Amino acid dipepetide frequency for Lactobacillus oeni DSM 19972

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.61AlaAla: 7.61 ± 0.165
0.484AlaCys: 0.484 ± 0.029
4.1AlaAsp: 4.1 ± 0.086
4.385AlaGlu: 4.385 ± 0.096
3.295AlaPhe: 3.295 ± 0.076
5.688AlaGly: 5.688 ± 0.128
1.431AlaHis: 1.431 ± 0.046
5.444AlaIle: 5.444 ± 0.111
5.386AlaLys: 5.386 ± 0.103
7.866AlaLeu: 7.866 ± 0.127
1.646AlaMet: 1.646 ± 0.05
3.113AlaAsn: 3.113 ± 0.073
2.067AlaPro: 2.067 ± 0.062
3.568AlaGln: 3.568 ± 0.088
2.945AlaArg: 2.945 ± 0.077
4.214AlaSer: 4.214 ± 0.081
3.952AlaThr: 3.952 ± 0.098
6.031AlaVal: 6.031 ± 0.106
0.544AlaTrp: 0.544 ± 0.031
2.379AlaTyr: 2.379 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.46CysAla: 0.46 ± 0.026
0.085CysCys: 0.085 ± 0.011
0.317CysAsp: 0.317 ± 0.024
0.334CysGlu: 0.334 ± 0.024
0.348CysPhe: 0.348 ± 0.026
0.578CysGly: 0.578 ± 0.032
0.157CysHis: 0.157 ± 0.018
0.385CysIle: 0.385 ± 0.028
0.287CysLys: 0.287 ± 0.025
0.73CysLeu: 0.73 ± 0.037
0.101CysMet: 0.101 ± 0.014
0.198CysAsn: 0.198 ± 0.021
0.23CysPro: 0.23 ± 0.02
0.211CysGln: 0.211 ± 0.021
0.266CysArg: 0.266 ± 0.02
0.394CysSer: 0.394 ± 0.027
0.256CysThr: 0.256 ± 0.022
0.433CysVal: 0.433 ± 0.027
0.061CysTrp: 0.061 ± 0.01
0.261CysTyr: 0.261 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.234AspAla: 3.234 ± 0.085
0.288AspCys: 0.288 ± 0.021
2.505AspAsp: 2.505 ± 0.076
3.604AspGlu: 3.604 ± 0.083
2.592AspPhe: 2.592 ± 0.064
3.038AspGly: 3.038 ± 0.08
1.023AspHis: 1.023 ± 0.039
3.421AspIle: 3.421 ± 0.082
3.672AspLys: 3.672 ± 0.09
4.897AspLeu: 4.897 ± 0.099
1.117AspMet: 1.117 ± 0.049
2.316AspAsn: 2.316 ± 0.08
1.994AspPro: 1.994 ± 0.059
1.997AspGln: 1.997 ± 0.069
1.825AspArg: 1.825 ± 0.06
3.01AspSer: 3.01 ± 0.075
2.47AspThr: 2.47 ± 0.068
3.532AspVal: 3.532 ± 0.091
0.573AspTrp: 0.573 ± 0.036
2.272AspTyr: 2.272 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.114GluAla: 4.114 ± 0.107
0.268GluCys: 0.268 ± 0.02
2.713GluAsp: 2.713 ± 0.077
4.02GluGlu: 4.02 ± 0.107
2.291GluPhe: 2.291 ± 0.071
2.947GluGly: 2.947 ± 0.08
1.24GluHis: 1.24 ± 0.049
4.61GluIle: 4.61 ± 0.1
6.085GluLys: 6.085 ± 0.116
6.715GluLeu: 6.715 ± 0.136
1.632GluMet: 1.632 ± 0.057
3.46GluAsn: 3.46 ± 0.08
1.593GluPro: 1.593 ± 0.052
2.782GluGln: 2.782 ± 0.08
2.915GluArg: 2.915 ± 0.075
2.818GluSer: 2.818 ± 0.078
3.298GluThr: 3.298 ± 0.086
4.008GluVal: 4.008 ± 0.092
0.479GluTrp: 0.479 ± 0.028
1.912GluTyr: 1.912 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.377PheAla: 3.377 ± 0.081
0.418PheCys: 0.418 ± 0.027
2.546PheAsp: 2.546 ± 0.07
2.674PheGlu: 2.674 ± 0.074
2.63PhePhe: 2.63 ± 0.091
3.275PheGly: 3.275 ± 0.07
0.795PheHis: 0.795 ± 0.036
3.467PheIle: 3.467 ± 0.103
3.235PheLys: 3.235 ± 0.077
4.746PheLeu: 4.746 ± 0.114
1.122PheMet: 1.122 ± 0.043
2.304PheAsn: 2.304 ± 0.064
1.537PhePro: 1.537 ± 0.047
1.351PheGln: 1.351 ± 0.055
1.436PheArg: 1.436 ± 0.051
3.679PheSer: 3.679 ± 0.086
2.466PheThr: 2.466 ± 0.074
3.256PheVal: 3.256 ± 0.092
0.525PheTrp: 0.525 ± 0.033
1.699PheTyr: 1.699 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.74GlyAla: 4.74 ± 0.11
0.426GlyCys: 0.426 ± 0.026
2.812GlyAsp: 2.812 ± 0.081
3.341GlyGlu: 3.341 ± 0.091
3.268GlyPhe: 3.268 ± 0.078
4.25GlyGly: 4.25 ± 0.108
1.346GlyHis: 1.346 ± 0.055
5.985GlyIle: 5.985 ± 0.119
5.379GlyLys: 5.379 ± 0.103
6.623GlyLeu: 6.623 ± 0.125
1.943GlyMet: 1.943 ± 0.069
2.935GlyAsn: 2.935 ± 0.069
1.537GlyPro: 1.537 ± 0.053
2.395GlyGln: 2.395 ± 0.066
2.638GlyArg: 2.638 ± 0.07
4.119GlySer: 4.119 ± 0.088
4.066GlyThr: 4.066 ± 0.101
4.552GlyVal: 4.552 ± 0.101
0.672GlyTrp: 0.672 ± 0.035
2.625GlyTyr: 2.625 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.315HisAla: 1.315 ± 0.045
0.128HisCys: 0.128 ± 0.015
0.95HisAsp: 0.95 ± 0.046
1.168HisGlu: 1.168 ± 0.046
1.112HisPhe: 1.112 ± 0.049
1.426HisGly: 1.426 ± 0.051
0.553HisHis: 0.553 ± 0.033
1.226HisIle: 1.226 ± 0.047
1.23HisLys: 1.23 ± 0.049
2.059HisLeu: 2.059 ± 0.061
0.387HisMet: 0.387 ± 0.029
0.892HisAsn: 0.892 ± 0.036
0.972HisPro: 0.972 ± 0.049
0.829HisGln: 0.829 ± 0.035
0.832HisArg: 0.832 ± 0.041
1.208HisSer: 1.208 ± 0.043
0.914HisThr: 0.914 ± 0.045
1.214HisVal: 1.214 ± 0.049
0.211HisTrp: 0.211 ± 0.019
0.856HisTyr: 0.856 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.358IleAla: 6.358 ± 0.1
0.592IleCys: 0.592 ± 0.038
3.75IleAsp: 3.75 ± 0.088
4.056IleGlu: 4.056 ± 0.091
3.466IlePhe: 3.466 ± 0.096
5.246IleGly: 5.246 ± 0.11
1.267IleHis: 1.267 ± 0.045
5.579IleIle: 5.579 ± 0.141
5.222IleLys: 5.222 ± 0.091
7.167IleLeu: 7.167 ± 0.138
1.775IleMet: 1.775 ± 0.063
3.566IleAsn: 3.566 ± 0.077
2.911IlePro: 2.911 ± 0.065
2.468IleGln: 2.468 ± 0.064
2.777IleArg: 2.777 ± 0.067
5.146IleSer: 5.146 ± 0.098
4.265IleThr: 4.265 ± 0.087
5.171IleVal: 5.171 ± 0.102
0.582IleTrp: 0.582 ± 0.036
2.304IleTyr: 2.304 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.084LysAla: 5.084 ± 0.098
0.278LysCys: 0.278 ± 0.022
3.767LysAsp: 3.767 ± 0.092
5.676LysGlu: 5.676 ± 0.136
2.511LysPhe: 2.511 ± 0.062
4.013LysGly: 4.013 ± 0.099
1.349LysHis: 1.349 ± 0.047
6.135LysIle: 6.135 ± 0.117
8.313LysLys: 8.313 ± 0.149
7.301LysLeu: 7.301 ± 0.129
2.609LysMet: 2.609 ± 0.068
4.576LysAsn: 4.576 ± 0.088
2.128LysPro: 2.128 ± 0.061
3.733LysGln: 3.733 ± 0.09
3.875LysArg: 3.875 ± 0.087
3.918LysSer: 3.918 ± 0.086
4.433LysThr: 4.433 ± 0.091
5.093LysVal: 5.093 ± 0.101
0.675LysTrp: 0.675 ± 0.038
2.739LysTyr: 2.739 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
8.272LeuAla: 8.272 ± 0.124
0.708LeuCys: 0.708 ± 0.036
5.018LeuAsp: 5.018 ± 0.098
5.78LeuGlu: 5.78 ± 0.113
4.953LeuPhe: 4.953 ± 0.142
6.901LeuGly: 6.901 ± 0.131
1.926LeuHis: 1.926 ± 0.058
7.332LeuIle: 7.332 ± 0.145
8.2LeuLys: 8.2 ± 0.139
11.014LeuLeu: 11.014 ± 0.211
2.292LeuMet: 2.292 ± 0.072
4.989LeuAsn: 4.989 ± 0.096
3.993LeuPro: 3.993 ± 0.085
4.231LeuGln: 4.231 ± 0.102
4.17LeuArg: 4.17 ± 0.083
7.216LeuSer: 7.216 ± 0.127
6.08LeuThr: 6.08 ± 0.107
6.82LeuVal: 6.82 ± 0.124
0.844LeuTrp: 0.844 ± 0.045
2.911LeuTyr: 2.911 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.835MetAla: 1.835 ± 0.06
0.157MetCys: 0.157 ± 0.016
1.132MetAsp: 1.132 ± 0.043
1.267MetGlu: 1.267 ± 0.045
0.853MetPhe: 0.853 ± 0.041
1.629MetGly: 1.629 ± 0.048
0.423MetHis: 0.423 ± 0.026
2.002MetIle: 2.002 ± 0.072
2.035MetLys: 2.035 ± 0.058
2.338MetLeu: 2.338 ± 0.07
0.675MetMet: 0.675 ± 0.034
1.366MetAsn: 1.366 ± 0.047
0.958MetPro: 0.958 ± 0.041
1.044MetGln: 1.044 ± 0.04
0.996MetArg: 0.996 ± 0.04
1.491MetSer: 1.491 ± 0.051
1.567MetThr: 1.567 ± 0.052
1.702MetVal: 1.702 ± 0.058
0.126MetTrp: 0.126 ± 0.013
0.634MetTyr: 0.634 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.314AsnAla: 3.314 ± 0.071
0.314AsnCys: 0.314 ± 0.023
2.422AsnAsp: 2.422 ± 0.066
3.229AsnGlu: 3.229 ± 0.068
2.401AsnPhe: 2.401 ± 0.066
3.486AsnGly: 3.486 ± 0.084
0.984AsnHis: 0.984 ± 0.039
3.365AsnIle: 3.365 ± 0.074
3.556AsnLys: 3.556 ± 0.084
4.612AsnLeu: 4.612 ± 0.095
1.151AsnMet: 1.151 ± 0.048
2.783AsnAsn: 2.783 ± 0.081
1.891AsnPro: 1.891 ± 0.049
1.984AsnGln: 1.984 ± 0.056
1.823AsnArg: 1.823 ± 0.056
3.029AsnSer: 3.029 ± 0.081
2.669AsnThr: 2.669 ± 0.076
3.196AsnVal: 3.196 ± 0.076
0.611AsnTrp: 0.611 ± 0.037
2.064AsnTyr: 2.064 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
2.657ProAla: 2.657 ± 0.068
0.164ProCys: 0.164 ± 0.016
1.977ProAsp: 1.977 ± 0.059
2.57ProGlu: 2.57 ± 0.065
1.724ProPhe: 1.724 ± 0.059
1.963ProGly: 1.963 ± 0.065
0.75ProHis: 0.75 ± 0.036
2.204ProIle: 2.204 ± 0.06
2.217ProLys: 2.217 ± 0.053
3.624ProLeu: 3.624 ± 0.079
0.604ProMet: 0.604 ± 0.029
1.477ProAsn: 1.477 ± 0.05
0.696ProPro: 0.696 ± 0.035
1.782ProGln: 1.782 ± 0.056
1.206ProArg: 1.206 ± 0.047
1.982ProSer: 1.982 ± 0.06
1.859ProThr: 1.859 ± 0.051
2.609ProVal: 2.609 ± 0.069
0.288ProTrp: 0.288 ± 0.023
1.231ProTyr: 1.231 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
3.084GlnAla: 3.084 ± 0.077
0.125GlnCys: 0.125 ± 0.015
1.729GlnAsp: 1.729 ± 0.058
2.541GlnGlu: 2.541 ± 0.076
1.516GlnPhe: 1.516 ± 0.05
2.258GlnGly: 2.258 ± 0.062
0.877GlnHis: 0.877 ± 0.039
3.084GlnIle: 3.084 ± 0.067
4.03GlnLys: 4.03 ± 0.087
4.958GlnLeu: 4.958 ± 0.116
1.049GlnMet: 1.049 ± 0.045
2.292GlnAsn: 2.292 ± 0.069
1.214GlnPro: 1.214 ± 0.048
2.534GlnGln: 2.534 ± 0.09
2.004GlnArg: 2.004 ± 0.058
2.152GlnSer: 2.152 ± 0.065
2.417GlnThr: 2.417 ± 0.061
2.881GlnVal: 2.881 ± 0.079
0.35GlnTrp: 0.35 ± 0.022
1.337GlnTyr: 1.337 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.751ArgAla: 2.751 ± 0.072
0.232ArgCys: 0.232 ± 0.023
1.948ArgAsp: 1.948 ± 0.064
2.444ArgGlu: 2.444 ± 0.071
2.018ArgPhe: 2.018 ± 0.058
2.294ArgGly: 2.294 ± 0.059
0.836ArgHis: 0.836 ± 0.041
3.106ArgIle: 3.106 ± 0.076
3.399ArgLys: 3.399 ± 0.082
4.141ArgLeu: 4.141 ± 0.078
1.022ArgMet: 1.022 ± 0.039
1.999ArgAsn: 1.999 ± 0.06
1.378ArgPro: 1.378 ± 0.042
2.011ArgGln: 2.011 ± 0.068
2.035ArgArg: 2.035 ± 0.069
2.314ArgSer: 2.314 ± 0.075
2.031ArgThr: 2.031 ± 0.054
2.749ArgVal: 2.749 ± 0.08
0.345ArgTrp: 0.345 ± 0.023
1.603ArgTyr: 1.603 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.569SerAla: 4.569 ± 0.095
0.345SerCys: 0.345 ± 0.026
3.055SerAsp: 3.055 ± 0.07
3.64SerGlu: 3.64 ± 0.086
3.379SerPhe: 3.379 ± 0.096
4.723SerGly: 4.723 ± 0.103
1.117SerHis: 1.117 ± 0.048
4.049SerIle: 4.049 ± 0.087
4.513SerLys: 4.513 ± 0.1
6.812SerLeu: 6.812 ± 0.116
1.341SerMet: 1.341 ± 0.053
2.942SerAsn: 2.942 ± 0.073
1.815SerPro: 1.815 ± 0.057
2.64SerGln: 2.64 ± 0.083
2.364SerArg: 2.364 ± 0.062
4.673SerSer: 4.673 ± 0.19
3.217SerThr: 3.217 ± 0.07
4.085SerVal: 4.085 ± 0.084
0.696SerTrp: 0.696 ± 0.038
2.326SerTyr: 2.326 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.839ThrAla: 4.839 ± 0.111
0.273ThrCys: 0.273 ± 0.025
2.862ThrAsp: 2.862 ± 0.076
3.106ThrGlu: 3.106 ± 0.089
2.567ThrPhe: 2.567 ± 0.066
4.26ThrGly: 4.26 ± 0.085
1.093ThrHis: 1.093 ± 0.038
4.035ThrIle: 4.035 ± 0.086
3.87ThrLys: 3.87 ± 0.084
5.635ThrLeu: 5.635 ± 0.109
1.187ThrMet: 1.187 ± 0.047
2.435ThrAsn: 2.435 ± 0.069
2.287ThrPro: 2.287 ± 0.067
2.048ThrGln: 2.048 ± 0.064
1.902ThrArg: 1.902 ± 0.06
3.38ThrSer: 3.38 ± 0.091
3.263ThrThr: 3.263 ± 0.087
4.323ThrVal: 4.323 ± 0.088
0.454ThrTrp: 0.454 ± 0.029
1.81ThrTyr: 1.81 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.696ValAla: 5.696 ± 0.103
0.476ValCys: 0.476 ± 0.03
3.495ValAsp: 3.495 ± 0.079
3.723ValGlu: 3.723 ± 0.092
3.123ValPhe: 3.123 ± 0.081
4.622ValGly: 4.622 ± 0.109
1.158ValHis: 1.158 ± 0.045
5.509ValIle: 5.509 ± 0.091
5.127ValLys: 5.127 ± 0.105
7.03ValLeu: 7.03 ± 0.117
1.622ValMet: 1.622 ± 0.047
3.186ValAsn: 3.186 ± 0.086
2.724ValPro: 2.724 ± 0.059
2.48ValGln: 2.48 ± 0.064
2.502ValArg: 2.502 ± 0.072
4.917ValSer: 4.917 ± 0.093
4.119ValThr: 4.119 ± 0.077
5.05ValVal: 5.05 ± 0.101
0.565ValTrp: 0.565 ± 0.03
2.256ValTyr: 2.256 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.498TrpAla: 0.498 ± 0.032
0.056TrpCys: 0.056 ± 0.012
0.433TrpAsp: 0.433 ± 0.029
0.46TrpGlu: 0.46 ± 0.027
0.474TrpPhe: 0.474 ± 0.035
0.6TrpGly: 0.6 ± 0.032
0.242TrpHis: 0.242 ± 0.02
0.699TrpIle: 0.699 ± 0.038
0.58TrpLys: 0.58 ± 0.03
1.173TrpLeu: 1.173 ± 0.052
0.269TrpMet: 0.269 ± 0.021
0.513TrpAsn: 0.513 ± 0.029
0.261TrpPro: 0.261 ± 0.023
0.508TrpGln: 0.508 ± 0.025
0.394TrpArg: 0.394 ± 0.028
0.547TrpSer: 0.547 ± 0.033
0.404TrpThr: 0.404 ± 0.027
0.515TrpVal: 0.515 ± 0.032
0.096TrpTrp: 0.096 ± 0.013
0.367TrpTyr: 0.367 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.342TyrAla: 2.342 ± 0.06
0.278TyrCys: 0.278 ± 0.023
1.847TyrAsp: 1.847 ± 0.055
1.881TyrGlu: 1.881 ± 0.06
2.019TyrPhe: 2.019 ± 0.066
2.456TyrGly: 2.456 ± 0.065
0.916TyrHis: 0.916 ± 0.045
2.031TyrIle: 2.031 ± 0.056
1.871TyrLys: 1.871 ± 0.065
4.209TyrLeu: 4.209 ± 0.095
0.686TyrMet: 0.686 ± 0.032
1.54TyrAsn: 1.54 ± 0.061
1.399TyrPro: 1.399 ± 0.048
1.835TyrGln: 1.835 ± 0.061
1.75TyrArg: 1.75 ± 0.061
2.091TyrSer: 2.091 ± 0.063
1.883TyrThr: 1.883 ± 0.063
2.157TyrVal: 2.157 ± 0.062
0.396TyrTrp: 0.396 ± 0.027
1.516TyrTyr: 1.516 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1945 proteins (586335 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski