Amino acid dipepetide frequency for Thalassobius mediterraneus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.388AlaAla: 16.388 ± 0.191	1.074AlaCys: 1.074 ± 0.039	7.451AlaAsp: 7.451 ± 0.089	8.353AlaGlu: 8.353 ± 0.113	3.989AlaPhe: 3.989 ± 0.069	9.964AlaGly: 9.964 ± 0.112	2.314AlaHis: 2.314 ± 0.05	5.651AlaIle: 5.651 ± 0.079	4.312AlaLys: 4.312 ± 0.078	13.644AlaLeu: 13.644 ± 0.158	3.789AlaMet: 3.789 ± 0.069	2.881AlaAsn: 2.881 ± 0.069	5.635AlaPro: 5.635 ± 0.088	4.894AlaGln: 4.894 ± 0.073	7.637AlaArg: 7.637 ± 0.089	5.436AlaSer: 5.436 ± 0.073	6.031AlaThr: 6.031 ± 0.088	8.181AlaVal: 8.181 ± 0.108	1.254AlaTrp: 1.254 ± 0.039	2.582AlaTyr: 2.582 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.072CysAla: 1.072 ± 0.034	0.113CysCys: 0.113 ± 0.011	0.67CysAsp: 0.67 ± 0.026	0.463CysGlu: 0.463 ± 0.02	0.374CysPhe: 0.374 ± 0.018	0.96CysGly: 0.96 ± 0.037	0.273CysHis: 0.273 ± 0.016	0.389CysIle: 0.389 ± 0.02	0.269CysLys: 0.269 ± 0.016	0.857CysLeu: 0.857 ± 0.026	0.18CysMet: 0.18 ± 0.013	0.231CysAsn: 0.231 ± 0.015	0.51CysPro: 0.51 ± 0.025	0.302CysGln: 0.302 ± 0.019	0.529CysArg: 0.529 ± 0.022	0.502CysSer: 0.502 ± 0.024	0.439CysThr: 0.439 ± 0.021	0.631CysVal: 0.631 ± 0.026	0.11CysTrp: 0.11 ± 0.01	0.247CysTyr: 0.247 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.195AspAla: 7.195 ± 0.095	0.544AspCys: 0.544 ± 0.027	3.442AspAsp: 3.442 ± 0.078	3.578AspGlu: 3.578 ± 0.064	2.276AspPhe: 2.276 ± 0.05	5.484AspGly: 5.484 ± 0.097	1.65AspHis: 1.65 ± 0.053	3.146AspIle: 3.146 ± 0.057	1.83AspLys: 1.83 ± 0.046	7.005AspLeu: 7.005 ± 0.098	1.912AspMet: 1.912 ± 0.046	1.452AspAsn: 1.452 ± 0.038	3.322AspPro: 3.322 ± 0.05	2.603AspGln: 2.603 ± 0.049	4.053AspArg: 4.053 ± 0.067	2.373AspSer: 2.373 ± 0.057	3.157AspThr: 3.157 ± 0.078	4.526AspVal: 4.526 ± 0.077	1.12AspTrp: 1.12 ± 0.036	1.599AspTyr: 1.599 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	8.215GluAla: 8.215 ± 0.107	0.398GluCys: 0.398 ± 0.019	3.517GluAsp: 3.517 ± 0.073	3.922GluGlu: 3.922 ± 0.087	1.813GluPhe: 1.813 ± 0.045	4.829GluGly: 4.829 ± 0.07	1.106GluHis: 1.106 ± 0.038	3.355GluIle: 3.355 ± 0.066	2.25GluLys: 2.25 ± 0.05	5.269GluLeu: 5.269 ± 0.101	1.894GluMet: 1.894 ± 0.047	1.88GluAsn: 1.88 ± 0.045	2.182GluPro: 2.182 ± 0.048	2.262GluGln: 2.262 ± 0.051	4.01GluArg: 4.01 ± 0.075	1.869GluSer: 1.869 ± 0.044	3.454GluThr: 3.454 ± 0.061	4.981GluVal: 4.981 ± 0.074	0.656GluTrp: 0.656 ± 0.025	1.093GluTyr: 1.093 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.467PheAla: 4.467 ± 0.078	0.434PheCys: 0.434 ± 0.022	2.842PheAsp: 2.842 ± 0.061	2.176PheGlu: 2.176 ± 0.052	1.43PhePhe: 1.43 ± 0.042	3.697PheGly: 3.697 ± 0.075	0.731PheHis: 0.731 ± 0.026	1.674PheIle: 1.674 ± 0.046	1.012PheLys: 1.012 ± 0.033	3.419PheLeu: 3.419 ± 0.067	0.889PheMet: 0.889 ± 0.032	1.094PheAsn: 1.094 ± 0.037	1.459PhePro: 1.459 ± 0.034	1.109PheGln: 1.109 ± 0.033	1.919PheArg: 1.919 ± 0.039	2.006PheSer: 2.006 ± 0.043	2.104PheThr: 2.104 ± 0.048	2.594PheVal: 2.594 ± 0.057	0.561PheTrp: 0.561 ± 0.025	0.958PheTyr: 0.958 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.602GlyAla: 9.602 ± 0.128	0.868GlyCys: 0.868 ± 0.031	4.969GlyAsp: 4.969 ± 0.098	4.654GlyGlu: 4.654 ± 0.074	3.535GlyPhe: 3.535 ± 0.069	7.07GlyGly: 7.07 ± 0.159	1.922GlyHis: 1.922 ± 0.041	4.279GlyIle: 4.279 ± 0.072	3.364GlyLys: 3.364 ± 0.069	8.69GlyLeu: 8.69 ± 0.106	2.663GlyMet: 2.663 ± 0.056	2.291GlyAsn: 2.291 ± 0.078	3.183GlyPro: 3.183 ± 0.053	3.399GlyGln: 3.399 ± 0.059	5.236GlyArg: 5.236 ± 0.085	4.031GlySer: 4.031 ± 0.067	4.361GlyThr: 4.361 ± 0.076	6.452GlyVal: 6.452 ± 0.082	1.417GlyTrp: 1.417 ± 0.038	2.422GlyTyr: 2.422 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.247HisAla: 2.247 ± 0.05	0.238HisCys: 0.238 ± 0.016	1.296HisAsp: 1.296 ± 0.041	1.055HisGlu: 1.055 ± 0.029	0.84HisPhe: 0.84 ± 0.03	1.879HisGly: 1.879 ± 0.042	0.631HisHis: 0.631 ± 0.031	1.053HisIle: 1.053 ± 0.037	0.637HisLys: 0.637 ± 0.021	2.171HisLeu: 2.171 ± 0.051	0.614HisMet: 0.614 ± 0.023	0.572HisAsn: 0.572 ± 0.024	1.389HisPro: 1.389 ± 0.037	0.726HisGln: 0.726 ± 0.028	1.303HisArg: 1.303 ± 0.038	1.046HisSer: 1.046 ± 0.033	0.922HisThr: 0.922 ± 0.028	1.548HisVal: 1.548 ± 0.039	0.371HisTrp: 0.371 ± 0.019	0.616HisTyr: 0.616 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.831IleAla: 6.831 ± 0.098	0.631IleCys: 0.631 ± 0.028	3.37IleAsp: 3.37 ± 0.063	3.449IleGlu: 3.449 ± 0.063	1.693IlePhe: 1.693 ± 0.045	4.672IleGly: 4.672 ± 0.069	0.942IleHis: 0.942 ± 0.034	2.304IleIle: 2.304 ± 0.058	1.681IleLys: 1.681 ± 0.045	4.69IleLeu: 4.69 ± 0.08	1.152IleMet: 1.152 ± 0.038	1.526IleAsn: 1.526 ± 0.043	2.189IlePro: 2.189 ± 0.049	1.286IleGln: 1.286 ± 0.037	2.999IleArg: 2.999 ± 0.054	3.002IleSer: 3.002 ± 0.054	3.066IleThr: 3.066 ± 0.047	3.516IleVal: 3.516 ± 0.076	0.734IleTrp: 0.734 ± 0.026	1.26IleTyr: 1.26 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.118LysAla: 4.118 ± 0.081	0.195LysCys: 0.195 ± 0.015	1.998LysAsp: 1.998 ± 0.047	1.869LysGlu: 1.869 ± 0.047	1.01LysPhe: 1.01 ± 0.035	3.08LysGly: 3.08 ± 0.069	0.697LysHis: 0.697 ± 0.028	1.759LysIle: 1.759 ± 0.045	1.4LysLys: 1.4 ± 0.047	3.311LysLeu: 3.311 ± 0.065	1.023LysMet: 1.023 ± 0.039	0.911LysAsn: 0.911 ± 0.028	1.918LysPro: 1.918 ± 0.053	1.205LysGln: 1.205 ± 0.037	2.49LysArg: 2.49 ± 0.051	1.867LysSer: 1.867 ± 0.045	2.107LysThr: 2.107 ± 0.048	2.612LysVal: 2.612 ± 0.056	0.431LysTrp: 0.431 ± 0.022	0.704LysTyr: 0.704 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.348LeuAla: 12.348 ± 0.154	0.989LeuCys: 0.989 ± 0.032	6.069LeuAsp: 6.069 ± 0.083	5.326LeuGlu: 5.326 ± 0.082	3.633LeuPhe: 3.633 ± 0.069	8.412LeuGly: 8.412 ± 0.105	2.036LeuHis: 2.036 ± 0.047	5.409LeuIle: 5.409 ± 0.09	3.539LeuLys: 3.539 ± 0.062	8.94LeuLeu: 8.94 ± 0.12	2.85LeuMet: 2.85 ± 0.059	3.14LeuAsn: 3.14 ± 0.057	5.599LeuPro: 5.599 ± 0.079	3.277LeuGln: 3.277 ± 0.055	6.869LeuArg: 6.869 ± 0.092	6.942LeuSer: 6.942 ± 0.1	6.157LeuThr: 6.157 ± 0.087	6.454LeuVal: 6.454 ± 0.091	1.253LeuTrp: 1.253 ± 0.042	1.928LeuTyr: 1.928 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.508MetAla: 3.508 ± 0.061	0.227MetCys: 0.227 ± 0.015	1.543MetAsp: 1.543 ± 0.043	1.429MetGlu: 1.429 ± 0.036	0.918MetPhe: 0.918 ± 0.029	2.413MetGly: 2.413 ± 0.054	0.488MetHis: 0.488 ± 0.023	1.613MetIle: 1.613 ± 0.041	1.157MetLys: 1.157 ± 0.036	2.766MetLeu: 2.766 ± 0.052	0.876MetMet: 0.876 ± 0.029	0.867MetAsn: 0.867 ± 0.03	1.559MetPro: 1.559 ± 0.04	1.263MetGln: 1.263 ± 0.039	1.933MetArg: 1.933 ± 0.044	1.851MetSer: 1.851 ± 0.044	2.184MetThr: 2.184 ± 0.046	2.007MetVal: 2.007 ± 0.051	0.259MetTrp: 0.259 ± 0.017	0.369MetTyr: 0.369 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.454AsnAla: 3.454 ± 0.055	0.282AsnCys: 0.282 ± 0.019	1.705AsnAsp: 1.705 ± 0.057	1.299AsnGlu: 1.299 ± 0.036	0.97AsnPhe: 0.97 ± 0.033	2.639AsnGly: 2.639 ± 0.062	0.555AsnHis: 0.555 ± 0.026	1.455AsnIle: 1.455 ± 0.043	0.804AsnLys: 0.804 ± 0.03	2.69AsnLeu: 2.69 ± 0.059	0.784AsnMet: 0.784 ± 0.027	0.781AsnAsn: 0.781 ± 0.032	1.861AsnPro: 1.861 ± 0.046	0.869AsnGln: 0.869 ± 0.024	1.806AsnArg: 1.806 ± 0.046	1.275AsnSer: 1.275 ± 0.037	1.497AsnThr: 1.497 ± 0.044	1.977AsnVal: 1.977 ± 0.042	0.477AsnTrp: 0.477 ± 0.022	0.701AsnTyr: 0.701 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.374ProAla: 5.374 ± 0.08	0.361ProCys: 0.361 ± 0.017	3.665ProAsp: 3.665 ± 0.062	3.898ProGlu: 3.898 ± 0.055	1.875ProPhe: 1.875 ± 0.044	3.464ProGly: 3.464 ± 0.067	1.091ProHis: 1.091 ± 0.033	2.178ProIle: 2.178 ± 0.051	1.877ProLys: 1.877 ± 0.051	4.735ProLeu: 4.735 ± 0.072	1.328ProMet: 1.328 ± 0.038	1.424ProAsn: 1.424 ± 0.039	1.788ProPro: 1.788 ± 0.047	1.929ProGln: 1.929 ± 0.047	2.499ProArg: 2.499 ± 0.055	2.411ProSer: 2.411 ± 0.051	2.498ProThr: 2.498 ± 0.051	3.911ProVal: 3.911 ± 0.064	0.587ProTrp: 0.587 ± 0.023	1.159ProTyr: 1.159 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.494GlnAla: 4.494 ± 0.061	0.24GlnCys: 0.24 ± 0.015	2.033GlnAsp: 2.033 ± 0.044	1.797GlnGlu: 1.797 ± 0.043	1.299GlnPhe: 1.299 ± 0.041	2.884GlnGly: 2.884 ± 0.058	0.771GlnHis: 0.771 ± 0.026	2.408GlnIle: 2.408 ± 0.046	1.296GlnLys: 1.296 ± 0.039	3.462GlnLeu: 3.462 ± 0.07	1.382GlnMet: 1.382 ± 0.043	1.137GlnAsn: 1.137 ± 0.031	1.783GlnPro: 1.783 ± 0.047	1.475GlnGln: 1.475 ± 0.049	2.439GlnArg: 2.439 ± 0.055	1.985GlnSer: 1.985 ± 0.042	2.064GlnThr: 2.064 ± 0.046	2.756GlnVal: 2.756 ± 0.054	0.456GlnTrp: 0.456 ± 0.022	0.627GlnTyr: 0.627 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.387ArgAla: 7.387 ± 0.104	0.489ArgCys: 0.489 ± 0.023	4.334ArgAsp: 4.334 ± 0.068	3.422ArgGlu: 3.422 ± 0.07	2.592ArgPhe: 2.592 ± 0.052	4.319ArgGly: 4.319 ± 0.067	1.462ArgHis: 1.462 ± 0.044	3.359ArgIle: 3.359 ± 0.06	2.335ArgLys: 2.335 ± 0.051	6.814ArgLeu: 6.814 ± 0.109	1.924ArgMet: 1.924 ± 0.045	1.775ArgAsn: 1.775 ± 0.047	2.97ArgPro: 2.97 ± 0.063	2.553ArgGln: 2.553 ± 0.056	4.409ArgArg: 4.409 ± 0.087	3.155ArgSer: 3.155 ± 0.056	2.752ArgThr: 2.752 ± 0.056	4.338ArgVal: 4.338 ± 0.07	0.86ArgTrp: 0.86 ± 0.034	1.533ArgTyr: 1.533 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.977SerAla: 5.977 ± 0.09	0.475SerCys: 0.475 ± 0.022	3.405SerAsp: 3.405 ± 0.061	2.789SerGlu: 2.789 ± 0.053	2.217SerPhe: 2.217 ± 0.046	5.109SerGly: 5.109 ± 0.073	1.104SerHis: 1.104 ± 0.034	2.523SerIle: 2.523 ± 0.052	1.639SerLys: 1.639 ± 0.042	5.031SerLeu: 5.031 ± 0.081	1.427SerMet: 1.427 ± 0.038	1.428SerAsn: 1.428 ± 0.037	2.324SerPro: 2.324 ± 0.045	1.796SerGln: 1.796 ± 0.041	3.072SerArg: 3.072 ± 0.059	2.502SerSer: 2.502 ± 0.055	2.545SerThr: 2.545 ± 0.053	3.729SerVal: 3.729 ± 0.07	0.68SerTrp: 0.68 ± 0.025	1.351SerTyr: 1.351 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.313ThrAla: 6.313 ± 0.083	0.518ThrCys: 0.518 ± 0.023	3.162ThrAsp: 3.162 ± 0.056	2.76ThrGlu: 2.76 ± 0.053	1.949ThrPhe: 1.949 ± 0.051	5.063ThrGly: 5.063 ± 0.073	1.178ThrHis: 1.178 ± 0.037	2.605ThrIle: 2.605 ± 0.055	1.724ThrLys: 1.724 ± 0.045	6.252ThrLeu: 6.252 ± 0.094	1.288ThrMet: 1.288 ± 0.036	1.423ThrAsn: 1.423 ± 0.035	3.355ThrPro: 3.355 ± 0.056	1.913ThrGln: 1.913 ± 0.048	3.168ThrArg: 3.168 ± 0.059	2.794ThrSer: 2.794 ± 0.052	2.921ThrThr: 2.921 ± 0.064	4.28ThrVal: 4.28 ± 0.07	0.626ThrTrp: 0.626 ± 0.026	1.292ThrTyr: 1.292 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.655ValAla: 8.655 ± 0.101	0.659ValCys: 0.659 ± 0.027	4.363ValAsp: 4.363 ± 0.075	4.826ValGlu: 4.826 ± 0.072	2.756ValPhe: 2.756 ± 0.058	5.234ValGly: 5.234 ± 0.094	1.296ValHis: 1.296 ± 0.037	4.2ValIle: 4.2 ± 0.072	2.491ValLys: 2.491 ± 0.055	7.542ValLeu: 7.542 ± 0.106	2.31ValMet: 2.31 ± 0.059	2.039ValAsn: 2.039 ± 0.043	3.322ValPro: 3.322 ± 0.061	2.425ValGln: 2.425 ± 0.061	3.887ValArg: 3.887 ± 0.071	4.168ValSer: 4.168 ± 0.07	4.517ValThr: 4.517 ± 0.075	5.704ValVal: 5.704 ± 0.098	0.874ValTrp: 0.874 ± 0.031	1.43ValTyr: 1.43 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.37TrpAla: 1.37 ± 0.038	0.118TrpCys: 0.118 ± 0.01	0.761TrpAsp: 0.761 ± 0.031	0.599TrpGlu: 0.599 ± 0.024	0.524TrpPhe: 0.524 ± 0.024	1.019TrpGly: 1.019 ± 0.038	0.337TrpHis: 0.337 ± 0.019	0.677TrpIle: 0.677 ± 0.028	0.431TrpLys: 0.431 ± 0.023	1.553TrpLeu: 1.553 ± 0.041	0.431TrpMet: 0.431 ± 0.023	0.407TrpAsn: 0.407 ± 0.02	0.655TrpPro: 0.655 ± 0.026	0.678TrpGln: 0.678 ± 0.025	1.001TrpArg: 1.001 ± 0.033	0.702TrpSer: 0.702 ± 0.027	0.654TrpThr: 0.654 ± 0.026	0.908TrpVal: 0.908 ± 0.029	0.203TrpTrp: 0.203 ± 0.013	0.266TrpTyr: 0.266 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.445TyrAla: 2.445 ± 0.049	0.267TyrCys: 0.267 ± 0.016	1.67TyrAsp: 1.67 ± 0.042	1.292TyrGlu: 1.292 ± 0.04	0.883TyrPhe: 0.883 ± 0.033	2.216TyrGly: 2.216 ± 0.052	0.57TyrHis: 0.57 ± 0.022	0.956TyrIle: 0.956 ± 0.029	0.658TyrLys: 0.658 ± 0.027	2.33TyrLeu: 2.33 ± 0.047	0.513TyrMet: 0.513 ± 0.024	0.623TyrAsn: 0.623 ± 0.026	1.051TyrPro: 1.051 ± 0.034	0.821TyrGln: 0.821 ± 0.032	1.523TyrArg: 1.523 ± 0.044	1.206TyrSer: 1.206 ± 0.039	1.153TyrThr: 1.153 ± 0.032	1.593TyrVal: 1.593 ± 0.043	0.366TyrTrp: 0.366 ± 0.019	0.615TyrTyr: 0.615 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3260 proteins (1013264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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