Amino acid dipepetide frequency for Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.817AlaAla: 8.817 ± 0.683
2.713AlaCys: 2.713 ± 0.839
4.747AlaAsp: 4.747 ± 0.662
2.939AlaGlu: 2.939 ± 0.494
4.86AlaPhe: 4.86 ± 0.716
6.443AlaGly: 6.443 ± 0.616
2.6AlaHis: 2.6 ± 0.449
3.052AlaIle: 3.052 ± 0.867
3.73AlaLys: 3.73 ± 0.46
10.06AlaLeu: 10.06 ± 0.728
0.904AlaMet: 0.904 ± 0.405
1.469AlaAsn: 1.469 ± 0.274
5.765AlaPro: 5.765 ± 0.778
3.052AlaGln: 3.052 ± 0.344
3.052AlaArg: 3.052 ± 0.537
6.104AlaSer: 6.104 ± 0.583
4.295AlaThr: 4.295 ± 0.434
7.121AlaVal: 7.121 ± 0.512
2.035AlaTrp: 2.035 ± 0.446
1.695AlaTyr: 1.695 ± 0.315
0.0AlaXaa: 0.0 ± 0.0
Cys
1.13CysAla: 1.13 ± 0.432
0.678CysCys: 0.678 ± 0.218
0.904CysAsp: 0.904 ± 0.35
0.791CysGlu: 0.791 ± 0.271
2.148CysPhe: 2.148 ± 0.539
3.843CysGly: 3.843 ± 0.58
1.356CysHis: 1.356 ± 0.285
0.452CysIle: 0.452 ± 0.191
0.904CysLys: 0.904 ± 0.252
4.069CysLeu: 4.069 ± 0.41
0.904CysMet: 0.904 ± 0.255
0.791CysAsn: 0.791 ± 0.236
1.582CysPro: 1.582 ± 0.51
0.226CysGln: 0.226 ± 0.203
1.809CysArg: 1.809 ± 0.559
2.487CysSer: 2.487 ± 0.701
2.374CysThr: 2.374 ± 0.361
2.374CysVal: 2.374 ± 0.491
1.243CysTrp: 1.243 ± 0.27
0.339CysTyr: 0.339 ± 0.217
0.0CysXaa: 0.0 ± 0.0
Asp
3.278AspAla: 3.278 ± 0.514
1.13AspCys: 1.13 ± 0.225
2.713AspAsp: 2.713 ± 0.232
1.582AspGlu: 1.582 ± 0.205
2.035AspPhe: 2.035 ± 0.316
4.295AspGly: 4.295 ± 0.471
0.904AspHis: 0.904 ± 0.252
2.374AspIle: 2.374 ± 0.645
1.695AspLys: 1.695 ± 0.286
5.539AspLeu: 5.539 ± 1.106
0.904AspMet: 0.904 ± 0.224
1.13AspAsn: 1.13 ± 0.191
3.278AspPro: 3.278 ± 0.571
1.356AspGln: 1.356 ± 0.303
2.826AspArg: 2.826 ± 0.272
3.843AspSer: 3.843 ± 0.448
1.695AspThr: 1.695 ± 0.391
3.278AspVal: 3.278 ± 0.568
1.469AspTrp: 1.469 ± 0.236
1.809AspTyr: 1.809 ± 0.484
0.0AspXaa: 0.0 ± 0.0
Glu
3.391GluAla: 3.391 ± 0.396
1.356GluCys: 1.356 ± 0.303
1.922GluAsp: 1.922 ± 0.291
2.148GluGlu: 2.148 ± 0.337
2.035GluPhe: 2.035 ± 0.451
3.617GluGly: 3.617 ± 0.516
1.017GluHis: 1.017 ± 0.273
1.356GluIle: 1.356 ± 0.38
1.469GluLys: 1.469 ± 0.513
4.634GluLeu: 4.634 ± 0.517
0.339GluMet: 0.339 ± 0.253
1.13GluAsn: 1.13 ± 0.225
2.374GluPro: 2.374 ± 0.46
2.374GluGln: 2.374 ± 0.39
2.826GluArg: 2.826 ± 0.296
3.052GluSer: 3.052 ± 0.607
1.922GluThr: 1.922 ± 0.558
3.956GluVal: 3.956 ± 0.702
0.678GluTrp: 0.678 ± 0.262
0.452GluTyr: 0.452 ± 0.291
0.0GluXaa: 0.0 ± 0.0
Phe
3.73PheAla: 3.73 ± 0.652
1.469PheCys: 1.469 ± 0.264
1.469PheAsp: 1.469 ± 0.265
2.487PheGlu: 2.487 ± 0.393
1.922PhePhe: 1.922 ± 0.445
2.713PheGly: 2.713 ± 0.722
0.904PheHis: 0.904 ± 0.619
2.035PheIle: 2.035 ± 0.548
0.904PheLys: 0.904 ± 0.293
5.539PheLeu: 5.539 ± 1.534
0.904PheMet: 0.904 ± 0.312
0.565PheAsn: 0.565 ± 0.158
3.391PhePro: 3.391 ± 0.396
1.243PheGln: 1.243 ± 0.311
1.469PheArg: 1.469 ± 0.308
5.991PheSer: 5.991 ± 0.762
2.939PheThr: 2.939 ± 0.808
3.052PheVal: 3.052 ± 0.905
1.13PheTrp: 1.13 ± 0.49
1.243PheTyr: 1.243 ± 0.299
0.0PheXaa: 0.0 ± 0.0
Gly
5.991GlyAla: 5.991 ± 0.692
2.6GlyCys: 2.6 ± 0.576
4.295GlyAsp: 4.295 ± 1.075
1.695GlyGlu: 1.695 ± 0.301
3.391GlyPhe: 3.391 ± 0.549
4.295GlyGly: 4.295 ± 0.49
2.148GlyHis: 2.148 ± 0.572
3.843GlyIle: 3.843 ± 0.823
3.278GlyLys: 3.278 ± 0.488
6.669GlyLeu: 6.669 ± 0.765
1.356GlyMet: 1.356 ± 0.311
2.939GlyAsn: 2.939 ± 0.915
4.521GlyPro: 4.521 ± 0.928
2.035GlyGln: 2.035 ± 0.33
4.973GlyArg: 4.973 ± 0.831
5.765GlySer: 5.765 ± 1.153
3.391GlyThr: 3.391 ± 0.328
5.765GlyVal: 5.765 ± 0.696
1.243GlyTrp: 1.243 ± 0.415
1.582GlyTyr: 1.582 ± 0.46
0.0GlyXaa: 0.0 ± 0.0
His
2.261HisAla: 2.261 ± 0.481
1.017HisCys: 1.017 ± 0.207
0.791HisAsp: 0.791 ± 0.553
0.791HisGlu: 0.791 ± 0.189
1.582HisPhe: 1.582 ± 0.829
1.582HisGly: 1.582 ± 0.203
1.13HisHis: 1.13 ± 0.605
0.791HisIle: 0.791 ± 0.748
1.469HisLys: 1.469 ± 0.236
2.826HisLeu: 2.826 ± 0.475
0.339HisMet: 0.339 ± 0.19
1.356HisAsn: 1.356 ± 0.353
1.469HisPro: 1.469 ± 0.228
1.356HisGln: 1.356 ± 0.569
0.678HisArg: 0.678 ± 0.246
2.148HisSer: 2.148 ± 0.625
1.017HisThr: 1.017 ± 0.345
2.713HisVal: 2.713 ± 0.549
1.017HisTrp: 1.017 ± 0.2
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
1.582IleAla: 1.582 ± 0.506
1.017IleCys: 1.017 ± 0.613
1.695IleAsp: 1.695 ± 0.306
0.791IleGlu: 0.791 ± 0.17
1.469IlePhe: 1.469 ± 0.546
2.939IleGly: 2.939 ± 0.564
1.356IleHis: 1.356 ± 0.306
1.582IleIle: 1.582 ± 0.623
2.261IleLys: 2.261 ± 0.315
4.747IleLeu: 4.747 ± 0.581
0.904IleMet: 0.904 ± 0.627
1.695IleAsn: 1.695 ± 0.187
2.035IlePro: 2.035 ± 0.37
1.695IleGln: 1.695 ± 0.286
2.148IleArg: 2.148 ± 0.52
1.809IleSer: 1.809 ± 0.679
2.261IleThr: 2.261 ± 0.508
2.374IleVal: 2.374 ± 0.48
0.452IleTrp: 0.452 ± 0.098
1.356IleTyr: 1.356 ± 0.493
0.0IleXaa: 0.0 ± 0.0
Lys
2.374LysAla: 2.374 ± 0.623
1.695LysCys: 1.695 ± 0.428
1.695LysAsp: 1.695 ± 0.41
1.695LysGlu: 1.695 ± 0.413
1.809LysPhe: 1.809 ± 0.321
1.922LysGly: 1.922 ± 0.492
0.565LysHis: 0.565 ± 0.274
1.469LysIle: 1.469 ± 0.311
2.035LysLys: 2.035 ± 1.082
5.2LysLeu: 5.2 ± 0.557
1.243LysMet: 1.243 ± 0.27
1.469LysAsn: 1.469 ± 0.302
2.939LysPro: 2.939 ± 0.429
1.243LysGln: 1.243 ± 0.253
2.261LysArg: 2.261 ± 0.596
2.148LysSer: 2.148 ± 0.633
1.695LysThr: 1.695 ± 0.543
3.504LysVal: 3.504 ± 0.417
0.904LysTrp: 0.904 ± 0.224
1.356LysTyr: 1.356 ± 0.203
0.0LysXaa: 0.0 ± 0.0
Leu
11.19LeuAla: 11.19 ± 0.879
3.504LeuCys: 3.504 ± 0.76
5.426LeuAsp: 5.426 ± 0.642
3.843LeuGlu: 3.843 ± 0.574
3.73LeuPhe: 3.73 ± 0.807
7.46LeuGly: 7.46 ± 1.253
1.922LeuHis: 1.922 ± 0.413
3.278LeuIle: 3.278 ± 0.548
4.295LeuLys: 4.295 ± 0.499
9.269LeuLeu: 9.269 ± 1.417
1.695LeuMet: 1.695 ± 0.269
3.617LeuAsn: 3.617 ± 0.437
7.008LeuPro: 7.008 ± 1.054
4.634LeuGln: 4.634 ± 0.757
3.504LeuArg: 3.504 ± 0.746
10.851LeuSer: 10.851 ± 0.953
7.008LeuThr: 7.008 ± 0.685
9.269LeuVal: 9.269 ± 1.063
2.148LeuTrp: 2.148 ± 0.355
1.695LeuTyr: 1.695 ± 0.354
0.0LeuXaa: 0.0 ± 0.0
Met
2.148MetAla: 2.148 ± 0.321
0.565MetCys: 0.565 ± 0.137
0.113MetAsp: 0.113 ± 0.073
0.226MetGlu: 0.226 ± 0.162
0.452MetPhe: 0.452 ± 0.333
1.356MetGly: 1.356 ± 0.452
0.565MetHis: 0.565 ± 0.137
1.13MetIle: 1.13 ± 0.302
1.695MetLys: 1.695 ± 0.391
3.165MetLeu: 3.165 ± 0.401
0.565MetMet: 0.565 ± 0.137
0.678MetAsn: 0.678 ± 0.143
0.339MetPro: 0.339 ± 0.217
0.113MetGln: 0.113 ± 0.165
0.565MetArg: 0.565 ± 0.388
1.13MetSer: 1.13 ± 0.187
1.017MetThr: 1.017 ± 0.241
0.791MetVal: 0.791 ± 0.438
1.017MetTrp: 1.017 ± 0.317
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.374AsnAla: 2.374 ± 0.437
1.356AsnCys: 1.356 ± 0.398
0.226AsnAsp: 0.226 ± 0.246
1.356AsnGlu: 1.356 ± 0.285
1.243AsnPhe: 1.243 ± 0.264
2.939AsnGly: 2.939 ± 0.409
0.452AsnHis: 0.452 ± 0.098
0.678AsnIle: 0.678 ± 0.372
0.791AsnLys: 0.791 ± 0.321
2.826AsnLeu: 2.826 ± 0.467
1.13AsnMet: 1.13 ± 0.222
0.791AsnAsn: 0.791 ± 0.181
1.695AsnPro: 1.695 ± 0.41
0.678AsnGln: 0.678 ± 0.569
2.939AsnArg: 2.939 ± 0.433
1.582AsnSer: 1.582 ± 0.354
1.922AsnThr: 1.922 ± 0.205
1.356AsnVal: 1.356 ± 0.505
0.678AsnTrp: 0.678 ± 0.177
0.339AsnTyr: 0.339 ± 0.29
0.0AsnXaa: 0.0 ± 0.0
Pro
4.634ProAla: 4.634 ± 0.673
0.791ProCys: 0.791 ± 0.269
3.278ProAsp: 3.278 ± 0.576
4.408ProGlu: 4.408 ± 0.413
2.939ProPhe: 2.939 ± 0.479
4.634ProGly: 4.634 ± 0.636
1.695ProHis: 1.695 ± 0.411
3.165ProIle: 3.165 ± 0.473
2.713ProLys: 2.713 ± 0.533
5.086ProLeu: 5.086 ± 0.406
1.017ProMet: 1.017 ± 0.202
1.922ProAsn: 1.922 ± 0.393
5.086ProPro: 5.086 ± 1.136
3.391ProGln: 3.391 ± 0.562
4.069ProArg: 4.069 ± 0.477
6.217ProSer: 6.217 ± 0.723
4.634ProThr: 4.634 ± 0.722
7.347ProVal: 7.347 ± 0.68
0.565ProTrp: 0.565 ± 0.22
1.809ProTyr: 1.809 ± 0.439
0.0ProXaa: 0.0 ± 0.0
Gln
4.182GlnAla: 4.182 ± 0.529
1.017GlnCys: 1.017 ± 0.236
1.809GlnAsp: 1.809 ± 0.242
2.035GlnGlu: 2.035 ± 0.392
1.017GlnPhe: 1.017 ± 0.459
1.469GlnGly: 1.469 ± 0.475
1.017GlnHis: 1.017 ± 0.565
1.243GlnIle: 1.243 ± 0.435
1.017GlnLys: 1.017 ± 0.275
3.278GlnLeu: 3.278 ± 0.522
0.113GlnMet: 0.113 ± 0.073
0.678GlnAsn: 0.678 ± 0.196
2.713GlnPro: 2.713 ± 0.322
1.356GlnGln: 1.356 ± 0.283
1.809GlnArg: 1.809 ± 0.452
2.035GlnSer: 2.035 ± 0.427
3.165GlnThr: 3.165 ± 0.522
4.408GlnVal: 4.408 ± 0.695
0.791GlnTrp: 0.791 ± 0.41
1.243GlnTyr: 1.243 ± 0.276
0.0GlnXaa: 0.0 ± 0.0
Arg
5.313ArgAla: 5.313 ± 0.54
2.826ArgCys: 2.826 ± 0.219
1.582ArgAsp: 1.582 ± 0.255
3.052ArgGlu: 3.052 ± 0.628
2.374ArgPhe: 2.374 ± 0.526
4.408ArgGly: 4.408 ± 0.421
1.695ArgHis: 1.695 ± 0.176
2.035ArgIle: 2.035 ± 0.347
1.582ArgLys: 1.582 ± 0.397
5.313ArgLeu: 5.313 ± 0.56
2.6ArgMet: 2.6 ± 0.368
1.356ArgAsn: 1.356 ± 0.224
2.6ArgPro: 2.6 ± 0.808
1.809ArgGln: 1.809 ± 0.314
2.826ArgArg: 2.826 ± 0.601
4.408ArgSer: 4.408 ± 0.479
2.261ArgThr: 2.261 ± 0.539
3.843ArgVal: 3.843 ± 0.433
0.791ArgTrp: 0.791 ± 0.419
1.809ArgTyr: 1.809 ± 0.45
0.0ArgXaa: 0.0 ± 0.0
Ser
8.364SerAla: 8.364 ± 0.953
2.939SerCys: 2.939 ± 0.4
5.2SerAsp: 5.2 ± 1.034
2.939SerGlu: 2.939 ± 0.468
3.052SerPhe: 3.052 ± 1.136
6.895SerGly: 6.895 ± 0.62
1.582SerHis: 1.582 ± 0.654
2.035SerIle: 2.035 ± 0.691
2.487SerLys: 2.487 ± 0.668
8.477SerLeu: 8.477 ± 1.072
1.13SerMet: 1.13 ± 0.228
1.695SerAsn: 1.695 ± 0.443
6.217SerPro: 6.217 ± 0.638
4.182SerGln: 4.182 ± 0.731
5.426SerArg: 5.426 ± 0.889
7.008SerSer: 7.008 ± 1.158
4.295SerThr: 4.295 ± 1.063
4.86SerVal: 4.86 ± 1.286
1.809SerTrp: 1.809 ± 0.73
2.035SerTyr: 2.035 ± 0.214
0.0SerXaa: 0.0 ± 0.0
Thr
4.408ThrAla: 4.408 ± 1.031
0.904ThrCys: 0.904 ± 0.222
3.165ThrAsp: 3.165 ± 0.416
2.6ThrGlu: 2.6 ± 0.338
2.035ThrPhe: 2.035 ± 0.395
3.617ThrGly: 3.617 ± 0.701
1.243ThrHis: 1.243 ± 0.399
1.922ThrIle: 1.922 ± 0.618
1.809ThrLys: 1.809 ± 0.353
4.86ThrLeu: 4.86 ± 0.557
0.452ThrMet: 0.452 ± 0.156
1.469ThrAsn: 1.469 ± 0.326
8.59ThrPro: 8.59 ± 1.124
1.582ThrGln: 1.582 ± 0.42
2.713ThrArg: 2.713 ± 0.425
5.652ThrSer: 5.652 ± 0.973
4.182ThrThr: 4.182 ± 0.477
3.504ThrVal: 3.504 ± 0.7
0.904ThrTrp: 0.904 ± 0.196
1.809ThrTyr: 1.809 ± 0.411
0.0ThrXaa: 0.0 ± 0.0
Val
6.217ValAla: 6.217 ± 0.685
1.582ValCys: 1.582 ± 0.343
3.843ValAsp: 3.843 ± 0.545
4.295ValGlu: 4.295 ± 0.52
5.539ValPhe: 5.539 ± 0.815
5.539ValGly: 5.539 ± 0.709
2.826ValHis: 2.826 ± 0.449
2.6ValIle: 2.6 ± 0.384
2.261ValLys: 2.261 ± 0.647
8.251ValLeu: 8.251 ± 0.65
0.452ValMet: 0.452 ± 0.328
0.904ValAsn: 0.904 ± 0.658
5.313ValPro: 5.313 ± 0.798
2.487ValGln: 2.487 ± 0.54
5.313ValArg: 5.313 ± 0.608
7.573ValSer: 7.573 ± 1.126
4.747ValThr: 4.747 ± 0.482
9.156ValVal: 9.156 ± 0.675
0.339ValTrp: 0.339 ± 0.214
2.374ValTyr: 2.374 ± 0.376
0.0ValXaa: 0.0 ± 0.0
Trp
1.13TrpAla: 1.13 ± 0.254
0.452TrpCys: 0.452 ± 0.191
1.017TrpAsp: 1.017 ± 0.212
1.13TrpGlu: 1.13 ± 0.216
0.904TrpPhe: 0.904 ± 0.619
0.791TrpGly: 0.791 ± 0.257
0.678TrpHis: 0.678 ± 0.158
0.339TrpIle: 0.339 ± 0.105
1.809TrpLys: 1.809 ± 0.337
3.165TrpLeu: 3.165 ± 1.087
0.226TrpMet: 0.226 ± 0.096
0.452TrpAsn: 0.452 ± 0.098
1.017TrpPro: 1.017 ± 0.2
0.678TrpGln: 0.678 ± 0.227
1.13TrpArg: 1.13 ± 0.311
1.13TrpSer: 1.13 ± 0.46
1.243TrpThr: 1.243 ± 0.245
1.582TrpVal: 1.582 ± 0.379
0.226TrpTrp: 0.226 ± 0.236
0.791TrpTyr: 0.791 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.939TyrAla: 2.939 ± 0.69
0.904TyrCys: 0.904 ± 0.288
1.243TyrAsp: 1.243 ± 0.262
1.243TyrGlu: 1.243 ± 0.195
0.565TyrPhe: 0.565 ± 0.137
1.017TyrGly: 1.017 ± 0.274
0.678TyrHis: 0.678 ± 0.372
0.791TyrIle: 0.791 ± 0.423
1.017TyrLys: 1.017 ± 0.226
2.374TyrLeu: 2.374 ± 0.415
0.339TyrMet: 0.339 ± 0.218
1.243TyrAsn: 1.243 ± 0.276
1.469TyrPro: 1.469 ± 0.236
0.904TyrGln: 0.904 ± 0.356
2.148TyrArg: 2.148 ± 0.306
1.695TyrSer: 1.695 ± 0.459
1.356TyrThr: 1.356 ± 0.369
1.356TyrVal: 1.356 ± 0.504
0.452TyrTrp: 0.452 ± 0.178
0.452TyrTyr: 0.452 ± 0.389
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (8848 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski