLeu: 2.263 ± 0.051	0.446AsnMet: 0.446 ± 0.019	0.678AsnAsn: 0.678 ± 0.032	1.761AsnPro: 1.761 ± 0.034	0.826AsnGln: 0.826 ± 0.021	1.831AsnArg: 1.831 ± 0.033	1.624AsnSer: 1.624 ± 0.04	1.537AsnThr: 1.537 ± 0.05	1.639AsnVal: 1.639 ± 0.036	0.408AsnTrp: 0.408 ± 0.014	0.551AsnTyr: 0.551 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.931ProAla: 7.931 ± 0.088	0.725ProCys: 0.725 ± 0.021	3.883ProAsp: 3.883 ± 0.054	3.069ProGlu: 3.069 ± 0.043	1.568ProPhe: 1.568 ± 0.029	5.703ProGly: 5.703 ± 0.066	1.311ProHis: 1.311 ± 0.03	2.363ProIle: 2.363 ± 0.043	1.285ProLys: 1.285 ± 0.024	4.545ProLeu: 4.545 ± 0.053	1.438ProMet: 1.438 ± 0.031	1.401ProAsn: 1.401 ± 0.028	4.05ProPro: 4.05 ± 0.073	1.94ProGln: 1.94 ± 0.035	4.48ProArg: 4.48 ± 0.063	4.057ProSer: 4.057 ± 0.061	4.205ProThr: 4.205 ± 0.053	4.611ProVal: 4.611 ± 0.056	1.088ProTrp: 1.088 ± 0.023	1.106ProTyr: 1.106 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.934GlnAla: 3.934 ± 0.053	0.324GlnCys: 0.324 ± 0.016	1.238GlnAsp: 1.238 ± 0.028	1.016GlnGlu: 1.016 ± 0.026	1.031GlnPhe: 1.031 ± 0.024	1.905GlnGly: 1.905 ± 0.035	1.007GlnHis: 1.007 ± 0.023	1.645GlnIle: 1.645 ± 0.034	0.529GlnLys: 0.529 ± 0.018	3.707GlnLeu: 3.707 ± 0.056	0.704GlnMet: 0.704 ± 0.023	0.644GlnAsn: 0.644 ± 0.018	2.015GlnPro: 2.015 ± 0.037	1.366GlnGln: 1.366 ± 0.029	3.251GlnArg: 3.251 ± 0.042	1.57GlnSer: 1.57 ± 0.031	1.649GlnThr: 1.649 ± 0.03	2.666GlnVal: 2.666 ± 0.04	0.51GlnTrp: 0.51 ± 0.019	0.584GlnTyr: 0.584 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.589ArgAla: 8.589 ± 0.088	1.626ArgCys: 1.626 ± 0.035	3.973ArgAsp: 3.973 ± 0.05	3.357ArgGlu: 3.357 ± 0.046	2.382ArgPhe: 2.382 ± 0.038	5.851ArgGly: 5.851 ± 0.06	2.139ArgHis: 2.139 ± 0.036	3.593ArgIle: 3.593 ± 0.052	1.529ArgLys: 1.529 ± 0.032	7.537ArgLeu: 7.537 ± 0.075	2.375ArgMet: 2.375 ± 0.036	1.835ArgAsn: 1.835 ± 0.029	5.301ArgPro: 5.301 ± 0.058	2.85ArgGln: 2.85 ± 0.038	8.668ArgArg: 8.668 ± 0.113	5.511ArgSer: 5.511 ± 0.061	3.98ArgThr: 3.98 ± 0.052	5.156ArgVal: 5.156 ± 0.056	2.046ArgTrp: 2.046 ± 0.036	1.879ArgTyr: 1.879 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.613SerAla: 7.613 ± 0.084	0.754SerCys: 0.754 ± 0.026	3.038SerAsp: 3.038 ± 0.038	2.622SerGlu: 2.622 ± 0.04	1.528SerPhe: 1.528 ± 0.03	6.375SerGly: 6.375 ± 0.075	1.187SerHis: 1.187 ± 0.023	2.265SerIle: 2.265 ± 0.044	1.184SerLys: 1.184 ± 0.023	5.093SerLeu: 5.093 ± 0.06	1.592SerMet: 1.592 ± 0.028	1.57SerAsn: 1.57 ± 0.035	3.937SerPro: 3.937 ± 0.05	1.696SerGln: 1.696 ± 0.03	4.881SerArg: 4.881 ± 0.056	4.542SerSer: 4.542 ± 0.058	4.024SerThr: 4.024 ± 0.049	4.709SerVal: 4.709 ± 0.053	1.187SerTrp: 1.187 ± 0.027	1.342SerTyr: 1.342 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	9.22ThrAla: 9.22 ± 0.103	0.64ThrCys: 0.64 ± 0.021	3.463ThrAsp: 3.463 ± 0.046	2.737ThrGlu: 2.737 ± 0.039	1.857ThrPhe: 1.857 ± 0.033	6.003ThrGly: 6.003 ± 0.07	1.242ThrHis: 1.242 ± 0.025	2.306ThrIle: 2.306 ± 0.048	1.218ThrLys: 1.218 ± 0.028	5.392ThrLeu: 5.392 ± 0.065	1.307ThrMet: 1.307 ± 0.024	1.346ThrAsn: 1.346 ± 0.031	3.886ThrPro: 3.886 ± 0.058	1.654ThrGln: 1.654 ± 0.033	4.225ThrArg: 4.225 ± 0.049	3.701ThrSer: 3.701 ± 0.047	3.962ThrThr: 3.962 ± 0.064	5.174ThrVal: 5.174 ± 0.06	1.094ThrTrp: 1.094 ± 0.028	1.088ThrTyr: 1.088 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.306ValAla: 10.306 ± 0.084	0.874ValCys: 0.874 ± 0.02	4.805ValAsp: 4.805 ± 0.06	3.922ValGlu: 3.922 ± 0.053	2.498ValPhe: 2.498 ± 0.039	6.535ValGly: 6.535 ± 0.064	1.587ValHis: 1.587 ± 0.034	3.438ValIle: 3.438 ± 0.051	1.611ValLys: 1.611 ± 0.032	8.401ValLeu: 8.401 ± 0.081	1.481ValMet: 1.481 ± 0.03	1.937ValAsn: 1.937 ± 0.037	4.597ValPro: 4.597 ± 0.057	1.98ValGln: 1.98 ± 0.033	5.359ValArg: 5.359 ± 0.063	4.861ValSer: 4.861 ± 0.051	5.051ValThr: 5.051 ± 0.048	7.693ValVal: 7.693 ± 0.084	0.923ValTrp: 0.923 ± 0.024	1.453ValTyr: 1.453 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.9TrpAla: 1.9 ± 0.034	0.408TrpCys: 0.408 ± 0.017	0.669TrpAsp: 0.669 ± 0.018	0.561TrpGlu: 0.561 ± 0.018	0.458TrpPhe: 0.458 ± 0.018	1.002TrpGly: 1.002 ± 0.026	0.401TrpHis: 0.401 ± 0.014	0.721TrpIle: 0.721 ± 0.02	0.328TrpLys: 0.328 ± 0.015	1.856TrpLeu: 1.856 ± 0.032	0.577TrpMet: 0.577 ± 0.019	0.437TrpAsn: 0.437 ± 0.017	1.29TrpPro: 1.29 ± 0.033	0.619TrpGln: 0.619 ± 0.021	1.563TrpArg: 1.563 ± 0.03	1.214TrpSer: 1.214 ± 0.029	0.935TrpThr: 0.935 ± 0.024	1.01TrpVal: 1.01 ± 0.023	0.422TrpTrp: 0.422 ± 0.016	0.274TrpTyr: 0.274 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.634TyrAla: 2.634 ± 0.035	0.232TyrCys: 0.232 ± 0.012	1.2TyrAsp: 1.2 ± 0.03	0.891TyrGlu: 0.891 ± 0.027	0.802TyrPhe: 0.802 ± 0.024	1.854TyrGly: 1.854 ± 0.037	0.445TyrHis: 0.445 ± 0.013	0.559TyrIle: 0.559 ± 0.02	0.285TyrLys: 0.285 ± 0.013	2.257TyrLeu: 2.257 ± 0.034	0.272TyrMet: 0.272 ± 0.012	0.436TyrAsn: 0.436 ± 0.021	1.157TyrPro: 1.157 ± 0.028	0.746TyrGln: 0.746 ± 0.02	1.751TyrArg: 1.751 ± 0.038	1.103TyrSer: 1.103 ± 0.028	1.054TyrThr: 1.054 ± 0.026	1.366TyrVal: 1.366 ± 0.031	0.37TyrTrp: 0.37 ± 0.014	0.427TyrTyr: 0.427 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9033 proteins (1677574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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