Amino acid dipepetide frequency for Nocardiopsis sp. L17-MgMaSL7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.653AlaAla: 16.653 ± 0.115
0.926AlaCys: 0.926 ± 0.023
7.829AlaAsp: 7.829 ± 0.073
8.961AlaGlu: 8.961 ± 0.089
3.381AlaPhe: 3.381 ± 0.045
10.658AlaGly: 10.658 ± 0.087
2.793AlaHis: 2.793 ± 0.042
3.551AlaIle: 3.551 ± 0.046
1.952AlaLys: 1.952 ± 0.038
14.026AlaLeu: 14.026 ± 0.118
2.479AlaMet: 2.479 ± 0.043
1.921AlaAsn: 1.921 ± 0.038
6.785AlaPro: 6.785 ± 0.081
3.285AlaGln: 3.285 ± 0.047
9.818AlaArg: 9.818 ± 0.09
6.131AlaSer: 6.131 ± 0.063
6.308AlaThr: 6.308 ± 0.065
11.241AlaVal: 11.241 ± 0.093
1.726AlaTrp: 1.726 ± 0.034
2.262AlaTyr: 2.262 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.901CysAla: 0.901 ± 0.025
0.089CysCys: 0.089 ± 0.01
0.444CysAsp: 0.444 ± 0.017
0.393CysGlu: 0.393 ± 0.016
0.205CysPhe: 0.205 ± 0.01
0.842CysGly: 0.842 ± 0.023
0.179CysHis: 0.179 ± 0.011
0.098CysIle: 0.098 ± 0.008
0.07CysLys: 0.07 ± 0.006
0.686CysLeu: 0.686 ± 0.019
0.123CysMet: 0.123 ± 0.008
0.098CysAsn: 0.098 ± 0.006
0.446CysPro: 0.446 ± 0.018
0.176CysGln: 0.176 ± 0.01
0.467CysArg: 0.467 ± 0.016
0.417CysSer: 0.417 ± 0.015
0.4CysThr: 0.4 ± 0.018
0.696CysVal: 0.696 ± 0.021
0.083CysTrp: 0.083 ± 0.006
0.134CysTyr: 0.134 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
6.857AspAla: 6.857 ± 0.061
0.34AspCys: 0.34 ± 0.016
3.958AspAsp: 3.958 ± 0.067
4.264AspGlu: 4.264 ± 0.056
1.665AspPhe: 1.665 ± 0.033
6.083AspGly: 6.083 ± 0.076
1.741AspHis: 1.741 ± 0.036
1.774AspIle: 1.774 ± 0.038
0.833AspLys: 0.833 ± 0.027
7.195AspLeu: 7.195 ± 0.077
0.958AspMet: 0.958 ± 0.023
1.025AspAsn: 1.025 ± 0.028
5.084AspPro: 5.084 ± 0.064
1.874AspGln: 1.874 ± 0.033
5.292AspArg: 5.292 ± 0.056
2.962AspSer: 2.962 ± 0.048
3.633AspThr: 3.633 ± 0.045
4.929AspVal: 4.929 ± 0.055
0.905AspTrp: 0.905 ± 0.026
1.222AspTyr: 1.222 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
7.992GluAla: 7.992 ± 0.072
0.361GluCys: 0.361 ± 0.015
3.717GluAsp: 3.717 ± 0.051
5.073GluGlu: 5.073 ± 0.064
1.751GluPhe: 1.751 ± 0.034
5.773GluGly: 5.773 ± 0.071
1.926GluHis: 1.926 ± 0.037
2.47GluIle: 2.47 ± 0.041
1.149GluLys: 1.149 ± 0.03
7.043GluLeu: 7.043 ± 0.07
1.067GluMet: 1.067 ± 0.026
1.323GluAsn: 1.323 ± 0.027
3.899GluPro: 3.899 ± 0.058
2.239GluGln: 2.239 ± 0.033
6.598GluArg: 6.598 ± 0.077
3.109GluSer: 3.109 ± 0.052
3.186GluThr: 3.186 ± 0.038
5.352GluVal: 5.352 ± 0.06
0.919GluTrp: 0.919 ± 0.022
1.23GluTyr: 1.23 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.522PheAla: 3.522 ± 0.046
0.233PheCys: 0.233 ± 0.011
2.113PheAsp: 2.113 ± 0.036
1.649PheGlu: 1.649 ± 0.032
0.896PhePhe: 0.896 ± 0.023
3.18PheGly: 3.18 ± 0.041
0.652PheHis: 0.652 ± 0.02
0.685PheIle: 0.685 ± 0.021
0.349PheLys: 0.349 ± 0.013
2.783PheLeu: 2.783 ± 0.047
0.464PheMet: 0.464 ± 0.016
0.582PheAsn: 0.582 ± 0.018
1.467PhePro: 1.467 ± 0.031
0.691PheGln: 0.691 ± 0.02
1.708PheArg: 1.708 ± 0.036
1.642PheSer: 1.642 ± 0.031
1.971PheThr: 1.971 ± 0.033
2.56PheVal: 2.56 ± 0.044
0.437PheTrp: 0.437 ± 0.017
0.551PheTyr: 0.551 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
10.942GlyAla: 10.942 ± 0.084
0.716GlyCys: 0.716 ± 0.021
5.567GlyAsp: 5.567 ± 0.064
5.879GlyGlu: 5.879 ± 0.071
2.995GlyPhe: 2.995 ± 0.042
8.941GlyGly: 8.941 ± 0.111
2.276GlyHis: 2.276 ± 0.039
3.165GlyIle: 3.165 ± 0.043
1.629GlyLys: 1.629 ± 0.034
9.458GlyLeu: 9.458 ± 0.093
2.122GlyMet: 2.122 ± 0.038
1.762GlyAsn: 1.762 ± 0.036
5.353GlyPro: 5.353 ± 0.068
2.694GlyGln: 2.694 ± 0.049
7.422GlyArg: 7.422 ± 0.068
5.489GlySer: 5.489 ± 0.064
5.971GlyThr: 5.971 ± 0.064
8.446GlyVal: 8.446 ± 0.081
1.578GlyTrp: 1.578 ± 0.033
2.215GlyTyr: 2.215 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.516HisAla: 2.516 ± 0.043
0.193HisCys: 0.193 ± 0.011
1.408HisAsp: 1.408 ± 0.03
1.375HisGlu: 1.375 ± 0.028
0.609HisPhe: 0.609 ± 0.018
2.455HisGly: 2.455 ± 0.04
0.739HisHis: 0.739 ± 0.024
0.611HisIle: 0.611 ± 0.018
0.296HisLys: 0.296 ± 0.014
2.557HisLeu: 2.557 ± 0.039
0.394HisMet: 0.394 ± 0.016
0.413HisAsn: 0.413 ± 0.017
1.809HisPro: 1.809 ± 0.037
0.688HisGln: 0.688 ± 0.021
2.142HisArg: 2.142 ± 0.038
1.102HisSer: 1.102 ± 0.025
1.428HisThr: 1.428 ± 0.033
1.864HisVal: 1.864 ± 0.033
0.362HisTrp: 0.362 ± 0.015
0.459HisTyr: 0.459 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
4.535IleAla: 4.535 ± 0.057
0.246IleCys: 0.246 ± 0.011
2.313IleAsp: 2.313 ± 0.039
2.008IleGlu: 2.008 ± 0.039
0.668IlePhe: 0.668 ± 0.02
3.433IleGly: 3.433 ± 0.054
0.605IleHis: 0.605 ± 0.019
1.069IleIle: 1.069 ± 0.027
0.502IleLys: 0.502 ± 0.019
2.638IleLeu: 2.638 ± 0.048
0.544IleMet: 0.544 ± 0.019
0.731IleAsn: 0.731 ± 0.019
1.731IlePro: 1.731 ± 0.029
0.711IleGln: 0.711 ± 0.021
2.159IleArg: 2.159 ± 0.036
1.735IleSer: 1.735 ± 0.034
2.145IleThr: 2.145 ± 0.036
2.836IleVal: 2.836 ± 0.05
0.289IleTrp: 0.289 ± 0.013
0.449IleTyr: 0.449 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
1.862LysAla: 1.862 ± 0.038
0.071LysCys: 0.071 ± 0.006
0.93LysAsp: 0.93 ± 0.025
1.067LysGlu: 1.067 ± 0.03
0.339LysPhe: 0.339 ± 0.015
1.391LysGly: 1.391 ± 0.03
0.351LysHis: 0.351 ± 0.014
0.57LysIle: 0.57 ± 0.018
0.531LysLys: 0.531 ± 0.03
1.407LysLeu: 1.407 ± 0.032
0.31LysMet: 0.31 ± 0.015
0.359LysAsn: 0.359 ± 0.016
0.935LysPro: 0.935 ± 0.031
0.451LysGln: 0.451 ± 0.019
1.26LysArg: 1.26 ± 0.033
0.839LysSer: 0.839 ± 0.023
0.79LysThr: 0.79 ± 0.022
1.433LysVal: 1.433 ± 0.033
0.195LysTrp: 0.195 ± 0.01
0.303LysTyr: 0.303 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
13.924LeuAla: 13.924 ± 0.111
0.76LeuCys: 0.76 ± 0.021
6.795LeuAsp: 6.795 ± 0.061
5.533LeuGlu: 5.533 ± 0.053
2.933LeuPhe: 2.933 ± 0.054
9.495LeuGly: 9.495 ± 0.093
2.14LeuHis: 2.14 ± 0.038
3.194LeuIle: 3.194 ± 0.054
1.349LeuLys: 1.349 ± 0.036
11.315LeuLeu: 11.315 ± 0.13
1.834LeuMet: 1.834 ± 0.038
1.81LeuAsn: 1.81 ± 0.035
6.347LeuPro: 6.347 ± 0.071
1.878LeuGln: 1.878 ± 0.039
8.747LeuArg: 8.747 ± 0.087
6.18LeuSer: 6.18 ± 0.063
6.722LeuThr: 6.722 ± 0.063
10.013LeuVal: 10.013 ± 0.098
1.419LeuTrp: 1.419 ± 0.028
1.737LeuTyr: 1.737 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.329MetAla: 2.329 ± 0.043
0.141MetCys: 0.141 ± 0.008
1.03MetAsp: 1.03 ± 0.025
0.946MetGlu: 0.946 ± 0.023
0.525MetPhe: 0.525 ± 0.018
1.576MetGly: 1.576 ± 0.028
0.328MetHis: 0.328 ± 0.014
0.717MetIle: 0.717 ± 0.022
0.301MetLys: 0.301 ± 0.014
1.777MetLeu: 1.777 ± 0.035
0.316MetMet: 0.316 ± 0.015
0.482MetAsn: 0.482 ± 0.016
1.113MetPro: 1.113 ± 0.029
0.374MetGln: 0.374 ± 0.015
1.58MetArg: 1.58 ± 0.029
1.511MetSer: 1.511 ± 0.03
1.484MetThr: 1.484 ± 0.03
1.722MetVal: 1.722 ± 0.037
0.23MetTrp: 0.23 ± 0.012
0.317MetTyr: 0.317 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.179AsnAla: 2.179 ± 0.04
0.149AsnCys: 0.149 ± 0.01
1.058AsnAsp: 1.058 ± 0.027
1.059AsnGlu: 1.059 ± 0.024
0.472AsnPhe: 0.472 ± 0.018
1.873AsnGly: 1.873 ± 0.041
0.425AsnHis: 0.425 ± 0.017
0.653AsnIle: 0.653 ± 0.021
0.321AsnLys: 0.321 ± 0.013
1.795AsnLeu: 1.795 ± 0.033
0.344AsnMet: 0.344 ± 0.015
0.465AsnAsn: 0.465 ± 0.02
1.485AsnPro: 1.485 ± 0.032
0.578AsnGln: 0.578 ± 0.021
1.426AsnArg: 1.426 ± 0.031
1.004AsnSer: 1.004 ± 0.026
1.199AsnThr: 1.199 ± 0.027
1.462AsnVal: 1.462 ± 0.033
0.298AsnTrp: 0.298 ± 0.013
0.397AsnTyr: 0.397 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
6.93ProAla: 6.93 ± 0.071
0.292ProCys: 0.292 ± 0.015
4.688ProAsp: 4.688 ± 0.058
5.672ProGlu: 5.672 ± 0.07
1.573ProPhe: 1.573 ± 0.027
6.764ProGly: 6.764 ± 0.091
1.464ProHis: 1.464 ± 0.033
1.433ProIle: 1.433 ± 0.028
0.925ProLys: 0.925 ± 0.025
5.367ProLeu: 5.367 ± 0.062
1.073ProMet: 1.073 ± 0.024
1.073ProAsn: 1.073 ± 0.029
3.518ProPro: 3.518 ± 0.075
1.595ProGln: 1.595 ± 0.039
4.194ProArg: 4.194 ± 0.057
3.39ProSer: 3.39 ± 0.048
3.308ProThr: 3.308 ± 0.048
5.547ProVal: 5.547 ± 0.062
0.957ProTrp: 0.957 ± 0.024
1.114ProTyr: 1.114 ± 0.026
0.001ProXaa: 0.001 ± 0.001
Gln
3.229GlnAla: 3.229 ± 0.042
0.141GlnCys: 0.141 ± 0.01
1.311GlnAsp: 1.311 ± 0.031
1.731GlnGlu: 1.731 ± 0.033
0.612GlnPhe: 0.612 ± 0.019
2.456GlnGly: 2.456 ± 0.042
0.566GlnHis: 0.566 ± 0.017
1.092GlnIle: 1.092 ± 0.026
0.394GlnLys: 0.394 ± 0.017
2.578GlnLeu: 2.578 ± 0.04
0.523GlnMet: 0.523 ± 0.018
0.528GlnAsn: 0.528 ± 0.02
1.496GlnPro: 1.496 ± 0.039
0.968GlnGln: 0.968 ± 0.041
2.427GlnArg: 2.427 ± 0.044
1.273GlnSer: 1.273 ± 0.027
1.281GlnThr: 1.281 ± 0.032
2.424GlnVal: 2.424 ± 0.037
0.391GlnTrp: 0.391 ± 0.015
0.479GlnTyr: 0.479 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
9.598ArgAla: 9.598 ± 0.097
0.496ArgCys: 0.496 ± 0.018
4.763ArgAsp: 4.763 ± 0.063
5.438ArgGlu: 5.438 ± 0.056
2.431ArgPhe: 2.431 ± 0.039
6.301ArgGly: 6.301 ± 0.066
1.982ArgHis: 1.982 ± 0.036
2.971ArgIle: 2.971 ± 0.046
1.348ArgLys: 1.348 ± 0.033
8.378ArgLeu: 8.378 ± 0.085
1.898ArgMet: 1.898 ± 0.035
1.444ArgAsn: 1.444 ± 0.032
4.791ArgPro: 4.791 ± 0.057
2.098ArgGln: 2.098 ± 0.039
7.615ArgArg: 7.615 ± 0.091
4.649ArgSer: 4.649 ± 0.065
5.012ArgThr: 5.012 ± 0.061
7.321ArgVal: 7.321 ± 0.069
1.311ArgTrp: 1.311 ± 0.031
1.691ArgTyr: 1.691 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.753SerAla: 6.753 ± 0.06
0.385SerCys: 0.385 ± 0.016
3.241SerAsp: 3.241 ± 0.046
3.511SerGlu: 3.511 ± 0.049
1.638SerPhe: 1.638 ± 0.034
6.518SerGly: 6.518 ± 0.067
1.151SerHis: 1.151 ± 0.025
1.515SerIle: 1.515 ± 0.031
0.803SerLys: 0.803 ± 0.02
5.362SerLeu: 5.362 ± 0.062
1.142SerMet: 1.142 ± 0.024
0.898SerAsn: 0.898 ± 0.022
3.438SerPro: 3.438 ± 0.05
1.321SerGln: 1.321 ± 0.023
3.97SerArg: 3.97 ± 0.051
3.073SerSer: 3.073 ± 0.05
3.213SerThr: 3.213 ± 0.048
4.841SerVal: 4.841 ± 0.053
0.971SerTrp: 0.971 ± 0.029
1.133SerTyr: 1.133 ± 0.021
0.0SerXaa: 0.0 ± 0.0
Thr
7.38ThrAla: 7.38 ± 0.067
0.378ThrCys: 0.378 ± 0.015
3.793ThrAsp: 3.793 ± 0.046
3.896ThrGlu: 3.896 ± 0.053
1.56ThrPhe: 1.56 ± 0.028
6.389ThrGly: 6.389 ± 0.066
1.312ThrHis: 1.312 ± 0.033
1.682ThrIle: 1.682 ± 0.036
0.865ThrLys: 0.865 ± 0.025
5.816ThrLeu: 5.816 ± 0.059
0.998ThrMet: 0.998 ± 0.026
1.1ThrAsn: 1.1 ± 0.026
4.042ThrPro: 4.042 ± 0.054
1.352ThrGln: 1.352 ± 0.034
4.197ThrArg: 4.197 ± 0.044
3.2ThrSer: 3.2 ± 0.042
3.646ThrThr: 3.646 ± 0.054
5.962ThrVal: 5.962 ± 0.073
0.861ThrTrp: 0.861 ± 0.025
1.104ThrTyr: 1.104 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
10.818ValAla: 10.818 ± 0.092
0.741ValCys: 0.741 ± 0.024
5.601ValAsp: 5.601 ± 0.058
5.65ValGlu: 5.65 ± 0.075
2.726ValPhe: 2.726 ± 0.05
7.415ValGly: 7.415 ± 0.075
2.039ValHis: 2.039 ± 0.039
3.124ValIle: 3.124 ± 0.048
1.211ValLys: 1.211 ± 0.033
10.079ValLeu: 10.079 ± 0.09
1.594ValMet: 1.594 ± 0.03
1.88ValAsn: 1.88 ± 0.04
5.345ValPro: 5.345 ± 0.06
1.884ValGln: 1.884 ± 0.035
7.482ValArg: 7.482 ± 0.071
5.145ValSer: 5.145 ± 0.053
5.783ValThr: 5.783 ± 0.057
8.917ValVal: 8.917 ± 0.081
1.293ValTrp: 1.293 ± 0.028
1.619ValTyr: 1.619 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.546TrpAla: 1.546 ± 0.031
0.128TrpCys: 0.128 ± 0.008
0.833TrpAsp: 0.833 ± 0.024
0.887TrpGlu: 0.887 ± 0.021
0.526TrpPhe: 0.526 ± 0.017
1.127TrpGly: 1.127 ± 0.03
0.365TrpHis: 0.365 ± 0.016
0.581TrpIle: 0.581 ± 0.02
0.285TrpLys: 0.285 ± 0.013
1.647TrpLeu: 1.647 ± 0.031
0.335TrpMet: 0.335 ± 0.016
0.415TrpAsn: 0.415 ± 0.015
0.744TrpPro: 0.744 ± 0.025
0.461TrpGln: 0.461 ± 0.017
1.362TrpArg: 1.362 ± 0.031
0.995TrpSer: 0.995 ± 0.022
0.921TrpThr: 0.921 ± 0.027
1.108TrpVal: 1.108 ± 0.025
0.378TrpTrp: 0.378 ± 0.015
0.271TrpTyr: 0.271 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.22TyrAla: 2.22 ± 0.035
0.159TyrCys: 0.159 ± 0.01
1.204TyrAsp: 1.204 ± 0.029
1.187TyrGlu: 1.187 ± 0.031
0.63TyrPhe: 0.63 ± 0.019
1.95TyrGly: 1.95 ± 0.034
0.386TyrHis: 0.386 ± 0.014
0.389TyrIle: 0.389 ± 0.016
0.28TyrLys: 0.28 ± 0.011
2.218TyrLeu: 2.218 ± 0.039
0.279TyrMet: 0.279 ± 0.013
0.334TyrAsn: 0.334 ± 0.015
1.049TyrPro: 1.049 ± 0.026
0.584TyrGln: 0.584 ± 0.023
1.67TyrArg: 1.67 ± 0.034
1.032TyrSer: 1.032 ± 0.026
1.136TyrThr: 1.136 ± 0.028
1.671TyrVal: 1.671 ± 0.034
0.312TyrTrp: 0.312 ± 0.013
0.435TyrTyr: 0.435 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 5387 proteins (1783097 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski