Amino acid dipepetide frequency for Penicillium roqueforti (strain FM164)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.042AlaAla: 8.042 ± 0.054	1.065AlaCys: 1.065 ± 0.017	4.19AlaAsp: 4.19 ± 0.032	4.981AlaGlu: 4.981 ± 0.043	3.079AlaPhe: 3.079 ± 0.031	5.424AlaGly: 5.424 ± 0.036	1.759AlaHis: 1.759 ± 0.02	4.388AlaIle: 4.388 ± 0.034	3.798AlaLys: 3.798 ± 0.033	7.53AlaLeu: 7.53 ± 0.046	1.996AlaMet: 1.996 ± 0.022	2.924AlaAsn: 2.924 ± 0.027	4.597AlaPro: 4.597 ± 0.043	3.303AlaGln: 3.303 ± 0.03	4.741AlaArg: 4.741 ± 0.032	7.078AlaSer: 7.078 ± 0.041	5.067AlaThr: 5.067 ± 0.037	5.19AlaVal: 5.19 ± 0.038	1.112AlaTrp: 1.112 ± 0.015	2.107AlaTyr: 2.107 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.016	0.27CysCys: 0.27 ± 0.008	0.702CysAsp: 0.702 ± 0.013	0.63CysGlu: 0.63 ± 0.012	0.576CysPhe: 0.576 ± 0.012	0.962CysGly: 0.962 ± 0.017	0.357CysHis: 0.357 ± 0.008	0.743CysIle: 0.743 ± 0.013	0.488CysLys: 0.488 ± 0.01	1.344CysLeu: 1.344 ± 0.019	0.29CysMet: 0.29 ± 0.008	0.454CysAsn: 0.454 ± 0.01	0.699CysPro: 0.699 ± 0.014	0.489CysGln: 0.489 ± 0.01	0.803CysArg: 0.803 ± 0.012	0.981CysSer: 0.981 ± 0.015	0.726CysThr: 0.726 ± 0.015	0.844CysVal: 0.844 ± 0.015	0.208CysTrp: 0.208 ± 0.006	0.365CysTyr: 0.365 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.384AspAla: 4.384 ± 0.031	0.653AspCys: 0.653 ± 0.012	3.888AspAsp: 3.888 ± 0.04	4.305AspGlu: 4.305 ± 0.042	2.18AspPhe: 2.18 ± 0.023	3.761AspGly: 3.761 ± 0.03	1.334AspHis: 1.334 ± 0.016	3.267AspIle: 3.267 ± 0.027	2.28AspLys: 2.28 ± 0.022	5.269AspLeu: 5.269 ± 0.035	1.332AspMet: 1.332 ± 0.015	1.953AspAsn: 1.953 ± 0.021	3.405AspPro: 3.405 ± 0.029	2.047AspGln: 2.047 ± 0.021	3.151AspArg: 3.151 ± 0.03	4.325AspSer: 4.325 ± 0.032	3.057AspThr: 3.057 ± 0.028	3.507AspVal: 3.507 ± 0.029	0.884AspTrp: 0.884 ± 0.014	1.631AspTyr: 1.631 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.047GluAla: 5.047 ± 0.041	0.667GluCys: 0.667 ± 0.013	4.139GluAsp: 4.139 ± 0.038	5.137GluGlu: 5.137 ± 0.054	2.039GluPhe: 2.039 ± 0.021	3.554GluGly: 3.554 ± 0.03	1.428GluHis: 1.428 ± 0.018	3.258GluIle: 3.258 ± 0.03	3.5GluLys: 3.5 ± 0.032	5.175GluLeu: 5.175 ± 0.037	1.513GluMet: 1.513 ± 0.018	2.414GluAsn: 2.414 ± 0.023	2.845GluPro: 2.845 ± 0.043	2.454GluGln: 2.454 ± 0.025	3.772GluArg: 3.772 ± 0.035	4.49GluSer: 4.49 ± 0.032	3.62GluThr: 3.62 ± 0.034	3.436GluVal: 3.436 ± 0.031	0.892GluTrp: 0.892 ± 0.015	1.734GluTyr: 1.734 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.033PheAla: 3.033 ± 0.031	0.593PheCys: 0.593 ± 0.011	2.334PheAsp: 2.334 ± 0.021	2.188PheGlu: 2.188 ± 0.021	1.717PhePhe: 1.717 ± 0.023	2.843PheGly: 2.843 ± 0.03	0.964PheHis: 0.964 ± 0.015	1.959PheIle: 1.959 ± 0.025	1.487PheLys: 1.487 ± 0.018	3.61PheLeu: 3.61 ± 0.028	0.857PheMet: 0.857 ± 0.013	1.48PheAsn: 1.48 ± 0.019	2.059PhePro: 2.059 ± 0.018	1.437PheGln: 1.437 ± 0.014	2.031PheArg: 2.031 ± 0.024	3.079PheSer: 3.079 ± 0.027	2.138PheThr: 2.138 ± 0.021	2.397PheVal: 2.397 ± 0.026	0.66PheTrp: 0.66 ± 0.014	1.171PheTyr: 1.171 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	4.984GlyAla: 4.984 ± 0.038	0.917GlyCys: 0.917 ± 0.015	3.527GlyAsp: 3.527 ± 0.028	3.467GlyGlu: 3.467 ± 0.027	2.817GlyPhe: 2.817 ± 0.028	5.183GlyGly: 5.183 ± 0.06	1.676GlyHis: 1.676 ± 0.021	3.65GlyIle: 3.65 ± 0.028	3.218GlyLys: 3.218 ± 0.03	6.091GlyLeu: 6.091 ± 0.041	1.594GlyMet: 1.594 ± 0.022	2.53GlyAsn: 2.53 ± 0.022	3.323GlyPro: 3.323 ± 0.028	2.523GlyGln: 2.523 ± 0.025	3.923GlyArg: 3.923 ± 0.031	5.679GlySer: 5.679 ± 0.046	3.841GlyThr: 3.841 ± 0.029	4.201GlyVal: 4.201 ± 0.031	1.145GlyTrp: 1.145 ± 0.017	2.131GlyTyr: 2.131 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.787HisAla: 1.787 ± 0.021	0.357HisCys: 0.357 ± 0.01	1.313HisAsp: 1.313 ± 0.019	1.387HisGlu: 1.387 ± 0.016	0.971HisPhe: 0.971 ± 0.017	1.766HisGly: 1.766 ± 0.019	0.816HisHis: 0.816 ± 0.015	1.31HisIle: 1.31 ± 0.018	0.894HisLys: 0.894 ± 0.013	2.309HisLeu: 2.309 ± 0.024	0.536HisMet: 0.536 ± 0.009	0.898HisAsn: 0.898 ± 0.013	1.686HisPro: 1.686 ± 0.023	0.988HisGln: 0.988 ± 0.014	1.645HisArg: 1.645 ± 0.018	1.964HisSer: 1.964 ± 0.022	1.338HisThr: 1.338 ± 0.016	1.464HisVal: 1.464 ± 0.017	0.37HisTrp: 0.37 ± 0.009	0.699HisTyr: 0.699 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.286IleAla: 4.286 ± 0.031	0.843IleCys: 0.843 ± 0.016	3.013IleAsp: 3.013 ± 0.027	3.018IleGlu: 3.018 ± 0.027	2.153IlePhe: 2.153 ± 0.025	3.356IleGly: 3.356 ± 0.032	1.299IleHis: 1.299 ± 0.014	2.77IleIle: 2.77 ± 0.029	2.192IleLys: 2.192 ± 0.023	4.829IleLeu: 4.829 ± 0.038	1.141IleMet: 1.141 ± 0.015	1.876IleAsn: 1.876 ± 0.021	3.357IlePro: 3.357 ± 0.023	2.075IleGln: 2.075 ± 0.024	2.913IleArg: 2.913 ± 0.026	4.251IleSer: 4.251 ± 0.032	2.91IleThr: 2.91 ± 0.027	3.246IleVal: 3.246 ± 0.028	0.792IleTrp: 0.792 ± 0.016	1.541IleTyr: 1.541 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.924LysAla: 3.924 ± 0.031	0.534LysCys: 0.534 ± 0.011	2.676LysAsp: 2.676 ± 0.025	3.201LysGlu: 3.201 ± 0.033	1.477LysPhe: 1.477 ± 0.018	2.771LysGly: 2.771 ± 0.026	1.083LysHis: 1.083 ± 0.014	2.326LysIle: 2.326 ± 0.024	3.049LysLys: 3.049 ± 0.038	3.955LysLeu: 3.955 ± 0.031	1.004LysMet: 1.004 ± 0.014	1.777LysAsn: 1.777 ± 0.02	2.667LysPro: 2.667 ± 0.029	1.845LysGln: 1.845 ± 0.02	3.285LysArg: 3.285 ± 0.029	3.5LysSer: 3.5 ± 0.032	2.727LysThr: 2.727 ± 0.024	2.666LysVal: 2.666 ± 0.026	0.673LysTrp: 0.673 ± 0.01	1.373LysTyr: 1.373 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.673LeuAla: 7.673 ± 0.052	1.258LeuCys: 1.258 ± 0.016	5.206LeuAsp: 5.206 ± 0.036	5.52LeuGlu: 5.52 ± 0.04	3.473LeuPhe: 3.473 ± 0.031	5.975LeuGly: 5.975 ± 0.037	2.289LeuHis: 2.289 ± 0.022	4.192LeuIle: 4.192 ± 0.032	4.111LeuLys: 4.111 ± 0.033	8.406LeuLeu: 8.406 ± 0.057	1.875LeuMet: 1.875 ± 0.02	3.331LeuAsn: 3.331 ± 0.028	5.538LeuPro: 5.538 ± 0.039	3.89LeuGln: 3.89 ± 0.03	5.787LeuArg: 5.787 ± 0.04	7.586LeuSer: 7.586 ± 0.05	4.795LeuThr: 4.795 ± 0.034	5.463LeuVal: 5.463 ± 0.044	1.225LeuTrp: 1.225 ± 0.017	2.436LeuTyr: 2.436 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.223MetAla: 2.223 ± 0.023	0.262MetCys: 0.262 ± 0.007	1.348MetAsp: 1.348 ± 0.018	1.341MetGlu: 1.341 ± 0.017	0.8MetPhe: 0.8 ± 0.013	1.517MetGly: 1.517 ± 0.02	0.527MetHis: 0.527 ± 0.012	1.122MetIle: 1.122 ± 0.015	1.013MetLys: 1.013 ± 0.013	1.88MetLeu: 1.88 ± 0.02	0.587MetMet: 0.587 ± 0.011	0.876MetAsn: 0.876 ± 0.014	1.306MetPro: 1.306 ± 0.017	0.916MetGln: 0.916 ± 0.014	1.314MetArg: 1.314 ± 0.015	1.989MetSer: 1.989 ± 0.017	1.393MetThr: 1.393 ± 0.017	1.375MetVal: 1.375 ± 0.019	0.281MetTrp: 0.281 ± 0.007	0.528MetTyr: 0.528 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.087AsnAla: 3.087 ± 0.027	0.483AsnCys: 0.483 ± 0.011	1.998AsnAsp: 1.998 ± 0.021	2.137AsnGlu: 2.137 ± 0.023	1.424AsnPhe: 1.424 ± 0.018	2.842AsnGly: 2.842 ± 0.029	0.893AsnHis: 0.893 ± 0.013	2.194AsnIle: 2.194 ± 0.021	1.553AsnLys: 1.553 ± 0.017	3.361AsnLeu: 3.361 ± 0.024	0.919AsnMet: 0.919 ± 0.013	1.45AsnAsn: 1.45 ± 0.021	2.599AsnPro: 2.599 ± 0.024	1.457AsnGln: 1.457 ± 0.016	2.04AsnArg: 2.04 ± 0.022	2.886AsnSer: 2.886 ± 0.025	2.266AsnThr: 2.266 ± 0.023	2.31AsnVal: 2.31 ± 0.023	0.576AsnTrp: 0.576 ± 0.012	1.092AsnTyr: 1.092 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.035ProAla: 5.035 ± 0.045	0.573ProCys: 0.573 ± 0.01	3.213ProAsp: 3.213 ± 0.029	3.886ProGlu: 3.886 ± 0.042	2.152ProPhe: 2.152 ± 0.019	3.857ProGly: 3.857 ± 0.032	1.364ProHis: 1.364 ± 0.015	2.761ProIle: 2.761 ± 0.024	2.64ProLys: 2.64 ± 0.026	4.81ProLeu: 4.81 ± 0.038	1.15ProMet: 1.15 ± 0.018	2.303ProAsn: 2.303 ± 0.024	4.59ProPro: 4.59 ± 0.06	2.427ProGln: 2.427 ± 0.03	3.569ProArg: 3.569 ± 0.036	6.118ProSer: 6.118 ± 0.044	4.099ProThr: 4.099 ± 0.036	3.684ProVal: 3.684 ± 0.033	0.776ProTrp: 0.776 ± 0.013	1.532ProTyr: 1.532 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.339GlnAla: 3.339 ± 0.032	0.486GlnCys: 0.486 ± 0.01	2.08GlnAsp: 2.08 ± 0.021	2.392GlnGlu: 2.392 ± 0.025	1.357GlnPhe: 1.357 ± 0.017	2.381GlnGly: 2.381 ± 0.022	1.083GlnHis: 1.083 ± 0.017	2.036GlnIle: 2.036 ± 0.019	1.98GlnLys: 1.98 ± 0.022	3.495GlnLeu: 3.495 ± 0.027	0.939GlnMet: 0.939 ± 0.015	1.641GlnAsn: 1.641 ± 0.021	2.574GlnPro: 2.574 ± 0.031	2.153GlnGln: 2.153 ± 0.036	2.618GlnArg: 2.618 ± 0.025	3.329GlnSer: 3.329 ± 0.033	2.435GlnThr: 2.435 ± 0.02	2.228GlnVal: 2.228 ± 0.019	0.598GlnTrp: 0.598 ± 0.009	1.207GlnTyr: 1.207 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.61ArgAla: 4.61 ± 0.034	0.75ArgCys: 0.75 ± 0.015	3.352ArgAsp: 3.352 ± 0.031	3.711ArgGlu: 3.711 ± 0.032	2.221ArgPhe: 2.221 ± 0.024	3.701ArgGly: 3.701 ± 0.035	1.581ArgHis: 1.581 ± 0.016	2.995ArgIle: 2.995 ± 0.028	3.356ArgLys: 3.356 ± 0.027	5.544ArgLeu: 5.544 ± 0.035	1.35ArgMet: 1.35 ± 0.018	2.288ArgAsn: 2.288 ± 0.023	3.563ArgPro: 3.563 ± 0.036	2.587ArgGln: 2.587 ± 0.028	4.974ArgArg: 4.974 ± 0.049	4.93ArgSer: 4.93 ± 0.039	3.298ArgThr: 3.298 ± 0.026	3.446ArgVal: 3.446 ± 0.028	0.951ArgTrp: 0.951 ± 0.014	1.678ArgTyr: 1.678 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.623SerAla: 6.623 ± 0.039	0.941SerCys: 0.941 ± 0.013	4.456SerAsp: 4.456 ± 0.036	4.397SerGlu: 4.397 ± 0.034	3.145SerPhe: 3.145 ± 0.029	5.514SerGly: 5.514 ± 0.047	2.096SerHis: 2.096 ± 0.021	4.268SerIle: 4.268 ± 0.033	3.721SerLys: 3.721 ± 0.033	7.49SerLeu: 7.49 ± 0.042	1.847SerMet: 1.847 ± 0.02	3.16SerAsn: 3.16 ± 0.027	5.658SerPro: 5.658 ± 0.052	3.453SerGln: 3.453 ± 0.025	5.129SerArg: 5.129 ± 0.041	8.794SerSer: 8.794 ± 0.09	5.687SerThr: 5.687 ± 0.051	4.798SerVal: 4.798 ± 0.04	1.169SerTrp: 1.169 ± 0.016	2.147SerTyr: 2.147 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.012ThrAla: 5.012 ± 0.034	0.768ThrCys: 0.768 ± 0.014	2.966ThrAsp: 2.966 ± 0.025	3.326ThrGlu: 3.326 ± 0.029	2.207ThrPhe: 2.207 ± 0.022	4.128ThrGly: 4.128 ± 0.029	1.331ThrHis: 1.331 ± 0.017	3.169ThrIle: 3.169 ± 0.029	2.601ThrLys: 2.601 ± 0.024	5.256ThrLeu: 5.256 ± 0.034	1.251ThrMet: 1.251 ± 0.016	2.145ThrAsn: 2.145 ± 0.023	4.292ThrPro: 4.292 ± 0.041	2.171ThrGln: 2.171 ± 0.023	3.192ThrArg: 3.192 ± 0.025	5.394ThrSer: 5.394 ± 0.051	4.19ThrThr: 4.19 ± 0.052	3.766ThrVal: 3.766 ± 0.029	0.862ThrTrp: 0.862 ± 0.013	1.623ThrTyr: 1.623 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.072ValAla: 5.072 ± 0.035	0.858ValCys: 0.858 ± 0.013	3.68ValAsp: 3.68 ± 0.029	3.696ValGlu: 3.696 ± 0.033	2.505ValPhe: 2.505 ± 0.026	3.918ValGly: 3.918 ± 0.035	1.462ValHis: 1.462 ± 0.026	3.152ValIle: 3.152 ± 0.03	2.721ValLys: 2.721 ± 0.023	5.57ValLeu: 5.57 ± 0.044	1.352ValMet: 1.352 ± 0.019	2.246ValAsn: 2.246 ± 0.022	3.605ValPro: 3.605 ± 0.033	2.41ValGln: 2.41 ± 0.025	3.356ValArg: 3.356 ± 0.027	4.817ValSer: 4.817 ± 0.034	3.484ValThr: 3.484 ± 0.032	4.103ValVal: 4.103 ± 0.03	0.843ValTrp: 0.843 ± 0.014	1.772ValTyr: 1.772 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.133TrpAla: 1.133 ± 0.013	0.196TrpCys: 0.196 ± 0.007	0.898TrpAsp: 0.898 ± 0.014	0.859TrpGlu: 0.859 ± 0.012	0.539TrpPhe: 0.539 ± 0.011	0.908TrpGly: 0.908 ± 0.013	0.367TrpHis: 0.367 ± 0.009	0.802TrpIle: 0.802 ± 0.014	0.806TrpLys: 0.806 ± 0.014	1.387TrpLeu: 1.387 ± 0.016	0.394TrpMet: 0.394 ± 0.01	0.662TrpAsn: 0.662 ± 0.013	0.614TrpPro: 0.614 ± 0.012	0.559TrpGln: 0.559 ± 0.011	0.963TrpArg: 0.963 ± 0.015	1.119TrpSer: 1.119 ± 0.016	0.922TrpThr: 0.922 ± 0.012	0.883TrpVal: 0.883 ± 0.014	0.287TrpTrp: 0.287 ± 0.008	0.451TrpTyr: 0.451 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.092TyrAla: 2.092 ± 0.022	0.439TyrCys: 0.439 ± 0.01	1.632TyrAsp: 1.632 ± 0.018	1.535TyrGlu: 1.535 ± 0.019	1.204TyrPhe: 1.204 ± 0.017	2.063TyrGly: 2.063 ± 0.026	0.788TyrHis: 0.788 ± 0.013	1.497TyrIle: 1.497 ± 0.019	1.107TyrLys: 1.107 ± 0.016	2.717TyrLeu: 2.717 ± 0.026	0.67TyrMet: 0.67 ± 0.01	1.16TyrAsn: 1.16 ± 0.016	1.564TyrPro: 1.564 ± 0.02	1.166TyrGln: 1.166 ± 0.017	1.68TyrArg: 1.68 ± 0.018	2.185TyrSer: 2.185 ± 0.022	1.657TyrThr: 1.657 ± 0.02	1.617TyrVal: 1.617 ± 0.019	0.443TyrTrp: 0.443 ± 0.01	0.948TyrTyr: 0.948 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12315 proteins (5087075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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