Amino acid dipepetide frequency for Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.576AlaAla: 6.576 ± 0.032	1.352AlaCys: 1.352 ± 0.01	2.971AlaAsp: 2.971 ± 0.013	4.881AlaGlu: 4.881 ± 0.027	2.554AlaPhe: 2.554 ± 0.014	4.54AlaGly: 4.54 ± 0.021	1.569AlaHis: 1.569 ± 0.009	2.668AlaIle: 2.668 ± 0.012	3.519AlaLys: 3.519 ± 0.027	7.196AlaLeu: 7.196 ± 0.03	1.421AlaMet: 1.421 ± 0.01	1.996AlaAsn: 1.996 ± 0.012	4.222AlaPro: 4.222 ± 0.031	3.36AlaGln: 3.36 ± 0.019	3.688AlaArg: 3.688 ± 0.016	5.948AlaSer: 5.948 ± 0.025	3.495AlaThr: 3.495 ± 0.017	4.72AlaVal: 4.72 ± 0.02	0.797AlaTrp: 0.797 ± 0.007	1.502AlaTyr: 1.502 ± 0.011	0.014AlaXaa: 0.014 ± 0.001
Cys	1.195CysAla: 1.195 ± 0.01	0.568CysCys: 0.568 ± 0.006	0.993CysAsp: 0.993 ± 0.011	1.261CysGlu: 1.261 ± 0.011	0.794CysPhe: 0.794 ± 0.009	1.679CysGly: 1.679 ± 0.018	0.655CysHis: 0.655 ± 0.008	0.91CysIle: 0.91 ± 0.009	1.139CysLys: 1.139 ± 0.01	2.118CysLeu: 2.118 ± 0.012	0.394CysMet: 0.394 ± 0.005	0.789CysAsn: 0.789 ± 0.009	1.363CysPro: 1.363 ± 0.013	1.044CysGln: 1.044 ± 0.011	1.254CysArg: 1.254 ± 0.011	1.977CysSer: 1.977 ± 0.014	1.057CysThr: 1.057 ± 0.01	1.252CysVal: 1.252 ± 0.01	0.279CysTrp: 0.279 ± 0.004	0.55CysTyr: 0.55 ± 0.006	0.005CysXaa: 0.005 ± 0.0
Asp	2.932AspAla: 2.932 ± 0.016	1.035AspCys: 1.035 ± 0.01	2.681AspAsp: 2.681 ± 0.017	3.516AspGlu: 3.516 ± 0.018	2.104AspPhe: 2.104 ± 0.012	3.301AspGly: 3.301 ± 0.019	1.152AspHis: 1.152 ± 0.008	2.544AspIle: 2.544 ± 0.016	2.535AspLys: 2.535 ± 0.016	5.076AspLeu: 5.076 ± 0.018	1.115AspMet: 1.115 ± 0.009	1.614AspAsn: 1.614 ± 0.012	2.947AspPro: 2.947 ± 0.013	1.904AspGln: 1.904 ± 0.01	2.468AspArg: 2.468 ± 0.013	4.274AspSer: 4.274 ± 0.019	2.491AspThr: 2.491 ± 0.014	3.123AspVal: 3.123 ± 0.019	0.616AspTrp: 0.616 ± 0.006	1.489AspTyr: 1.489 ± 0.013	0.007AspXaa: 0.007 ± 0.001
Glu	5.351GluAla: 5.351 ± 0.024	1.467GluCys: 1.467 ± 0.018	4.526GluAsp: 4.526 ± 0.019	8.273GluGlu: 8.273 ± 0.042	2.031GluPhe: 2.031 ± 0.012	4.29GluGly: 4.29 ± 0.018	1.529GluHis: 1.529 ± 0.009	3.238GluIle: 3.238 ± 0.017	5.679GluLys: 5.679 ± 0.036	6.64GluLeu: 6.64 ± 0.031	1.717GluMet: 1.717 ± 0.012	3.211GluAsn: 3.211 ± 0.017	3.297GluPro: 3.297 ± 0.02	3.309GluGln: 3.309 ± 0.02	4.181GluArg: 4.181 ± 0.024	4.582GluSer: 4.582 ± 0.02	3.522GluThr: 3.522 ± 0.018	4.322GluVal: 4.322 ± 0.021	0.69GluTrp: 0.69 ± 0.007	1.556GluTyr: 1.556 ± 0.014	0.013GluXaa: 0.013 ± 0.001
Phe	1.917PheAla: 1.917 ± 0.013	0.879PheCys: 0.879 ± 0.008	1.623PheAsp: 1.623 ± 0.01	1.998PheGlu: 1.998 ± 0.013	1.491PhePhe: 1.491 ± 0.012	2.123PheGly: 2.123 ± 0.014	1.043PheHis: 1.043 ± 0.008	1.715PheIle: 1.715 ± 0.012	1.733PheLys: 1.733 ± 0.012	3.881PheLeu: 3.881 ± 0.019	0.739PheMet: 0.739 ± 0.007	1.288PheAsn: 1.288 ± 0.009	1.986PhePro: 1.986 ± 0.012	1.786PheGln: 1.786 ± 0.011	1.921PheArg: 1.921 ± 0.011	3.388PheSer: 3.388 ± 0.016	1.969PheThr: 1.969 ± 0.011	2.04PheVal: 2.04 ± 0.013	0.464PheTrp: 0.464 ± 0.005	1.106PheTyr: 1.106 ± 0.009	0.009PheXaa: 0.009 ± 0.001
Gly	4.404GlyAla: 4.404 ± 0.027	1.253GlyCys: 1.253 ± 0.01	3.134GlyAsp: 3.134 ± 0.017	4.254GlyGlu: 4.254 ± 0.026	2.337GlyPhe: 2.337 ± 0.015	4.773GlyGly: 4.773 ± 0.029	1.72GlyHis: 1.72 ± 0.013	2.647GlyIle: 2.647 ± 0.015	3.802GlyLys: 3.802 ± 0.021	5.76GlyLeu: 5.76 ± 0.025	1.26GlyMet: 1.26 ± 0.01	2.309GlyAsn: 2.309 ± 0.014	4.287GlyPro: 4.287 ± 0.041	2.81GlyGln: 2.81 ± 0.016	3.801GlyArg: 3.801 ± 0.017	5.815GlySer: 5.815 ± 0.026	3.568GlyThr: 3.568 ± 0.019	3.474GlyVal: 3.474 ± 0.019	0.788GlyTrp: 0.788 ± 0.008	1.678GlyTyr: 1.678 ± 0.012	0.016GlyXaa: 0.016 ± 0.001
His	1.355HisAla: 1.355 ± 0.009	0.691HisCys: 0.691 ± 0.007	0.902HisAsp: 0.902 ± 0.007	1.307HisGlu: 1.307 ± 0.009	1.039HisPhe: 1.039 ± 0.008	1.524HisGly: 1.524 ± 0.011	0.898HisHis: 0.898 ± 0.01	1.212HisIle: 1.212 ± 0.008	1.278HisLys: 1.278 ± 0.009	2.932HisLeu: 2.932 ± 0.015	0.568HisMet: 0.568 ± 0.006	0.831HisAsn: 0.831 ± 0.006	1.676HisPro: 1.676 ± 0.01	1.439HisGln: 1.439 ± 0.013	1.631HisArg: 1.631 ± 0.01	2.309HisSer: 2.309 ± 0.013	1.53HisThr: 1.53 ± 0.013	1.556HisVal: 1.556 ± 0.01	0.358HisTrp: 0.358 ± 0.005	0.786HisTyr: 0.786 ± 0.008	0.005HisXaa: 0.005 ± 0.0
Ile	2.5IleAla: 2.5 ± 0.011	1.002IleCys: 1.002 ± 0.008	1.985IleAsp: 1.985 ± 0.012	2.59IleGlu: 2.59 ± 0.017	1.789IlePhe: 1.789 ± 0.012	2.148IleGly: 2.148 ± 0.013	1.355IleHis: 1.355 ± 0.011	2.219IleIle: 2.219 ± 0.015	2.596IleLys: 2.596 ± 0.015	4.376IleLeu: 4.376 ± 0.02	0.954IleMet: 0.954 ± 0.006	1.777IleAsn: 1.777 ± 0.012	2.576IlePro: 2.576 ± 0.015	2.34IleGln: 2.34 ± 0.013	2.325IleArg: 2.325 ± 0.012	3.681IleSer: 3.681 ± 0.015	2.48IleThr: 2.48 ± 0.015	2.388IleVal: 2.388 ± 0.013	0.488IleTrp: 0.488 ± 0.006	1.308IleTyr: 1.308 ± 0.009	0.007IleXaa: 0.007 ± 0.001
Lys	4.086LysAla: 4.086 ± 0.023	1.132LysCys: 1.132 ± 0.011	3.21LysAsp: 3.21 ± 0.019	5.365LysGlu: 5.365 ± 0.033	1.701LysPhe: 1.701 ± 0.011	3.297LysGly: 3.297 ± 0.023	1.438LysHis: 1.438 ± 0.011	2.734LysIle: 2.734 ± 0.015	4.791LysLys: 4.791 ± 0.03	5.257LysLeu: 5.257 ± 0.027	1.428LysMet: 1.428 ± 0.012	2.404LysAsn: 2.404 ± 0.015	3.163LysPro: 3.163 ± 0.022	2.726LysGln: 2.726 ± 0.018	3.34LysArg: 3.34 ± 0.017	4.018LysSer: 4.018 ± 0.018	3.193LysThr: 3.193 ± 0.017	3.486LysVal: 3.486 ± 0.021	0.616LysTrp: 0.616 ± 0.007	1.545LysTyr: 1.545 ± 0.016	0.01LysXaa: 0.01 ± 0.001
Leu	6.784LeuAla: 6.784 ± 0.029	2.135LeuCys: 2.135 ± 0.013	4.785LeuAsp: 4.785 ± 0.019	7.466LeuGlu: 7.466 ± 0.038	3.219LeuPhe: 3.219 ± 0.019	5.826LeuGly: 5.826 ± 0.02	2.72LeuHis: 2.72 ± 0.016	3.792LeuIle: 3.792 ± 0.019	5.853LeuLys: 5.853 ± 0.025	10.533LeuLeu: 10.533 ± 0.047	1.975LeuMet: 1.975 ± 0.012	3.489LeuAsn: 3.489 ± 0.017	6.065LeuPro: 6.065 ± 0.027	5.993LeuGln: 5.993 ± 0.028	5.92LeuArg: 5.92 ± 0.022	8.042LeuSer: 8.042 ± 0.026	4.985LeuThr: 4.985 ± 0.017	5.378LeuVal: 5.378 ± 0.022	1.118LeuTrp: 1.118 ± 0.01	2.465LeuTyr: 2.465 ± 0.017	0.024LeuXaa: 0.024 ± 0.001
Met	1.819MetAla: 1.819 ± 0.01	0.372MetCys: 0.372 ± 0.004	1.216MetAsp: 1.216 ± 0.008	1.882MetGlu: 1.882 ± 0.012	0.699MetPhe: 0.699 ± 0.007	1.244MetGly: 1.244 ± 0.011	0.463MetHis: 0.463 ± 0.005	0.816MetIle: 0.816 ± 0.007	1.434MetLys: 1.434 ± 0.01	1.935MetLeu: 1.935 ± 0.013	0.551MetMet: 0.551 ± 0.006	0.88MetAsn: 0.88 ± 0.008	1.079MetPro: 1.079 ± 0.011	0.94MetGln: 0.94 ± 0.009	1.039MetArg: 1.039 ± 0.008	1.532MetSer: 1.532 ± 0.01	1.1MetThr: 1.1 ± 0.008	1.371MetVal: 1.371 ± 0.009	0.234MetTrp: 0.234 ± 0.004	0.544MetTyr: 0.544 ± 0.006	0.003MetXaa: 0.003 ± 0.0
Asn	2.027AsnAla: 2.027 ± 0.013	0.798AsnCys: 0.798 ± 0.008	1.521AsnAsp: 1.521 ± 0.011	2.245AsnGlu: 2.245 ± 0.013	1.404AsnPhe: 1.404 ± 0.01	2.368AsnGly: 2.368 ± 0.015	0.938AsnHis: 0.938 ± 0.008	2.029AsnIle: 2.029 ± 0.013	2.221AsnLys: 2.221 ± 0.014	3.677AsnLeu: 3.677 ± 0.018	0.885AsnMet: 0.885 ± 0.007	1.481AsnAsn: 1.481 ± 0.011	2.15AsnPro: 2.15 ± 0.012	1.705AsnGln: 1.705 ± 0.011	1.806AsnArg: 1.806 ± 0.01	3.156AsnSer: 3.156 ± 0.015	1.956AsnThr: 1.956 ± 0.011	2.177AsnVal: 2.177 ± 0.012	0.437AsnTrp: 0.437 ± 0.005	1.106AsnTyr: 1.106 ± 0.011	0.005AsnXaa: 0.005 ± 0.0
Pro	4.966ProAla: 4.966 ± 0.029	1.122ProCys: 1.122 ± 0.01	2.832ProAsp: 2.832 ± 0.017	4.593ProGlu: 4.593 ± 0.022	1.889ProPhe: 1.889 ± 0.012	5.278ProGly: 5.278 ± 0.052	1.422ProHis: 1.422 ± 0.011	1.824ProIle: 1.824 ± 0.012	2.821ProLys: 2.821 ± 0.019	5.283ProLeu: 5.283 ± 0.024	1.018ProMet: 1.018 ± 0.007	1.794ProAsn: 1.794 ± 0.013	6.079ProPro: 6.079 ± 0.05	2.9ProGln: 2.9 ± 0.019	3.448ProArg: 3.448 ± 0.021	5.922ProSer: 5.922 ± 0.031	3.104ProThr: 3.104 ± 0.016	3.918ProVal: 3.918 ± 0.02	0.691ProTrp: 0.691 ± 0.006	1.507ProTyr: 1.507 ± 0.015	0.018ProXaa: 0.018 ± 0.001
Gln	3.662GlnAla: 3.662 ± 0.018	0.929GlnCys: 0.929 ± 0.01	2.415GlnAsp: 2.415 ± 0.013	4.111GlnGlu: 4.111 ± 0.02	1.364GlnPhe: 1.364 ± 0.009	2.913GlnGly: 2.913 ± 0.017	1.329GlnHis: 1.329 ± 0.011	2.007GlnIle: 2.007 ± 0.011	3.097GlnLys: 3.097 ± 0.02	4.914GlnLeu: 4.914 ± 0.026	1.125GlnMet: 1.125 ± 0.009	1.892GlnAsn: 1.892 ± 0.011	2.86GlnPro: 2.86 ± 0.018	3.168GlnGln: 3.168 ± 0.03	3.113GlnArg: 3.113 ± 0.018	3.282GlnSer: 3.282 ± 0.02	2.387GlnThr: 2.387 ± 0.014	2.876GlnVal: 2.876 ± 0.012	0.556GlnTrp: 0.556 ± 0.005	1.154GlnTyr: 1.154 ± 0.009	0.009GlnXaa: 0.009 ± 0.001
Arg	3.907ArgAla: 3.907 ± 0.019	1.197ArgCys: 1.197 ± 0.013	2.755ArgAsp: 2.755 ± 0.014	4.178ArgGlu: 4.178 ± 0.019	1.799ArgPhe: 1.799 ± 0.012	3.67ArgGly: 3.67 ± 0.019	1.533ArgHis: 1.533 ± 0.01	2.402ArgIle: 2.402 ± 0.011	3.703ArgLys: 3.703 ± 0.016	5.459ArgLeu: 5.459 ± 0.02	1.189ArgMet: 1.189 ± 0.009	2.098ArgAsn: 2.098 ± 0.012	3.306ArgPro: 3.306 ± 0.021	2.744ArgGln: 2.744 ± 0.016	4.362ArgArg: 4.362 ± 0.023	4.432ArgSer: 4.432 ± 0.024	2.856ArgThr: 2.856 ± 0.015	3.198ArgVal: 3.198 ± 0.015	0.684ArgTrp: 0.684 ± 0.006	1.396ArgTyr: 1.396 ± 0.01	0.014ArgXaa: 0.014 ± 0.001
Ser	5.44SerAla: 5.44 ± 0.019	1.8SerCys: 1.8 ± 0.013	4.024SerAsp: 4.024 ± 0.022	5.459SerGlu: 5.459 ± 0.023	2.976SerPhe: 2.976 ± 0.014	5.682SerGly: 5.682 ± 0.027	2.133SerHis: 2.133 ± 0.014	3.157SerIle: 3.157 ± 0.014	4.223SerLys: 4.223 ± 0.019	8.365SerLeu: 8.365 ± 0.025	1.557SerMet: 1.557 ± 0.01	2.674SerAsn: 2.674 ± 0.015	6.222SerPro: 6.222 ± 0.033	4.1SerGln: 4.1 ± 0.02	4.681SerArg: 4.681 ± 0.022	9.722SerSer: 9.722 ± 0.047	4.523SerThr: 4.523 ± 0.02	4.953SerVal: 4.953 ± 0.017	1.053SerTrp: 1.053 ± 0.009	2.02SerTyr: 2.02 ± 0.012	0.016SerXaa: 0.016 ± 0.001
Thr	3.727ThrAla: 3.727 ± 0.016	1.257ThrCys: 1.257 ± 0.014	2.471ThrAsp: 2.471 ± 0.011	3.595ThrGlu: 3.595 ± 0.019	2.041ThrPhe: 2.041 ± 0.013	3.561ThrGly: 3.561 ± 0.021	1.3ThrHis: 1.3 ± 0.01	2.278ThrIle: 2.278 ± 0.014	2.665ThrLys: 2.665 ± 0.015	5.257ThrLeu: 5.257 ± 0.016	1.082ThrMet: 1.082 ± 0.008	1.724ThrAsn: 1.724 ± 0.009	3.655ThrPro: 3.655 ± 0.022	2.329ThrGln: 2.329 ± 0.014	2.487ThrArg: 2.487 ± 0.012	4.75ThrSer: 4.75 ± 0.021	2.974ThrThr: 2.974 ± 0.021	3.809ThrVal: 3.809 ± 0.019	0.68ThrTrp: 0.68 ± 0.008	1.381ThrTyr: 1.381 ± 0.008	0.009ThrXaa: 0.009 ± 0.001
Val	4.218ValAla: 4.218 ± 0.019	1.397ValCys: 1.397 ± 0.01	2.964ValAsp: 2.964 ± 0.017	3.892ValGlu: 3.892 ± 0.017	2.3ValPhe: 2.3 ± 0.011	3.34ValGly: 3.34 ± 0.015	1.579ValHis: 1.579 ± 0.009	2.849ValIle: 2.849 ± 0.016	3.486ValLys: 3.486 ± 0.018	6.158ValLeu: 6.158 ± 0.022	1.293ValMet: 1.293 ± 0.01	2.258ValAsn: 2.258 ± 0.011	3.701ValPro: 3.701 ± 0.022	2.786ValGln: 2.786 ± 0.014	3.04ValArg: 3.04 ± 0.014	4.908ValSer: 4.908 ± 0.018	3.732ValThr: 3.732 ± 0.023	3.889ValVal: 3.889 ± 0.017	0.713ValTrp: 0.713 ± 0.006	1.592ValTyr: 1.592 ± 0.01	0.011ValXaa: 0.011 ± 0.001
Trp	0.775TrpAla: 0.775 ± 0.006	0.242TrpCys: 0.242 ± 0.004	0.66TrpAsp: 0.66 ± 0.007	0.818TrpGlu: 0.818 ± 0.006	0.43TrpPhe: 0.43 ± 0.005	0.722TrpGly: 0.722 ± 0.008	0.306TrpHis: 0.306 ± 0.004	0.534TrpIle: 0.534 ± 0.006	0.795TrpLys: 0.795 ± 0.007	1.19TrpLeu: 1.19 ± 0.009	0.317TrpMet: 0.317 ± 0.004	0.525TrpAsn: 0.525 ± 0.005	0.526TrpPro: 0.526 ± 0.006	0.519TrpGln: 0.519 ± 0.005	0.74TrpArg: 0.74 ± 0.007	0.854TrpSer: 0.854 ± 0.008	0.665TrpThr: 0.665 ± 0.007	0.665TrpVal: 0.665 ± 0.006	0.191TrpTrp: 0.191 ± 0.003	0.321TrpTyr: 0.321 ± 0.005	0.002TrpXaa: 0.002 ± 0.0
Tyr	1.331TyrAla: 1.331 ± 0.008	0.643TyrCys: 0.643 ± 0.007	1.249TyrAsp: 1.249 ± 0.01	1.729TyrGlu: 1.729 ± 0.013	1.131TyrPhe: 1.131 ± 0.009	1.594TyrGly: 1.594 ± 0.011	0.739TyrHis: 0.739 ± 0.008	1.301TyrIle: 1.301 ± 0.009	1.559TyrLys: 1.559 ± 0.028	2.538TyrLeu: 2.538 ± 0.015	0.559TyrMet: 0.559 ± 0.006	1.051TyrAsn: 1.051 ± 0.007	1.253TyrPro: 1.253 ± 0.01	1.254TyrGln: 1.254 ± 0.009	1.624TyrArg: 1.624 ± 0.013	2.173TyrSer: 2.173 ± 0.011	1.437TyrThr: 1.437 ± 0.013	1.498TyrVal: 1.498 ± 0.008	0.342TyrTrp: 0.342 ± 0.005	0.893TyrTyr: 0.893 ± 0.007	0.005TyrXaa: 0.005 ± 0.001
Xaa	0.017XaaAla: 0.017 ± 0.001	0.004XaaCys: 0.004 ± 0.0	0.008XaaAsp: 0.008 ± 0.001	0.013XaaGlu: 0.013 ± 0.001	0.008XaaPhe: 0.008 ± 0.001	0.016XaaGly: 0.016 ± 0.001	0.004XaaHis: 0.004 ± 0.0	0.007XaaIle: 0.007 ± 0.001	0.011XaaLys: 0.011 ± 0.001	0.022XaaLeu: 0.022 ± 0.001	0.004XaaMet: 0.004 ± 0.0	0.006XaaAsn: 0.006 ± 0.001	0.017XaaPro: 0.017 ± 0.001	0.01XaaGln: 0.01 ± 0.001	0.012XaaArg: 0.012 ± 0.001	0.015XaaSer: 0.015 ± 0.001	0.008XaaThr: 0.008 ± 0.001	0.012XaaVal: 0.012 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.004XaaTyr: 0.004 ± 0.0	0.639XaaXaa: 0.639 ± 0.026

Statistics based on 32130 proteins (20399175 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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