Amino acid dipepetide frequency for Dolosicoccus paucivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.792AlaAla: 4.792 ± 0.152
0.383AlaCys: 0.383 ± 0.031
3.588AlaAsp: 3.588 ± 0.105
4.02AlaGlu: 4.02 ± 0.12
2.84AlaPhe: 2.84 ± 0.068
4.774AlaGly: 4.774 ± 0.13
1.446AlaHis: 1.446 ± 0.053
5.624AlaIle: 5.624 ± 0.131
4.508AlaLys: 4.508 ± 0.123
7.702AlaLeu: 7.702 ± 0.138
2.068AlaMet: 2.068 ± 0.073
2.849AlaAsn: 2.849 ± 0.072
2.22AlaPro: 2.22 ± 0.082
3.32AlaGln: 3.32 ± 0.097
2.861AlaArg: 2.861 ± 0.085
4.069AlaSer: 4.069 ± 0.106
4.206AlaThr: 4.206 ± 0.098
4.962AlaVal: 4.962 ± 0.112
0.557AlaTrp: 0.557 ± 0.033
2.529AlaTyr: 2.529 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.35CysAla: 0.35 ± 0.029
0.031CysCys: 0.031 ± 0.007
0.279CysAsp: 0.279 ± 0.021
0.266CysGlu: 0.266 ± 0.022
0.211CysPhe: 0.211 ± 0.019
0.397CysGly: 0.397 ± 0.03
0.162CysHis: 0.162 ± 0.021
0.352CysIle: 0.352 ± 0.028
0.158CysLys: 0.158 ± 0.02
0.532CysLeu: 0.532 ± 0.036
0.074CysMet: 0.074 ± 0.011
0.192CysAsn: 0.192 ± 0.022
0.26CysPro: 0.26 ± 0.029
0.231CysGln: 0.231 ± 0.021
0.182CysArg: 0.182 ± 0.017
0.283CysSer: 0.283 ± 0.026
0.227CysThr: 0.227 ± 0.022
0.291CysVal: 0.291 ± 0.023
0.027CysTrp: 0.027 ± 0.008
0.233CysTyr: 0.233 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.701AspAla: 3.701 ± 0.099
0.235AspCys: 0.235 ± 0.021
3.043AspAsp: 3.043 ± 0.084
5.593AspGlu: 5.593 ± 0.119
2.761AspPhe: 2.761 ± 0.077
3.631AspGly: 3.631 ± 0.109
1.618AspHis: 1.618 ± 0.061
4.151AspIle: 4.151 ± 0.094
3.08AspLys: 3.08 ± 0.078
5.931AspLeu: 5.931 ± 0.103
1.311AspMet: 1.311 ± 0.057
2.238AspAsn: 2.238 ± 0.074
2.308AspPro: 2.308 ± 0.083
3.18AspGln: 3.18 ± 0.081
2.539AspArg: 2.539 ± 0.084
2.81AspSer: 2.81 ± 0.071
2.931AspThr: 2.931 ± 0.087
4.264AspVal: 4.264 ± 0.11
0.635AspTrp: 0.635 ± 0.039
2.916AspTyr: 2.916 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
6.086GluAla: 6.086 ± 0.173
0.264GluCys: 0.264 ± 0.021
4.723GluAsp: 4.723 ± 0.114
7.889GluGlu: 7.889 ± 0.183
2.488GluPhe: 2.488 ± 0.065
4.497GluGly: 4.497 ± 0.095
1.526GluHis: 1.526 ± 0.051
4.892GluIle: 4.892 ± 0.114
4.587GluLys: 4.587 ± 0.124
7.323GluLeu: 7.323 ± 0.124
2.312GluMet: 2.312 ± 0.076
3.07GluAsn: 3.07 ± 0.105
2.388GluPro: 2.388 ± 0.082
3.572GluGln: 3.572 ± 0.107
3.541GluArg: 3.541 ± 0.089
3.817GluSer: 3.817 ± 0.115
4.401GluThr: 4.401 ± 0.122
5.904GluVal: 5.904 ± 0.136
0.85GluTrp: 0.85 ± 0.049
2.478GluTyr: 2.478 ± 0.075
0.0GluXaa: 0.0 ± 0.0
Phe
2.552PheAla: 2.552 ± 0.075
0.205PheCys: 0.205 ± 0.021
2.886PheAsp: 2.886 ± 0.08
2.922PheGlu: 2.922 ± 0.08
1.802PhePhe: 1.802 ± 0.062
2.871PheGly: 2.871 ± 0.087
0.801PheHis: 0.801 ± 0.036
3.438PheIle: 3.438 ± 0.082
2.72PheLys: 2.72 ± 0.067
3.617PheLeu: 3.617 ± 0.103
1.169PheMet: 1.169 ± 0.05
2.392PheAsn: 2.392 ± 0.071
1.311PhePro: 1.311 ± 0.047
1.423PheGln: 1.423 ± 0.059
1.337PheArg: 1.337 ± 0.046
2.593PheSer: 2.593 ± 0.086
2.314PheThr: 2.314 ± 0.066
2.941PheVal: 2.941 ± 0.072
0.338PheTrp: 0.338 ± 0.026
1.692PheTyr: 1.692 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.636GlyAla: 4.636 ± 0.123
0.387GlyCys: 0.387 ± 0.024
3.398GlyAsp: 3.398 ± 0.083
4.233GlyGlu: 4.233 ± 0.109
3.045GlyPhe: 3.045 ± 0.076
4.239GlyGly: 4.239 ± 0.101
1.489GlyHis: 1.489 ± 0.057
4.962GlyIle: 4.962 ± 0.112
3.561GlyLys: 3.561 ± 0.098
6.623GlyLeu: 6.623 ± 0.138
1.898GlyMet: 1.898 ± 0.061
2.257GlyAsn: 2.257 ± 0.069
1.645GlyPro: 1.645 ± 0.062
2.769GlyGln: 2.769 ± 0.088
2.89GlyArg: 2.89 ± 0.079
3.588GlySer: 3.588 ± 0.089
3.944GlyThr: 3.944 ± 0.119
5.142GlyVal: 5.142 ± 0.11
0.659GlyTrp: 0.659 ± 0.043
2.857GlyTyr: 2.857 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
1.237HisAla: 1.237 ± 0.041
0.127HisCys: 0.127 ± 0.017
1.12HisAsp: 1.12 ± 0.051
1.436HisGlu: 1.436 ± 0.051
1.169HisPhe: 1.169 ± 0.054
1.216HisGly: 1.216 ± 0.059
0.793HisHis: 0.793 ± 0.041
1.513HisIle: 1.513 ± 0.054
0.856HisLys: 0.856 ± 0.038
2.558HisLeu: 2.558 ± 0.075
0.465HisMet: 0.465 ± 0.029
0.772HisAsn: 0.772 ± 0.042
1.305HisPro: 1.305 ± 0.055
1.352HisGln: 1.352 ± 0.061
1.036HisArg: 1.036 ± 0.05
1.235HisSer: 1.235 ± 0.047
1.157HisThr: 1.157 ± 0.053
1.296HisVal: 1.296 ± 0.06
0.297HisTrp: 0.297 ± 0.024
1.106HisTyr: 1.106 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.746IleAla: 5.746 ± 0.128
0.393IleCys: 0.393 ± 0.029
4.991IleAsp: 4.991 ± 0.097
5.763IleGlu: 5.763 ± 0.119
2.619IlePhe: 2.619 ± 0.084
5.134IleGly: 5.134 ± 0.124
1.589IleHis: 1.589 ± 0.055
5.294IleIle: 5.294 ± 0.106
4.069IleLys: 4.069 ± 0.096
6.584IleLeu: 6.584 ± 0.132
1.647IleMet: 1.647 ± 0.059
3.129IleAsn: 3.129 ± 0.085
3.072IlePro: 3.072 ± 0.091
3.645IleGln: 3.645 ± 0.101
2.83IleArg: 2.83 ± 0.078
3.963IleSer: 3.963 ± 0.107
4.022IleThr: 4.022 ± 0.09
4.968IleVal: 4.968 ± 0.111
0.539IleTrp: 0.539 ± 0.034
2.685IleTyr: 2.685 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
4.383LysAla: 4.383 ± 0.116
0.199LysCys: 0.199 ± 0.021
4.417LysAsp: 4.417 ± 0.102
7.008LysGlu: 7.008 ± 0.155
1.432LysPhe: 1.432 ± 0.061
3.909LysGly: 3.909 ± 0.076
1.161LysHis: 1.161 ± 0.051
3.361LysIle: 3.361 ± 0.077
3.75LysLys: 3.75 ± 0.1
4.385LysLeu: 4.385 ± 0.094
1.659LysMet: 1.659 ± 0.052
2.48LysAsn: 2.48 ± 0.08
2.152LysPro: 2.152 ± 0.1
2.969LysGln: 2.969 ± 0.083
2.894LysArg: 2.894 ± 0.085
2.623LysSer: 2.623 ± 0.074
3.199LysThr: 3.199 ± 0.078
4.139LysVal: 4.139 ± 0.114
0.463LysTrp: 0.463 ± 0.031
2.056LysTyr: 2.056 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
7.301LeuAla: 7.301 ± 0.151
0.475LeuCys: 0.475 ± 0.039
5.99LeuAsp: 5.99 ± 0.132
7.028LeuGlu: 7.028 ± 0.127
4.344LeuPhe: 4.344 ± 0.111
6.246LeuGly: 6.246 ± 0.119
1.731LeuHis: 1.731 ± 0.059
7.17LeuIle: 7.17 ± 0.147
6.293LeuLys: 6.293 ± 0.114
10.117LeuLeu: 10.117 ± 0.208
2.931LeuMet: 2.931 ± 0.086
5.194LeuAsn: 5.194 ± 0.092
4.03LeuPro: 4.03 ± 0.094
3.686LeuGln: 3.686 ± 0.106
3.539LeuArg: 3.539 ± 0.09
6.867LeuSer: 6.867 ± 0.128
6.594LeuThr: 6.594 ± 0.113
6.562LeuVal: 6.562 ± 0.13
0.854LeuTrp: 0.854 ± 0.044
3.176LeuTyr: 3.176 ± 0.084
0.002LeuXaa: 0.002 ± 0.002
Met
2.068MetAla: 2.068 ± 0.071
0.121MetCys: 0.121 ± 0.017
1.636MetAsp: 1.636 ± 0.056
1.8MetGlu: 1.8 ± 0.062
0.856MetPhe: 0.856 ± 0.042
1.708MetGly: 1.708 ± 0.062
0.446MetHis: 0.446 ± 0.03
2.105MetIle: 2.105 ± 0.071
2.085MetLys: 2.085 ± 0.058
2.111MetLeu: 2.111 ± 0.071
0.899MetMet: 0.899 ± 0.051
1.491MetAsn: 1.491 ± 0.059
0.946MetPro: 0.946 ± 0.042
0.944MetGln: 0.944 ± 0.044
1.051MetArg: 1.051 ± 0.05
1.718MetSer: 1.718 ± 0.061
1.937MetThr: 1.937 ± 0.062
1.759MetVal: 1.759 ± 0.063
0.137MetTrp: 0.137 ± 0.015
0.768MetTyr: 0.768 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.834AsnAla: 2.834 ± 0.067
0.227AsnCys: 0.227 ± 0.023
2.544AsnAsp: 2.544 ± 0.081
3.525AsnGlu: 3.525 ± 0.092
1.735AsnPhe: 1.735 ± 0.064
2.681AsnGly: 2.681 ± 0.076
1.155AsnHis: 1.155 ± 0.053
3.285AsnIle: 3.285 ± 0.076
2.619AsnLys: 2.619 ± 0.067
3.77AsnLeu: 3.77 ± 0.104
1.118AsnMet: 1.118 ± 0.048
2.011AsnAsn: 2.011 ± 0.067
2.165AsnPro: 2.165 ± 0.062
2.445AsnGln: 2.445 ± 0.079
1.948AsnArg: 1.948 ± 0.055
1.896AsnSer: 1.896 ± 0.064
2.189AsnThr: 2.189 ± 0.071
2.808AsnVal: 2.808 ± 0.069
0.449AsnTrp: 0.449 ± 0.03
2.007AsnTyr: 2.007 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.382ProAla: 2.382 ± 0.079
0.168ProCys: 0.168 ± 0.022
2.011ProAsp: 2.011 ± 0.081
3.531ProGlu: 3.531 ± 0.187
1.839ProPhe: 1.839 ± 0.063
2.351ProGly: 2.351 ± 0.087
0.891ProHis: 0.891 ± 0.042
2.742ProIle: 2.742 ± 0.078
2.04ProLys: 2.04 ± 0.071
3.672ProLeu: 3.672 ± 0.095
0.92ProMet: 0.92 ± 0.044
1.808ProAsn: 1.808 ± 0.068
0.887ProPro: 0.887 ± 0.045
1.735ProGln: 1.735 ± 0.063
1.206ProArg: 1.206 ± 0.046
2.347ProSer: 2.347 ± 0.078
2.498ProThr: 2.498 ± 0.066
2.904ProVal: 2.904 ± 0.077
0.324ProTrp: 0.324 ± 0.026
1.448ProTyr: 1.448 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.553GlnAla: 3.553 ± 0.109
0.141GlnCys: 0.141 ± 0.017
2.247GlnAsp: 2.247 ± 0.071
4.004GlnGlu: 4.004 ± 0.103
1.849GlnPhe: 1.849 ± 0.06
2.546GlnGly: 2.546 ± 0.067
0.889GlnHis: 0.889 ± 0.041
3.205GlnIle: 3.205 ± 0.088
2.97GlnLys: 2.97 ± 0.098
5.628GlnLeu: 5.628 ± 0.143
1.419GlnMet: 1.419 ± 0.05
1.634GlnAsn: 1.634 ± 0.059
1.741GlnPro: 1.741 ± 0.068
2.898GlnGln: 2.898 ± 0.113
2.177GlnArg: 2.177 ± 0.073
2.687GlnSer: 2.687 ± 0.068
2.863GlnThr: 2.863 ± 0.079
3.25GlnVal: 3.25 ± 0.081
0.655GlnTrp: 0.655 ± 0.037
1.558GlnTyr: 1.558 ± 0.059
0.0GlnXaa: 0.0 ± 0.0
Arg
2.298ArgAla: 2.298 ± 0.076
0.201ArgCys: 0.201 ± 0.02
2.027ArgAsp: 2.027 ± 0.07
2.601ArgGlu: 2.601 ± 0.078
1.872ArgPhe: 1.872 ± 0.066
2.333ArgGly: 2.333 ± 0.064
1.006ArgHis: 1.006 ± 0.051
3.049ArgIle: 3.049 ± 0.093
2.474ArgLys: 2.474 ± 0.064
4.722ArgLeu: 4.722 ± 0.105
1.184ArgMet: 1.184 ± 0.052
1.782ArgAsn: 1.782 ± 0.057
1.561ArgPro: 1.561 ± 0.068
2.72ArgGln: 2.72 ± 0.081
2.533ArgArg: 2.533 ± 0.087
2.302ArgSer: 2.302 ± 0.06
2.054ArgThr: 2.054 ± 0.069
2.851ArgVal: 2.851 ± 0.067
0.406ArgTrp: 0.406 ± 0.026
1.907ArgTyr: 1.907 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
3.371SerAla: 3.371 ± 0.084
0.236SerCys: 0.236 ± 0.023
3.062SerAsp: 3.062 ± 0.077
3.205SerGlu: 3.205 ± 0.1
2.951SerPhe: 2.951 ± 0.078
3.91SerGly: 3.91 ± 0.095
1.358SerHis: 1.358 ± 0.054
4.372SerIle: 4.372 ± 0.097
3.322SerLys: 3.322 ± 0.08
6.265SerLeu: 6.265 ± 0.12
1.438SerMet: 1.438 ± 0.057
2.455SerAsn: 2.455 ± 0.072
2.025SerPro: 2.025 ± 0.065
2.687SerGln: 2.687 ± 0.085
2.46SerArg: 2.46 ± 0.068
3.74SerSer: 3.74 ± 0.108
3.269SerThr: 3.269 ± 0.082
3.983SerVal: 3.983 ± 0.08
0.549SerTrp: 0.549 ± 0.034
2.32SerTyr: 2.32 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.727ThrAla: 3.727 ± 0.082
0.291ThrCys: 0.291 ± 0.03
3.139ThrAsp: 3.139 ± 0.095
2.992ThrGlu: 2.992 ± 0.077
2.527ThrPhe: 2.527 ± 0.065
4.018ThrGly: 4.018 ± 0.099
1.444ThrHis: 1.444 ± 0.052
4.503ThrIle: 4.503 ± 0.097
3.387ThrLys: 3.387 ± 0.089
6.406ThrLeu: 6.406 ± 0.126
1.331ThrMet: 1.331 ± 0.048
2.584ThrAsn: 2.584 ± 0.074
3.029ThrPro: 3.029 ± 0.1
2.701ThrGln: 2.701 ± 0.077
2.134ThrArg: 2.134 ± 0.063
3.459ThrSer: 3.459 ± 0.09
3.432ThrThr: 3.432 ± 0.109
4.323ThrVal: 4.323 ± 0.12
0.518ThrTrp: 0.518 ± 0.032
2.331ThrTyr: 2.331 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
5.316ValAla: 5.316 ± 0.096
0.381ValCys: 0.381 ± 0.028
4.692ValAsp: 4.692 ± 0.109
5.644ValGlu: 5.644 ± 0.141
2.691ValPhe: 2.691 ± 0.092
4.847ValGly: 4.847 ± 0.101
1.407ValHis: 1.407 ± 0.055
5.38ValIle: 5.38 ± 0.103
3.989ValLys: 3.989 ± 0.083
6.662ValLeu: 6.662 ± 0.126
1.706ValMet: 1.706 ± 0.059
2.92ValAsn: 2.92 ± 0.062
2.806ValPro: 2.806 ± 0.097
2.671ValGln: 2.671 ± 0.074
2.488ValArg: 2.488 ± 0.064
4.254ValSer: 4.254 ± 0.101
4.413ValThr: 4.413 ± 0.131
5.448ValVal: 5.448 ± 0.127
0.52ValTrp: 0.52 ± 0.03
2.457ValTyr: 2.457 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.608TrpAla: 0.608 ± 0.035
0.039TrpCys: 0.039 ± 0.009
0.502TrpAsp: 0.502 ± 0.03
0.449TrpGlu: 0.449 ± 0.031
0.428TrpPhe: 0.428 ± 0.034
0.506TrpGly: 0.506 ± 0.032
0.215TrpHis: 0.215 ± 0.021
0.752TrpIle: 0.752 ± 0.042
0.465TrpLys: 0.465 ± 0.034
1.167TrpLeu: 1.167 ± 0.06
0.299TrpMet: 0.299 ± 0.024
0.455TrpAsn: 0.455 ± 0.033
0.278TrpPro: 0.278 ± 0.021
0.664TrpGln: 0.664 ± 0.036
0.375TrpArg: 0.375 ± 0.028
0.557TrpSer: 0.557 ± 0.034
0.477TrpThr: 0.477 ± 0.032
0.594TrpVal: 0.594 ± 0.039
0.084TrpTrp: 0.084 ± 0.012
0.346TrpTyr: 0.346 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.378TyrAla: 2.378 ± 0.069
0.233TyrCys: 0.233 ± 0.021
2.58TyrAsp: 2.58 ± 0.065
2.699TyrGlu: 2.699 ± 0.08
1.866TyrPhe: 1.866 ± 0.069
2.406TyrGly: 2.406 ± 0.069
0.917TyrHis: 0.917 ± 0.05
2.533TyrIle: 2.533 ± 0.069
1.706TyrLys: 1.706 ± 0.069
4.356TyrLeu: 4.356 ± 0.107
0.733TyrMet: 0.733 ± 0.035
1.7TyrAsn: 1.7 ± 0.058
1.575TyrPro: 1.575 ± 0.057
2.302TyrGln: 2.302 ± 0.07
1.864TyrArg: 1.864 ± 0.059
2.171TyrSer: 2.171 ± 0.07
2.15TyrThr: 2.15 ± 0.076
2.302TyrVal: 2.302 ± 0.068
0.399TyrTrp: 0.399 ± 0.032
1.837TyrTyr: 1.837 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1609 proteins (511702 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski