Amino acid dipepetide frequency for cyanobacterium endosymbiont of Rhopalodia gibberula

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.431AlaAla: 5.431 ± 0.124
0.764AlaCys: 0.764 ± 0.037
3.096AlaAsp: 3.096 ± 0.083
3.953AlaGlu: 3.953 ± 0.087
2.42AlaPhe: 2.42 ± 0.08
4.515AlaGly: 4.515 ± 0.094
1.169AlaHis: 1.169 ± 0.051
6.254AlaIle: 6.254 ± 0.119
3.973AlaLys: 3.973 ± 0.082
7.206AlaLeu: 7.206 ± 0.122
1.574AlaMet: 1.574 ± 0.055
2.689AlaAsn: 2.689 ± 0.084
2.147AlaPro: 2.147 ± 0.08
3.638AlaGln: 3.638 ± 0.089
3.059AlaArg: 3.059 ± 0.099
3.86AlaSer: 3.86 ± 0.087
3.799AlaThr: 3.799 ± 0.09
4.726AlaVal: 4.726 ± 0.106
0.833AlaTrp: 0.833 ± 0.042
2.14AlaTyr: 2.14 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.577CysAla: 0.577 ± 0.036
0.196CysCys: 0.196 ± 0.021
0.568CysAsp: 0.568 ± 0.031
0.528CysGlu: 0.528 ± 0.03
0.423CysPhe: 0.423 ± 0.028
0.91CysGly: 0.91 ± 0.046
0.284CysHis: 0.284 ± 0.024
0.637CysIle: 0.637 ± 0.032
0.401CysLys: 0.401 ± 0.025
1.297CysLeu: 1.297 ± 0.056
0.139CysMet: 0.139 ± 0.017
0.407CysAsn: 0.407 ± 0.031
0.735CysPro: 0.735 ± 0.04
0.694CysGln: 0.694 ± 0.035
0.65CysArg: 0.65 ± 0.039
0.669CysSer: 0.669 ± 0.04
0.559CysThr: 0.559 ± 0.032
0.61CysVal: 0.61 ± 0.035
0.161CysTrp: 0.161 ± 0.018
0.43CysTyr: 0.43 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.704AspAla: 2.704 ± 0.073
0.676AspCys: 0.676 ± 0.038
1.982AspAsp: 1.982 ± 0.065
2.673AspGlu: 2.673 ± 0.085
2.187AspPhe: 2.187 ± 0.063
2.933AspGly: 2.933 ± 0.092
1.026AspHis: 1.026 ± 0.044
3.728AspIle: 3.728 ± 0.075
2.524AspLys: 2.524 ± 0.073
5.574AspLeu: 5.574 ± 0.095
0.793AspMet: 0.793 ± 0.039
2.182AspAsn: 2.182 ± 0.055
2.314AspPro: 2.314 ± 0.063
1.751AspGln: 1.751 ± 0.06
2.737AspArg: 2.737 ± 0.068
2.946AspSer: 2.946 ± 0.078
2.339AspThr: 2.339 ± 0.063
2.859AspVal: 2.859 ± 0.071
0.909AspTrp: 0.909 ± 0.045
2.0AspTyr: 2.0 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.746GluAla: 4.746 ± 0.109
0.458GluCys: 0.458 ± 0.031
2.722GluAsp: 2.722 ± 0.08
4.393GluGlu: 4.393 ± 0.119
2.383GluPhe: 2.383 ± 0.066
3.567GluGly: 3.567 ± 0.077
0.987GluHis: 0.987 ± 0.046
5.419GluIle: 5.419 ± 0.109
4.384GluLys: 4.384 ± 0.102
6.743GluLeu: 6.743 ± 0.123
1.418GluMet: 1.418 ± 0.051
2.775GluAsn: 2.775 ± 0.072
2.167GluPro: 2.167 ± 0.066
3.246GluGln: 3.246 ± 0.103
3.138GluArg: 3.138 ± 0.082
3.27GluSer: 3.27 ± 0.078
3.99GluThr: 3.99 ± 0.102
4.548GluVal: 4.548 ± 0.107
0.654GluTrp: 0.654 ± 0.035
1.628GluTyr: 1.628 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
2.37PheAla: 2.37 ± 0.066
0.594PheCys: 0.594 ± 0.032
2.129PheAsp: 2.129 ± 0.064
2.358PheGlu: 2.358 ± 0.066
1.843PhePhe: 1.843 ± 0.072
2.759PheGly: 2.759 ± 0.076
0.724PheHis: 0.724 ± 0.04
2.795PheIle: 2.795 ± 0.081
1.933PheLys: 1.933 ± 0.066
4.378PheLeu: 4.378 ± 0.101
0.703PheMet: 0.703 ± 0.04
1.907PheAsn: 1.907 ± 0.058
2.121PhePro: 2.121 ± 0.066
1.623PheGln: 1.623 ± 0.059
1.812PheArg: 1.812 ± 0.052
3.043PheSer: 3.043 ± 0.079
2.167PheThr: 2.167 ± 0.065
2.268PheVal: 2.268 ± 0.069
0.707PheTrp: 0.707 ± 0.043
1.486PheTyr: 1.486 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.296GlyAla: 4.296 ± 0.096
0.876GlyCys: 0.876 ± 0.045
3.147GlyAsp: 3.147 ± 0.069
3.946GlyGlu: 3.946 ± 0.088
2.843GlyPhe: 2.843 ± 0.073
4.913GlyGly: 4.913 ± 0.115
1.286GlyHis: 1.286 ± 0.051
6.069GlyIle: 6.069 ± 0.109
4.45GlyLys: 4.45 ± 0.101
7.36GlyLeu: 7.36 ± 0.141
1.579GlyMet: 1.579 ± 0.062
2.746GlyAsn: 2.746 ± 0.079
1.542GlyPro: 1.542 ± 0.057
2.949GlyGln: 2.949 ± 0.079
3.365GlyArg: 3.365 ± 0.086
3.83GlySer: 3.83 ± 0.08
4.094GlyThr: 4.094 ± 0.08
4.935GlyVal: 4.935 ± 0.109
1.033GlyTrp: 1.033 ± 0.049
2.42GlyTyr: 2.42 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.006HisAla: 1.006 ± 0.05
0.284HisCys: 0.284 ± 0.025
0.707HisAsp: 0.707 ± 0.035
0.844HisGlu: 0.844 ± 0.046
0.879HisPhe: 0.879 ± 0.044
1.319HisGly: 1.319 ± 0.062
0.632HisHis: 0.632 ± 0.042
1.193HisIle: 1.193 ± 0.047
0.942HisLys: 0.942 ± 0.042
2.372HisLeu: 2.372 ± 0.069
0.255HisMet: 0.255 ± 0.023
0.874HisAsn: 0.874 ± 0.042
1.414HisPro: 1.414 ± 0.058
1.255HisGln: 1.255 ± 0.053
1.191HisArg: 1.191 ± 0.052
1.215HisSer: 1.215 ± 0.054
0.899HisThr: 0.899 ± 0.042
0.843HisVal: 0.843 ± 0.04
0.352HisTrp: 0.352 ± 0.026
0.762HisTyr: 0.762 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.505IleAla: 6.505 ± 0.118
0.934IleCys: 0.934 ± 0.047
4.156IleAsp: 4.156 ± 0.089
5.023IleGlu: 5.023 ± 0.109
3.055IlePhe: 3.055 ± 0.088
5.017IleGly: 5.017 ± 0.11
1.361IleHis: 1.361 ± 0.053
5.55IleIle: 5.55 ± 0.131
3.905IleLys: 3.905 ± 0.089
8.263IleLeu: 8.263 ± 0.154
1.143IleMet: 1.143 ± 0.044
3.62IleAsn: 3.62 ± 0.112
4.266IlePro: 4.266 ± 0.09
2.902IleGln: 2.902 ± 0.08
3.568IleArg: 3.568 ± 0.092
5.252IleSer: 5.252 ± 0.107
4.548IleThr: 4.548 ± 0.106
4.862IleVal: 4.862 ± 0.091
0.92IleTrp: 0.92 ± 0.048
2.306IleTyr: 2.306 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
3.911LysAla: 3.911 ± 0.097
0.357LysCys: 0.357 ± 0.024
2.449LysAsp: 2.449 ± 0.061
3.781LysGlu: 3.781 ± 0.101
1.819LysPhe: 1.819 ± 0.057
3.088LysGly: 3.088 ± 0.072
0.839LysHis: 0.839 ± 0.041
4.953LysIle: 4.953 ± 0.116
3.545LysLys: 3.545 ± 0.095
6.155LysLeu: 6.155 ± 0.124
1.161LysMet: 1.161 ± 0.047
2.724LysAsn: 2.724 ± 0.077
2.445LysPro: 2.445 ± 0.075
2.891LysGln: 2.891 ± 0.073
2.685LysArg: 2.685 ± 0.081
3.372LysSer: 3.372 ± 0.081
3.733LysThr: 3.733 ± 0.086
3.821LysVal: 3.821 ± 0.081
0.562LysTrp: 0.562 ± 0.035
1.585LysTyr: 1.585 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
8.223LeuAla: 8.223 ± 0.137
1.101LeuCys: 1.101 ± 0.047
5.446LeuAsp: 5.446 ± 0.112
8.137LeuGlu: 8.137 ± 0.134
3.935LeuPhe: 3.935 ± 0.107
8.421LeuGly: 8.421 ± 0.121
1.799LeuHis: 1.799 ± 0.059
8.06LeuIle: 8.06 ± 0.163
6.655LeuLys: 6.655 ± 0.127
11.132LeuLeu: 11.132 ± 0.187
2.248LeuMet: 2.248 ± 0.067
4.843LeuAsn: 4.843 ± 0.115
5.325LeuPro: 5.325 ± 0.109
4.79LeuGln: 4.79 ± 0.114
5.177LeuArg: 5.177 ± 0.093
7.974LeuSer: 7.974 ± 0.138
6.908LeuThr: 6.908 ± 0.121
7.745LeuVal: 7.745 ± 0.133
1.394LeuTrp: 1.394 ± 0.062
2.872LeuTyr: 2.872 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
1.74MetAla: 1.74 ± 0.06
0.134MetCys: 0.134 ± 0.015
0.736MetAsp: 0.736 ± 0.043
0.991MetGlu: 0.991 ± 0.043
0.621MetPhe: 0.621 ± 0.034
1.634MetGly: 1.634 ± 0.052
0.284MetHis: 0.284 ± 0.023
1.585MetIle: 1.585 ± 0.058
1.092MetLys: 1.092 ± 0.048
1.839MetLeu: 1.839 ± 0.07
0.462MetMet: 0.462 ± 0.028
0.784MetAsn: 0.784 ± 0.038
0.777MetPro: 0.777 ± 0.038
0.667MetGln: 0.667 ± 0.034
0.945MetArg: 0.945 ± 0.049
1.42MetSer: 1.42 ± 0.047
1.498MetThr: 1.498 ± 0.049
1.475MetVal: 1.475 ± 0.055
0.141MetTrp: 0.141 ± 0.016
0.333MetTyr: 0.333 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.467AsnAla: 2.467 ± 0.068
0.628AsnCys: 0.628 ± 0.037
1.672AsnAsp: 1.672 ± 0.051
1.812AsnGlu: 1.812 ± 0.06
2.052AsnPhe: 2.052 ± 0.07
2.359AsnGly: 2.359 ± 0.078
1.057AsnHis: 1.057 ± 0.046
3.118AsnIle: 3.118 ± 0.088
2.237AsnLys: 2.237 ± 0.065
5.822AsnLeu: 5.822 ± 0.121
0.7AsnMet: 0.7 ± 0.038
2.217AsnAsn: 2.217 ± 0.072
2.878AsnPro: 2.878 ± 0.078
2.497AsnGln: 2.497 ± 0.078
2.407AsnArg: 2.407 ± 0.07
2.98AsnSer: 2.98 ± 0.083
2.152AsnThr: 2.152 ± 0.055
2.264AsnVal: 2.264 ± 0.069
0.735AsnTrp: 0.735 ± 0.037
1.753AsnTyr: 1.753 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.217ProAla: 2.217 ± 0.068
0.405ProCys: 0.405 ± 0.027
2.528ProAsp: 2.528 ± 0.061
3.508ProGlu: 3.508 ± 0.092
1.867ProPhe: 1.867 ± 0.055
2.957ProGly: 2.957 ± 0.083
1.009ProHis: 1.009 ± 0.043
3.543ProIle: 3.543 ± 0.086
2.33ProLys: 2.33 ± 0.063
5.122ProLeu: 5.122 ± 0.11
0.76ProMet: 0.76 ± 0.041
2.215ProAsn: 2.215 ± 0.065
1.958ProPro: 1.958 ± 0.083
2.467ProGln: 2.467 ± 0.079
1.821ProArg: 1.821 ± 0.068
2.876ProSer: 2.876 ± 0.073
2.638ProThr: 2.638 ± 0.079
3.004ProVal: 3.004 ± 0.08
0.634ProTrp: 0.634 ± 0.035
1.506ProTyr: 1.506 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
3.345GlnAla: 3.345 ± 0.081
0.35GlnCys: 0.35 ± 0.028
1.978GlnAsp: 1.978 ± 0.061
3.698GlnGlu: 3.698 ± 0.097
1.702GlnPhe: 1.702 ± 0.062
3.656GlnGly: 3.656 ± 0.086
0.78GlnHis: 0.78 ± 0.042
3.418GlnIle: 3.418 ± 0.085
3.125GlnLys: 3.125 ± 0.092
5.765GlnLeu: 5.765 ± 0.133
0.969GlnMet: 0.969 ± 0.042
1.821GlnAsn: 1.821 ± 0.064
1.931GlnPro: 1.931 ± 0.068
2.968GlnGln: 2.968 ± 0.099
2.649GlnArg: 2.649 ± 0.068
2.964GlnSer: 2.964 ± 0.087
2.717GlnThr: 2.717 ± 0.074
3.66GlnVal: 3.66 ± 0.078
0.757GlnTrp: 0.757 ± 0.038
1.233GlnTyr: 1.233 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.828ArgAla: 2.828 ± 0.076
0.485ArgCys: 0.485 ± 0.032
2.328ArgAsp: 2.328 ± 0.065
3.173ArgGlu: 3.173 ± 0.092
2.121ArgPhe: 2.121 ± 0.059
3.041ArgGly: 3.041 ± 0.08
1.097ArgHis: 1.097 ± 0.048
3.658ArgIle: 3.658 ± 0.084
2.627ArgLys: 2.627 ± 0.065
5.891ArgLeu: 5.891 ± 0.1
0.907ArgMet: 0.907 ± 0.045
2.108ArgAsn: 2.108 ± 0.058
1.98ArgPro: 1.98 ± 0.066
3.054ArgGln: 3.054 ± 0.074
3.165ArgArg: 3.165 ± 0.09
2.984ArgSer: 2.984 ± 0.078
2.504ArgThr: 2.504 ± 0.073
3.325ArgVal: 3.325 ± 0.081
0.779ArgTrp: 0.779 ± 0.044
1.865ArgTyr: 1.865 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
3.453SerAla: 3.453 ± 0.08
0.779SerCys: 0.779 ± 0.04
2.918SerAsp: 2.918 ± 0.071
3.62SerGlu: 3.62 ± 0.085
2.702SerPhe: 2.702 ± 0.086
4.268SerGly: 4.268 ± 0.096
1.48SerHis: 1.48 ± 0.055
4.44SerIle: 4.44 ± 0.088
3.206SerLys: 3.206 ± 0.088
8.194SerLeu: 8.194 ± 0.125
1.249SerMet: 1.249 ± 0.049
2.744SerAsn: 2.744 ± 0.07
3.437SerPro: 3.437 ± 0.087
3.726SerGln: 3.726 ± 0.079
3.169SerArg: 3.169 ± 0.079
4.867SerSer: 4.867 ± 0.14
3.25SerThr: 3.25 ± 0.076
3.882SerVal: 3.882 ± 0.088
0.883SerTrp: 0.883 ± 0.037
2.041SerTyr: 2.041 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
4.103ThrAla: 4.103 ± 0.086
0.539ThrCys: 0.539 ± 0.032
2.629ThrAsp: 2.629 ± 0.071
3.404ThrGlu: 3.404 ± 0.075
2.191ThrPhe: 2.191 ± 0.066
4.14ThrGly: 4.14 ± 0.099
1.127ThrHis: 1.127 ± 0.048
4.473ThrIle: 4.473 ± 0.093
2.702ThrLys: 2.702 ± 0.08
6.831ThrLeu: 6.831 ± 0.135
0.964ThrMet: 0.964 ± 0.041
2.317ThrAsn: 2.317 ± 0.066
3.198ThrPro: 3.198 ± 0.089
2.667ThrGln: 2.667 ± 0.079
2.515ThrArg: 2.515 ± 0.073
3.642ThrSer: 3.642 ± 0.091
3.352ThrThr: 3.352 ± 0.09
3.988ThrVal: 3.988 ± 0.096
0.747ThrTrp: 0.747 ± 0.041
1.738ThrTyr: 1.738 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
4.929ValAla: 4.929 ± 0.099
0.758ValCys: 0.758 ± 0.035
3.548ValAsp: 3.548 ± 0.097
4.228ValGlu: 4.228 ± 0.101
2.618ValPhe: 2.618 ± 0.07
4.88ValGly: 4.88 ± 0.1
1.171ValHis: 1.171 ± 0.041
5.411ValIle: 5.411 ± 0.113
3.623ValLys: 3.623 ± 0.085
6.274ValLeu: 6.274 ± 0.102
1.396ValMet: 1.396 ± 0.061
2.958ValAsn: 2.958 ± 0.069
2.748ValPro: 2.748 ± 0.069
2.59ValGln: 2.59 ± 0.069
3.138ValArg: 3.138 ± 0.083
4.329ValSer: 4.329 ± 0.105
4.006ValThr: 4.006 ± 0.089
4.704ValVal: 4.704 ± 0.108
0.795ValTrp: 0.795 ± 0.039
1.89ValTyr: 1.89 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.661TrpAla: 0.661 ± 0.042
0.134TrpCys: 0.134 ± 0.016
0.632TrpAsp: 0.632 ± 0.039
0.839TrpGlu: 0.839 ± 0.046
0.636TrpPhe: 0.636 ± 0.038
1.07TrpGly: 1.07 ± 0.047
0.308TrpHis: 0.308 ± 0.025
0.918TrpIle: 0.918 ± 0.043
0.768TrpLys: 0.768 ± 0.035
1.876TrpLeu: 1.876 ± 0.068
0.286TrpMet: 0.286 ± 0.023
0.572TrpAsn: 0.572 ± 0.037
0.275TrpPro: 0.275 ± 0.022
1.008TrpGln: 1.008 ± 0.046
0.753TrpArg: 0.753 ± 0.037
0.788TrpSer: 0.788 ± 0.035
0.7TrpThr: 0.7 ± 0.036
0.91TrpVal: 0.91 ± 0.04
0.234TrpTrp: 0.234 ± 0.02
0.416TrpTyr: 0.416 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.733TyrAla: 1.733 ± 0.051
0.425TyrCys: 0.425 ± 0.029
1.464TyrAsp: 1.464 ± 0.053
1.729TyrGlu: 1.729 ± 0.073
1.422TyrPhe: 1.422 ± 0.051
2.231TyrGly: 2.231 ± 0.066
0.817TyrHis: 0.817 ± 0.041
1.936TyrIle: 1.936 ± 0.066
1.46TyrLys: 1.46 ± 0.059
4.09TyrLeu: 4.09 ± 0.091
0.451TyrMet: 0.451 ± 0.027
1.304TyrAsn: 1.304 ± 0.053
1.705TyrPro: 1.705 ± 0.067
2.103TyrGln: 2.103 ± 0.058
1.977TyrArg: 1.977 ± 0.062
2.028TyrSer: 2.028 ± 0.056
1.412TyrThr: 1.412 ± 0.049
1.566TyrVal: 1.566 ± 0.052
0.551TyrTrp: 0.551 ± 0.037
1.064TyrTyr: 1.064 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1671 proteins (545903 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski