Amino acid dipepetide frequency for Prochlorothrix hollandica PCC 9006 = CALU 1027

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.67AlaAla: 9.67 ± 0.139	0.897AlaCys: 0.897 ± 0.03	4.99AlaAsp: 4.99 ± 0.08	5.135AlaGlu: 5.135 ± 0.085	2.89AlaPhe: 2.89 ± 0.053	6.231AlaGly: 6.231 ± 0.094	1.734AlaHis: 1.734 ± 0.042	5.925AlaIle: 5.925 ± 0.085	3.092AlaLys: 3.092 ± 0.067	11.535AlaLeu: 11.535 ± 0.128	2.107AlaMet: 2.107 ± 0.043	2.624AlaAsn: 2.624 ± 0.072	4.404AlaPro: 4.404 ± 0.086	5.835AlaGln: 5.835 ± 0.097	3.902AlaArg: 3.902 ± 0.061	4.559AlaSer: 4.559 ± 0.075	5.436AlaThr: 5.436 ± 0.074	6.532AlaVal: 6.532 ± 0.09	1.24AlaTrp: 1.24 ± 0.039	2.322AlaTyr: 2.322 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.672CysAla: 0.672 ± 0.024	0.204CysCys: 0.204 ± 0.015	0.652CysAsp: 0.652 ± 0.024	0.437CysGlu: 0.437 ± 0.019	0.397CysPhe: 0.397 ± 0.019	0.894CysGly: 0.894 ± 0.031	0.348CysHis: 0.348 ± 0.018	0.442CysIle: 0.442 ± 0.022	0.223CysLys: 0.223 ± 0.013	1.191CysLeu: 1.191 ± 0.034	0.141CysMet: 0.141 ± 0.011	0.326CysAsn: 0.326 ± 0.019	0.688CysPro: 0.688 ± 0.03	0.651CysGln: 0.651 ± 0.024	0.636CysArg: 0.636 ± 0.025	0.585CysSer: 0.585 ± 0.025	0.451CysThr: 0.451 ± 0.021	0.581CysVal: 0.581 ± 0.023	0.163CysTrp: 0.163 ± 0.012	0.354CysTyr: 0.354 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.826AspAla: 3.826 ± 0.06	0.578AspCys: 0.578 ± 0.024	2.548AspAsp: 2.548 ± 0.06	2.449AspGlu: 2.449 ± 0.061	2.361AspPhe: 2.361 ± 0.048	3.77AspGly: 3.77 ± 0.069	1.233AspHis: 1.233 ± 0.038	2.601AspIle: 2.601 ± 0.056	1.302AspLys: 1.302 ± 0.041	7.58AspLeu: 7.58 ± 0.082	0.804AspMet: 0.804 ± 0.027	1.518AspAsn: 1.518 ± 0.042	4.169AspPro: 4.169 ± 0.072	2.918AspGln: 2.918 ± 0.055	6.252AspArg: 6.252 ± 0.079	3.048AspSer: 3.048 ± 0.059	2.507AspThr: 2.507 ± 0.057	2.868AspVal: 2.868 ± 0.063	1.045AspTrp: 1.045 ± 0.03	1.926AspTyr: 1.926 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.861GluAla: 5.861 ± 0.078	0.38GluCys: 0.38 ± 0.017	2.722GluAsp: 2.722 ± 0.055	3.26GluGlu: 3.26 ± 0.073	1.931GluPhe: 1.931 ± 0.041	3.558GluGly: 3.558 ± 0.062	0.893GluHis: 0.893 ± 0.032	3.18GluIle: 3.18 ± 0.056	1.946GluLys: 1.946 ± 0.054	5.848GluLeu: 5.848 ± 0.081	1.183GluMet: 1.183 ± 0.032	1.646GluAsn: 1.646 ± 0.049	2.865GluPro: 2.865 ± 0.064	3.287GluGln: 3.287 ± 0.063	3.165GluArg: 3.165 ± 0.055	2.99GluSer: 2.99 ± 0.054	3.647GluThr: 3.647 ± 0.062	4.057GluVal: 4.057 ± 0.063	0.702GluTrp: 0.702 ± 0.029	1.242GluTyr: 1.242 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	2.845PheAla: 2.845 ± 0.048	0.526PheCys: 0.526 ± 0.023	2.041PheAsp: 2.041 ± 0.043	1.876PheGlu: 1.876 ± 0.046	1.485PhePhe: 1.485 ± 0.037	2.781PheGly: 2.781 ± 0.055	0.773PheHis: 0.773 ± 0.028	1.676PheIle: 1.676 ± 0.045	1.233PheLys: 1.233 ± 0.043	3.885PheLeu: 3.885 ± 0.069	0.664PheMet: 0.664 ± 0.027	1.305PheAsn: 1.305 ± 0.035	1.908PhePro: 1.908 ± 0.041	1.939PheGln: 1.939 ± 0.037	1.919PheArg: 1.919 ± 0.041	2.467PheSer: 2.467 ± 0.056	1.931PheThr: 1.931 ± 0.046	2.171PheVal: 2.171 ± 0.044	0.667PheTrp: 0.667 ± 0.032	1.245PheTyr: 1.245 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.032GlyAla: 6.032 ± 0.112	0.83GlyCys: 0.83 ± 0.031	4.637GlyAsp: 4.637 ± 0.08	4.308GlyGlu: 4.308 ± 0.073	3.204GlyPhe: 3.204 ± 0.062	5.893GlyGly: 5.893 ± 0.118	1.647GlyHis: 1.647 ± 0.052	4.336GlyIle: 4.336 ± 0.07	2.808GlyLys: 2.808 ± 0.056	9.01GlyLeu: 9.01 ± 0.113	1.536GlyMet: 1.536 ± 0.039	2.595GlyAsn: 2.595 ± 0.068	1.992GlyPro: 1.992 ± 0.041	4.504GlyGln: 4.504 ± 0.07	4.23GlyArg: 4.23 ± 0.072	5.502GlySer: 5.502 ± 0.113	4.468GlyThr: 4.468 ± 0.104	5.527GlyVal: 5.527 ± 0.081	1.437GlyTrp: 1.437 ± 0.042	2.315GlyTyr: 2.315 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.26HisAla: 1.26 ± 0.037	0.388HisCys: 0.388 ± 0.02	1.0HisAsp: 1.0 ± 0.033	0.748HisGlu: 0.748 ± 0.027	0.795HisPhe: 0.795 ± 0.026	1.594HisGly: 1.594 ± 0.049	0.9HisHis: 0.9 ± 0.032	0.97HisIle: 0.97 ± 0.03	0.569HisLys: 0.569 ± 0.03	2.961HisLeu: 2.961 ± 0.057	0.282HisMet: 0.282 ± 0.017	0.672HisAsn: 0.672 ± 0.027	1.671HisPro: 1.671 ± 0.047	1.581HisGln: 1.581 ± 0.042	1.535HisArg: 1.535 ± 0.039	1.27HisSer: 1.27 ± 0.037	0.954HisThr: 0.954 ± 0.031	0.851HisVal: 0.851 ± 0.031	0.573HisTrp: 0.573 ± 0.025	0.838HisTyr: 0.838 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.762IleAla: 5.762 ± 0.085	0.583IleCys: 0.583 ± 0.023	2.992IleAsp: 2.992 ± 0.054	3.024IleGlu: 3.024 ± 0.056	1.833IlePhe: 1.833 ± 0.04	3.37IleGly: 3.37 ± 0.064	1.191IleHis: 1.191 ± 0.033	2.339IleIle: 2.339 ± 0.051	1.643IleLys: 1.643 ± 0.045	5.677IleLeu: 5.677 ± 0.08	0.696IleMet: 0.696 ± 0.025	1.693IleAsn: 1.693 ± 0.043	3.044IlePro: 3.044 ± 0.053	2.681IleGln: 2.681 ± 0.048	2.719IleArg: 2.719 ± 0.051	2.994IleSer: 2.994 ± 0.062	3.139IleThr: 3.139 ± 0.064	3.425IleVal: 3.425 ± 0.052	0.662IleTrp: 0.662 ± 0.028	1.44IleTyr: 1.44 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.284LysAla: 3.284 ± 0.068	0.179LysCys: 0.179 ± 0.012	1.543LysAsp: 1.543 ± 0.041	1.554LysGlu: 1.554 ± 0.043	0.973LysPhe: 0.973 ± 0.034	2.203LysGly: 2.203 ± 0.047	0.546LysHis: 0.546 ± 0.021	1.899LysIle: 1.899 ± 0.048	1.346LysLys: 1.346 ± 0.053	3.45LysLeu: 3.45 ± 0.072	0.546LysMet: 0.546 ± 0.021	1.052LysAsn: 1.052 ± 0.037	1.886LysPro: 1.886 ± 0.05	1.511LysGln: 1.511 ± 0.043	1.832LysArg: 1.832 ± 0.044	1.788LysSer: 1.788 ± 0.053	2.376LysThr: 2.376 ± 0.054	2.286LysVal: 2.286 ± 0.051	0.308LysTrp: 0.308 ± 0.02	0.72LysTyr: 0.72 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.616LeuAla: 11.616 ± 0.13	1.13LeuCys: 1.13 ± 0.029	7.101LeuAsp: 7.101 ± 0.093	7.487LeuGlu: 7.487 ± 0.098	3.539LeuPhe: 3.539 ± 0.058	10.308LeuGly: 10.308 ± 0.119	2.229LeuHis: 2.229 ± 0.05	5.125LeuIle: 5.125 ± 0.093	4.114LeuLys: 4.114 ± 0.066	11.998LeuLeu: 11.998 ± 0.141	2.323LeuMet: 2.323 ± 0.051	3.758LeuAsn: 3.758 ± 0.067	6.814LeuPro: 6.814 ± 0.09	6.607LeuGln: 6.607 ± 0.097	6.789LeuArg: 6.789 ± 0.092	7.386LeuSer: 7.386 ± 0.085	6.893LeuThr: 6.893 ± 0.098	8.229LeuVal: 8.229 ± 0.093	1.833LeuTrp: 1.833 ± 0.052	2.817LeuTyr: 2.817 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.447MetAla: 2.447 ± 0.048	0.11MetCys: 0.11 ± 0.011	0.976MetAsp: 0.976 ± 0.031	1.012MetGlu: 1.012 ± 0.032	0.413MetPhe: 0.413 ± 0.018	1.778MetGly: 1.778 ± 0.038	0.276MetHis: 0.276 ± 0.015	0.931MetIle: 0.931 ± 0.028	0.623MetLys: 0.623 ± 0.025	1.671MetLeu: 1.671 ± 0.041	0.365MetMet: 0.365 ± 0.018	0.625MetAsn: 0.625 ± 0.026	1.009MetPro: 1.009 ± 0.03	0.749MetGln: 0.749 ± 0.028	0.932MetArg: 0.932 ± 0.026	0.999MetSer: 0.999 ± 0.028	1.327MetThr: 1.327 ± 0.033	1.697MetVal: 1.697 ± 0.042	0.141MetTrp: 0.141 ± 0.011	0.258MetTyr: 0.258 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.441AsnAla: 2.441 ± 0.056	0.307AsnCys: 0.307 ± 0.015	1.286AsnAsp: 1.286 ± 0.04	1.081AsnGlu: 1.081 ± 0.032	1.25AsnPhe: 1.25 ± 0.032	2.167AsnGly: 2.167 ± 0.06	0.752AsnHis: 0.752 ± 0.029	1.517AsnIle: 1.517 ± 0.044	0.756AsnLys: 0.756 ± 0.03	4.365AsnLeu: 4.365 ± 0.095	0.419AsnMet: 0.419 ± 0.022	0.988AsnAsn: 0.988 ± 0.039	3.039AsnPro: 3.039 ± 0.059	1.898AsnGln: 1.898 ± 0.042	1.966AsnArg: 1.966 ± 0.04	1.805AsnSer: 1.805 ± 0.049	1.614AsnThr: 1.614 ± 0.043	1.61AsnVal: 1.61 ± 0.041	0.497AsnTrp: 0.497 ± 0.021	0.945AsnTyr: 0.945 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.708ProAla: 4.708 ± 0.092	0.478ProCys: 0.478 ± 0.025	4.125ProAsp: 4.125 ± 0.067	3.811ProGlu: 3.811 ± 0.07	1.795ProPhe: 1.795 ± 0.041	4.374ProGly: 4.374 ± 0.077	1.496ProHis: 1.496 ± 0.043	2.549ProIle: 2.549 ± 0.05	1.653ProLys: 1.653 ± 0.039	6.637ProLeu: 6.637 ± 0.091	1.152ProMet: 1.152 ± 0.031	1.795ProAsn: 1.795 ± 0.045	4.093ProPro: 4.093 ± 0.102	3.776ProGln: 3.776 ± 0.058	2.631ProArg: 2.631 ± 0.053	3.857ProSer: 3.857 ± 0.079	3.431ProThr: 3.431 ± 0.06	3.768ProVal: 3.768 ± 0.066	1.138ProTrp: 1.138 ± 0.038	1.435ProTyr: 1.435 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.885GlnAla: 5.885 ± 0.098	0.447GlnCys: 0.447 ± 0.021	2.993GlnAsp: 2.993 ± 0.054	3.376GlnGlu: 3.376 ± 0.065	1.89GlnPhe: 1.89 ± 0.042	5.533GlnGly: 5.533 ± 0.086	1.082GlnHis: 1.082 ± 0.037	2.817GlnIle: 2.817 ± 0.056	1.691GlnLys: 1.691 ± 0.044	5.848GlnLeu: 5.848 ± 0.08	0.967GlnMet: 0.967 ± 0.027	1.533GlnAsn: 1.533 ± 0.039	3.313GlnPro: 3.313 ± 0.062	4.054GlnGln: 4.054 ± 0.102	4.254GlnArg: 4.254 ± 0.077	3.083GlnSer: 3.083 ± 0.06	3.338GlnThr: 3.338 ± 0.059	4.742GlnVal: 4.742 ± 0.069	1.166GlnTrp: 1.166 ± 0.033	1.205GlnTyr: 1.205 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.017ArgAla: 4.017 ± 0.069	0.672ArgCys: 0.672 ± 0.024	3.329ArgAsp: 3.329 ± 0.059	3.004ArgGlu: 3.004 ± 0.058	2.501ArgPhe: 2.501 ± 0.054	3.825ArgGly: 3.825 ± 0.07	1.502ArgHis: 1.502 ± 0.047	3.069ArgIle: 3.069 ± 0.061	1.826ArgLys: 1.826 ± 0.046	7.452ArgLeu: 7.452 ± 0.097	0.973ArgMet: 0.973 ± 0.029	1.793ArgAsn: 1.793 ± 0.043	3.0ArgPro: 3.0 ± 0.061	4.018ArgGln: 4.018 ± 0.064	3.791ArgArg: 3.791 ± 0.067	4.495ArgSer: 4.495 ± 0.065	2.624ArgThr: 2.624 ± 0.052	3.891ArgVal: 3.891 ± 0.065	1.223ArgTrp: 1.223 ± 0.035	2.037ArgTyr: 2.037 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.789SerAla: 4.789 ± 0.076	0.563SerCys: 0.563 ± 0.023	3.047SerAsp: 3.047 ± 0.057	2.651SerGlu: 2.651 ± 0.051	2.074SerPhe: 2.074 ± 0.049	4.768SerGly: 4.768 ± 0.104	1.429SerHis: 1.429 ± 0.039	2.87SerIle: 2.87 ± 0.052	1.639SerLys: 1.639 ± 0.045	7.937SerLeu: 7.937 ± 0.104	1.151SerMet: 1.151 ± 0.037	1.787SerAsn: 1.787 ± 0.046	4.771SerPro: 4.771 ± 0.075	3.677SerGln: 3.677 ± 0.068	3.416SerArg: 3.416 ± 0.06	3.915SerSer: 3.915 ± 0.078	3.216SerThr: 3.216 ± 0.061	3.728SerVal: 3.728 ± 0.066	0.903SerTrp: 0.903 ± 0.027	1.637SerTyr: 1.637 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.863ThrAla: 5.863 ± 0.086	0.545ThrCys: 0.545 ± 0.021	2.833ThrAsp: 2.833 ± 0.053	2.784ThrGlu: 2.784 ± 0.05	1.914ThrPhe: 1.914 ± 0.04	4.469ThrGly: 4.469 ± 0.096	1.163ThrHis: 1.163 ± 0.032	3.016ThrIle: 3.016 ± 0.063	1.404ThrLys: 1.404 ± 0.044	8.125ThrLeu: 8.125 ± 0.111	0.837ThrMet: 0.837 ± 0.03	1.441ThrAsn: 1.441 ± 0.038	4.208ThrPro: 4.208 ± 0.075	2.926ThrGln: 2.926 ± 0.054	2.334ThrArg: 2.334 ± 0.049	2.84ThrSer: 2.84 ± 0.06	3.463ThrThr: 3.463 ± 0.085	4.447ThrVal: 4.447 ± 0.07	0.858ThrTrp: 0.858 ± 0.03	1.574ThrTyr: 1.574 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	6.95ValAla: 6.95 ± 0.091	0.65ValCys: 0.65 ± 0.027	3.945ValAsp: 3.945 ± 0.06	4.071ValGlu: 4.071 ± 0.065	2.368ValPhe: 2.368 ± 0.049	5.169ValGly: 5.169 ± 0.074	1.052ValHis: 1.052 ± 0.032	3.653ValIle: 3.653 ± 0.059	2.267ValLys: 2.267 ± 0.051	7.636ValLeu: 7.636 ± 0.092	1.531ValMet: 1.531 ± 0.039	2.18ValAsn: 2.18 ± 0.044	3.707ValPro: 3.707 ± 0.069	3.492ValGln: 3.492 ± 0.063	3.715ValArg: 3.715 ± 0.065	3.945ValSer: 3.945 ± 0.067	4.213ValThr: 4.213 ± 0.067	5.584ValVal: 5.584 ± 0.081	0.896ValTrp: 0.896 ± 0.03	1.767ValTyr: 1.767 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.206TrpAla: 1.206 ± 0.035	0.189TrpCys: 0.189 ± 0.012	0.9TrpAsp: 0.9 ± 0.03	0.904TrpGlu: 0.904 ± 0.03	0.638TrpPhe: 0.638 ± 0.027	1.393TrpGly: 1.393 ± 0.036	0.414TrpHis: 0.414 ± 0.02	0.859TrpIle: 0.859 ± 0.03	0.432TrpLys: 0.432 ± 0.02	2.152TrpLeu: 2.152 ± 0.053	0.316TrpMet: 0.316 ± 0.016	0.467TrpAsn: 0.467 ± 0.025	0.6TrpPro: 0.6 ± 0.025	1.322TrpGln: 1.322 ± 0.041	0.97TrpArg: 0.97 ± 0.03	0.864TrpSer: 0.864 ± 0.032	0.682TrpThr: 0.682 ± 0.026	1.24TrpVal: 1.24 ± 0.036	0.264TrpTrp: 0.264 ± 0.017	0.414TrpTyr: 0.414 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.927TyrAla: 1.927 ± 0.039	0.38TyrCys: 0.38 ± 0.019	1.644TyrAsp: 1.644 ± 0.05	1.387TyrGlu: 1.387 ± 0.043	1.086TyrPhe: 1.086 ± 0.035	2.733TyrGly: 2.733 ± 0.059	0.752TyrHis: 0.752 ± 0.024	1.135TyrIle: 1.135 ± 0.038	0.714TyrLys: 0.714 ± 0.028	3.139TyrLeu: 3.139 ± 0.055	0.345TyrMet: 0.345 ± 0.017	0.907TyrAsn: 0.907 ± 0.028	1.52TyrPro: 1.52 ± 0.036	1.787TyrGln: 1.787 ± 0.042	2.055TyrArg: 2.055 ± 0.046	1.576TyrSer: 1.576 ± 0.038	1.335TyrThr: 1.335 ± 0.034	1.557TyrVal: 1.557 ± 0.043	0.51TyrTrp: 0.51 ± 0.022	0.861TyrTyr: 0.861 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3617 proteins (1111657 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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