Amino acid dipepetide frequency for Microvirga brassicacearum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.991AlaAla: 15.991 ± 0.131
1.019AlaCys: 1.019 ± 0.027
6.452AlaAsp: 6.452 ± 0.077
6.878AlaGlu: 6.878 ± 0.082
4.743AlaPhe: 4.743 ± 0.066
10.15AlaGly: 10.15 ± 0.089
2.125AlaHis: 2.125 ± 0.042
6.817AlaIle: 6.817 ± 0.066
4.005AlaLys: 4.005 ± 0.061
13.135AlaLeu: 13.135 ± 0.128
3.268AlaMet: 3.268 ± 0.047
2.899AlaAsn: 2.899 ± 0.056
5.268AlaPro: 5.268 ± 0.068
3.846AlaGln: 3.846 ± 0.055
8.377AlaArg: 8.377 ± 0.087
6.575AlaSer: 6.575 ± 0.079
6.103AlaThr: 6.103 ± 0.063
8.792AlaVal: 8.792 ± 0.091
1.392AlaTrp: 1.392 ± 0.032
2.598AlaTyr: 2.598 ± 0.048
0.001AlaXaa: 0.001 ± 0.001
Cys
0.881CysAla: 0.881 ± 0.026
0.096CysCys: 0.096 ± 0.007
0.487CysAsp: 0.487 ± 0.019
0.405CysGlu: 0.405 ± 0.016
0.321CysPhe: 0.321 ± 0.015
0.844CysGly: 0.844 ± 0.026
0.243CysHis: 0.243 ± 0.013
0.401CysIle: 0.401 ± 0.016
0.156CysLys: 0.156 ± 0.009
0.788CysLeu: 0.788 ± 0.023
0.132CysMet: 0.132 ± 0.01
0.193CysAsn: 0.193 ± 0.012
0.415CysPro: 0.415 ± 0.018
0.198CysGln: 0.198 ± 0.011
0.633CysArg: 0.633 ± 0.022
0.43CysSer: 0.43 ± 0.016
0.394CysThr: 0.394 ± 0.018
0.574CysVal: 0.574 ± 0.022
0.107CysTrp: 0.107 ± 0.007
0.153CysTyr: 0.153 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.583AspAla: 6.583 ± 0.08
0.412AspCys: 0.412 ± 0.017
3.039AspAsp: 3.039 ± 0.055
3.577AspGlu: 3.577 ± 0.047
2.15AspPhe: 2.15 ± 0.04
5.036AspGly: 5.036 ± 0.073
1.171AspHis: 1.171 ± 0.03
2.96AspIle: 2.96 ± 0.052
1.697AspLys: 1.697 ± 0.039
6.255AspLeu: 6.255 ± 0.068
1.229AspMet: 1.229 ± 0.028
1.286AspAsn: 1.286 ± 0.042
3.595AspPro: 3.595 ± 0.052
1.704AspGln: 1.704 ± 0.037
4.415AspArg: 4.415 ± 0.067
2.255AspSer: 2.255 ± 0.042
2.552AspThr: 2.552 ± 0.06
4.332AspVal: 4.332 ± 0.055
0.873AspTrp: 0.873 ± 0.022
1.332AspTyr: 1.332 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.258GluAla: 7.258 ± 0.075
0.349GluCys: 0.349 ± 0.018
2.566GluAsp: 2.566 ± 0.044
2.916GluGlu: 2.916 ± 0.057
1.8GluPhe: 1.8 ± 0.036
4.247GluGly: 4.247 ± 0.062
1.159GluHis: 1.159 ± 0.03
3.628GluIle: 3.628 ± 0.051
2.1GluLys: 2.1 ± 0.044
5.018GluLeu: 5.018 ± 0.06
1.395GluMet: 1.395 ± 0.034
1.564GluAsn: 1.564 ± 0.035
2.948GluPro: 2.948 ± 0.047
2.015GluGln: 2.015 ± 0.035
5.193GluArg: 5.193 ± 0.072
2.56GluSer: 2.56 ± 0.044
3.442GluThr: 3.442 ± 0.044
3.655GluVal: 3.655 ± 0.052
0.721GluTrp: 0.721 ± 0.024
0.937GluTyr: 0.937 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.52PheAla: 4.52 ± 0.064
0.364PheCys: 0.364 ± 0.017
2.6PheAsp: 2.6 ± 0.042
2.158PheGlu: 2.158 ± 0.04
1.478PhePhe: 1.478 ± 0.031
3.764PheGly: 3.764 ± 0.055
0.799PheHis: 0.799 ± 0.02
1.84PheIle: 1.84 ± 0.043
1.062PheLys: 1.062 ± 0.029
3.522PheLeu: 3.522 ± 0.059
0.82PheMet: 0.82 ± 0.024
1.042PheAsn: 1.042 ± 0.028
1.665PhePro: 1.665 ± 0.033
1.105PheGln: 1.105 ± 0.028
2.455PheArg: 2.455 ± 0.041
2.329PheSer: 2.329 ± 0.041
2.069PheThr: 2.069 ± 0.044
3.06PheVal: 3.06 ± 0.05
0.6PheTrp: 0.6 ± 0.021
0.892PheTyr: 0.892 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.096GlyAla: 9.096 ± 0.081
0.81GlyCys: 0.81 ± 0.024
4.55GlyAsp: 4.55 ± 0.074
4.665GlyGlu: 4.665 ± 0.064
3.672GlyPhe: 3.672 ± 0.054
7.465GlyGly: 7.465 ± 0.111
1.812GlyHis: 1.812 ± 0.035
4.852GlyIle: 4.852 ± 0.061
3.129GlyLys: 3.129 ± 0.054
9.128GlyLeu: 9.128 ± 0.093
2.086GlyMet: 2.086 ± 0.039
2.409GlyAsn: 2.409 ± 0.068
3.639GlyPro: 3.639 ± 0.053
2.801GlyGln: 2.801 ± 0.052
6.395GlyArg: 6.395 ± 0.064
5.08GlySer: 5.08 ± 0.067
4.801GlyThr: 4.801 ± 0.083
5.999GlyVal: 5.999 ± 0.059
1.342GlyTrp: 1.342 ± 0.031
2.218GlyTyr: 2.218 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.257HisAla: 2.257 ± 0.036
0.205HisCys: 0.205 ± 0.013
1.204HisAsp: 1.204 ± 0.026
1.086HisGlu: 1.086 ± 0.028
0.793HisPhe: 0.793 ± 0.023
1.816HisGly: 1.816 ± 0.038
0.584HisHis: 0.584 ± 0.02
0.917HisIle: 0.917 ± 0.025
0.467HisLys: 0.467 ± 0.019
2.139HisLeu: 2.139 ± 0.046
0.449HisMet: 0.449 ± 0.019
0.457HisAsn: 0.457 ± 0.016
1.384HisPro: 1.384 ± 0.031
0.601HisGln: 0.601 ± 0.022
1.493HisArg: 1.493 ± 0.032
0.924HisSer: 0.924 ± 0.027
0.849HisThr: 0.849 ± 0.024
1.527HisVal: 1.527 ± 0.035
0.301HisTrp: 0.301 ± 0.015
0.499HisTyr: 0.499 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.469IleAla: 7.469 ± 0.092
0.502IleCys: 0.502 ± 0.021
3.573IleAsp: 3.573 ± 0.052
3.587IleGlu: 3.587 ± 0.051
1.834IlePhe: 1.834 ± 0.037
5.262IleGly: 5.262 ± 0.064
0.936IleHis: 0.936 ± 0.027
2.46IleIle: 2.46 ± 0.047
1.481IleLys: 1.481 ± 0.033
5.111IleLeu: 5.111 ± 0.062
1.077IleMet: 1.077 ± 0.026
1.372IleAsn: 1.372 ± 0.03
2.576IlePro: 2.576 ± 0.044
1.296IleGln: 1.296 ± 0.032
3.523IleArg: 3.523 ± 0.05
3.004IleSer: 3.004 ± 0.048
2.739IleThr: 2.739 ± 0.046
4.861IleVal: 4.861 ± 0.061
0.604IleTrp: 0.604 ± 0.02
1.167IleTyr: 1.167 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.186LysAla: 4.186 ± 0.061
0.16LysCys: 0.16 ± 0.01
1.77LysAsp: 1.77 ± 0.037
1.523LysGlu: 1.523 ± 0.043
0.918LysPhe: 0.918 ± 0.028
2.713LysGly: 2.713 ± 0.049
0.59LysHis: 0.59 ± 0.016
1.763LysIle: 1.763 ± 0.035
1.279LysLys: 1.279 ± 0.043
3.234LysLeu: 3.234 ± 0.054
0.717LysMet: 0.717 ± 0.021
0.94LysAsn: 0.94 ± 0.025
2.124LysPro: 2.124 ± 0.043
0.938LysGln: 0.938 ± 0.03
2.466LysArg: 2.466 ± 0.041
1.844LysSer: 1.844 ± 0.035
1.959LysThr: 1.959 ± 0.037
2.371LysVal: 2.371 ± 0.045
0.33LysTrp: 0.33 ± 0.014
0.562LysTyr: 0.562 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.273LeuAla: 13.273 ± 0.133
0.813LeuCys: 0.813 ± 0.023
6.157LeuAsp: 6.157 ± 0.067
5.205LeuGlu: 5.205 ± 0.067
3.677LeuPhe: 3.677 ± 0.06
8.644LeuGly: 8.644 ± 0.093
1.857LeuHis: 1.857 ± 0.039
5.272LeuIle: 5.272 ± 0.068
3.663LeuLys: 3.663 ± 0.049
9.672LeuLeu: 9.672 ± 0.118
2.351LeuMet: 2.351 ± 0.04
2.632LeuAsn: 2.632 ± 0.039
5.49LeuPro: 5.49 ± 0.07
2.81LeuGln: 2.81 ± 0.045
7.007LeuArg: 7.007 ± 0.079
6.743LeuSer: 6.743 ± 0.075
5.685LeuThr: 5.685 ± 0.065
8.15LeuVal: 8.15 ± 0.088
1.187LeuTrp: 1.187 ± 0.028
2.084LeuTyr: 2.084 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.84MetAla: 2.84 ± 0.049
0.145MetCys: 0.145 ± 0.011
1.074MetAsp: 1.074 ± 0.028
1.002MetGlu: 1.002 ± 0.026
0.674MetPhe: 0.674 ± 0.019
1.754MetGly: 1.754 ± 0.039
0.421MetHis: 0.421 ± 0.015
1.368MetIle: 1.368 ± 0.033
0.968MetLys: 0.968 ± 0.028
2.285MetLeu: 2.285 ± 0.044
0.676MetMet: 0.676 ± 0.022
0.807MetAsn: 0.807 ± 0.022
1.406MetPro: 1.406 ± 0.036
0.726MetGln: 0.726 ± 0.027
1.937MetArg: 1.937 ± 0.036
1.701MetSer: 1.701 ± 0.033
1.87MetThr: 1.87 ± 0.034
1.653MetVal: 1.653 ± 0.039
0.195MetTrp: 0.195 ± 0.013
0.305MetTyr: 0.305 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.159AsnAla: 3.159 ± 0.05
0.204AsnCys: 0.204 ± 0.013
1.598AsnAsp: 1.598 ± 0.051
1.316AsnGlu: 1.316 ± 0.03
0.976AsnPhe: 0.976 ± 0.031
2.451AsnGly: 2.451 ± 0.054
0.483AsnHis: 0.483 ± 0.019
1.301AsnIle: 1.301 ± 0.034
0.771AsnLys: 0.771 ± 0.025
2.841AsnLeu: 2.841 ± 0.044
0.554AsnMet: 0.554 ± 0.023
0.705AsnAsn: 0.705 ± 0.023
1.881AsnPro: 1.881 ± 0.038
0.697AsnGln: 0.697 ± 0.022
1.847AsnArg: 1.847 ± 0.034
1.301AsnSer: 1.301 ± 0.034
1.277AsnThr: 1.277 ± 0.032
2.106AsnVal: 2.106 ± 0.043
0.413AsnTrp: 0.413 ± 0.02
0.668AsnTyr: 0.668 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
5.982ProAla: 5.982 ± 0.07
0.296ProCys: 0.296 ± 0.014
3.51ProAsp: 3.51 ± 0.051
3.424ProGlu: 3.424 ± 0.049
2.108ProPhe: 2.108 ± 0.044
4.487ProGly: 4.487 ± 0.061
1.132ProHis: 1.132 ± 0.027
2.571ProIle: 2.571 ± 0.038
1.755ProLys: 1.755 ± 0.034
4.842ProLeu: 4.842 ± 0.06
1.172ProMet: 1.172 ± 0.028
1.536ProAsn: 1.536 ± 0.033
2.648ProPro: 2.648 ± 0.052
1.578ProGln: 1.578 ± 0.036
3.169ProArg: 3.169 ± 0.056
3.091ProSer: 3.091 ± 0.047
2.737ProThr: 2.737 ± 0.046
4.19ProVal: 4.19 ± 0.059
0.696ProTrp: 0.696 ± 0.025
1.225ProTyr: 1.225 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.888GlnAla: 3.888 ± 0.056
0.165GlnCys: 0.165 ± 0.009
1.5GlnAsp: 1.5 ± 0.037
1.519GlnGlu: 1.519 ± 0.034
1.058GlnPhe: 1.058 ± 0.026
2.371GlnGly: 2.371 ± 0.037
0.64GlnHis: 0.64 ± 0.021
1.875GlnIle: 1.875 ± 0.031
1.019GlnLys: 1.019 ± 0.027
2.654GlnLeu: 2.654 ± 0.043
0.789GlnMet: 0.789 ± 0.023
0.894GlnAsn: 0.894 ± 0.03
1.639GlnPro: 1.639 ± 0.032
1.139GlnGln: 1.139 ± 0.031
2.437GlnArg: 2.437 ± 0.045
1.787GlnSer: 1.787 ± 0.032
1.659GlnThr: 1.659 ± 0.039
2.264GlnVal: 2.264 ± 0.046
0.385GlnTrp: 0.385 ± 0.016
0.585GlnTyr: 0.585 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
7.979ArgAla: 7.979 ± 0.088
0.539ArgCys: 0.539 ± 0.02
4.182ArgAsp: 4.182 ± 0.054
4.262ArgGlu: 4.262 ± 0.055
3.013ArgPhe: 3.013 ± 0.05
4.929ArgGly: 4.929 ± 0.059
1.705ArgHis: 1.705 ± 0.041
4.365ArgIle: 4.365 ± 0.059
2.208ArgLys: 2.208 ± 0.04
8.073ArgLeu: 8.073 ± 0.076
1.89ArgMet: 1.89 ± 0.034
1.937ArgAsn: 1.937 ± 0.035
3.661ArgPro: 3.661 ± 0.072
2.584ArgGln: 2.584 ± 0.047
5.834ArgArg: 5.834 ± 0.082
3.973ArgSer: 3.973 ± 0.049
3.51ArgThr: 3.51 ± 0.05
5.118ArgVal: 5.118 ± 0.057
1.018ArgTrp: 1.018 ± 0.027
1.75ArgTyr: 1.75 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.224SerAla: 6.224 ± 0.073
0.408SerCys: 0.408 ± 0.018
3.133SerAsp: 3.133 ± 0.051
2.936SerGlu: 2.936 ± 0.043
2.403SerPhe: 2.403 ± 0.04
5.865SerGly: 5.865 ± 0.082
1.13SerHis: 1.13 ± 0.024
3.096SerIle: 3.096 ± 0.046
1.645SerLys: 1.645 ± 0.039
5.892SerLeu: 5.892 ± 0.069
1.303SerMet: 1.303 ± 0.033
1.426SerAsn: 1.426 ± 0.032
2.974SerPro: 2.974 ± 0.045
1.612SerGln: 1.612 ± 0.035
3.944SerArg: 3.944 ± 0.047
3.158SerSer: 3.158 ± 0.052
2.882SerThr: 2.882 ± 0.05
4.085SerVal: 4.085 ± 0.052
0.772SerTrp: 0.772 ± 0.026
1.294SerTyr: 1.294 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
5.983ThrAla: 5.983 ± 0.074
0.409ThrCys: 0.409 ± 0.016
2.782ThrAsp: 2.782 ± 0.049
2.654ThrGlu: 2.654 ± 0.047
2.201ThrPhe: 2.201 ± 0.044
5.111ThrGly: 5.111 ± 0.076
1.078ThrHis: 1.078 ± 0.027
3.311ThrIle: 3.311 ± 0.051
1.502ThrLys: 1.502 ± 0.039
6.072ThrLeu: 6.072 ± 0.084
1.247ThrMet: 1.247 ± 0.027
1.392ThrAsn: 1.392 ± 0.036
3.132ThrPro: 3.132 ± 0.042
1.397ThrGln: 1.397 ± 0.034
3.418ThrArg: 3.418 ± 0.049
3.006ThrSer: 3.006 ± 0.054
3.011ThrThr: 3.011 ± 0.054
4.313ThrVal: 4.313 ± 0.069
0.734ThrTrp: 0.734 ± 0.022
1.298ThrTyr: 1.298 ± 0.035
0.001ThrXaa: 0.001 ± 0.001
Val
9.238ValAla: 9.238 ± 0.081
0.602ValCys: 0.602 ± 0.019
4.206ValAsp: 4.206 ± 0.06
4.612ValGlu: 4.612 ± 0.06
2.909ValPhe: 2.909 ± 0.05
5.93ValGly: 5.93 ± 0.069
1.344ValHis: 1.344 ± 0.03
4.132ValIle: 4.132 ± 0.057
2.416ValLys: 2.416 ± 0.044
7.767ValLeu: 7.767 ± 0.085
1.899ValMet: 1.899 ± 0.035
1.974ValAsn: 1.974 ± 0.036
3.875ValPro: 3.875 ± 0.059
2.095ValGln: 2.095 ± 0.042
5.098ValArg: 5.098 ± 0.056
4.447ValSer: 4.447 ± 0.057
4.618ValThr: 4.618 ± 0.065
6.399ValVal: 6.399 ± 0.078
0.871ValTrp: 0.871 ± 0.025
1.501ValTyr: 1.501 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.154TrpAla: 1.154 ± 0.026
0.134TrpCys: 0.134 ± 0.01
0.666TrpAsp: 0.666 ± 0.023
0.538TrpGlu: 0.538 ± 0.019
0.52TrpPhe: 0.52 ± 0.019
0.947TrpGly: 0.947 ± 0.031
0.3TrpHis: 0.3 ± 0.013
0.648TrpIle: 0.648 ± 0.024
0.433TrpLys: 0.433 ± 0.018
1.657TrpLeu: 1.657 ± 0.037
0.329TrpMet: 0.329 ± 0.014
0.489TrpAsn: 0.489 ± 0.021
0.676TrpPro: 0.676 ± 0.024
0.483TrpGln: 0.483 ± 0.017
1.151TrpArg: 1.151 ± 0.026
0.853TrpSer: 0.853 ± 0.027
0.802TrpThr: 0.802 ± 0.027
0.794TrpVal: 0.794 ± 0.025
0.211TrpTrp: 0.211 ± 0.01
0.302TrpTyr: 0.302 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.471TyrAla: 2.471 ± 0.045
0.219TyrCys: 0.219 ± 0.013
1.402TyrAsp: 1.402 ± 0.036
1.208TyrGlu: 1.208 ± 0.03
0.899TyrPhe: 0.899 ± 0.024
2.165TyrGly: 2.165 ± 0.041
0.443TyrHis: 0.443 ± 0.02
0.855TyrIle: 0.855 ± 0.024
0.634TyrLys: 0.634 ± 0.021
2.287TyrLeu: 2.287 ± 0.039
0.42TyrMet: 0.42 ± 0.018
0.592TyrAsn: 0.592 ± 0.021
1.151TyrPro: 1.151 ± 0.028
0.644TyrGln: 0.644 ± 0.021
1.737TyrArg: 1.737 ± 0.035
1.119TyrSer: 1.119 ± 0.03
1.092TyrThr: 1.092 ± 0.032
1.692TyrVal: 1.692 ± 0.038
0.339TyrTrp: 0.339 ± 0.016
0.622TyrTyr: 0.622 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.002
Statistics based on 4754 proteins (1497474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski