Amino acid dipepetide frequency for Protomyces lactucaedebilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.705AlaAla: 10.705 ± 0.097	1.452AlaCys: 1.452 ± 0.025	4.807AlaAsp: 4.807 ± 0.045	5.592AlaGlu: 5.592 ± 0.055	3.466AlaPhe: 3.466 ± 0.038	6.214AlaGly: 6.214 ± 0.054	2.148AlaHis: 2.148 ± 0.027	4.584AlaIle: 4.584 ± 0.042	5.038AlaLys: 5.038 ± 0.057	9.414AlaLeu: 9.414 ± 0.072	2.324AlaMet: 2.324 ± 0.027	2.955AlaAsn: 2.955 ± 0.039	4.535AlaPro: 4.535 ± 0.057	4.516AlaGln: 4.516 ± 0.047	5.531AlaArg: 5.531 ± 0.05	8.316AlaSer: 8.316 ± 0.07	5.823AlaThr: 5.823 ± 0.048	5.836AlaVal: 5.836 ± 0.046	1.182AlaTrp: 1.182 ± 0.021	2.384AlaTyr: 2.384 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.199CysAla: 1.199 ± 0.02	0.31CysCys: 0.31 ± 0.011	0.735CysAsp: 0.735 ± 0.015	0.691CysGlu: 0.691 ± 0.016	0.669CysPhe: 0.669 ± 0.014	0.978CysGly: 0.978 ± 0.025	0.388CysHis: 0.388 ± 0.011	0.818CysIle: 0.818 ± 0.017	0.744CysLys: 0.744 ± 0.018	1.563CysLeu: 1.563 ± 0.032	0.347CysMet: 0.347 ± 0.011	0.507CysAsn: 0.507 ± 0.016	0.717CysPro: 0.717 ± 0.017	0.585CysGln: 0.585 ± 0.015	0.866CysArg: 0.866 ± 0.019	1.158CysSer: 1.158 ± 0.026	0.873CysThr: 0.873 ± 0.019	0.958CysVal: 0.958 ± 0.019	0.232CysTrp: 0.232 ± 0.01	0.459CysTyr: 0.459 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.859AspAla: 5.859 ± 0.056	0.731AspCys: 0.731 ± 0.018	3.711AspAsp: 3.711 ± 0.051	4.211AspGlu: 4.211 ± 0.045	2.155AspPhe: 2.155 ± 0.027	3.641AspGly: 3.641 ± 0.04	1.176AspHis: 1.176 ± 0.02	2.69AspIle: 2.69 ± 0.034	2.636AspLys: 2.636 ± 0.033	5.485AspLeu: 5.485 ± 0.048	1.357AspMet: 1.357 ± 0.023	1.567AspAsn: 1.567 ± 0.026	2.688AspPro: 2.688 ± 0.03	1.937AspGln: 1.937 ± 0.028	2.858AspArg: 2.858 ± 0.036	3.508AspSer: 3.508 ± 0.033	2.891AspThr: 2.891 ± 0.03	3.729AspVal: 3.729 ± 0.038	0.796AspTrp: 0.796 ± 0.017	1.578AspTyr: 1.578 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.125GluAla: 6.125 ± 0.061	0.703GluCys: 0.703 ± 0.017	3.78GluAsp: 3.78 ± 0.046	4.954GluGlu: 4.954 ± 0.06	1.709GluPhe: 1.709 ± 0.026	3.319GluGly: 3.319 ± 0.053	1.541GluHis: 1.541 ± 0.028	2.651GluIle: 2.651 ± 0.033	3.06GluLys: 3.06 ± 0.037	5.365GluLeu: 5.365 ± 0.05	1.468GluMet: 1.468 ± 0.023	1.663GluAsn: 1.663 ± 0.027	2.371GluPro: 2.371 ± 0.031	3.209GluGln: 3.209 ± 0.044	3.976GluArg: 3.976 ± 0.043	3.949GluSer: 3.949 ± 0.043	3.488GluThr: 3.488 ± 0.037	3.56GluVal: 3.56 ± 0.047	0.629GluTrp: 0.629 ± 0.014	1.501GluTyr: 1.501 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.474PheAla: 3.474 ± 0.039	0.687PheCys: 0.687 ± 0.018	2.348PheAsp: 2.348 ± 0.031	2.239PheGlu: 2.239 ± 0.028	1.64PhePhe: 1.64 ± 0.03	2.753PheGly: 2.753 ± 0.038	0.819PheHis: 0.819 ± 0.019	1.703PheIle: 1.703 ± 0.028	1.84PheLys: 1.84 ± 0.029	3.567PheLeu: 3.567 ± 0.05	0.848PheMet: 0.848 ± 0.016	1.367PheAsn: 1.367 ± 0.024	1.619PhePro: 1.619 ± 0.024	1.334PheGln: 1.334 ± 0.027	1.75PheArg: 1.75 ± 0.026	2.933PheSer: 2.933 ± 0.034	2.088PheThr: 2.088 ± 0.029	2.519PheVal: 2.519 ± 0.032	0.552PheTrp: 0.552 ± 0.016	1.103PheTyr: 1.103 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	5.105GlyAla: 5.105 ± 0.057	0.936GlyCys: 0.936 ± 0.021	3.272GlyAsp: 3.272 ± 0.039	3.215GlyGlu: 3.215 ± 0.034	2.594GlyPhe: 2.594 ± 0.033	4.711GlyGly: 4.711 ± 0.069	1.675GlyHis: 1.675 ± 0.029	3.228GlyIle: 3.228 ± 0.043	3.646GlyLys: 3.646 ± 0.051	5.965GlyLeu: 5.965 ± 0.042	1.452GlyMet: 1.452 ± 0.024	2.195GlyAsn: 2.195 ± 0.035	2.689GlyPro: 2.689 ± 0.031	2.9GlyGln: 2.9 ± 0.035	3.625GlyArg: 3.625 ± 0.041	5.253GlySer: 5.253 ± 0.052	3.79GlyThr: 3.79 ± 0.047	3.963GlyVal: 3.963 ± 0.043	0.858GlyTrp: 0.858 ± 0.02	1.948GlyTyr: 1.948 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.487HisAla: 2.487 ± 0.035	0.439HisCys: 0.439 ± 0.013	1.319HisAsp: 1.319 ± 0.026	1.361HisGlu: 1.361 ± 0.022	1.031HisPhe: 1.031 ± 0.018	1.763HisGly: 1.763 ± 0.03	0.792HisHis: 0.792 ± 0.022	1.244HisIle: 1.244 ± 0.022	1.081HisLys: 1.081 ± 0.021	2.538HisLeu: 2.538 ± 0.035	0.515HisMet: 0.515 ± 0.013	0.754HisAsn: 0.754 ± 0.016	1.389HisPro: 1.389 ± 0.027	1.019HisGln: 1.019 ± 0.021	1.445HisArg: 1.445 ± 0.026	1.692HisSer: 1.692 ± 0.027	1.356HisThr: 1.356 ± 0.023	1.61HisVal: 1.61 ± 0.023	0.337HisTrp: 0.337 ± 0.013	0.732HisTyr: 0.732 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	4.518IleAla: 4.518 ± 0.042	0.82IleCys: 0.82 ± 0.017	2.815IleAsp: 2.815 ± 0.034	2.834IleGlu: 2.834 ± 0.038	1.838IlePhe: 1.838 ± 0.032	2.912IleGly: 2.912 ± 0.04	1.182IleHis: 1.182 ± 0.023	2.166IleIle: 2.166 ± 0.034	2.491IleLys: 2.491 ± 0.032	4.65IleLeu: 4.65 ± 0.048	1.071IleMet: 1.071 ± 0.022	1.618IleAsn: 1.618 ± 0.026	2.364IlePro: 2.364 ± 0.03	2.037IleGln: 2.037 ± 0.028	2.622IleArg: 2.622 ± 0.033	3.415IleSer: 3.415 ± 0.034	2.633IleThr: 2.633 ± 0.036	3.14IleVal: 3.14 ± 0.039	0.627IleTrp: 0.627 ± 0.015	1.3IleTyr: 1.3 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.886LysAla: 4.886 ± 0.048	0.576LysCys: 0.576 ± 0.016	2.797LysAsp: 2.797 ± 0.037	3.311LysGlu: 3.311 ± 0.044	1.502LysPhe: 1.502 ± 0.025	2.661LysGly: 2.661 ± 0.034	1.441LysHis: 1.441 ± 0.023	2.217LysIle: 2.217 ± 0.029	3.171LysLys: 3.171 ± 0.05	4.909LysLeu: 4.909 ± 0.048	1.126LysMet: 1.126 ± 0.023	1.522LysAsn: 1.522 ± 0.023	2.534LysPro: 2.534 ± 0.038	2.86LysGln: 2.86 ± 0.037	3.77LysArg: 3.77 ± 0.041	3.517LysSer: 3.517 ± 0.038	3.133LysThr: 3.133 ± 0.038	3.129LysVal: 3.129 ± 0.041	0.515LysTrp: 0.515 ± 0.016	1.352LysTyr: 1.352 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	9.53LeuAla: 9.53 ± 0.067	1.605LeuCys: 1.605 ± 0.023	5.626LeuAsp: 5.626 ± 0.047	5.724LeuGlu: 5.724 ± 0.06	3.694LeuPhe: 3.694 ± 0.045	5.853LeuGly: 5.853 ± 0.054	2.439LeuHis: 2.439 ± 0.034	4.051LeuIle: 4.051 ± 0.046	4.837LeuLys: 4.837 ± 0.047	10.084LeuLeu: 10.084 ± 0.091	2.106LeuMet: 2.106 ± 0.03	3.112LeuAsn: 3.112 ± 0.038	5.441LeuPro: 5.441 ± 0.048	5.032LeuGln: 5.032 ± 0.063	5.727LeuArg: 5.727 ± 0.055	7.733LeuSer: 7.733 ± 0.066	5.39LeuThr: 5.39 ± 0.044	6.176LeuVal: 6.176 ± 0.056	1.145LeuTrp: 1.145 ± 0.024	2.609LeuTyr: 2.609 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.205MetAla: 2.205 ± 0.029	0.279MetCys: 0.279 ± 0.01	1.288MetAsp: 1.288 ± 0.021	1.224MetGlu: 1.224 ± 0.02	0.683MetPhe: 0.683 ± 0.017	1.254MetGly: 1.254 ± 0.021	0.641MetHis: 0.641 ± 0.014	0.941MetIle: 0.941 ± 0.02	1.034MetLys: 1.034 ± 0.018	2.395MetLeu: 2.395 ± 0.029	0.594MetMet: 0.594 ± 0.015	0.754MetAsn: 0.754 ± 0.017	1.423MetPro: 1.423 ± 0.021	1.308MetGln: 1.308 ± 0.021	1.433MetArg: 1.433 ± 0.023	2.047MetSer: 2.047 ± 0.027	1.515MetThr: 1.515 ± 0.024	1.271MetVal: 1.271 ± 0.023	0.193MetTrp: 0.193 ± 0.009	0.509MetTyr: 0.509 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.28AsnAla: 3.28 ± 0.039	0.434AsnCys: 0.434 ± 0.012	1.767AsnAsp: 1.767 ± 0.024	1.747AsnGlu: 1.747 ± 0.026	1.184AsnPhe: 1.184 ± 0.021	2.324AsnGly: 2.324 ± 0.029	0.743AsnHis: 0.743 ± 0.017	1.659AsnIle: 1.659 ± 0.026	1.68AsnLys: 1.68 ± 0.023	3.167AsnLeu: 3.167 ± 0.038	0.783AsnMet: 0.783 ± 0.019	1.129AsnAsn: 1.129 ± 0.023	1.766AsnPro: 1.766 ± 0.026	1.201AsnGln: 1.201 ± 0.022	1.583AsnArg: 1.583 ± 0.028	1.931AsnSer: 1.931 ± 0.027	1.866AsnThr: 1.866 ± 0.028	2.195AsnVal: 2.195 ± 0.034	0.436AsnTrp: 0.436 ± 0.011	0.912AsnTyr: 0.912 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.491ProAla: 5.491 ± 0.065	0.588ProCys: 0.588 ± 0.016	2.655ProAsp: 2.655 ± 0.03	3.084ProGlu: 3.084 ± 0.033	1.941ProPhe: 1.941 ± 0.027	3.258ProGly: 3.258 ± 0.04	1.066ProHis: 1.066 ± 0.022	2.418ProIle: 2.418 ± 0.03	2.395ProLys: 2.395 ± 0.034	4.511ProLeu: 4.511 ± 0.041	1.061ProMet: 1.061 ± 0.024	1.57ProAsn: 1.57 ± 0.026	3.274ProPro: 3.274 ± 0.071	2.193ProGln: 2.193 ± 0.036	2.755ProArg: 2.755 ± 0.038	4.684ProSer: 4.684 ± 0.058	3.264ProThr: 3.264 ± 0.044	3.653ProVal: 3.653 ± 0.043	0.588ProTrp: 0.588 ± 0.018	1.249ProTyr: 1.249 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.867GlnAla: 4.867 ± 0.05	0.625GlnCys: 0.625 ± 0.017	2.46GlnAsp: 2.46 ± 0.036	2.91GlnGlu: 2.91 ± 0.035	1.491GlnPhe: 1.491 ± 0.022	2.792GlnGly: 2.792 ± 0.036	1.407GlnHis: 1.407 ± 0.024	2.099GlnIle: 2.099 ± 0.031	2.086GlnLys: 2.086 ± 0.034	4.406GlnLeu: 4.406 ± 0.044	1.069GlnMet: 1.069 ± 0.021	1.308GlnAsn: 1.308 ± 0.022	2.436GlnPro: 2.436 ± 0.038	3.777GlnGln: 3.777 ± 0.093	3.124GlnArg: 3.124 ± 0.037	3.423GlnSer: 3.423 ± 0.042	2.605GlnThr: 2.605 ± 0.031	3.16GlnVal: 3.16 ± 0.039	0.482GlnTrp: 0.482 ± 0.016	1.213GlnTyr: 1.213 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.904ArgAla: 4.904 ± 0.046	0.839ArgCys: 0.839 ± 0.017	3.127ArgAsp: 3.127 ± 0.04	3.392ArgGlu: 3.392 ± 0.044	2.247ArgPhe: 2.247 ± 0.031	3.261ArgGly: 3.261 ± 0.044	1.689ArgHis: 1.689 ± 0.025	2.956ArgIle: 2.956 ± 0.035	3.39ArgLys: 3.39 ± 0.04	5.747ArgLeu: 5.747 ± 0.053	1.352ArgMet: 1.352 ± 0.021	1.937ArgAsn: 1.937 ± 0.029	3.238ArgPro: 3.238 ± 0.041	3.2ArgGln: 3.2 ± 0.037	4.443ArgArg: 4.443 ± 0.055	4.487ArgSer: 4.487 ± 0.058	3.226ArgThr: 3.226 ± 0.035	3.371ArgVal: 3.371 ± 0.036	0.747ArgTrp: 0.747 ± 0.017	1.641ArgTyr: 1.641 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	7.23SerAla: 7.23 ± 0.06	1.053SerCys: 1.053 ± 0.024	3.928SerAsp: 3.928 ± 0.042	3.746SerGlu: 3.746 ± 0.036	2.957SerPhe: 2.957 ± 0.036	5.141SerGly: 5.141 ± 0.055	1.841SerHis: 1.841 ± 0.026	3.887SerIle: 3.887 ± 0.037	3.866SerLys: 3.866 ± 0.04	7.655SerLeu: 7.655 ± 0.067	1.855SerMet: 1.855 ± 0.03	2.481SerAsn: 2.481 ± 0.032	4.432SerPro: 4.432 ± 0.064	3.383SerGln: 3.383 ± 0.042	4.519SerArg: 4.519 ± 0.051	7.698SerSer: 7.698 ± 0.092	5.194SerThr: 5.194 ± 0.057	4.589SerVal: 4.589 ± 0.044	0.962SerTrp: 0.962 ± 0.022	1.869SerTyr: 1.869 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.608ThrAla: 5.608 ± 0.049	0.954ThrCys: 0.954 ± 0.02	2.832ThrAsp: 2.832 ± 0.037	2.963ThrGlu: 2.963 ± 0.034	2.278ThrPhe: 2.278 ± 0.029	4.026ThrGly: 4.026 ± 0.042	1.367ThrHis: 1.367 ± 0.023	2.886ThrIle: 2.886 ± 0.034	2.679ThrLys: 2.679 ± 0.032	6.011ThrLeu: 6.011 ± 0.055	1.304ThrMet: 1.304 ± 0.022	1.766ThrAsn: 1.766 ± 0.027	3.587ThrPro: 3.587 ± 0.048	2.504ThrGln: 2.504 ± 0.034	3.348ThrArg: 3.348 ± 0.037	4.967ThrSer: 4.967 ± 0.051	4.09ThrThr: 4.09 ± 0.055	3.702ThrVal: 3.702 ± 0.043	0.775ThrTrp: 0.775 ± 0.017	1.466ThrTyr: 1.466 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	5.991ValAla: 5.991 ± 0.054	1.039ValCys: 1.039 ± 0.023	3.698ValAsp: 3.698 ± 0.044	3.753ValGlu: 3.753 ± 0.045	2.431ValPhe: 2.431 ± 0.035	3.64ValGly: 3.64 ± 0.04	1.507ValHis: 1.507 ± 0.024	2.895ValIle: 2.895 ± 0.039	3.26ValLys: 3.26 ± 0.038	6.509ValLeu: 6.509 ± 0.053	1.446ValMet: 1.446 ± 0.022	2.044ValAsn: 2.044 ± 0.029	3.485ValPro: 3.485 ± 0.038	2.932ValGln: 2.932 ± 0.035	3.46ValArg: 3.46 ± 0.041	4.832ValSer: 4.832 ± 0.046	3.425ValThr: 3.425 ± 0.04	4.358ValVal: 4.358 ± 0.048	0.747ValTrp: 0.747 ± 0.016	1.718ValTyr: 1.718 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	0.894TrpAla: 0.894 ± 0.018	0.215TrpCys: 0.215 ± 0.009	0.673TrpAsp: 0.673 ± 0.017	0.57TrpGlu: 0.57 ± 0.015	0.503TrpPhe: 0.503 ± 0.016	0.574TrpGly: 0.574 ± 0.017	0.394TrpHis: 0.394 ± 0.013	0.658TrpIle: 0.658 ± 0.018	0.572TrpLys: 0.572 ± 0.015	1.312TrpLeu: 1.312 ± 0.026	0.303TrpMet: 0.303 ± 0.01	0.46TrpAsn: 0.46 ± 0.014	0.526TrpPro: 0.526 ± 0.013	0.78TrpGln: 0.78 ± 0.018	0.878TrpArg: 0.878 ± 0.022	0.991TrpSer: 0.991 ± 0.025	0.852TrpThr: 0.852 ± 0.018	0.663TrpVal: 0.663 ± 0.017	0.188TrpTrp: 0.188 ± 0.008	0.384TrpTyr: 0.384 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.462TyrAla: 2.462 ± 0.03	0.514TyrCys: 0.514 ± 0.012	1.567TyrAsp: 1.567 ± 0.024	1.502TyrGlu: 1.502 ± 0.024	1.169TyrPhe: 1.169 ± 0.023	1.944TyrGly: 1.944 ± 0.034	0.647TyrHis: 0.647 ± 0.017	1.304TyrIle: 1.304 ± 0.023	1.418TyrLys: 1.418 ± 0.022	2.66TyrLeu: 2.66 ± 0.035	0.609TyrMet: 0.609 ± 0.014	1.076TyrAsn: 1.076 ± 0.023	1.186TyrPro: 1.186 ± 0.026	1.031TyrGln: 1.031 ± 0.02	1.483TyrArg: 1.483 ± 0.023	1.754TyrSer: 1.754 ± 0.026	1.612TyrThr: 1.612 ± 0.027	1.587TyrVal: 1.587 ± 0.026	0.401TyrTrp: 0.401 ± 0.014	0.862TyrTyr: 0.862 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6702 proteins (2729480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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