Amino acid dipepetide frequency for Roseivivax lentus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.774AlaAla: 18.774 ± 0.196	1.104AlaCys: 1.104 ± 0.027	7.332AlaAsp: 7.332 ± 0.082	9.303AlaGlu: 9.303 ± 0.119	4.609AlaPhe: 4.609 ± 0.068	11.117AlaGly: 11.117 ± 0.107	2.582AlaHis: 2.582 ± 0.053	5.983AlaIle: 5.983 ± 0.072	3.385AlaLys: 3.385 ± 0.065	14.917AlaLeu: 14.917 ± 0.144	3.806AlaMet: 3.806 ± 0.06	2.464AlaAsn: 2.464 ± 0.044	6.89AlaPro: 6.89 ± 0.085	4.446AlaGln: 4.446 ± 0.055	10.317AlaArg: 10.317 ± 0.115	5.576AlaSer: 5.576 ± 0.069	6.286AlaThr: 6.286 ± 0.074	8.41AlaVal: 8.41 ± 0.088	1.579AlaTrp: 1.579 ± 0.037	2.53AlaTyr: 2.53 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.144CysAla: 1.144 ± 0.033	0.11CysCys: 0.11 ± 0.01	0.615CysAsp: 0.615 ± 0.024	0.444CysGlu: 0.444 ± 0.017	0.32CysPhe: 0.32 ± 0.018	0.914CysGly: 0.914 ± 0.032	0.274CysHis: 0.274 ± 0.016	0.382CysIle: 0.382 ± 0.018	0.182CysLys: 0.182 ± 0.013	0.913CysLeu: 0.913 ± 0.031	0.147CysMet: 0.147 ± 0.011	0.215CysAsn: 0.215 ± 0.012	0.483CysPro: 0.483 ± 0.021	0.208CysGln: 0.208 ± 0.013	0.589CysArg: 0.589 ± 0.021	0.414CysSer: 0.414 ± 0.018	0.435CysThr: 0.435 ± 0.023	0.599CysVal: 0.599 ± 0.025	0.099CysTrp: 0.099 ± 0.008	0.197CysTyr: 0.197 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.354AspAla: 8.354 ± 0.099	0.494AspCys: 0.494 ± 0.022	3.567AspAsp: 3.567 ± 0.082	3.487AspGlu: 3.487 ± 0.069	2.37AspPhe: 2.37 ± 0.046	5.874AspGly: 5.874 ± 0.084	1.35AspHis: 1.35 ± 0.035	3.105AspIle: 3.105 ± 0.047	1.508AspLys: 1.508 ± 0.041	6.546AspLeu: 6.546 ± 0.072	1.659AspMet: 1.659 ± 0.037	1.238AspAsn: 1.238 ± 0.035	4.087AspPro: 4.087 ± 0.063	1.665AspGln: 1.665 ± 0.039	4.814AspArg: 4.814 ± 0.066	2.051AspSer: 2.051 ± 0.047	2.988AspThr: 2.988 ± 0.058	4.151AspVal: 4.151 ± 0.068	1.305AspTrp: 1.305 ± 0.03	1.501AspTyr: 1.501 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	9.438GluAla: 9.438 ± 0.102	0.367GluCys: 0.367 ± 0.016	3.734GluAsp: 3.734 ± 0.057	3.799GluGlu: 3.799 ± 0.073	1.707GluPhe: 1.707 ± 0.037	5.017GluGly: 5.017 ± 0.069	1.057GluHis: 1.057 ± 0.026	3.74GluIle: 3.74 ± 0.052	2.084GluLys: 2.084 ± 0.049	4.731GluLeu: 4.731 ± 0.062	2.032GluMet: 2.032 ± 0.04	1.618GluAsn: 1.618 ± 0.036	2.58GluPro: 2.58 ± 0.043	1.663GluGln: 1.663 ± 0.041	4.338GluArg: 4.338 ± 0.057	2.028GluSer: 2.028 ± 0.04	4.416GluThr: 4.416 ± 0.065	4.319GluVal: 4.319 ± 0.066	0.693GluTrp: 0.693 ± 0.022	1.087GluTyr: 1.087 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.662PheAla: 4.662 ± 0.067	0.428PheCys: 0.428 ± 0.02	2.854PheAsp: 2.854 ± 0.049	2.367PheGlu: 2.367 ± 0.05	1.457PhePhe: 1.457 ± 0.044	3.647PheGly: 3.647 ± 0.056	0.747PheHis: 0.747 ± 0.025	1.589PheIle: 1.589 ± 0.037	0.785PheLys: 0.785 ± 0.026	3.571PheLeu: 3.571 ± 0.071	0.806PheMet: 0.806 ± 0.027	0.936PheAsn: 0.936 ± 0.028	1.581PhePro: 1.581 ± 0.034	1.021PheGln: 1.021 ± 0.028	2.32PheArg: 2.32 ± 0.043	2.036PheSer: 2.036 ± 0.041	2.146PheThr: 2.146 ± 0.045	2.671PheVal: 2.671 ± 0.047	0.606PheTrp: 0.606 ± 0.024	0.869PheTyr: 0.869 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.961GlyAla: 10.961 ± 0.109	0.871GlyCys: 0.871 ± 0.031	4.951GlyAsp: 4.951 ± 0.076	4.633GlyGlu: 4.633 ± 0.063	3.616GlyPhe: 3.616 ± 0.055	7.556GlyGly: 7.556 ± 0.105	1.958GlyHis: 1.958 ± 0.038	4.572GlyIle: 4.572 ± 0.059	2.625GlyLys: 2.625 ± 0.054	9.394GlyLeu: 9.394 ± 0.097	2.524GlyMet: 2.524 ± 0.045	2.0GlyAsn: 2.0 ± 0.055	4.129GlyPro: 4.129 ± 0.051	3.094GlyGln: 3.094 ± 0.049	6.123GlyArg: 6.123 ± 0.083	4.102GlySer: 4.102 ± 0.088	4.994GlyThr: 4.994 ± 0.077	6.14GlyVal: 6.14 ± 0.074	1.509GlyTrp: 1.509 ± 0.038	2.272GlyTyr: 2.272 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.508HisAla: 2.508 ± 0.046	0.243HisCys: 0.243 ± 0.014	1.307HisAsp: 1.307 ± 0.034	1.038HisGlu: 1.038 ± 0.03	0.788HisPhe: 0.788 ± 0.022	1.957HisGly: 1.957 ± 0.042	0.516HisHis: 0.516 ± 0.023	0.898HisIle: 0.898 ± 0.026	0.47HisLys: 0.47 ± 0.019	2.154HisLeu: 2.154 ± 0.045	0.511HisMet: 0.511 ± 0.021	0.421HisAsn: 0.421 ± 0.02	1.368HisPro: 1.368 ± 0.035	0.5HisGln: 0.5 ± 0.02	1.412HisArg: 1.412 ± 0.037	0.867HisSer: 0.867 ± 0.027	0.754HisThr: 0.754 ± 0.027	1.573HisVal: 1.573 ± 0.039	0.339HisTrp: 0.339 ± 0.018	0.551HisTyr: 0.551 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.412IleAla: 7.412 ± 0.082	0.537IleCys: 0.537 ± 0.02	3.593IleAsp: 3.593 ± 0.055	3.616IleGlu: 3.616 ± 0.054	1.807IlePhe: 1.807 ± 0.042	4.713IleGly: 4.713 ± 0.063	0.835IleHis: 0.835 ± 0.029	1.934IleIle: 1.934 ± 0.039	1.125IleLys: 1.125 ± 0.036	4.859IleLeu: 4.859 ± 0.085	0.991IleMet: 0.991 ± 0.031	1.177IleAsn: 1.177 ± 0.031	2.26IlePro: 2.26 ± 0.044	1.088IleGln: 1.088 ± 0.031	3.157IleArg: 3.157 ± 0.048	2.672IleSer: 2.672 ± 0.047	2.641IleThr: 2.641 ± 0.05	3.793IleVal: 3.793 ± 0.058	0.709IleTrp: 0.709 ± 0.027	1.127IleTyr: 1.127 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.568LysAla: 3.568 ± 0.063	0.162LysCys: 0.162 ± 0.01	1.53LysAsp: 1.53 ± 0.04	1.359LysGlu: 1.359 ± 0.038	0.757LysPhe: 0.757 ± 0.024	2.397LysGly: 2.397 ± 0.049	0.519LysHis: 0.519 ± 0.019	1.444LysIle: 1.444 ± 0.037	1.067LysLys: 1.067 ± 0.035	2.579LysLeu: 2.579 ± 0.053	0.77LysMet: 0.77 ± 0.027	0.688LysAsn: 0.688 ± 0.022	1.619LysPro: 1.619 ± 0.045	0.678LysGln: 0.678 ± 0.027	2.089LysArg: 2.089 ± 0.046	1.602LysSer: 1.602 ± 0.037	1.866LysThr: 1.866 ± 0.042	1.964LysVal: 1.964 ± 0.048	0.324LysTrp: 0.324 ± 0.017	0.566LysTyr: 0.566 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.044LeuAla: 13.044 ± 0.145	1.009LeuCys: 1.009 ± 0.027	6.334LeuAsp: 6.334 ± 0.073	5.439LeuGlu: 5.439 ± 0.074	3.646LeuPhe: 3.646 ± 0.06	8.694LeuGly: 8.694 ± 0.097	1.866LeuHis: 1.866 ± 0.042	5.048LeuIle: 5.048 ± 0.071	2.945LeuLys: 2.945 ± 0.056	8.772LeuLeu: 8.772 ± 0.105	2.612LeuMet: 2.612 ± 0.05	2.401LeuAsn: 2.401 ± 0.046	5.72LeuPro: 5.72 ± 0.069	2.684LeuGln: 2.684 ± 0.047	7.342LeuArg: 7.342 ± 0.084	6.824LeuSer: 6.824 ± 0.083	5.771LeuThr: 5.771 ± 0.07	6.837LeuVal: 6.837 ± 0.087	1.429LeuTrp: 1.429 ± 0.038	2.048LeuTyr: 2.048 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.563MetAla: 3.563 ± 0.057	0.185MetCys: 0.185 ± 0.012	1.302MetAsp: 1.302 ± 0.029	1.237MetGlu: 1.237 ± 0.033	0.772MetPhe: 0.772 ± 0.031	2.203MetGly: 2.203 ± 0.04	0.467MetHis: 0.467 ± 0.017	1.473MetIle: 1.473 ± 0.036	0.959MetLys: 0.959 ± 0.026	2.516MetLeu: 2.516 ± 0.049	0.704MetMet: 0.704 ± 0.028	0.796MetAsn: 0.796 ± 0.027	1.59MetPro: 1.59 ± 0.036	0.933MetGln: 0.933 ± 0.028	2.019MetArg: 2.019 ± 0.043	1.775MetSer: 1.775 ± 0.038	1.987MetThr: 1.987 ± 0.042	1.73MetVal: 1.73 ± 0.039	0.225MetTrp: 0.225 ± 0.015	0.312MetTyr: 0.312 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.01AsnAla: 3.01 ± 0.049	0.231AsnCys: 0.231 ± 0.013	1.394AsnAsp: 1.394 ± 0.04	1.051AsnGlu: 1.051 ± 0.029	0.917AsnPhe: 0.917 ± 0.028	2.112AsnGly: 2.112 ± 0.05	0.454AsnHis: 0.454 ± 0.02	1.235AsnIle: 1.235 ± 0.034	0.53AsnLys: 0.53 ± 0.02	2.308AsnLeu: 2.308 ± 0.051	0.599AsnMet: 0.599 ± 0.022	0.606AsnAsn: 0.606 ± 0.023	1.723AsnPro: 1.723 ± 0.041	0.622AsnGln: 0.622 ± 0.023	1.634AsnArg: 1.634 ± 0.034	1.0AsnSer: 1.0 ± 0.028	1.189AsnThr: 1.189 ± 0.033	1.785AsnVal: 1.785 ± 0.04	0.385AsnTrp: 0.385 ± 0.02	0.621AsnTyr: 0.621 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.365ProAla: 6.365 ± 0.082	0.355ProCys: 0.355 ± 0.016	4.377ProAsp: 4.377 ± 0.057	4.617ProGlu: 4.617 ± 0.064	2.062ProPhe: 2.062 ± 0.042	5.066ProGly: 5.066 ± 0.067	1.045ProHis: 1.045 ± 0.027	2.222ProIle: 2.222 ± 0.041	1.531ProLys: 1.531 ± 0.042	4.639ProLeu: 4.639 ± 0.075	1.287ProMet: 1.287 ± 0.036	1.22ProAsn: 1.22 ± 0.029	2.578ProPro: 2.578 ± 0.057	1.578ProGln: 1.578 ± 0.039	3.256ProArg: 3.256 ± 0.059	2.537ProSer: 2.537 ± 0.041	2.294ProThr: 2.294 ± 0.04	4.282ProVal: 4.282 ± 0.059	0.684ProTrp: 0.684 ± 0.025	1.104ProTyr: 1.104 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.806GlnAla: 3.806 ± 0.063	0.201GlnCys: 0.201 ± 0.011	1.625GlnAsp: 1.625 ± 0.036	1.549GlnGlu: 1.549 ± 0.039	0.959GlnPhe: 0.959 ± 0.027	2.575GlnGly: 2.575 ± 0.048	0.54GlnHis: 0.54 ± 0.019	1.786GlnIle: 1.786 ± 0.038	0.936GlnLys: 0.936 ± 0.028	2.54GlnLeu: 2.54 ± 0.047	0.927GlnMet: 0.927 ± 0.028	0.839GlnAsn: 0.839 ± 0.027	1.561GlnPro: 1.561 ± 0.033	0.856GlnGln: 0.856 ± 0.033	2.022GlnArg: 2.022 ± 0.04	1.746GlnSer: 1.746 ± 0.038	1.747GlnThr: 1.747 ± 0.033	2.197GlnVal: 2.197 ± 0.042	0.377GlnTrp: 0.377 ± 0.017	0.516GlnTyr: 0.516 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.489ArgAla: 9.489 ± 0.109	0.495ArgCys: 0.495 ± 0.022	4.839ArgAsp: 4.839 ± 0.06	3.98ArgGlu: 3.98 ± 0.057	2.888ArgPhe: 2.888 ± 0.05	4.897ArgGly: 4.897 ± 0.068	1.678ArgHis: 1.678 ± 0.038	4.113ArgIle: 4.113 ± 0.058	2.042ArgLys: 2.042 ± 0.037	7.716ArgLeu: 7.716 ± 0.108	2.044ArgMet: 2.044 ± 0.041	1.694ArgAsn: 1.694 ± 0.033	3.609ArgPro: 3.609 ± 0.061	2.237ArgGln: 2.237 ± 0.042	5.551ArgArg: 5.551 ± 0.091	3.239ArgSer: 3.239 ± 0.048	3.154ArgThr: 3.154 ± 0.049	5.03ArgVal: 5.03 ± 0.059	0.997ArgTrp: 0.997 ± 0.028	1.571ArgTyr: 1.571 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.899SerAla: 5.899 ± 0.067	0.413SerCys: 0.413 ± 0.02	3.272SerAsp: 3.272 ± 0.055	3.038SerGlu: 3.038 ± 0.048	2.136SerPhe: 2.136 ± 0.043	5.312SerGly: 5.312 ± 0.092	1.017SerHis: 1.017 ± 0.03	2.312SerIle: 2.312 ± 0.039	1.32SerLys: 1.32 ± 0.032	4.797SerLeu: 4.797 ± 0.067	1.226SerMet: 1.226 ± 0.031	1.232SerAsn: 1.232 ± 0.033	2.432SerPro: 2.432 ± 0.039	1.455SerGln: 1.455 ± 0.039	3.285SerArg: 3.285 ± 0.052	2.316SerSer: 2.316 ± 0.047	2.2SerThr: 2.2 ± 0.043	3.769SerVal: 3.769 ± 0.06	0.69SerTrp: 0.69 ± 0.027	1.215SerTyr: 1.215 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.243ThrAla: 6.243 ± 0.081	0.482ThrCys: 0.482 ± 0.02	3.204ThrAsp: 3.204 ± 0.046	3.304ThrGlu: 3.304 ± 0.05	2.008ThrPhe: 2.008 ± 0.039	5.609ThrGly: 5.609 ± 0.069	1.117ThrHis: 1.117 ± 0.032	2.621ThrIle: 2.621 ± 0.045	1.3ThrLys: 1.3 ± 0.042	6.303ThrLeu: 6.303 ± 0.064	1.244ThrMet: 1.244 ± 0.031	1.222ThrAsn: 1.222 ± 0.035	3.393ThrPro: 3.393 ± 0.05	1.481ThrGln: 1.481 ± 0.041	3.871ThrArg: 3.871 ± 0.057	2.527ThrSer: 2.527 ± 0.045	2.634ThrThr: 2.634 ± 0.052	3.882ThrVal: 3.882 ± 0.056	0.681ThrTrp: 0.681 ± 0.028	1.206ThrTyr: 1.206 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.114ValAla: 9.114 ± 0.094	0.635ValCys: 0.635 ± 0.027	3.904ValAsp: 3.904 ± 0.06	4.246ValGlu: 4.246 ± 0.061	2.822ValPhe: 2.822 ± 0.056	5.24ValGly: 5.24 ± 0.073	1.338ValHis: 1.338 ± 0.035	3.958ValIle: 3.958 ± 0.065	1.833ValLys: 1.833 ± 0.04	7.324ValLeu: 7.324 ± 0.081	2.015ValMet: 2.015 ± 0.045	1.714ValAsn: 1.714 ± 0.042	3.724ValPro: 3.724 ± 0.062	1.879ValGln: 1.879 ± 0.035	4.356ValArg: 4.356 ± 0.054	4.089ValSer: 4.089 ± 0.053	4.89ValThr: 4.89 ± 0.068	5.302ValVal: 5.302 ± 0.084	0.953ValTrp: 0.953 ± 0.031	1.45ValTyr: 1.45 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.491TrpAla: 1.491 ± 0.039	0.132TrpCys: 0.132 ± 0.011	0.791TrpAsp: 0.791 ± 0.028	0.661TrpGlu: 0.661 ± 0.022	0.569TrpPhe: 0.569 ± 0.024	1.066TrpGly: 1.066 ± 0.035	0.333TrpHis: 0.333 ± 0.018	0.73TrpIle: 0.73 ± 0.024	0.408TrpLys: 0.408 ± 0.017	1.601TrpLeu: 1.601 ± 0.038	0.398TrpMet: 0.398 ± 0.017	0.413TrpAsn: 0.413 ± 0.017	0.727TrpPro: 0.727 ± 0.027	0.615TrpGln: 0.615 ± 0.021	1.19TrpArg: 1.19 ± 0.031	0.813TrpSer: 0.813 ± 0.027	0.862TrpThr: 0.862 ± 0.029	0.883TrpVal: 0.883 ± 0.027	0.222TrpTrp: 0.222 ± 0.013	0.262TrpTyr: 0.262 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.564TyrAla: 2.564 ± 0.043	0.232TyrCys: 0.232 ± 0.013	1.591TyrAsp: 1.591 ± 0.04	1.281TyrGlu: 1.281 ± 0.032	0.89TyrPhe: 0.89 ± 0.024	2.057TyrGly: 2.057 ± 0.04	0.481TyrHis: 0.481 ± 0.02	0.899TyrIle: 0.899 ± 0.029	0.516TyrLys: 0.516 ± 0.019	2.287TyrLeu: 2.287 ± 0.034	0.445TyrMet: 0.445 ± 0.019	0.509TyrAsn: 0.509 ± 0.021	1.048TyrPro: 1.048 ± 0.028	0.602TyrGln: 0.602 ± 0.024	1.576TyrArg: 1.576 ± 0.035	1.122TyrSer: 1.122 ± 0.033	1.078TyrThr: 1.078 ± 0.029	1.467TyrVal: 1.467 ± 0.036	0.36TyrTrp: 0.36 ± 0.017	0.545TyrTyr: 0.545 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4153 proteins (1304865 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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