Amino acid dipepetide frequency for Haloterrigena daqingensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.621AlaAla: 10.621 ± 0.142	0.718AlaCys: 0.718 ± 0.027	9.147AlaAsp: 9.147 ± 0.128	7.855AlaGlu: 7.855 ± 0.104	3.722AlaPhe: 3.722 ± 0.067	8.461AlaGly: 8.461 ± 0.105	1.785AlaHis: 1.785 ± 0.044	5.474AlaIle: 5.474 ± 0.082	1.844AlaLys: 1.844 ± 0.049	9.603AlaLeu: 9.603 ± 0.139	2.006AlaMet: 2.006 ± 0.045	2.445AlaAsn: 2.445 ± 0.049	3.431AlaPro: 3.431 ± 0.065	2.185AlaGln: 2.185 ± 0.044	5.312AlaArg: 5.312 ± 0.066	5.555AlaSer: 5.555 ± 0.069	6.841AlaThr: 6.841 ± 0.092	8.802AlaVal: 8.802 ± 0.119	1.004AlaTrp: 1.004 ± 0.035	2.668AlaTyr: 2.668 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.608CysAla: 0.608 ± 0.025	0.112CysCys: 0.112 ± 0.01	0.572CysAsp: 0.572 ± 0.025	0.664CysGlu: 0.664 ± 0.029	0.216CysPhe: 0.216 ± 0.014	0.84CysGly: 0.84 ± 0.034	0.221CysHis: 0.221 ± 0.015	0.303CysIle: 0.303 ± 0.017	0.128CysLys: 0.128 ± 0.01	0.61CysLeu: 0.61 ± 0.023	0.116CysMet: 0.116 ± 0.01	0.195CysAsn: 0.195 ± 0.013	0.505CysPro: 0.505 ± 0.025	0.195CysGln: 0.195 ± 0.014	0.509CysArg: 0.509 ± 0.022	0.519CysSer: 0.519 ± 0.022	0.478CysThr: 0.478 ± 0.021	0.489CysVal: 0.489 ± 0.024	0.108CysTrp: 0.108 ± 0.009	0.248CysTyr: 0.248 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.538AspAla: 9.538 ± 0.123	0.599AspCys: 0.599 ± 0.026	10.204AspAsp: 10.204 ± 0.252	9.775AspGlu: 9.775 ± 0.155	1.934AspPhe: 1.934 ± 0.044	8.142AspGly: 8.142 ± 0.123	1.995AspHis: 1.995 ± 0.047	3.399AspIle: 3.399 ± 0.071	0.922AspLys: 0.922 ± 0.036	7.218AspLeu: 7.218 ± 0.094	1.179AspMet: 1.179 ± 0.034	1.428AspAsn: 1.428 ± 0.04	4.385AspPro: 4.385 ± 0.075	1.853AspGln: 1.853 ± 0.046	5.722AspArg: 5.722 ± 0.08	4.527AspSer: 4.527 ± 0.081	4.193AspThr: 4.193 ± 0.067	7.803AspVal: 7.803 ± 0.088	0.913AspTrp: 0.913 ± 0.032	1.856AspTyr: 1.856 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	8.637GluAla: 8.637 ± 0.109	0.665GluCys: 0.665 ± 0.027	7.313GluAsp: 7.313 ± 0.121	8.118GluGlu: 8.118 ± 0.13	3.3GluPhe: 3.3 ± 0.052	5.63GluGly: 5.63 ± 0.086	2.407GluHis: 2.407 ± 0.043	4.635GluIle: 4.635 ± 0.08	1.83GluLys: 1.83 ± 0.054	8.128GluLeu: 8.128 ± 0.109	2.072GluMet: 2.072 ± 0.049	2.677GluAsn: 2.677 ± 0.052	4.411GluPro: 4.411 ± 0.069	3.133GluGln: 3.133 ± 0.056	7.782GluArg: 7.782 ± 0.111	6.432GluSer: 6.432 ± 0.088	7.801GluThr: 7.801 ± 0.09	5.38GluVal: 5.38 ± 0.076	1.437GluTrp: 1.437 ± 0.038	3.262GluTyr: 3.262 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.499PheAla: 3.499 ± 0.063	0.313PheCys: 0.313 ± 0.016	3.431PheAsp: 3.431 ± 0.061	3.342PheGlu: 3.342 ± 0.06	1.073PhePhe: 1.073 ± 0.035	3.146PheGly: 3.146 ± 0.06	0.688PheHis: 0.688 ± 0.026	1.166PheIle: 1.166 ± 0.034	0.484PheLys: 0.484 ± 0.022	2.896PheLeu: 2.896 ± 0.062	0.528PheMet: 0.528 ± 0.023	0.679PheAsn: 0.679 ± 0.03	1.272PhePro: 1.272 ± 0.034	0.804PheGln: 0.804 ± 0.027	1.596PheArg: 1.596 ± 0.036	1.744PheSer: 1.744 ± 0.04	1.825PheThr: 1.825 ± 0.041	3.256PheVal: 3.256 ± 0.064	0.404PheTrp: 0.404 ± 0.021	0.873PheTyr: 0.873 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.161GlyAla: 7.161 ± 0.106	0.774GlyCys: 0.774 ± 0.028	6.658GlyAsp: 6.658 ± 0.092	7.412GlyGlu: 7.412 ± 0.095	3.049GlyPhe: 3.049 ± 0.068	6.597GlyGly: 6.597 ± 0.097	1.71GlyHis: 1.71 ± 0.043	4.444GlyIle: 4.444 ± 0.06	1.808GlyLys: 1.808 ± 0.048	7.099GlyLeu: 7.099 ± 0.096	1.6GlyMet: 1.6 ± 0.042	1.936GlyAsn: 1.936 ± 0.051	3.056GlyPro: 3.056 ± 0.057	1.966GlyGln: 1.966 ± 0.048	4.29GlyArg: 4.29 ± 0.067	5.138GlySer: 5.138 ± 0.069	5.497GlyThr: 5.497 ± 0.073	7.027GlyVal: 7.027 ± 0.088	1.056GlyTrp: 1.056 ± 0.033	2.643GlyTyr: 2.643 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.022HisAla: 2.022 ± 0.044	0.211HisCys: 0.211 ± 0.013	1.991HisAsp: 1.991 ± 0.047	1.927HisGlu: 1.927 ± 0.042	0.561HisPhe: 0.561 ± 0.024	1.994HisGly: 1.994 ± 0.043	0.559HisHis: 0.559 ± 0.024	0.777HisIle: 0.777 ± 0.029	0.314HisLys: 0.314 ± 0.017	1.823HisLeu: 1.823 ± 0.042	0.315HisMet: 0.315 ± 0.016	0.494HisAsn: 0.494 ± 0.021	1.296HisPro: 1.296 ± 0.037	0.526HisGln: 0.526 ± 0.022	1.259HisArg: 1.259 ± 0.042	1.135HisSer: 1.135 ± 0.035	1.152HisThr: 1.152 ± 0.034	1.869HisVal: 1.869 ± 0.043	0.27HisTrp: 0.27 ± 0.015	0.648HisTyr: 0.648 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.123IleAla: 5.123 ± 0.081	0.312IleCys: 0.312 ± 0.019	4.9IleAsp: 4.9 ± 0.077	4.65IleGlu: 4.65 ± 0.072	1.173IlePhe: 1.173 ± 0.036	4.328IleGly: 4.328 ± 0.068	0.961IleHis: 0.961 ± 0.032	1.631IleIle: 1.631 ± 0.049	0.699IleLys: 0.699 ± 0.027	3.4IleLeu: 3.4 ± 0.06	0.593IleMet: 0.593 ± 0.021	1.012IleAsn: 1.012 ± 0.036	2.251IlePro: 2.251 ± 0.05	1.163IleGln: 1.163 ± 0.034	2.565IleArg: 2.565 ± 0.051	2.595IleSer: 2.595 ± 0.052	2.698IleThr: 2.698 ± 0.055	4.413IleVal: 4.413 ± 0.068	0.413IleTrp: 0.413 ± 0.022	1.068IleTyr: 1.068 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	1.606LysAla: 1.606 ± 0.046	0.136LysCys: 0.136 ± 0.012	1.022LysAsp: 1.022 ± 0.033	1.238LysGlu: 1.238 ± 0.041	0.487LysPhe: 0.487 ± 0.023	1.232LysGly: 1.232 ± 0.035	0.506LysHis: 0.506 ± 0.025	0.87LysIle: 0.87 ± 0.038	0.521LysLys: 0.521 ± 0.026	1.646LysLeu: 1.646 ± 0.042	0.393LysMet: 0.393 ± 0.022	0.594LysAsn: 0.594 ± 0.03	0.974LysPro: 0.974 ± 0.031	0.732LysGln: 0.732 ± 0.031	1.677LysArg: 1.677 ± 0.037	1.204LysSer: 1.204 ± 0.035	1.337LysThr: 1.337 ± 0.038	1.096LysVal: 1.096 ± 0.035	0.21LysTrp: 0.21 ± 0.014	0.565LysTyr: 0.565 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	10.08LeuAla: 10.08 ± 0.127	0.639LeuCys: 0.639 ± 0.023	5.496LeuAsp: 5.496 ± 0.064	13.021LeuGlu: 13.021 ± 0.143	3.028LeuPhe: 3.028 ± 0.063	7.098LeuGly: 7.098 ± 0.092	1.436LeuHis: 1.436 ± 0.037	3.324LeuIle: 3.324 ± 0.058	1.485LeuLys: 1.485 ± 0.039	8.073LeuLeu: 8.073 ± 0.109	1.25LeuMet: 1.25 ± 0.038	1.746LeuAsn: 1.746 ± 0.044	3.772LeuPro: 3.772 ± 0.06	2.019LeuGln: 2.019 ± 0.042	4.559LeuArg: 4.559 ± 0.076	5.548LeuSer: 5.548 ± 0.076	5.136LeuThr: 5.136 ± 0.071	7.846LeuVal: 7.846 ± 0.115	0.843LeuTrp: 0.843 ± 0.031	2.11LeuTyr: 2.11 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.848MetAla: 1.848 ± 0.043	0.129MetCys: 0.129 ± 0.011	1.298MetAsp: 1.298 ± 0.036	1.103MetGlu: 1.103 ± 0.036	0.545MetPhe: 0.545 ± 0.024	1.447MetGly: 1.447 ± 0.035	0.363MetHis: 0.363 ± 0.019	0.846MetIle: 0.846 ± 0.029	0.445MetLys: 0.445 ± 0.024	1.506MetLeu: 1.506 ± 0.04	0.347MetMet: 0.347 ± 0.017	0.652MetAsn: 0.652 ± 0.025	0.765MetPro: 0.765 ± 0.026	0.514MetGln: 0.514 ± 0.021	1.024MetArg: 1.024 ± 0.033	1.557MetSer: 1.557 ± 0.036	1.54MetThr: 1.54 ± 0.036	1.271MetVal: 1.271 ± 0.037	0.172MetTrp: 0.172 ± 0.013	0.434MetTyr: 0.434 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.54AsnAla: 2.54 ± 0.053	0.243AsnCys: 0.243 ± 0.017	1.935AsnAsp: 1.935 ± 0.046	2.021AsnGlu: 2.021 ± 0.048	0.681AsnPhe: 0.681 ± 0.019	2.142AsnGly: 2.142 ± 0.058	0.561AsnHis: 0.561 ± 0.025	0.973AsnIle: 0.973 ± 0.033	0.446AsnLys: 0.446 ± 0.025	1.867AsnLeu: 1.867 ± 0.046	0.446AsnMet: 0.446 ± 0.023	0.578AsnAsn: 0.578 ± 0.029	1.541AsnPro: 1.541 ± 0.036	0.672AsnGln: 0.672 ± 0.028	1.768AsnArg: 1.768 ± 0.039	1.142AsnSer: 1.142 ± 0.036	1.347AsnThr: 1.347 ± 0.037	2.33AsnVal: 2.33 ± 0.05	0.343AsnTrp: 0.343 ± 0.018	0.685AsnTyr: 0.685 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.208ProAla: 4.208 ± 0.072	0.246ProCys: 0.246 ± 0.016	4.664ProAsp: 4.664 ± 0.081	4.555ProGlu: 4.555 ± 0.059	1.532ProPhe: 1.532 ± 0.04	3.344ProGly: 3.344 ± 0.056	0.931ProHis: 0.931 ± 0.032	2.211ProIle: 2.211 ± 0.044	0.907ProLys: 0.907 ± 0.031	3.543ProLeu: 3.543 ± 0.069	0.88ProMet: 0.88 ± 0.027	1.274ProAsn: 1.274 ± 0.042	2.071ProPro: 2.071 ± 0.046	1.02ProGln: 1.02 ± 0.029	2.12ProArg: 2.12 ± 0.04	2.79ProSer: 2.79 ± 0.047	3.291ProThr: 3.291 ± 0.059	3.747ProVal: 3.747 ± 0.059	0.487ProTrp: 0.487 ± 0.022	1.09ProTyr: 1.09 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.319GlnAla: 2.319 ± 0.046	0.177GlnCys: 0.177 ± 0.015	1.452GlnAsp: 1.452 ± 0.034	1.936GlnGlu: 1.936 ± 0.054	1.043GlnPhe: 1.043 ± 0.033	1.568GlnGly: 1.568 ± 0.044	0.589GlnHis: 0.589 ± 0.024	1.295GlnIle: 1.295 ± 0.037	0.553GlnLys: 0.553 ± 0.025	2.598GlnLeu: 2.598 ± 0.052	0.574GlnMet: 0.574 ± 0.024	0.756GlnAsn: 0.756 ± 0.029	1.293GlnPro: 1.293 ± 0.035	1.08GlnGln: 1.08 ± 0.039	1.937GlnArg: 1.937 ± 0.043	1.737GlnSer: 1.737 ± 0.048	1.931GlnThr: 1.931 ± 0.047	1.779GlnVal: 1.779 ± 0.045	0.364GlnTrp: 0.364 ± 0.018	0.887GlnTyr: 0.887 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.585ArgAla: 5.585 ± 0.076	0.446ArgCys: 0.446 ± 0.019	4.671ArgAsp: 4.671 ± 0.072	6.462ArgGlu: 6.462 ± 0.097	2.195ArgPhe: 2.195 ± 0.044	3.931ArgGly: 3.931 ± 0.061	1.186ArgHis: 1.186 ± 0.034	2.903ArgIle: 2.903 ± 0.052	1.362ArgLys: 1.362 ± 0.038	5.663ArgLeu: 5.663 ± 0.086	1.23ArgMet: 1.23 ± 0.034	1.631ArgAsn: 1.631 ± 0.047	2.267ArgPro: 2.267 ± 0.052	1.768ArgGln: 1.768 ± 0.042	4.304ArgArg: 4.304 ± 0.073	3.607ArgSer: 3.607 ± 0.066	3.919ArgThr: 3.919 ± 0.06	4.695ArgVal: 4.695 ± 0.07	0.711ArgTrp: 0.711 ± 0.03	1.855ArgTyr: 1.855 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.354SerAla: 5.354 ± 0.069	0.383SerCys: 0.383 ± 0.019	5.248SerAsp: 5.248 ± 0.084	5.084SerGlu: 5.084 ± 0.082	2.054SerPhe: 2.054 ± 0.044	5.222SerGly: 5.222 ± 0.073	1.195SerHis: 1.195 ± 0.032	2.998SerIle: 2.998 ± 0.052	1.235SerLys: 1.235 ± 0.038	5.285SerLeu: 5.285 ± 0.063	1.201SerMet: 1.201 ± 0.037	1.611SerAsn: 1.611 ± 0.04	2.624SerPro: 2.624 ± 0.057	1.558SerGln: 1.558 ± 0.041	3.363SerArg: 3.363 ± 0.056	4.169SerSer: 4.169 ± 0.081	3.988SerThr: 3.988 ± 0.06	5.226SerVal: 5.226 ± 0.078	0.647SerTrp: 0.647 ± 0.023	1.525SerTyr: 1.525 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.473ThrAla: 6.473 ± 0.083	0.456ThrCys: 0.456 ± 0.023	6.091ThrAsp: 6.091 ± 0.092	5.071ThrGlu: 5.071 ± 0.063	2.092ThrPhe: 2.092 ± 0.042	5.441ThrGly: 5.441 ± 0.07	1.4ThrHis: 1.4 ± 0.036	3.578ThrIle: 3.578 ± 0.066	1.104ThrLys: 1.104 ± 0.032	5.959ThrLeu: 5.959 ± 0.068	1.139ThrMet: 1.139 ± 0.03	1.656ThrAsn: 1.656 ± 0.037	3.296ThrPro: 3.296 ± 0.053	1.549ThrGln: 1.549 ± 0.039	3.39ThrArg: 3.39 ± 0.054	3.212ThrSer: 3.212 ± 0.054	4.539ThrThr: 4.539 ± 0.08	6.826ThrVal: 6.826 ± 0.084	0.622ThrTrp: 0.622 ± 0.027	1.718ThrTyr: 1.718 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.663ValAla: 8.663 ± 0.112	0.705ValCys: 0.705 ± 0.024	7.853ValAsp: 7.853 ± 0.103	7.214ValGlu: 7.214 ± 0.087	2.968ValPhe: 2.968 ± 0.06	7.173ValGly: 7.173 ± 0.105	1.736ValHis: 1.736 ± 0.043	3.603ValIle: 3.603 ± 0.064	1.221ValLys: 1.221 ± 0.036	7.825ValLeu: 7.825 ± 0.112	1.326ValMet: 1.326 ± 0.039	1.845ValAsn: 1.845 ± 0.044	4.041ValPro: 4.041 ± 0.065	1.957ValGln: 1.957 ± 0.042	4.631ValArg: 4.631 ± 0.075	5.449ValSer: 5.449 ± 0.069	5.828ValThr: 5.828 ± 0.08	8.098ValVal: 8.098 ± 0.112	0.744ValTrp: 0.744 ± 0.029	2.134ValTyr: 2.134 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.869TrpAla: 0.869 ± 0.031	0.093TrpCys: 0.093 ± 0.009	0.82TrpAsp: 0.82 ± 0.025	0.953TrpGlu: 0.953 ± 0.032	0.482TrpPhe: 0.482 ± 0.021	0.826TrpGly: 0.826 ± 0.026	0.263TrpHis: 0.263 ± 0.014	0.642TrpIle: 0.642 ± 0.027	0.277TrpLys: 0.277 ± 0.017	1.246TrpLeu: 1.246 ± 0.038	0.216TrpMet: 0.216 ± 0.014	0.369TrpAsn: 0.369 ± 0.017	0.425TrpPro: 0.425 ± 0.019	0.381TrpGln: 0.381 ± 0.021	0.752TrpArg: 0.752 ± 0.028	0.624TrpSer: 0.624 ± 0.024	0.717TrpThr: 0.717 ± 0.027	0.791TrpVal: 0.791 ± 0.028	0.182TrpTrp: 0.182 ± 0.014	0.363TrpTyr: 0.363 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.721TyrAla: 2.721 ± 0.054	0.281TyrCys: 0.281 ± 0.017	2.821TyrAsp: 2.821 ± 0.059	2.651TyrGlu: 2.651 ± 0.05	0.884TyrPhe: 0.884 ± 0.033	2.359TyrGly: 2.359 ± 0.05	0.653TyrHis: 0.653 ± 0.021	0.875TyrIle: 0.875 ± 0.032	0.459TyrLys: 0.459 ± 0.024	2.519TyrLeu: 2.519 ± 0.046	0.393TyrMet: 0.393 ± 0.019	0.684TyrAsn: 0.684 ± 0.026	1.237TyrPro: 1.237 ± 0.028	0.793TyrGln: 0.793 ± 0.031	1.832TyrArg: 1.832 ± 0.043	1.283TyrSer: 1.283 ± 0.031	1.555TyrThr: 1.555 ± 0.039	2.271TyrVal: 2.271 ± 0.048	0.36TyrTrp: 0.36 ± 0.02	0.907TyrTyr: 0.907 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3795 proteins (1090797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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