Amino acid dipepetide frequency for Mycoplasma sp. Mirounga ES2806-GEN

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.236AlaAla: 3.236 ± 0.163
0.405AlaCys: 0.405 ± 0.045
2.915AlaAsp: 2.915 ± 0.106
3.278AlaGlu: 3.278 ± 0.187
2.844AlaPhe: 2.844 ± 0.139
2.853AlaGly: 2.853 ± 0.134
0.93AlaHis: 0.93 ± 0.063
5.351AlaIle: 5.351 ± 0.177
6.519AlaLys: 6.519 ± 0.287
5.543AlaLeu: 5.543 ± 0.166
1.285AlaMet: 1.285 ± 0.086
3.633AlaAsn: 3.633 ± 0.153
1.38AlaPro: 1.38 ± 0.081
2.173AlaGln: 2.173 ± 0.147
2.039AlaArg: 2.039 ± 0.103
3.512AlaSer: 3.512 ± 0.126
3.316AlaThr: 3.316 ± 0.149
3.128AlaVal: 3.128 ± 0.125
0.409AlaTrp: 0.409 ± 0.047
1.994AlaTyr: 1.994 ± 0.098
0.0AlaXaa: 0.0 ± 0.0
Cys
0.384CysAla: 0.384 ± 0.042
0.071CysCys: 0.071 ± 0.017
0.354CysAsp: 0.354 ± 0.041
0.396CysGlu: 0.396 ± 0.041
0.354CysPhe: 0.354 ± 0.039
0.321CysGly: 0.321 ± 0.041
0.133CysHis: 0.133 ± 0.025
0.405CysIle: 0.405 ± 0.041
0.455CysLys: 0.455 ± 0.042
0.663CysLeu: 0.663 ± 0.057
0.113CysMet: 0.113 ± 0.021
0.384CysAsn: 0.384 ± 0.039
0.217CysPro: 0.217 ± 0.032
0.146CysGln: 0.146 ± 0.028
0.175CysArg: 0.175 ± 0.026
0.434CysSer: 0.434 ± 0.045
0.229CysThr: 0.229 ± 0.034
0.425CysVal: 0.425 ± 0.043
0.075CysTrp: 0.075 ± 0.017
0.259CysTyr: 0.259 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.332AspAla: 3.332 ± 0.226
0.25AspCys: 0.25 ± 0.032
2.982AspAsp: 2.982 ± 0.127
4.629AspGlu: 4.629 ± 0.14
3.403AspPhe: 3.403 ± 0.109
2.769AspGly: 2.769 ± 0.113
0.742AspHis: 0.742 ± 0.051
4.842AspIle: 4.842 ± 0.158
6.189AspLys: 6.189 ± 0.176
6.064AspLeu: 6.064 ± 0.181
0.863AspMet: 0.863 ± 0.06
3.937AspAsn: 3.937 ± 0.16
1.514AspPro: 1.514 ± 0.082
1.664AspGln: 1.664 ± 0.089
1.51AspArg: 1.51 ± 0.086
3.995AspSer: 3.995 ± 0.147
2.728AspThr: 2.728 ± 0.123
3.386AspVal: 3.386 ± 0.122
0.68AspTrp: 0.68 ± 0.053
2.728AspTyr: 2.728 ± 0.107
0.0AspXaa: 0.0 ± 0.0
Glu
3.587GluAla: 3.587 ± 0.185
0.3GluCys: 0.3 ± 0.036
2.732GluAsp: 2.732 ± 0.149
4.229GluGlu: 4.229 ± 0.17
4.062GluPhe: 4.062 ± 0.149
2.427GluGly: 2.427 ± 0.118
1.013GluHis: 1.013 ± 0.054
6.635GluIle: 6.635 ± 0.195
6.589GluLys: 6.589 ± 0.184
7.54GluLeu: 7.54 ± 0.196
1.464GluMet: 1.464 ± 0.083
5.372GluAsn: 5.372 ± 0.153
1.443GluPro: 1.443 ± 0.082
2.552GluGln: 2.552 ± 0.124
1.839GluArg: 1.839 ± 0.108
3.499GluSer: 3.499 ± 0.128
3.424GluThr: 3.424 ± 0.123
3.537GluVal: 3.537 ± 0.144
0.601GluTrp: 0.601 ± 0.054
2.974GluTyr: 2.974 ± 0.128
0.0GluXaa: 0.0 ± 0.0
Phe
3.011PheAla: 3.011 ± 0.119
0.396PheCys: 0.396 ± 0.041
3.745PheAsp: 3.745 ± 0.142
3.307PheGlu: 3.307 ± 0.101
2.206PhePhe: 2.206 ± 0.113
2.782PheGly: 2.782 ± 0.12
0.663PheHis: 0.663 ± 0.056
4.796PheIle: 4.796 ± 0.169
5.084PheLys: 5.084 ± 0.151
4.116PheLeu: 4.116 ± 0.162
0.93PheMet: 0.93 ± 0.068
4.166PheAsn: 4.166 ± 0.138
1.001PhePro: 1.001 ± 0.07
1.205PheGln: 1.205 ± 0.069
1.372PheArg: 1.372 ± 0.072
3.416PheSer: 3.416 ± 0.146
2.894PheThr: 2.894 ± 0.129
3.37PheVal: 3.37 ± 0.142
0.534PheTrp: 0.534 ± 0.047
1.898PheTyr: 1.898 ± 0.105
0.0PheXaa: 0.0 ± 0.0
Gly
2.894GlyAla: 2.894 ± 0.107
0.296GlyCys: 0.296 ± 0.035
2.652GlyAsp: 2.652 ± 0.127
2.857GlyGlu: 2.857 ± 0.121
2.582GlyPhe: 2.582 ± 0.107
2.903GlyGly: 2.903 ± 0.148
0.963GlyHis: 0.963 ± 0.07
4.241GlyIle: 4.241 ± 0.152
4.367GlyLys: 4.367 ± 0.145
4.533GlyLeu: 4.533 ± 0.136
0.951GlyMet: 0.951 ± 0.071
2.498GlyAsn: 2.498 ± 0.114
1.08GlyPro: 1.08 ± 0.077
1.677GlyGln: 1.677 ± 0.085
1.714GlyArg: 1.714 ± 0.108
3.065GlySer: 3.065 ± 0.149
2.527GlyThr: 2.527 ± 0.092
3.403GlyVal: 3.403 ± 0.134
0.592GlyTrp: 0.592 ± 0.052
2.014GlyTyr: 2.014 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
0.792HisAla: 0.792 ± 0.059
0.113HisCys: 0.113 ± 0.024
0.926HisAsp: 0.926 ± 0.064
1.084HisGlu: 1.084 ± 0.063
0.855HisPhe: 0.855 ± 0.053
0.993HisGly: 0.993 ± 0.064
0.35HisHis: 0.35 ± 0.041
1.33HisIle: 1.33 ± 0.082
1.335HisLys: 1.335 ± 0.075
1.251HisLeu: 1.251 ± 0.077
0.259HisMet: 0.259 ± 0.028
1.105HisAsn: 1.105 ± 0.072
0.696HisPro: 0.696 ± 0.058
0.563HisGln: 0.563 ± 0.055
0.484HisArg: 0.484 ± 0.042
1.101HisSer: 1.101 ± 0.087
0.763HisThr: 0.763 ± 0.059
0.847HisVal: 0.847 ± 0.062
0.167HisTrp: 0.167 ± 0.025
0.667HisTyr: 0.667 ± 0.059
0.0HisXaa: 0.0 ± 0.0
Ile
5.401IleAla: 5.401 ± 0.158
0.759IleCys: 0.759 ± 0.075
6.335IleAsp: 6.335 ± 0.186
6.156IleGlu: 6.156 ± 0.191
4.321IlePhe: 4.321 ± 0.188
4.212IleGly: 4.212 ± 0.145
1.193IleHis: 1.193 ± 0.075
7.953IleIle: 7.953 ± 0.231
9.038IleLys: 9.038 ± 0.21
7.211IleLeu: 7.211 ± 0.208
1.539IleMet: 1.539 ± 0.089
7.928IleAsn: 7.928 ± 0.201
2.677IlePro: 2.677 ± 0.111
2.64IleGln: 2.64 ± 0.122
2.486IleArg: 2.486 ± 0.093
6.844IleSer: 6.844 ± 0.176
5.397IleThr: 5.397 ± 0.171
5.388IleVal: 5.388 ± 0.171
0.784IleTrp: 0.784 ± 0.076
3.266IleTyr: 3.266 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
5.301LysAla: 5.301 ± 0.302
0.413LysCys: 0.413 ± 0.042
5.651LysAsp: 5.651 ± 0.212
6.573LysGlu: 6.573 ± 0.182
4.337LysPhe: 4.337 ± 0.154
3.653LysGly: 3.653 ± 0.133
1.731LysHis: 1.731 ± 0.089
9.396LysIle: 9.396 ± 0.201
8.654LysLys: 8.654 ± 0.211
9.421LysLeu: 9.421 ± 0.229
2.607LysMet: 2.607 ± 0.102
8.554LysAsn: 8.554 ± 0.221
2.778LysPro: 2.778 ± 0.134
3.866LysGln: 3.866 ± 0.153
2.882LysArg: 2.882 ± 0.113
5.943LysSer: 5.943 ± 0.129
6.072LysThr: 6.072 ± 0.179
5.096LysVal: 5.096 ± 0.158
1.013LysTrp: 1.013 ± 0.071
4.721LysTyr: 4.721 ± 0.156
0.0LysXaa: 0.0 ± 0.0
Leu
5.63LeuAla: 5.63 ± 0.168
0.667LeuCys: 0.667 ± 0.057
5.793LeuAsp: 5.793 ± 0.17
5.868LeuGlu: 5.868 ± 0.171
4.321LeuPhe: 4.321 ± 0.178
4.629LeuGly: 4.629 ± 0.149
1.451LeuHis: 1.451 ± 0.077
8.871LeuIle: 8.871 ± 0.274
8.687LeuLys: 8.687 ± 0.22
8.433LeuLeu: 8.433 ± 0.215
1.668LeuMet: 1.668 ± 0.076
7.991LeuAsn: 7.991 ± 0.247
2.807LeuPro: 2.807 ± 0.1
2.498LeuGln: 2.498 ± 0.111
2.803LeuArg: 2.803 ± 0.114
6.69LeuSer: 6.69 ± 0.174
5.463LeuThr: 5.463 ± 0.174
5.572LeuVal: 5.572 ± 0.156
0.734LeuTrp: 0.734 ± 0.06
2.919LeuTyr: 2.919 ± 0.11
0.0LeuXaa: 0.0 ± 0.0
Met
1.18MetAla: 1.18 ± 0.076
0.113MetCys: 0.113 ± 0.017
0.922MetAsp: 0.922 ± 0.067
0.934MetGlu: 0.934 ± 0.068
1.143MetPhe: 1.143 ± 0.08
0.842MetGly: 0.842 ± 0.061
0.279MetHis: 0.279 ± 0.037
1.71MetIle: 1.71 ± 0.083
2.114MetLys: 2.114 ± 0.082
1.86MetLeu: 1.86 ± 0.089
0.417MetMet: 0.417 ± 0.041
1.526MetAsn: 1.526 ± 0.07
0.751MetPro: 0.751 ± 0.062
0.613MetGln: 0.613 ± 0.044
0.567MetArg: 0.567 ± 0.051
1.497MetSer: 1.497 ± 0.071
0.863MetThr: 0.863 ± 0.061
1.076MetVal: 1.076 ± 0.068
0.142MetTrp: 0.142 ± 0.022
0.521MetTyr: 0.521 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
4.058AsnAla: 4.058 ± 0.21
0.359AsnCys: 0.359 ± 0.04
4.446AsnAsp: 4.446 ± 0.174
5.384AsnGlu: 5.384 ± 0.19
3.745AsnPhe: 3.745 ± 0.128
3.37AsnGly: 3.37 ± 0.117
1.084AsnHis: 1.084 ± 0.076
7.132AsnIle: 7.132 ± 0.19
8.587AsnLys: 8.587 ± 0.238
6.664AsnLeu: 6.664 ± 0.173
1.197AsnMet: 1.197 ± 0.076
6.581AsnAsn: 6.581 ± 0.281
2.494AsnPro: 2.494 ± 0.116
2.519AsnGln: 2.519 ± 0.12
2.094AsnArg: 2.094 ± 0.106
5.372AsnSer: 5.372 ± 0.172
3.649AsnThr: 3.649 ± 0.128
4.237AsnVal: 4.237 ± 0.139
0.701AsnTrp: 0.701 ± 0.065
3.341AsnTyr: 3.341 ± 0.136
0.0AsnXaa: 0.0 ± 0.0
Pro
1.397ProAla: 1.397 ± 0.077
0.129ProCys: 0.129 ± 0.023
1.597ProAsp: 1.597 ± 0.089
2.461ProGlu: 2.461 ± 0.118
1.364ProPhe: 1.364 ± 0.071
1.335ProGly: 1.335 ± 0.071
0.48ProHis: 0.48 ± 0.045
2.361ProIle: 2.361 ± 0.106
2.456ProLys: 2.456 ± 0.117
2.352ProLeu: 2.352 ± 0.102
0.467ProMet: 0.467 ± 0.044
2.114ProAsn: 2.114 ± 0.106
0.509ProPro: 0.509 ± 0.047
0.934ProGln: 0.934 ± 0.062
0.776ProArg: 0.776 ± 0.074
1.764ProSer: 1.764 ± 0.081
1.71ProThr: 1.71 ± 0.101
1.702ProVal: 1.702 ± 0.097
0.346ProTrp: 0.346 ± 0.035
1.118ProTyr: 1.118 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.956GlnAla: 1.956 ± 0.126
0.154GlnCys: 0.154 ± 0.022
1.76GlnAsp: 1.76 ± 0.097
2.014GlnGlu: 2.014 ± 0.108
1.506GlnPhe: 1.506 ± 0.08
1.335GlnGly: 1.335 ± 0.085
0.525GlnHis: 0.525 ± 0.054
3.341GlnIle: 3.341 ± 0.128
3.491GlnLys: 3.491 ± 0.152
2.861GlnLeu: 2.861 ± 0.115
0.676GlnMet: 0.676 ± 0.063
2.732GlnAsn: 2.732 ± 0.13
0.842GlnPro: 0.842 ± 0.068
1.36GlnGln: 1.36 ± 0.089
1.13GlnArg: 1.13 ± 0.068
1.918GlnSer: 1.918 ± 0.1
2.123GlnThr: 2.123 ± 0.107
1.693GlnVal: 1.693 ± 0.096
0.279GlnTrp: 0.279 ± 0.034
1.38GlnTyr: 1.38 ± 0.07
0.0GlnXaa: 0.0 ± 0.0
Arg
1.823ArgAla: 1.823 ± 0.087
0.184ArgCys: 0.184 ± 0.029
1.568ArgAsp: 1.568 ± 0.102
2.094ArgGlu: 2.094 ± 0.101
1.514ArgPhe: 1.514 ± 0.095
1.551ArgGly: 1.551 ± 0.092
0.517ArgHis: 0.517 ± 0.044
2.832ArgIle: 2.832 ± 0.122
2.694ArgLys: 2.694 ± 0.116
2.652ArgLeu: 2.652 ± 0.132
0.617ArgMet: 0.617 ± 0.053
2.19ArgAsn: 2.19 ± 0.1
0.83ArgPro: 0.83 ± 0.065
1.076ArgGln: 1.076 ± 0.065
1.143ArgArg: 1.143 ± 0.079
1.677ArgSer: 1.677 ± 0.087
1.426ArgThr: 1.426 ± 0.074
1.977ArgVal: 1.977 ± 0.09
0.263ArgTrp: 0.263 ± 0.034
1.205ArgTyr: 1.205 ± 0.079
0.0ArgXaa: 0.0 ± 0.0
Ser
3.462SerAla: 3.462 ± 0.142
0.421SerCys: 0.421 ± 0.04
3.708SerAsp: 3.708 ± 0.138
3.77SerGlu: 3.77 ± 0.131
3.553SerPhe: 3.553 ± 0.134
3.516SerGly: 3.516 ± 0.122
1.005SerHis: 1.005 ± 0.062
6.206SerIle: 6.206 ± 0.193
6.627SerLys: 6.627 ± 0.166
6.998SerLeu: 6.998 ± 0.179
1.101SerMet: 1.101 ± 0.08
4.642SerAsn: 4.642 ± 0.175
1.547SerPro: 1.547 ± 0.076
2.315SerGln: 2.315 ± 0.121
2.006SerArg: 2.006 ± 0.089
4.513SerSer: 4.513 ± 0.142
3.724SerThr: 3.724 ± 0.128
3.958SerVal: 3.958 ± 0.129
0.592SerTrp: 0.592 ± 0.05
2.569SerTyr: 2.569 ± 0.117
0.0SerXaa: 0.0 ± 0.0
Thr
2.836ThrAla: 2.836 ± 0.122
0.267ThrCys: 0.267 ± 0.036
3.015ThrAsp: 3.015 ± 0.116
3.232ThrGlu: 3.232 ± 0.134
2.924ThrPhe: 2.924 ± 0.117
2.994ThrGly: 2.994 ± 0.133
1.005ThrHis: 1.005 ± 0.067
5.005ThrIle: 5.005 ± 0.15
5.655ThrLys: 5.655 ± 0.156
5.159ThrLeu: 5.159 ± 0.172
0.976ThrMet: 0.976 ± 0.078
4.133ThrAsn: 4.133 ± 0.167
1.898ThrPro: 1.898 ± 0.102
2.044ThrGln: 2.044 ± 0.112
1.631ThrArg: 1.631 ± 0.082
3.562ThrSer: 3.562 ± 0.112
3.099ThrThr: 3.099 ± 0.125
2.924ThrVal: 2.924 ± 0.113
0.492ThrTrp: 0.492 ± 0.045
2.006ThrTyr: 2.006 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
3.833ValAla: 3.833 ± 0.147
0.417ValCys: 0.417 ± 0.049
3.912ValAsp: 3.912 ± 0.113
4.041ValGlu: 4.041 ± 0.144
2.953ValPhe: 2.953 ± 0.124
2.878ValGly: 2.878 ± 0.136
0.788ValHis: 0.788 ± 0.065
5.334ValIle: 5.334 ± 0.184
5.563ValLys: 5.563 ± 0.162
5.288ValLeu: 5.288 ± 0.158
1.068ValMet: 1.068 ± 0.062
4.187ValAsn: 4.187 ± 0.133
1.572ValPro: 1.572 ± 0.089
1.618ValGln: 1.618 ± 0.082
1.593ValArg: 1.593 ± 0.092
3.929ValSer: 3.929 ± 0.121
2.919ValThr: 2.919 ± 0.116
4.004ValVal: 4.004 ± 0.149
0.53ValTrp: 0.53 ± 0.049
2.114ValTyr: 2.114 ± 0.098
0.0ValXaa: 0.0 ± 0.0
Trp
0.492TrpAla: 0.492 ± 0.043
0.054TrpCys: 0.054 ± 0.015
0.534TrpAsp: 0.534 ± 0.043
0.659TrpGlu: 0.659 ± 0.057
0.621TrpPhe: 0.621 ± 0.059
0.421TrpGly: 0.421 ± 0.042
0.117TrpHis: 0.117 ± 0.023
0.817TrpIle: 0.817 ± 0.057
0.776TrpLys: 0.776 ± 0.053
1.009TrpLeu: 1.009 ± 0.067
0.288TrpMet: 0.288 ± 0.036
0.713TrpAsn: 0.713 ± 0.052
0.263TrpPro: 0.263 ± 0.032
0.259TrpGln: 0.259 ± 0.032
0.288TrpArg: 0.288 ± 0.034
0.546TrpSer: 0.546 ± 0.054
0.555TrpThr: 0.555 ± 0.047
0.605TrpVal: 0.605 ± 0.049
0.121TrpTrp: 0.121 ± 0.022
0.405TrpTyr: 0.405 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.135TyrAla: 2.135 ± 0.107
0.225TyrCys: 0.225 ± 0.032
2.661TyrAsp: 2.661 ± 0.109
2.853TyrGlu: 2.853 ± 0.122
2.285TyrPhe: 2.285 ± 0.119
2.027TyrGly: 2.027 ± 0.102
0.709TyrHis: 0.709 ± 0.066
2.969TyrIle: 2.969 ± 0.127
3.787TyrLys: 3.787 ± 0.153
3.874TyrLeu: 3.874 ± 0.152
0.584TyrMet: 0.584 ± 0.045
2.627TyrAsn: 2.627 ± 0.129
1.072TyrPro: 1.072 ± 0.071
1.355TyrGln: 1.355 ± 0.081
1.301TyrArg: 1.301 ± 0.076
2.957TyrSer: 2.957 ± 0.123
1.973TyrThr: 1.973 ± 0.094
2.215TyrVal: 2.215 ± 0.099
0.488TyrTrp: 0.488 ± 0.046
1.539TyrTyr: 1.539 ± 0.106
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 659 proteins (239779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski