Amino acid dipepetide frequency for Zhihengliuella halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.886AlaAla: 21.886 ± 0.252	0.868AlaCys: 0.868 ± 0.029	8.344AlaAsp: 8.344 ± 0.087	9.27AlaGlu: 9.27 ± 0.12	3.963AlaPhe: 3.963 ± 0.057	13.539AlaGly: 13.539 ± 0.148	2.513AlaHis: 2.513 ± 0.05	5.044AlaIle: 5.044 ± 0.077	2.905AlaLys: 2.905 ± 0.056	13.073AlaLeu: 13.073 ± 0.146	2.798AlaMet: 2.798 ± 0.052	2.54AlaAsn: 2.54 ± 0.056	6.487AlaPro: 6.487 ± 0.102	3.665AlaGln: 3.665 ± 0.06	8.628AlaArg: 8.628 ± 0.111	7.134AlaSer: 7.134 ± 0.084	7.158AlaThr: 7.158 ± 0.086	11.375AlaVal: 11.375 ± 0.133	1.893AlaTrp: 1.893 ± 0.041	2.409AlaTyr: 2.409 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.759CysAla: 0.759 ± 0.028	0.067CysCys: 0.067 ± 0.009	0.355CysAsp: 0.355 ± 0.019	0.346CysGlu: 0.346 ± 0.017	0.184CysPhe: 0.184 ± 0.012	0.679CysGly: 0.679 ± 0.025	0.147CysHis: 0.147 ± 0.012	0.204CysIle: 0.204 ± 0.015	0.076CysLys: 0.076 ± 0.009	0.58CysLeu: 0.58 ± 0.023	0.103CysMet: 0.103 ± 0.01	0.131CysAsn: 0.131 ± 0.012	0.319CysPro: 0.319 ± 0.018	0.148CysGln: 0.148 ± 0.011	0.416CysArg: 0.416 ± 0.02	0.38CysSer: 0.38 ± 0.021	0.384CysThr: 0.384 ± 0.019	0.455CysVal: 0.455 ± 0.024	0.094CysTrp: 0.094 ± 0.01	0.12CysTyr: 0.12 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.616AspAla: 8.616 ± 0.108	0.32AspCys: 0.32 ± 0.017	4.277AspAsp: 4.277 ± 0.081	4.333AspGlu: 4.333 ± 0.078	1.948AspPhe: 1.948 ± 0.044	6.373AspGly: 6.373 ± 0.098	1.223AspHis: 1.223 ± 0.034	2.146AspIle: 2.146 ± 0.052	1.091AspLys: 1.091 ± 0.037	5.99AspLeu: 5.99 ± 0.089	0.989AspMet: 0.989 ± 0.031	0.924AspAsn: 0.924 ± 0.034	4.008AspPro: 4.008 ± 0.078	1.477AspGln: 1.477 ± 0.035	3.696AspArg: 3.696 ± 0.071	2.771AspSer: 2.771 ± 0.048	2.626AspThr: 2.626 ± 0.052	5.78AspVal: 5.78 ± 0.076	0.941AspTrp: 0.941 ± 0.029	1.451AspTyr: 1.451 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.317GluAla: 8.317 ± 0.111	0.288GluCys: 0.288 ± 0.02	3.423GluAsp: 3.423 ± 0.071	3.683GluGlu: 3.683 ± 0.079	1.954GluPhe: 1.954 ± 0.047	4.17GluGly: 4.17 ± 0.071	1.753GluHis: 1.753 ± 0.044	2.82GluIle: 2.82 ± 0.054	1.626GluLys: 1.626 ± 0.042	6.862GluLeu: 6.862 ± 0.09	1.092GluMet: 1.092 ± 0.028	1.695GluAsn: 1.695 ± 0.047	3.335GluPro: 3.335 ± 0.071	2.458GluGln: 2.458 ± 0.059	5.056GluArg: 5.056 ± 0.086	3.485GluSer: 3.485 ± 0.056	3.461GluThr: 3.461 ± 0.059	4.497GluVal: 4.497 ± 0.078	0.855GluTrp: 0.855 ± 0.031	1.262GluTyr: 1.262 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.414PheAla: 4.414 ± 0.062	0.235PheCys: 0.235 ± 0.016	2.275PheAsp: 2.275 ± 0.051	1.913PheGlu: 1.913 ± 0.045	1.189PhePhe: 1.189 ± 0.041	3.517PheGly: 3.517 ± 0.074	0.57PheHis: 0.57 ± 0.021	1.193PheIle: 1.193 ± 0.033	0.633PheLys: 0.633 ± 0.024	2.871PheLeu: 2.871 ± 0.055	0.6PheMet: 0.6 ± 0.026	0.768PheAsn: 0.768 ± 0.027	1.338PhePro: 1.338 ± 0.038	0.693PheGln: 0.693 ± 0.026	1.744PheArg: 1.744 ± 0.041	1.897PheSer: 1.897 ± 0.046	2.111PheThr: 2.111 ± 0.05	2.881PheVal: 2.881 ± 0.059	0.503PheTrp: 0.503 ± 0.023	0.686PheTyr: 0.686 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	11.162GlyAla: 11.162 ± 0.126	0.652GlyCys: 0.652 ± 0.024	5.14GlyAsp: 5.14 ± 0.097	5.431GlyGlu: 5.431 ± 0.082	3.243GlyPhe: 3.243 ± 0.06	7.984GlyGly: 7.984 ± 0.132	2.044GlyHis: 2.044 ± 0.051	4.332GlyIle: 4.332 ± 0.069	2.246GlyLys: 2.246 ± 0.053	9.317GlyLeu: 9.317 ± 0.137	1.982GlyMet: 1.982 ± 0.045	1.956GlyAsn: 1.956 ± 0.06	4.067GlyPro: 4.067 ± 0.06	2.698GlyGln: 2.698 ± 0.051	6.592GlyArg: 6.592 ± 0.083	5.292GlySer: 5.292 ± 0.084	5.753GlyThr: 5.753 ± 0.08	7.553GlyVal: 7.553 ± 0.108	1.649GlyTrp: 1.649 ± 0.047	2.287GlyTyr: 2.287 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.428HisAla: 2.428 ± 0.055	0.121HisCys: 0.121 ± 0.011	1.413HisAsp: 1.413 ± 0.034	1.231HisGlu: 1.231 ± 0.033	0.697HisPhe: 0.697 ± 0.025	2.094HisGly: 2.094 ± 0.047	0.613HisHis: 0.613 ± 0.024	0.659HisIle: 0.659 ± 0.026	0.348HisLys: 0.348 ± 0.018	2.295HisLeu: 2.295 ± 0.051	0.34HisMet: 0.34 ± 0.021	0.421HisAsn: 0.421 ± 0.019	1.414HisPro: 1.414 ± 0.041	0.612HisGln: 0.612 ± 0.02	1.597HisArg: 1.597 ± 0.038	1.081HisSer: 1.081 ± 0.033	1.028HisThr: 1.028 ± 0.032	1.889HisVal: 1.889 ± 0.05	0.303HisTrp: 0.303 ± 0.019	0.436HisTyr: 0.436 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.245IleAla: 6.245 ± 0.096	0.272IleCys: 0.272 ± 0.015	3.01IleAsp: 3.01 ± 0.049	2.825IleGlu: 2.825 ± 0.061	1.248IlePhe: 1.248 ± 0.043	4.391IleGly: 4.391 ± 0.076	0.727IleHis: 0.727 ± 0.028	1.687IleIle: 1.687 ± 0.057	0.921IleLys: 0.921 ± 0.032	3.59IleLeu: 3.59 ± 0.058	0.734IleMet: 0.734 ± 0.031	1.045IleAsn: 1.045 ± 0.031	2.078IlePro: 2.078 ± 0.043	0.891IleGln: 0.891 ± 0.033	2.413IleArg: 2.413 ± 0.049	2.349IleSer: 2.349 ± 0.049	2.446IleThr: 2.446 ± 0.057	3.951IleVal: 3.951 ± 0.07	0.439IleTrp: 0.439 ± 0.02	0.724IleTyr: 0.724 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.573LysAla: 2.573 ± 0.061	0.079LysCys: 0.079 ± 0.009	1.242LysAsp: 1.242 ± 0.04	1.181LysGlu: 1.181 ± 0.035	0.661LysPhe: 0.661 ± 0.026	1.572LysGly: 1.572 ± 0.044	0.542LysHis: 0.542 ± 0.024	1.132LysIle: 1.132 ± 0.036	0.885LysLys: 0.885 ± 0.04	2.116LysLeu: 2.116 ± 0.051	0.543LysMet: 0.543 ± 0.021	0.671LysAsn: 0.671 ± 0.023	1.326LysPro: 1.326 ± 0.044	0.705LysGln: 0.705 ± 0.029	1.63LysArg: 1.63 ± 0.045	1.366LysSer: 1.366 ± 0.04	1.422LysThr: 1.422 ± 0.045	1.863LysVal: 1.863 ± 0.041	0.277LysTrp: 0.277 ± 0.015	0.552LysTyr: 0.552 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.422LeuAla: 14.422 ± 0.162	0.577LeuCys: 0.577 ± 0.023	6.272LeuAsp: 6.272 ± 0.09	5.881LeuGlu: 5.881 ± 0.077	2.921LeuPhe: 2.921 ± 0.058	9.342LeuGly: 9.342 ± 0.104	1.836LeuHis: 1.836 ± 0.042	4.229LeuIle: 4.229 ± 0.073	2.105LeuLys: 2.105 ± 0.05	9.973LeuLeu: 9.973 ± 0.136	1.914LeuMet: 1.914 ± 0.047	2.177LeuAsn: 2.177 ± 0.046	5.531LeuPro: 5.531 ± 0.07	2.375LeuGln: 2.375 ± 0.049	6.982LeuArg: 6.982 ± 0.104	5.69LeuSer: 5.69 ± 0.086	6.191LeuThr: 6.191 ± 0.086	8.566LeuVal: 8.566 ± 0.108	1.281LeuTrp: 1.281 ± 0.042	1.655LeuTyr: 1.655 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.402MetAla: 2.402 ± 0.042	0.131MetCys: 0.131 ± 0.011	0.929MetAsp: 0.929 ± 0.027	0.886MetGlu: 0.886 ± 0.026	0.595MetPhe: 0.595 ± 0.024	1.518MetGly: 1.518 ± 0.037	0.382MetHis: 0.382 ± 0.019	0.974MetIle: 0.974 ± 0.03	0.557MetLys: 0.557 ± 0.026	1.948MetLeu: 1.948 ± 0.047	0.403MetMet: 0.403 ± 0.02	0.61MetAsn: 0.61 ± 0.025	1.114MetPro: 1.114 ± 0.031	0.532MetGln: 0.532 ± 0.024	1.348MetArg: 1.348 ± 0.041	1.613MetSer: 1.613 ± 0.037	1.62MetThr: 1.62 ± 0.039	1.463MetVal: 1.463 ± 0.036	0.214MetTrp: 0.214 ± 0.014	0.33MetTyr: 0.33 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.697AsnAla: 2.697 ± 0.053	0.139AsnCys: 0.139 ± 0.013	1.32AsnAsp: 1.32 ± 0.04	1.207AsnGlu: 1.207 ± 0.036	0.712AsnPhe: 0.712 ± 0.023	2.048AsnGly: 2.048 ± 0.053	0.492AsnHis: 0.492 ± 0.023	0.953AsnIle: 0.953 ± 0.034	0.538AsnLys: 0.538 ± 0.024	2.099AsnLeu: 2.099 ± 0.046	0.444AsnMet: 0.444 ± 0.021	0.593AsnAsn: 0.593 ± 0.025	1.66AsnPro: 1.66 ± 0.044	0.712AsnGln: 0.712 ± 0.026	1.474AsnArg: 1.474 ± 0.042	1.163AsnSer: 1.163 ± 0.033	1.308AsnThr: 1.308 ± 0.037	1.795AsnVal: 1.795 ± 0.041	0.372AsnTrp: 0.372 ± 0.02	0.579AsnTyr: 0.579 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.716ProAla: 7.716 ± 0.118	0.212ProCys: 0.212 ± 0.014	3.527ProAsp: 3.527 ± 0.077	4.388ProGlu: 4.388 ± 0.081	1.536ProPhe: 1.536 ± 0.035	5.311ProGly: 5.311 ± 0.084	1.086ProHis: 1.086 ± 0.029	1.716ProIle: 1.716 ± 0.049	1.15ProLys: 1.15 ± 0.037	4.763ProLeu: 4.763 ± 0.075	0.932ProMet: 0.932 ± 0.032	1.115ProAsn: 1.115 ± 0.033	2.089ProPro: 2.089 ± 0.06	1.525ProGln: 1.525 ± 0.041	3.101ProArg: 3.101 ± 0.05	2.933ProSer: 2.933 ± 0.061	2.995ProThr: 2.995 ± 0.057	4.671ProVal: 4.671 ± 0.071	0.803ProTrp: 0.803 ± 0.024	1.021ProTyr: 1.021 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.472GlnAla: 3.472 ± 0.062	0.131GlnCys: 0.131 ± 0.01	1.491GlnAsp: 1.491 ± 0.043	1.513GlnGlu: 1.513 ± 0.038	0.807GlnPhe: 0.807 ± 0.027	1.95GlnGly: 1.95 ± 0.048	0.685GlnHis: 0.685 ± 0.025	1.45GlnIle: 1.45 ± 0.041	0.718GlnLys: 0.718 ± 0.026	3.24GlnLeu: 3.24 ± 0.058	0.572GlnMet: 0.572 ± 0.019	0.666GlnAsn: 0.666 ± 0.029	1.5GlnPro: 1.5 ± 0.046	1.204GlnGln: 1.204 ± 0.038	2.36GlnArg: 2.36 ± 0.053	1.381GlnSer: 1.381 ± 0.041	1.507GlnThr: 1.507 ± 0.045	2.258GlnVal: 2.258 ± 0.049	0.455GlnTrp: 0.455 ± 0.02	0.577GlnTyr: 0.577 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.197ArgAla: 8.197 ± 0.115	0.376ArgCys: 0.376 ± 0.02	3.873ArgAsp: 3.873 ± 0.063	4.371ArgGlu: 4.371 ± 0.075	2.335ArgPhe: 2.335 ± 0.046	5.165ArgGly: 5.165 ± 0.077	1.631ArgHis: 1.631 ± 0.044	3.453ArgIle: 3.453 ± 0.065	1.566ArgLys: 1.566 ± 0.047	7.228ArgLeu: 7.228 ± 0.092	1.491ArgMet: 1.491 ± 0.043	1.529ArgAsn: 1.529 ± 0.037	3.532ArgPro: 3.532 ± 0.063	2.142ArgGln: 2.142 ± 0.05	6.3ArgArg: 6.3 ± 0.101	3.841ArgSer: 3.841 ± 0.055	3.959ArgThr: 3.959 ± 0.056	5.369ArgVal: 5.369 ± 0.075	1.093ArgTrp: 1.093 ± 0.036	1.482ArgTyr: 1.482 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.253SerAla: 7.253 ± 0.081	0.322SerCys: 0.322 ± 0.018	2.934SerAsp: 2.934 ± 0.049	3.097SerGlu: 3.097 ± 0.06	1.865SerPhe: 1.865 ± 0.05	5.903SerGly: 5.903 ± 0.085	1.057SerHis: 1.057 ± 0.027	2.507SerIle: 2.507 ± 0.053	1.285SerLys: 1.285 ± 0.041	5.468SerLeu: 5.468 ± 0.07	1.263SerMet: 1.263 ± 0.039	1.313SerAsn: 1.313 ± 0.034	2.917SerPro: 2.917 ± 0.058	1.49SerGln: 1.49 ± 0.044	3.693SerArg: 3.693 ± 0.069	3.47SerSer: 3.47 ± 0.091	3.503SerThr: 3.503 ± 0.056	4.617SerVal: 4.617 ± 0.074	0.856SerTrp: 0.856 ± 0.029	1.246SerTyr: 1.246 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.665ThrAla: 7.665 ± 0.084	0.334ThrCys: 0.334 ± 0.018	3.236ThrAsp: 3.236 ± 0.068	3.317ThrGlu: 3.317 ± 0.059	1.929ThrPhe: 1.929 ± 0.044	5.989ThrGly: 5.989 ± 0.077	1.234ThrHis: 1.234 ± 0.037	2.503ThrIle: 2.503 ± 0.054	1.13ThrLys: 1.13 ± 0.035	5.661ThrLeu: 5.661 ± 0.066	1.061ThrMet: 1.061 ± 0.03	1.27ThrAsn: 1.27 ± 0.037	3.538ThrPro: 3.538 ± 0.068	1.422ThrGln: 1.422 ± 0.039	3.689ThrArg: 3.689 ± 0.072	3.308ThrSer: 3.308 ± 0.059	3.836ThrThr: 3.836 ± 0.056	5.238ThrVal: 5.238 ± 0.095	0.864ThrTrp: 0.864 ± 0.03	1.24ThrTyr: 1.24 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	11.103ValAla: 11.103 ± 0.124	0.563ValCys: 0.563 ± 0.024	5.622ValAsp: 5.622 ± 0.074	5.251ValGlu: 5.251 ± 0.074	2.884ValPhe: 2.884 ± 0.061	6.791ValGly: 6.791 ± 0.093	1.783ValHis: 1.783 ± 0.042	3.636ValIle: 3.636 ± 0.075	1.801ValLys: 1.801 ± 0.042	9.035ValLeu: 9.035 ± 0.119	1.622ValMet: 1.622 ± 0.043	1.935ValAsn: 1.935 ± 0.047	4.676ValPro: 4.676 ± 0.073	2.038ValGln: 2.038 ± 0.041	5.53ValArg: 5.53 ± 0.07	4.906ValSer: 4.906 ± 0.068	5.129ValThr: 5.129 ± 0.083	8.823ValVal: 8.823 ± 0.108	1.086ValTrp: 1.086 ± 0.035	1.599ValTyr: 1.599 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.596TrpAla: 1.596 ± 0.047	0.11TrpCys: 0.11 ± 0.011	0.883TrpAsp: 0.883 ± 0.031	0.767TrpGlu: 0.767 ± 0.027	0.569TrpPhe: 0.569 ± 0.021	1.052TrpGly: 1.052 ± 0.03	0.373TrpHis: 0.373 ± 0.021	0.722TrpIle: 0.722 ± 0.028	0.357TrpLys: 0.357 ± 0.02	1.655TrpLeu: 1.655 ± 0.04	0.371TrpMet: 0.371 ± 0.018	0.485TrpAsn: 0.485 ± 0.022	0.652TrpPro: 0.652 ± 0.026	0.529TrpGln: 0.529 ± 0.021	1.087TrpArg: 1.087 ± 0.033	0.848TrpSer: 0.848 ± 0.028	0.834TrpThr: 0.834 ± 0.032	1.136TrpVal: 1.136 ± 0.034	0.365TrpTrp: 0.365 ± 0.022	0.292TrpTyr: 0.292 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.567TyrAla: 2.567 ± 0.051	0.152TyrCys: 0.152 ± 0.01	1.413TyrAsp: 1.413 ± 0.031	1.2TyrGlu: 1.2 ± 0.036	0.789TyrPhe: 0.789 ± 0.029	1.988TyrGly: 1.988 ± 0.049	0.33TyrHis: 0.33 ± 0.018	0.629TyrIle: 0.629 ± 0.027	0.399TyrLys: 0.399 ± 0.022	2.159TyrLeu: 2.159 ± 0.045	0.313TyrMet: 0.313 ± 0.017	0.462TyrAsn: 0.462 ± 0.021	1.011TyrPro: 1.011 ± 0.029	0.619TyrGln: 0.619 ± 0.022	1.596TyrArg: 1.596 ± 0.046	1.153TyrSer: 1.153 ± 0.037	1.191TyrThr: 1.191 ± 0.036	1.637TyrVal: 1.637 ± 0.037	0.34TyrTrp: 0.34 ± 0.019	0.519TyrTyr: 0.519 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3241 proteins (1082384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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