Amino acid dipepetide frequency for Sphingomonas solaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.395AlaAla: 22.395 ± 0.236	1.145AlaCys: 1.145 ± 0.03	8.601AlaAsp: 8.601 ± 0.097	7.477AlaGlu: 7.477 ± 0.089	4.442AlaPhe: 4.442 ± 0.066	13.702AlaGly: 13.702 ± 0.133	2.36AlaHis: 2.36 ± 0.052	7.142AlaIle: 7.142 ± 0.083	3.607AlaLys: 3.607 ± 0.067	14.613AlaLeu: 14.613 ± 0.149	3.965AlaMet: 3.965 ± 0.056	2.964AlaAsn: 2.964 ± 0.05	6.947AlaPro: 6.947 ± 0.085	4.113AlaGln: 4.113 ± 0.061	11.315AlaArg: 11.315 ± 0.12	6.442AlaSer: 6.442 ± 0.077	8.016AlaThr: 8.016 ± 0.085	9.596AlaVal: 9.596 ± 0.1	1.729AlaTrp: 1.729 ± 0.04	2.549AlaTyr: 2.549 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.027	0.092CysCys: 0.092 ± 0.009	0.546CysAsp: 0.546 ± 0.021	0.366CysGlu: 0.366 ± 0.018	0.283CysPhe: 0.283 ± 0.014	0.847CysGly: 0.847 ± 0.024	0.222CysHis: 0.222 ± 0.017	0.313CysIle: 0.313 ± 0.015	0.132CysLys: 0.132 ± 0.01	0.696CysLeu: 0.696 ± 0.021	0.141CysMet: 0.141 ± 0.011	0.177CysAsn: 0.177 ± 0.012	0.452CysPro: 0.452 ± 0.022	0.168CysGln: 0.168 ± 0.011	0.654CysArg: 0.654 ± 0.025	0.39CysSer: 0.39 ± 0.019	0.418CysThr: 0.418 ± 0.02	0.508CysVal: 0.508 ± 0.021	0.095CysTrp: 0.095 ± 0.009	0.154CysTyr: 0.154 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.342AspAla: 8.342 ± 0.094	0.452AspCys: 0.452 ± 0.02	3.525AspAsp: 3.525 ± 0.064	3.298AspGlu: 3.298 ± 0.056	2.0AspPhe: 2.0 ± 0.04	5.95AspGly: 5.95 ± 0.082	1.421AspHis: 1.421 ± 0.035	2.688AspIle: 2.688 ± 0.051	1.42AspLys: 1.42 ± 0.037	5.855AspLeu: 5.855 ± 0.073	1.328AspMet: 1.328 ± 0.034	1.172AspAsn: 1.172 ± 0.033	4.155AspPro: 4.155 ± 0.062	1.601AspGln: 1.601 ± 0.036	5.66AspArg: 5.66 ± 0.081	2.087AspSer: 2.087 ± 0.041	2.874AspThr: 2.874 ± 0.06	4.29AspVal: 4.29 ± 0.062	1.006AspTrp: 1.006 ± 0.032	1.614AspTyr: 1.614 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.909GluAla: 7.909 ± 0.08	0.284GluCys: 0.284 ± 0.016	2.411GluAsp: 2.411 ± 0.044	2.464GluGlu: 2.464 ± 0.058	1.282GluPhe: 1.282 ± 0.036	4.387GluGly: 4.387 ± 0.067	1.001GluHis: 1.001 ± 0.028	2.589GluIle: 2.589 ± 0.058	1.611GluLys: 1.611 ± 0.046	4.273GluLeu: 4.273 ± 0.061	1.291GluMet: 1.291 ± 0.032	1.127GluAsn: 1.127 ± 0.032	2.335GluPro: 2.335 ± 0.049	1.904GluGln: 1.904 ± 0.041	4.742GluArg: 4.742 ± 0.061	1.924GluSer: 1.924 ± 0.042	3.32GluThr: 3.32 ± 0.053	3.436GluVal: 3.436 ± 0.051	0.703GluTrp: 0.703 ± 0.022	0.852GluTyr: 0.852 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.835PheAla: 4.835 ± 0.063	0.304PheCys: 0.304 ± 0.015	2.615PheAsp: 2.615 ± 0.046	1.771PheGlu: 1.771 ± 0.035	1.126PhePhe: 1.126 ± 0.038	3.572PheGly: 3.572 ± 0.058	0.699PheHis: 0.699 ± 0.024	1.233PheIle: 1.233 ± 0.035	0.687PheLys: 0.687 ± 0.025	2.904PheLeu: 2.904 ± 0.057	0.639PheMet: 0.639 ± 0.023	0.902PheAsn: 0.902 ± 0.031	1.465PhePro: 1.465 ± 0.034	0.789PheGln: 0.789 ± 0.023	2.243PheArg: 2.243 ± 0.048	1.872PheSer: 1.872 ± 0.041	2.049PheThr: 2.049 ± 0.047	2.644PheVal: 2.644 ± 0.047	0.511PheTrp: 0.511 ± 0.019	0.84PheTyr: 0.84 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.948GlyAla: 10.948 ± 0.125	0.837GlyCys: 0.837 ± 0.027	5.34GlyAsp: 5.34 ± 0.062	4.77GlyGlu: 4.77 ± 0.063	3.667GlyPhe: 3.667 ± 0.052	9.083GlyGly: 9.083 ± 0.136	1.948GlyHis: 1.948 ± 0.045	4.477GlyIle: 4.477 ± 0.054	2.821GlyLys: 2.821 ± 0.053	9.182GlyLeu: 9.182 ± 0.087	2.405GlyMet: 2.405 ± 0.05	2.114GlyAsn: 2.114 ± 0.049	3.922GlyPro: 3.922 ± 0.056	2.852GlyGln: 2.852 ± 0.051	7.512GlyArg: 7.512 ± 0.087	4.636GlySer: 4.636 ± 0.075	5.243GlyThr: 5.243 ± 0.08	6.657GlyVal: 6.657 ± 0.07	1.691GlyTrp: 1.691 ± 0.04	2.395GlyTyr: 2.395 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.644HisAla: 2.644 ± 0.04	0.208HisCys: 0.208 ± 0.014	1.343HisAsp: 1.343 ± 0.035	0.976HisGlu: 0.976 ± 0.028	0.694HisPhe: 0.694 ± 0.022	2.068HisGly: 2.068 ± 0.047	0.598HisHis: 0.598 ± 0.025	0.786HisIle: 0.786 ± 0.022	0.345HisLys: 0.345 ± 0.017	1.903HisLeu: 1.903 ± 0.04	0.42HisMet: 0.42 ± 0.021	0.387HisAsn: 0.387 ± 0.018	1.329HisPro: 1.329 ± 0.038	0.482HisGln: 0.482 ± 0.023	1.638HisArg: 1.638 ± 0.044	0.833HisSer: 0.833 ± 0.024	0.689HisThr: 0.689 ± 0.023	1.524HisVal: 1.524 ± 0.039	0.311HisTrp: 0.311 ± 0.014	0.546HisTyr: 0.546 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.964IleAla: 7.964 ± 0.089	0.381IleCys: 0.381 ± 0.017	3.877IleAsp: 3.877 ± 0.066	3.421IleGlu: 3.421 ± 0.052	1.284IlePhe: 1.284 ± 0.035	5.042IleGly: 5.042 ± 0.065	0.86IleHis: 0.86 ± 0.026	1.707IleIle: 1.707 ± 0.045	0.942IleLys: 0.942 ± 0.03	3.73IleLeu: 3.73 ± 0.062	0.756IleMet: 0.756 ± 0.026	1.15IleAsn: 1.15 ± 0.032	2.135IlePro: 2.135 ± 0.037	0.959IleGln: 0.959 ± 0.031	3.116IleArg: 3.116 ± 0.051	2.176IleSer: 2.176 ± 0.044	2.45IleThr: 2.45 ± 0.05	4.375IleVal: 4.375 ± 0.057	0.503IleTrp: 0.503 ± 0.018	0.898IleTyr: 0.898 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.711LysAla: 3.711 ± 0.055	0.123LysCys: 0.123 ± 0.012	1.24LysAsp: 1.24 ± 0.043	0.988LysGlu: 0.988 ± 0.03	0.678LysPhe: 0.678 ± 0.025	2.289LysGly: 2.289 ± 0.049	0.45LysHis: 0.45 ± 0.017	1.166LysIle: 1.166 ± 0.033	0.842LysLys: 0.842 ± 0.032	2.702LysLeu: 2.702 ± 0.045	0.62LysMet: 0.62 ± 0.021	0.579LysAsn: 0.579 ± 0.021	1.787LysPro: 1.787 ± 0.044	0.73LysGln: 0.73 ± 0.025	1.948LysArg: 1.948 ± 0.042	1.274LysSer: 1.274 ± 0.034	1.49LysThr: 1.49 ± 0.033	1.885LysVal: 1.885 ± 0.042	0.307LysTrp: 0.307 ± 0.015	0.487LysTyr: 0.487 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.348LeuAla: 15.348 ± 0.142	0.77LeuCys: 0.77 ± 0.028	6.512LeuAsp: 6.512 ± 0.075	4.151LeuGlu: 4.151 ± 0.063	3.525LeuPhe: 3.525 ± 0.065	8.593LeuGly: 8.593 ± 0.083	1.917LeuHis: 1.917 ± 0.04	4.599LeuIle: 4.599 ± 0.065	2.599LeuLys: 2.599 ± 0.055	9.782LeuLeu: 9.782 ± 0.128	2.054LeuMet: 2.054 ± 0.041	2.195LeuAsn: 2.195 ± 0.047	5.821LeuPro: 5.821 ± 0.066	2.14LeuGln: 2.14 ± 0.042	7.334LeuArg: 7.334 ± 0.081	5.509LeuSer: 5.509 ± 0.071	5.578LeuThr: 5.578 ± 0.069	7.386LeuVal: 7.386 ± 0.094	1.213LeuTrp: 1.213 ± 0.03	1.927LeuTyr: 1.927 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.301MetAla: 3.301 ± 0.054	0.148MetCys: 0.148 ± 0.01	0.984MetAsp: 0.984 ± 0.029	0.891MetGlu: 0.891 ± 0.026	0.638MetPhe: 0.638 ± 0.027	1.706MetGly: 1.706 ± 0.048	0.421MetHis: 0.421 ± 0.018	1.281MetIle: 1.281 ± 0.034	0.794MetLys: 0.794 ± 0.024	2.541MetLeu: 2.541 ± 0.045	0.618MetMet: 0.618 ± 0.021	0.595MetAsn: 0.595 ± 0.022	1.507MetPro: 1.507 ± 0.035	0.605MetGln: 0.605 ± 0.02	1.818MetArg: 1.818 ± 0.037	1.412MetSer: 1.412 ± 0.031	1.695MetThr: 1.695 ± 0.04	1.541MetVal: 1.541 ± 0.04	0.231MetTrp: 0.231 ± 0.014	0.248MetTyr: 0.248 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.956AsnAla: 2.956 ± 0.056	0.185AsnCys: 0.185 ± 0.012	1.367AsnAsp: 1.367 ± 0.038	0.98AsnGlu: 0.98 ± 0.033	0.827AsnPhe: 0.827 ± 0.03	2.248AsnGly: 2.248 ± 0.049	0.425AsnHis: 0.425 ± 0.018	1.116AsnIle: 1.116 ± 0.031	0.506AsnLys: 0.506 ± 0.019	2.163AsnLeu: 2.163 ± 0.045	0.487AsnMet: 0.487 ± 0.019	0.596AsnAsn: 0.596 ± 0.027	1.65AsnPro: 1.65 ± 0.042	0.63AsnGln: 0.63 ± 0.026	1.771AsnArg: 1.771 ± 0.034	1.034AsnSer: 1.034 ± 0.033	1.06AsnThr: 1.06 ± 0.036	1.784AsnVal: 1.784 ± 0.039	0.329AsnTrp: 0.329 ± 0.016	0.596AsnTyr: 0.596 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.744ProAla: 8.744 ± 0.097	0.353ProCys: 0.353 ± 0.017	3.901ProAsp: 3.901 ± 0.05	3.1ProGlu: 3.1 ± 0.051	1.955ProPhe: 1.955 ± 0.04	5.379ProGly: 5.379 ± 0.067	1.081ProHis: 1.081 ± 0.029	2.395ProIle: 2.395 ± 0.043	1.341ProLys: 1.341 ± 0.037	5.183ProLeu: 5.183 ± 0.067	1.129ProMet: 1.129 ± 0.033	1.194ProAsn: 1.194 ± 0.033	3.308ProPro: 3.308 ± 0.068	1.473ProGln: 1.473 ± 0.033	3.464ProArg: 3.464 ± 0.059	2.581ProSer: 2.581 ± 0.049	2.679ProThr: 2.679 ± 0.05	4.612ProVal: 4.612 ± 0.067	0.699ProTrp: 0.699 ± 0.025	1.037ProTyr: 1.037 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.227GlnAla: 4.227 ± 0.062	0.171GlnCys: 0.171 ± 0.01	1.304GlnAsp: 1.304 ± 0.031	1.078GlnGlu: 1.078 ± 0.033	0.867GlnPhe: 0.867 ± 0.028	2.274GlnGly: 2.274 ± 0.045	0.519GlnHis: 0.519 ± 0.021	1.481GlnIle: 1.481 ± 0.036	0.75GlnLys: 0.75 ± 0.026	2.649GlnLeu: 2.649 ± 0.044	0.666GlnMet: 0.666 ± 0.023	0.618GlnAsn: 0.618 ± 0.028	1.719GlnPro: 1.719 ± 0.038	0.948GlnGln: 0.948 ± 0.029	2.423GlnArg: 2.423 ± 0.042	1.462GlnSer: 1.462 ± 0.043	1.53GlnThr: 1.53 ± 0.037	2.143GlnVal: 2.143 ± 0.047	0.344GlnTrp: 0.344 ± 0.017	0.539GlnTyr: 0.539 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.093ArgAla: 10.093 ± 0.115	0.583ArgCys: 0.583 ± 0.02	4.652ArgAsp: 4.652 ± 0.066	3.977ArgGlu: 3.977 ± 0.062	3.221ArgPhe: 3.221 ± 0.054	5.741ArgGly: 5.741 ± 0.078	1.865ArgHis: 1.865 ± 0.037	4.191ArgIle: 4.191 ± 0.062	1.818ArgLys: 1.818 ± 0.039	9.199ArgLeu: 9.199 ± 0.1	1.972ArgMet: 1.972 ± 0.039	1.827ArgAsn: 1.827 ± 0.037	4.387ArgPro: 4.387 ± 0.065	2.472ArgGln: 2.472 ± 0.043	6.933ArgArg: 6.933 ± 0.1	3.652ArgSer: 3.652 ± 0.058	3.966ArgThr: 3.966 ± 0.053	5.388ArgVal: 5.388 ± 0.064	1.322ArgTrp: 1.322 ± 0.034	1.927ArgTyr: 1.927 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.122SerAla: 6.122 ± 0.077	0.392SerCys: 0.392 ± 0.017	2.749SerAsp: 2.749 ± 0.049	2.122SerGlu: 2.122 ± 0.041	1.969SerPhe: 1.969 ± 0.043	5.119SerGly: 5.119 ± 0.068	0.857SerHis: 0.857 ± 0.025	2.492SerIle: 2.492 ± 0.047	1.166SerLys: 1.166 ± 0.034	4.896SerLeu: 4.896 ± 0.059	1.026SerMet: 1.026 ± 0.029	1.171SerAsn: 1.171 ± 0.039	2.852SerPro: 2.852 ± 0.043	1.305SerGln: 1.305 ± 0.038	3.609SerArg: 3.609 ± 0.05	2.478SerSer: 2.478 ± 0.045	2.548SerThr: 2.548 ± 0.049	3.605SerVal: 3.605 ± 0.054	0.656SerTrp: 0.656 ± 0.024	1.224SerTyr: 1.224 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.299ThrAla: 7.299 ± 0.081	0.367ThrCys: 0.367 ± 0.02	3.036ThrAsp: 3.036 ± 0.05	2.191ThrGlu: 2.191 ± 0.037	1.849ThrPhe: 1.849 ± 0.043	5.704ThrGly: 5.704 ± 0.082	0.963ThrHis: 0.963 ± 0.027	3.15ThrIle: 3.15 ± 0.051	1.233ThrLys: 1.233 ± 0.034	6.124ThrLeu: 6.124 ± 0.069	1.174ThrMet: 1.174 ± 0.033	1.213ThrAsn: 1.213 ± 0.037	3.741ThrPro: 3.741 ± 0.061	1.424ThrGln: 1.424 ± 0.039	3.845ThrArg: 3.845 ± 0.056	2.58ThrSer: 2.58 ± 0.05	3.1ThrThr: 3.1 ± 0.054	4.557ThrVal: 4.557 ± 0.059	0.578ThrTrp: 0.578 ± 0.021	1.16ThrTyr: 1.16 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	11.17ValAla: 11.17 ± 0.103	0.517ValCys: 0.517 ± 0.021	4.506ValAsp: 4.506 ± 0.064	4.268ValGlu: 4.268 ± 0.064	2.108ValPhe: 2.108 ± 0.044	5.757ValGly: 5.757 ± 0.074	1.311ValHis: 1.311 ± 0.034	3.494ValIle: 3.494 ± 0.054	1.828ValLys: 1.828 ± 0.039	6.763ValLeu: 6.763 ± 0.082	1.56ValMet: 1.56 ± 0.038	1.844ValAsn: 1.844 ± 0.051	4.352ValPro: 4.352 ± 0.061	1.934ValGln: 1.934 ± 0.039	5.775ValArg: 5.775 ± 0.076	4.151ValSer: 4.151 ± 0.055	4.755ValThr: 4.755 ± 0.062	5.774ValVal: 5.774 ± 0.079	0.853ValTrp: 0.853 ± 0.027	1.348ValTyr: 1.348 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.407TrpAla: 1.407 ± 0.032	0.116TrpCys: 0.116 ± 0.01	0.72TrpAsp: 0.72 ± 0.022	0.507TrpGlu: 0.507 ± 0.021	0.523TrpPhe: 0.523 ± 0.022	0.934TrpGly: 0.934 ± 0.027	0.368TrpHis: 0.368 ± 0.018	0.64TrpIle: 0.64 ± 0.022	0.369TrpLys: 0.369 ± 0.016	1.696TrpLeu: 1.696 ± 0.039	0.331TrpMet: 0.331 ± 0.017	0.376TrpAsn: 0.376 ± 0.018	0.726TrpPro: 0.726 ± 0.022	0.544TrpGln: 0.544 ± 0.022	1.424TrpArg: 1.424 ± 0.035	0.824TrpSer: 0.824 ± 0.023	0.84TrpThr: 0.84 ± 0.025	0.762TrpVal: 0.762 ± 0.026	0.258TrpTrp: 0.258 ± 0.012	0.288TrpTyr: 0.288 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.732TyrAla: 2.732 ± 0.049	0.197TyrCys: 0.197 ± 0.015	1.508TyrAsp: 1.508 ± 0.036	1.05TyrGlu: 1.05 ± 0.03	0.758TyrPhe: 0.758 ± 0.025	2.101TyrGly: 2.101 ± 0.049	0.439TyrHis: 0.439 ± 0.017	0.788TyrIle: 0.788 ± 0.026	0.487TyrLys: 0.487 ± 0.019	2.101TyrLeu: 2.101 ± 0.047	0.394TyrMet: 0.394 ± 0.017	0.506TyrAsn: 0.506 ± 0.022	1.017TyrPro: 1.017 ± 0.028	0.642TyrGln: 0.642 ± 0.024	1.964TyrArg: 1.964 ± 0.043	1.042TyrSer: 1.042 ± 0.031	0.989TyrThr: 0.989 ± 0.028	1.605TyrVal: 1.605 ± 0.036	0.311TyrTrp: 0.311 ± 0.016	0.583TyrTyr: 0.583 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4080 proteins (1288240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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