Amino acid dipepetide frequency for Butyrivibrio sp. TB

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.999AlaAla: 5.999 ± 0.1	0.979AlaCys: 0.979 ± 0.029	5.082AlaAsp: 5.082 ± 0.066	4.155AlaGlu: 4.155 ± 0.062	3.175AlaPhe: 3.175 ± 0.061	5.374AlaGly: 5.374 ± 0.073	0.992AlaHis: 0.992 ± 0.028	5.319AlaIle: 5.319 ± 0.061	4.244AlaLys: 4.244 ± 0.075	6.341AlaLeu: 6.341 ± 0.072	2.193AlaMet: 2.193 ± 0.041	2.61AlaAsn: 2.61 ± 0.047	1.929AlaPro: 1.929 ± 0.047	2.207AlaGln: 2.207 ± 0.048	2.845AlaArg: 2.845 ± 0.055	4.616AlaSer: 4.616 ± 0.069	3.484AlaThr: 3.484 ± 0.062	5.286AlaVal: 5.286 ± 0.07	0.563AlaTrp: 0.563 ± 0.02	2.883AlaTyr: 2.883 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.915CysAla: 0.915 ± 0.027	0.212CysCys: 0.212 ± 0.013	1.004CysAsp: 1.004 ± 0.027	0.806CysGlu: 0.806 ± 0.024	0.608CysPhe: 0.608 ± 0.023	1.294CysGly: 1.294 ± 0.036	0.286CysHis: 0.286 ± 0.014	1.159CysIle: 1.159 ± 0.031	0.81CysLys: 0.81 ± 0.025	1.031CysLeu: 1.031 ± 0.029	0.377CysMet: 0.377 ± 0.016	0.635CysAsn: 0.635 ± 0.022	0.54CysPro: 0.54 ± 0.022	0.34CysGln: 0.34 ± 0.017	0.528CysArg: 0.528 ± 0.021	0.906CysSer: 0.906 ± 0.029	0.671CysThr: 0.671 ± 0.024	0.907CysVal: 0.907 ± 0.031	0.11CysTrp: 0.11 ± 0.01	0.616CysTyr: 0.616 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.695AspAla: 4.695 ± 0.071	0.748AspCys: 0.748 ± 0.026	4.66AspAsp: 4.66 ± 0.073	5.659AspGlu: 5.659 ± 0.085	3.004AspPhe: 3.004 ± 0.055	4.907AspGly: 4.907 ± 0.082	1.121AspHis: 1.121 ± 0.032	5.832AspIle: 5.832 ± 0.073	4.997AspLys: 4.997 ± 0.077	5.114AspLeu: 5.114 ± 0.067	2.136AspMet: 2.136 ± 0.043	3.72AspAsn: 3.72 ± 0.06	2.213AspPro: 2.213 ± 0.043	1.539AspGln: 1.539 ± 0.038	2.687AspArg: 2.687 ± 0.054	4.18AspSer: 4.18 ± 0.064	3.725AspThr: 3.725 ± 0.07	4.259AspVal: 4.259 ± 0.062	0.589AspTrp: 0.589 ± 0.023	3.52AspTyr: 3.52 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	5.091GluAla: 5.091 ± 0.076	0.759GluCys: 0.759 ± 0.025	5.173GluAsp: 5.173 ± 0.074	5.725GluGlu: 5.725 ± 0.092	2.597GluPhe: 2.597 ± 0.047	4.216GluGly: 4.216 ± 0.064	1.253GluHis: 1.253 ± 0.033	5.051GluIle: 5.051 ± 0.071	5.479GluLys: 5.479 ± 0.082	6.144GluLeu: 6.144 ± 0.084	2.053GluMet: 2.053 ± 0.039	3.832GluAsn: 3.832 ± 0.052	1.66GluPro: 1.66 ± 0.044	2.073GluGln: 2.073 ± 0.044	2.648GluArg: 2.648 ± 0.054	3.987GluSer: 3.987 ± 0.056	3.213GluThr: 3.213 ± 0.053	4.15GluVal: 4.15 ± 0.06	0.619GluTrp: 0.619 ± 0.023	3.42GluTyr: 3.42 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.954PheAla: 2.954 ± 0.054	0.691PheCys: 0.691 ± 0.023	3.152PheAsp: 3.152 ± 0.052	2.906PheGlu: 2.906 ± 0.05	2.029PhePhe: 2.029 ± 0.048	3.145PheGly: 3.145 ± 0.054	0.725PheHis: 0.725 ± 0.026	3.401PheIle: 3.401 ± 0.059	2.541PheLys: 2.541 ± 0.05	3.668PheLeu: 3.668 ± 0.058	1.306PheMet: 1.306 ± 0.033	1.847PheAsn: 1.847 ± 0.037	1.322PhePro: 1.322 ± 0.03	0.883PheGln: 0.883 ± 0.029	1.613PheArg: 1.613 ± 0.039	2.832PheSer: 2.832 ± 0.052	2.386PheThr: 2.386 ± 0.043	2.904PheVal: 2.904 ± 0.053	0.475PheTrp: 0.475 ± 0.02	2.019PheTyr: 2.019 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.657GlyAla: 4.657 ± 0.077	1.136GlyCys: 1.136 ± 0.039	4.364GlyAsp: 4.364 ± 0.073	3.946GlyGlu: 3.946 ± 0.059	3.207GlyPhe: 3.207 ± 0.047	4.475GlyGly: 4.475 ± 0.085	1.281GlyHis: 1.281 ± 0.032	6.085GlyIle: 6.085 ± 0.072	4.727GlyLys: 4.727 ± 0.06	5.501GlyLeu: 5.501 ± 0.075	2.176GlyMet: 2.176 ± 0.042	3.131GlyAsn: 3.131 ± 0.054	1.264GlyPro: 1.264 ± 0.04	2.02GlyGln: 2.02 ± 0.046	2.919GlyArg: 2.919 ± 0.052	4.682GlySer: 4.682 ± 0.087	4.077GlyThr: 4.077 ± 0.072	4.491GlyVal: 4.491 ± 0.059	0.674GlyTrp: 0.674 ± 0.028	3.44GlyTyr: 3.44 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.965HisAla: 0.965 ± 0.026	0.243HisCys: 0.243 ± 0.017	1.136HisAsp: 1.136 ± 0.035	1.115HisGlu: 1.115 ± 0.032	0.869HisPhe: 0.869 ± 0.027	1.192HisGly: 1.192 ± 0.028	0.392HisHis: 0.392 ± 0.036	1.392HisIle: 1.392 ± 0.037	1.057HisLys: 1.057 ± 0.032	1.329HisLeu: 1.329 ± 0.031	0.585HisMet: 0.585 ± 0.022	0.816HisAsn: 0.816 ± 0.023	0.709HisPro: 0.709 ± 0.026	0.422HisGln: 0.422 ± 0.019	0.703HisArg: 0.703 ± 0.024	0.916HisSer: 0.916 ± 0.028	0.862HisThr: 0.862 ± 0.03	1.071HisVal: 1.071 ± 0.026	0.154HisTrp: 0.154 ± 0.012	0.78HisTyr: 0.78 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.824IleAla: 5.824 ± 0.066	1.381IleCys: 1.381 ± 0.037	5.409IleAsp: 5.409 ± 0.061	5.233IleGlu: 5.233 ± 0.068	3.17IlePhe: 3.17 ± 0.053	5.19IleGly: 5.19 ± 0.072	1.302IleHis: 1.302 ± 0.036	6.35IleIle: 6.35 ± 0.097	5.017IleLys: 5.017 ± 0.064	6.908IleLeu: 6.908 ± 0.092	2.219IleMet: 2.219 ± 0.042	3.479IleAsn: 3.479 ± 0.05	3.129IlePro: 3.129 ± 0.057	1.9IleGln: 1.9 ± 0.038	3.484IleArg: 3.484 ± 0.058	5.782IleSer: 5.782 ± 0.085	4.769IleThr: 4.769 ± 0.068	5.32IleVal: 5.32 ± 0.076	0.682IleTrp: 0.682 ± 0.023	3.337IleTyr: 3.337 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.238LysAla: 5.238 ± 0.077	0.741LysCys: 0.741 ± 0.024	5.03LysAsp: 5.03 ± 0.067	6.156LysGlu: 6.156 ± 0.092	2.07LysPhe: 2.07 ± 0.044	4.209LysGly: 4.209 ± 0.055	1.007LysHis: 1.007 ± 0.028	4.977LysIle: 4.977 ± 0.071	5.995LysLys: 5.995 ± 0.088	5.369LysLeu: 5.369 ± 0.064	1.989LysMet: 1.989 ± 0.04	3.602LysAsn: 3.602 ± 0.056	1.824LysPro: 1.824 ± 0.037	1.721LysGln: 1.721 ± 0.046	2.767LysArg: 2.767 ± 0.051	3.804LysSer: 3.804 ± 0.06	3.617LysThr: 3.617 ± 0.055	4.251LysVal: 4.251 ± 0.064	0.613LysTrp: 0.613 ± 0.024	3.099LysTyr: 3.099 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	5.663LeuAla: 5.663 ± 0.078	1.313LeuCys: 1.313 ± 0.032	5.252LeuAsp: 5.252 ± 0.08	5.529LeuGlu: 5.529 ± 0.07	3.828LeuPhe: 3.828 ± 0.069	5.417LeuGly: 5.417 ± 0.064	1.377LeuHis: 1.377 ± 0.031	6.473LeuIle: 6.473 ± 0.099	5.77LeuLys: 5.77 ± 0.073	7.513LeuLeu: 7.513 ± 0.107	2.587LeuMet: 2.587 ± 0.052	3.746LeuAsn: 3.746 ± 0.056	2.993LeuPro: 2.993 ± 0.058	2.204LeuGln: 2.204 ± 0.045	3.332LeuArg: 3.332 ± 0.06	6.685LeuSer: 6.685 ± 0.087	4.73LeuThr: 4.73 ± 0.067	5.256LeuVal: 5.256 ± 0.066	0.701LeuTrp: 0.701 ± 0.025	3.614LeuTyr: 3.614 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.243MetAla: 2.243 ± 0.045	0.406MetCys: 0.406 ± 0.015	2.001MetAsp: 2.001 ± 0.039	1.96MetGlu: 1.96 ± 0.04	1.12MetPhe: 1.12 ± 0.033	1.833MetGly: 1.833 ± 0.036	0.519MetHis: 0.519 ± 0.018	2.437MetIle: 2.437 ± 0.043	2.206MetLys: 2.206 ± 0.043	2.608MetLeu: 2.608 ± 0.052	0.944MetMet: 0.944 ± 0.032	1.649MetAsn: 1.649 ± 0.034	1.13MetPro: 1.13 ± 0.029	0.995MetGln: 0.995 ± 0.031	1.143MetArg: 1.143 ± 0.032	2.005MetSer: 2.005 ± 0.043	1.785MetThr: 1.785 ± 0.039	1.866MetVal: 1.866 ± 0.039	0.27MetTrp: 0.27 ± 0.015	1.117MetTyr: 1.117 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.402AsnAla: 3.402 ± 0.065	0.638AsnCys: 0.638 ± 0.023	2.888AsnAsp: 2.888 ± 0.043	3.094AsnGlu: 3.094 ± 0.057	1.683AsnPhe: 1.683 ± 0.036	3.544AsnGly: 3.544 ± 0.065	0.789AsnHis: 0.789 ± 0.024	4.132AsnIle: 4.132 ± 0.062	3.167AsnLys: 3.167 ± 0.049	3.689AsnLeu: 3.689 ± 0.056	1.521AsnMet: 1.521 ± 0.036	2.392AsnAsn: 2.392 ± 0.05	1.853AsnPro: 1.853 ± 0.04	1.208AsnGln: 1.208 ± 0.038	1.851AsnArg: 1.851 ± 0.04	2.991AsnSer: 2.991 ± 0.048	2.74AsnThr: 2.74 ± 0.054	3.117AsnVal: 3.117 ± 0.043	0.457AsnTrp: 0.457 ± 0.018	2.161AsnTyr: 2.161 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.027ProAla: 2.027 ± 0.052	0.397ProCys: 0.397 ± 0.019	2.64ProAsp: 2.64 ± 0.049	2.858ProGlu: 2.858 ± 0.055	1.451ProPhe: 1.451 ± 0.035	1.991ProGly: 1.991 ± 0.042	0.493ProHis: 0.493 ± 0.018	2.099ProIle: 2.099 ± 0.047	1.773ProLys: 1.773 ± 0.037	2.404ProLeu: 2.404 ± 0.046	0.831ProMet: 0.831 ± 0.028	1.202ProAsn: 1.202 ± 0.037	0.585ProPro: 0.585 ± 0.026	0.932ProGln: 0.932 ± 0.029	0.946ProArg: 0.946 ± 0.029	2.069ProSer: 2.069 ± 0.041	1.44ProThr: 1.44 ± 0.037	2.637ProVal: 2.637 ± 0.05	0.349ProTrp: 0.349 ± 0.018	1.507ProTyr: 1.507 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.924GlnAla: 1.924 ± 0.046	0.254GlnCys: 0.254 ± 0.013	1.66GlnAsp: 1.66 ± 0.043	2.014GlnGlu: 2.014 ± 0.042	1.015GlnPhe: 1.015 ± 0.03	1.703GlnGly: 1.703 ± 0.043	0.45GlnHis: 0.45 ± 0.019	2.329GlnIle: 2.329 ± 0.046	2.266GlnLys: 2.266 ± 0.043	2.278GlnLeu: 2.278 ± 0.05	0.977GlnMet: 0.977 ± 0.031	1.5GlnAsn: 1.5 ± 0.037	0.717GlnPro: 0.717 ± 0.029	0.89GlnGln: 0.89 ± 0.03	1.151GlnArg: 1.151 ± 0.034	1.614GlnSer: 1.614 ± 0.039	1.507GlnThr: 1.507 ± 0.036	1.599GlnVal: 1.599 ± 0.037	0.243GlnTrp: 0.243 ± 0.012	1.303GlnTyr: 1.303 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.407ArgAla: 2.407 ± 0.043	0.536ArgCys: 0.536 ± 0.02	2.479ArgAsp: 2.479 ± 0.051	2.682ArgGlu: 2.682 ± 0.049	1.882ArgPhe: 1.882 ± 0.038	2.178ArgGly: 2.178 ± 0.04	0.755ArgHis: 0.755 ± 0.025	3.513ArgIle: 3.513 ± 0.053	3.129ArgLys: 3.129 ± 0.057	3.494ArgLeu: 3.494 ± 0.058	1.33ArgMet: 1.33 ± 0.034	2.142ArgAsn: 2.142 ± 0.047	1.175ArgPro: 1.175 ± 0.036	1.435ArgGln: 1.435 ± 0.038	1.915ArgArg: 1.915 ± 0.048	2.38ArgSer: 2.38 ± 0.042	1.967ArgThr: 1.967 ± 0.039	2.299ArgVal: 2.299 ± 0.046	0.364ArgTrp: 0.364 ± 0.017	1.932ArgTyr: 1.932 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.446SerAla: 4.446 ± 0.066	0.808SerCys: 0.808 ± 0.028	5.0SerAsp: 5.0 ± 0.086	4.349SerGlu: 4.349 ± 0.059	3.3SerPhe: 3.3 ± 0.056	5.347SerGly: 5.347 ± 0.099	1.064SerHis: 1.064 ± 0.027	5.007SerIle: 5.007 ± 0.07	4.302SerLys: 4.302 ± 0.06	5.466SerLeu: 5.466 ± 0.073	1.927SerMet: 1.927 ± 0.037	2.798SerAsn: 2.798 ± 0.048	1.659SerPro: 1.659 ± 0.036	1.944SerGln: 1.944 ± 0.04	2.524SerArg: 2.524 ± 0.055	4.803SerSer: 4.803 ± 0.097	3.264SerThr: 3.264 ± 0.063	4.414SerVal: 4.414 ± 0.063	0.615SerTrp: 0.615 ± 0.024	3.154SerTyr: 3.154 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.952ThrAla: 3.952 ± 0.067	0.66ThrCys: 0.66 ± 0.023	4.118ThrAsp: 4.118 ± 0.069	3.116ThrGlu: 3.116 ± 0.056	2.381ThrPhe: 2.381 ± 0.047	4.555ThrGly: 4.555 ± 0.066	0.829ThrHis: 0.829 ± 0.026	4.43ThrIle: 4.43 ± 0.068	2.993ThrLys: 2.993 ± 0.052	4.479ThrLeu: 4.479 ± 0.06	1.457ThrMet: 1.457 ± 0.034	2.249ThrAsn: 2.249 ± 0.053	1.951ThrPro: 1.951 ± 0.047	1.547ThrGln: 1.547 ± 0.041	2.001ThrArg: 2.001 ± 0.038	3.661ThrSer: 3.661 ± 0.067	3.021ThrThr: 3.021 ± 0.069	4.078ThrVal: 4.078 ± 0.064	0.473ThrTrp: 0.473 ± 0.022	2.62ThrTyr: 2.62 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.48ValAla: 4.48 ± 0.062	1.073ValCys: 1.073 ± 0.032	4.164ValAsp: 4.164 ± 0.067	3.967ValGlu: 3.967 ± 0.052	2.993ValPhe: 2.993 ± 0.063	3.898ValGly: 3.898 ± 0.062	0.985ValHis: 0.985 ± 0.028	5.544ValIle: 5.544 ± 0.064	4.06ValLys: 4.06 ± 0.062	5.94ValLeu: 5.94 ± 0.074	2.001ValMet: 2.001 ± 0.037	3.025ValAsn: 3.025 ± 0.045	2.296ValPro: 2.296 ± 0.045	1.581ValGln: 1.581 ± 0.035	2.718ValArg: 2.718 ± 0.045	4.799ValSer: 4.799 ± 0.063	4.28ValThr: 4.28 ± 0.064	4.645ValVal: 4.645 ± 0.074	0.611ValTrp: 0.611 ± 0.021	2.943ValTyr: 2.943 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.561TrpAla: 0.561 ± 0.021	0.15TrpCys: 0.15 ± 0.011	0.623TrpAsp: 0.623 ± 0.025	0.568TrpGlu: 0.568 ± 0.023	0.402TrpPhe: 0.402 ± 0.019	0.621TrpGly: 0.621 ± 0.021	0.207TrpHis: 0.207 ± 0.014	0.715TrpIle: 0.715 ± 0.025	0.59TrpLys: 0.59 ± 0.022	0.823TrpLeu: 0.823 ± 0.03	0.29TrpMet: 0.29 ± 0.016	0.596TrpAsn: 0.596 ± 0.022	0.223TrpPro: 0.223 ± 0.014	0.323TrpGln: 0.323 ± 0.016	0.358TrpArg: 0.358 ± 0.017	0.535TrpSer: 0.535 ± 0.024	0.469TrpThr: 0.469 ± 0.021	0.476TrpVal: 0.476 ± 0.023	0.118TrpTrp: 0.118 ± 0.01	0.441TrpTyr: 0.441 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.834TyrAla: 2.834 ± 0.053	0.627TyrCys: 0.627 ± 0.021	3.472TyrAsp: 3.472 ± 0.064	3.308TyrGlu: 3.308 ± 0.059	2.014TyrPhe: 2.014 ± 0.047	3.164TyrGly: 3.164 ± 0.054	0.881TyrHis: 0.881 ± 0.03	3.638TyrIle: 3.638 ± 0.051	2.958TyrLys: 2.958 ± 0.048	3.884TyrLeu: 3.884 ± 0.064	1.338TyrMet: 1.338 ± 0.037	2.346TyrAsn: 2.346 ± 0.047	1.457TyrPro: 1.457 ± 0.036	1.233TyrGln: 1.233 ± 0.032	1.862TyrArg: 1.862 ± 0.039	2.945TyrSer: 2.945 ± 0.052	2.561TyrThr: 2.561 ± 0.06	2.973TyrVal: 2.973 ± 0.048	0.408TyrTrp: 0.408 ± 0.021	2.48TyrTyr: 2.48 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3714 proteins (1257469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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