Amino acid dipepetide frequency for Cohnella sp. OV330

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.447AlaAla: 13.447 ± 0.137	0.851AlaCys: 0.851 ± 0.02	6.222AlaAsp: 6.222 ± 0.072	7.059AlaGlu: 7.059 ± 0.076	4.074AlaPhe: 4.074 ± 0.048	9.541AlaGly: 9.541 ± 0.094	1.653AlaHis: 1.653 ± 0.026	5.513AlaIle: 5.513 ± 0.061	4.523AlaLys: 4.523 ± 0.056	10.413AlaLeu: 10.413 ± 0.085	2.644AlaMet: 2.644 ± 0.041	3.007AlaAsn: 3.007 ± 0.049	3.931AlaPro: 3.931 ± 0.057	3.156AlaGln: 3.156 ± 0.045	5.214AlaArg: 5.214 ± 0.057	7.299AlaSer: 7.299 ± 0.073	4.604AlaThr: 4.604 ± 0.065	7.816AlaVal: 7.816 ± 0.067	1.434AlaTrp: 1.434 ± 0.024	3.517AlaTyr: 3.517 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.683CysAla: 0.683 ± 0.02	0.083CysCys: 0.083 ± 0.006	0.358CysAsp: 0.358 ± 0.012	0.406CysGlu: 0.406 ± 0.015	0.251CysPhe: 0.251 ± 0.011	0.756CysGly: 0.756 ± 0.019	0.152CysHis: 0.152 ± 0.008	0.342CysIle: 0.342 ± 0.013	0.221CysLys: 0.221 ± 0.01	0.665CysLeu: 0.665 ± 0.019	0.147CysMet: 0.147 ± 0.009	0.18CysAsn: 0.18 ± 0.009	0.333CysPro: 0.333 ± 0.015	0.147CysGln: 0.147 ± 0.009	0.491CysArg: 0.491 ± 0.019	0.412CysSer: 0.412 ± 0.014	0.317CysThr: 0.317 ± 0.014	0.431CysVal: 0.431 ± 0.015	0.092CysTrp: 0.092 ± 0.007	0.216CysTyr: 0.216 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.988AspAla: 5.988 ± 0.071	0.35AspCys: 0.35 ± 0.013	2.924AspAsp: 2.924 ± 0.043	3.805AspGlu: 3.805 ± 0.044	2.057AspPhe: 2.057 ± 0.032	5.312AspGly: 5.312 ± 0.067	0.929AspHis: 0.929 ± 0.022	3.183AspIle: 3.183 ± 0.044	2.565AspLys: 2.565 ± 0.038	4.96AspLeu: 4.96 ± 0.055	1.275AspMet: 1.275 ± 0.023	1.704AspAsn: 1.704 ± 0.029	2.848AspPro: 2.848 ± 0.035	1.566AspGln: 1.566 ± 0.026	3.683AspArg: 3.683 ± 0.042	2.715AspSer: 2.715 ± 0.039	2.647AspThr: 2.647 ± 0.041	3.698AspVal: 3.698 ± 0.041	1.095AspTrp: 1.095 ± 0.025	2.15AspTyr: 2.15 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.53GluAla: 7.53 ± 0.077	0.302GluCys: 0.302 ± 0.012	3.018GluAsp: 3.018 ± 0.04	4.452GluGlu: 4.452 ± 0.067	1.805GluPhe: 1.805 ± 0.029	4.718GluGly: 4.718 ± 0.053	1.179GluHis: 1.179 ± 0.028	3.519GluIle: 3.519 ± 0.045	2.841GluLys: 2.841 ± 0.043	6.78GluLeu: 6.78 ± 0.063	1.654GluMet: 1.654 ± 0.03	1.738GluAsn: 1.738 ± 0.033	2.619GluPro: 2.619 ± 0.037	2.703GluGln: 2.703 ± 0.04	4.96GluArg: 4.96 ± 0.07	3.354GluSer: 3.354 ± 0.045	3.338GluThr: 3.338 ± 0.042	3.754GluVal: 3.754 ± 0.043	0.961GluTrp: 0.961 ± 0.025	1.688GluTyr: 1.688 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.073PheAla: 4.073 ± 0.048	0.297PheCys: 0.297 ± 0.013	2.42PheAsp: 2.42 ± 0.033	2.459PheGlu: 2.459 ± 0.035	1.581PhePhe: 1.581 ± 0.032	3.501PheGly: 3.501 ± 0.04	0.715PheHis: 0.715 ± 0.017	2.073PheIle: 2.073 ± 0.034	1.905PheLys: 1.905 ± 0.028	3.436PheLeu: 3.436 ± 0.044	0.988PheMet: 0.988 ± 0.023	1.381PheAsn: 1.381 ± 0.024	1.533PhePro: 1.533 ± 0.028	1.062PheGln: 1.062 ± 0.025	2.193PheArg: 2.193 ± 0.031	2.418PheSer: 2.418 ± 0.039	2.029PheThr: 2.029 ± 0.037	2.968PheVal: 2.968 ± 0.037	0.528PheTrp: 0.528 ± 0.019	1.415PheTyr: 1.415 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.924GlyAla: 7.924 ± 0.072	0.67GlyCys: 0.67 ± 0.016	4.399GlyAsp: 4.399 ± 0.049	5.205GlyGlu: 5.205 ± 0.057	3.295GlyPhe: 3.295 ± 0.035	7.061GlyGly: 7.061 ± 0.092	1.501GlyHis: 1.501 ± 0.029	5.242GlyIle: 5.242 ± 0.052	4.245GlyLys: 4.245 ± 0.052	7.807GlyLeu: 7.807 ± 0.068	2.367GlyMet: 2.367 ± 0.033	2.556GlyAsn: 2.556 ± 0.044	2.457GlyPro: 2.457 ± 0.044	2.649GlyGln: 2.649 ± 0.037	4.776GlyArg: 4.776 ± 0.055	5.277GlySer: 5.277 ± 0.07	5.099GlyThr: 5.099 ± 0.078	5.515GlyVal: 5.515 ± 0.058	1.396GlyTrp: 1.396 ± 0.029	3.031GlyTyr: 3.031 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.872HisAla: 1.872 ± 0.03	0.157HisCys: 0.157 ± 0.01	0.992HisAsp: 0.992 ± 0.022	1.055HisGlu: 1.055 ± 0.024	0.879HisPhe: 0.879 ± 0.021	1.607HisGly: 1.607 ± 0.028	0.502HisHis: 0.502 ± 0.017	0.965HisIle: 0.965 ± 0.022	0.601HisLys: 0.601 ± 0.016	1.918HisLeu: 1.918 ± 0.029	0.48HisMet: 0.48 ± 0.015	0.51HisAsn: 0.51 ± 0.016	1.22HisPro: 1.22 ± 0.023	0.532HisGln: 0.532 ± 0.016	1.163HisArg: 1.163 ± 0.023	0.906HisSer: 0.906 ± 0.022	0.896HisThr: 0.896 ± 0.022	1.25HisVal: 1.25 ± 0.026	0.325HisTrp: 0.325 ± 0.012	0.767HisTyr: 0.767 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.393IleAla: 6.393 ± 0.061	0.417IleCys: 0.417 ± 0.014	3.532IleAsp: 3.532 ± 0.041	3.61IleGlu: 3.61 ± 0.044	1.805IlePhe: 1.805 ± 0.039	5.146IleGly: 5.146 ± 0.049	1.046IleHis: 1.046 ± 0.022	2.419IleIle: 2.419 ± 0.045	2.184IleLys: 2.184 ± 0.035	4.525IleLeu: 4.525 ± 0.059	1.22IleMet: 1.22 ± 0.027	1.682IleAsn: 1.682 ± 0.025	2.616IlePro: 2.616 ± 0.042	1.818IleGln: 1.818 ± 0.034	3.727IleArg: 3.727 ± 0.043	3.192IleSer: 3.192 ± 0.043	2.64IleThr: 2.64 ± 0.044	5.095IleVal: 5.095 ± 0.055	0.659IleTrp: 0.659 ± 0.019	1.739IleTyr: 1.739 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.266LysAla: 4.266 ± 0.051	0.166LysCys: 0.166 ± 0.01	2.526LysAsp: 2.526 ± 0.04	2.939LysGlu: 2.939 ± 0.042	1.339LysPhe: 1.339 ± 0.027	3.199LysGly: 3.199 ± 0.039	0.869LysHis: 0.869 ± 0.02	2.396LysIle: 2.396 ± 0.035	2.305LysLys: 2.305 ± 0.037	5.057LysLeu: 5.057 ± 0.062	1.19LysMet: 1.19 ± 0.023	1.551LysAsn: 1.551 ± 0.032	2.144LysPro: 2.144 ± 0.029	1.735LysGln: 1.735 ± 0.031	2.771LysArg: 2.771 ± 0.036	2.573LysSer: 2.573 ± 0.035	2.647LysThr: 2.647 ± 0.035	2.806LysVal: 2.806 ± 0.04	0.619LysTrp: 0.619 ± 0.019	1.492LysTyr: 1.492 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.692LeuAla: 10.692 ± 0.094	0.729LeuCys: 0.729 ± 0.02	5.325LeuAsp: 5.325 ± 0.058	5.644LeuGlu: 5.644 ± 0.063	4.218LeuPhe: 4.218 ± 0.054	7.052LeuGly: 7.052 ± 0.061	1.944LeuHis: 1.944 ± 0.03	5.396LeuIle: 5.396 ± 0.069	4.568LeuLys: 4.568 ± 0.05	11.081LeuLeu: 11.081 ± 0.11	2.326LeuMet: 2.326 ± 0.031	3.383LeuAsn: 3.383 ± 0.042	4.99LeuPro: 4.99 ± 0.051	3.57LeuGln: 3.57 ± 0.038	6.085LeuArg: 6.085 ± 0.068	7.043LeuSer: 7.043 ± 0.055	5.661LeuThr: 5.661 ± 0.061	6.31LeuVal: 6.31 ± 0.057	1.092LeuTrp: 1.092 ± 0.025	3.181LeuTyr: 3.181 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.356MetAla: 2.356 ± 0.035	0.127MetCys: 0.127 ± 0.007	1.346MetAsp: 1.346 ± 0.027	1.444MetGlu: 1.444 ± 0.03	0.9MetPhe: 0.9 ± 0.023	1.522MetGly: 1.522 ± 0.027	0.449MetHis: 0.449 ± 0.014	1.451MetIle: 1.451 ± 0.03	1.553MetLys: 1.553 ± 0.027	2.759MetLeu: 2.759 ± 0.038	0.685MetMet: 0.685 ± 0.019	1.258MetAsn: 1.258 ± 0.022	1.273MetPro: 1.273 ± 0.024	0.844MetGln: 0.844 ± 0.02	1.518MetArg: 1.518 ± 0.029	1.744MetSer: 1.744 ± 0.024	1.66MetThr: 1.66 ± 0.032	1.35MetVal: 1.35 ± 0.029	0.228MetTrp: 0.228 ± 0.012	0.671MetTyr: 0.671 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.439AsnAla: 3.439 ± 0.048	0.167AsnCys: 0.167 ± 0.008	1.782AsnAsp: 1.782 ± 0.033	1.984AsnGlu: 1.984 ± 0.034	1.117AsnPhe: 1.117 ± 0.023	3.188AsnGly: 3.188 ± 0.049	0.631AsnHis: 0.631 ± 0.018	1.636AsnIle: 1.636 ± 0.03	1.44AsnLys: 1.44 ± 0.026	2.901AsnLeu: 2.901 ± 0.042	0.759AsnMet: 0.759 ± 0.02	1.272AsnAsn: 1.272 ± 0.032	1.78AsnPro: 1.78 ± 0.035	0.988AsnGln: 0.988 ± 0.02	1.973AsnArg: 1.973 ± 0.032	1.553AsnSer: 1.553 ± 0.033	1.673AsnThr: 1.673 ± 0.035	2.485AsnVal: 2.485 ± 0.037	0.499AsnTrp: 0.499 ± 0.017	1.177AsnTyr: 1.177 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.974ProAla: 4.974 ± 0.067	0.243ProCys: 0.243 ± 0.014	3.092ProAsp: 3.092 ± 0.043	3.343ProGlu: 3.343 ± 0.04	1.928ProPhe: 1.928 ± 0.031	3.721ProGly: 3.721 ± 0.048	0.884ProHis: 0.884 ± 0.021	2.388ProIle: 2.388 ± 0.032	1.602ProLys: 1.602 ± 0.032	4.219ProLeu: 4.219 ± 0.053	0.988ProMet: 0.988 ± 0.022	1.426ProAsn: 1.426 ± 0.024	1.585ProPro: 1.585 ± 0.035	1.322ProGln: 1.322 ± 0.026	1.76ProArg: 1.76 ± 0.03	2.948ProSer: 2.948 ± 0.046	2.168ProThr: 2.168 ± 0.041	3.387ProVal: 3.387 ± 0.039	0.588ProTrp: 0.588 ± 0.015	1.581ProTyr: 1.581 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.743GlnAla: 3.743 ± 0.05	0.156GlnCys: 0.156 ± 0.01	1.576GlnAsp: 1.576 ± 0.029	1.875GlnGlu: 1.875 ± 0.035	1.26GlnPhe: 1.26 ± 0.025	2.45GlnGly: 2.45 ± 0.039	0.576GlnHis: 0.576 ± 0.017	1.924GlnIle: 1.924 ± 0.034	1.357GlnLys: 1.357 ± 0.024	3.528GlnLeu: 3.528 ± 0.044	0.873GlnMet: 0.873 ± 0.019	1.007GlnAsn: 1.007 ± 0.023	1.494GlnPro: 1.494 ± 0.029	1.382GlnGln: 1.382 ± 0.031	1.879GlnArg: 1.879 ± 0.034	2.099GlnSer: 2.099 ± 0.028	1.919GlnThr: 1.919 ± 0.031	2.211GlnVal: 2.211 ± 0.03	0.501GlnTrp: 0.501 ± 0.015	1.165GlnTyr: 1.165 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.96ArgAla: 4.96 ± 0.054	0.376ArgCys: 0.376 ± 0.014	3.028ArgAsp: 3.028 ± 0.041	4.384ArgGlu: 4.384 ± 0.063	2.637ArgPhe: 2.637 ± 0.036	3.84ArgGly: 3.84 ± 0.045	1.328ArgHis: 1.328 ± 0.026	4.113ArgIle: 4.113 ± 0.048	2.704ArgLys: 2.704 ± 0.035	6.81ArgLeu: 6.81 ± 0.073	1.9ArgMet: 1.9 ± 0.029	1.668ArgAsn: 1.668 ± 0.032	2.341ArgPro: 2.341 ± 0.036	2.262ArgGln: 2.262 ± 0.037	3.976ArgArg: 3.976 ± 0.061	3.637ArgSer: 3.637 ± 0.047	3.326ArgThr: 3.326 ± 0.042	3.555ArgVal: 3.555 ± 0.042	0.867ArgTrp: 0.867 ± 0.022	2.175ArgTyr: 2.175 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.857SerAla: 6.857 ± 0.076	0.378SerCys: 0.378 ± 0.013	3.298SerAsp: 3.298 ± 0.038	3.526SerGlu: 3.526 ± 0.04	2.757SerPhe: 2.757 ± 0.031	6.097SerGly: 6.097 ± 0.069	1.07SerHis: 1.07 ± 0.022	3.293SerIle: 3.293 ± 0.044	2.507SerLys: 2.507 ± 0.039	6.154SerLeu: 6.154 ± 0.063	1.508SerMet: 1.508 ± 0.024	1.878SerAsn: 1.878 ± 0.033	2.776SerPro: 2.776 ± 0.049	1.79SerGln: 1.79 ± 0.03	3.458SerArg: 3.458 ± 0.05	3.825SerSer: 3.825 ± 0.055	2.866SerThr: 2.866 ± 0.048	4.59SerVal: 4.59 ± 0.058	0.932SerTrp: 0.932 ± 0.021	2.167SerTyr: 2.167 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.755ThrAla: 5.755 ± 0.075	0.276ThrCys: 0.276 ± 0.011	3.095ThrAsp: 3.095 ± 0.042	2.872ThrGlu: 2.872 ± 0.032	2.24ThrPhe: 2.24 ± 0.038	4.881ThrGly: 4.881 ± 0.063	0.864ThrHis: 0.864 ± 0.02	3.327ThrIle: 3.327 ± 0.044	1.952ThrLys: 1.952 ± 0.032	5.549ThrLeu: 5.549 ± 0.059	1.212ThrMet: 1.212 ± 0.025	1.756ThrAsn: 1.756 ± 0.03	2.667ThrPro: 2.667 ± 0.051	1.464ThrGln: 1.464 ± 0.029	2.375ThrArg: 2.375 ± 0.03	3.034ThrSer: 3.034 ± 0.044	2.84ThrThr: 2.84 ± 0.054	4.639ThrVal: 4.639 ± 0.06	0.671ThrTrp: 0.671 ± 0.017	1.906ThrTyr: 1.906 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	6.366ValAla: 6.366 ± 0.057	0.579ValCys: 0.579 ± 0.019	3.676ValAsp: 3.676 ± 0.041	3.86ValGlu: 3.86 ± 0.039	2.771ValPhe: 2.771 ± 0.037	4.98ValGly: 4.98 ± 0.057	1.346ValHis: 1.346 ± 0.025	3.759ValIle: 3.759 ± 0.047	3.42ValLys: 3.42 ± 0.048	6.878ValLeu: 6.878 ± 0.068	1.661ValMet: 1.661 ± 0.03	2.557ValAsn: 2.557 ± 0.038	3.411ValPro: 3.411 ± 0.041	2.388ValGln: 2.388 ± 0.034	4.551ValArg: 4.551 ± 0.051	4.962ValSer: 4.962 ± 0.047	4.348ValThr: 4.348 ± 0.057	5.289ValVal: 5.289 ± 0.052	0.957ValTrp: 0.957 ± 0.022	2.546ValTyr: 2.546 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.06TrpAla: 1.06 ± 0.021	0.109TrpCys: 0.109 ± 0.007	0.768TrpAsp: 0.768 ± 0.019	0.784TrpGlu: 0.784 ± 0.021	0.58TrpPhe: 0.58 ± 0.017	0.943TrpGly: 0.943 ± 0.024	0.31TrpHis: 0.31 ± 0.013	0.877TrpIle: 0.877 ± 0.023	0.676TrpLys: 0.676 ± 0.02	1.565TrpLeu: 1.565 ± 0.03	0.424TrpMet: 0.424 ± 0.015	0.675TrpAsn: 0.675 ± 0.017	0.522TrpPro: 0.522 ± 0.017	0.576TrpGln: 0.576 ± 0.021	0.896TrpArg: 0.896 ± 0.02	0.945TrpSer: 0.945 ± 0.022	1.003TrpThr: 1.003 ± 0.027	0.774TrpVal: 0.774 ± 0.022	0.227TrpTrp: 0.227 ± 0.011	0.481TrpTyr: 0.481 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.539TyrAla: 3.539 ± 0.046	0.253TyrCys: 0.253 ± 0.011	2.077TyrAsp: 2.077 ± 0.036	2.206TyrGlu: 2.206 ± 0.034	1.48TyrPhe: 1.48 ± 0.028	2.957TyrGly: 2.957 ± 0.039	0.649TyrHis: 0.649 ± 0.018	1.649TyrIle: 1.649 ± 0.028	1.422TyrLys: 1.422 ± 0.024	3.282TyrLeu: 3.282 ± 0.037	0.836TyrMet: 0.836 ± 0.019	1.252TyrAsn: 1.252 ± 0.028	1.605TyrPro: 1.605 ± 0.03	1.022TyrGln: 1.022 ± 0.021	2.439TyrArg: 2.439 ± 0.038	1.791TyrSer: 1.791 ± 0.033	1.697TyrThr: 1.697 ± 0.035	2.383TyrVal: 2.383 ± 0.033	0.525TyrTrp: 0.525 ± 0.015	1.386TyrTyr: 1.386 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6192 proteins (2204178 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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