Amino acid dipepetide frequency for Gracilibacillus ureilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.094AlaAla: 5.094 ± 0.084	0.562AlaCys: 0.562 ± 0.024	3.524AlaAsp: 3.524 ± 0.065	4.925AlaGlu: 4.925 ± 0.077	3.038AlaPhe: 3.038 ± 0.063	5.05AlaGly: 5.05 ± 0.071	1.158AlaHis: 1.158 ± 0.034	5.781AlaIle: 5.781 ± 0.078	4.489AlaLys: 4.489 ± 0.062	6.354AlaLeu: 6.354 ± 0.085	1.875AlaMet: 1.875 ± 0.04	2.927AlaAsn: 2.927 ± 0.051	1.813AlaPro: 1.813 ± 0.045	2.008AlaGln: 2.008 ± 0.043	2.343AlaArg: 2.343 ± 0.045	3.848AlaSer: 3.848 ± 0.067	3.414AlaThr: 3.414 ± 0.059	5.119AlaVal: 5.119 ± 0.068	0.584AlaTrp: 0.584 ± 0.022	2.293AlaTyr: 2.293 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.369CysAla: 0.369 ± 0.019	0.092CysCys: 0.092 ± 0.011	0.347CysAsp: 0.347 ± 0.02	0.444CysGlu: 0.444 ± 0.02	0.292CysPhe: 0.292 ± 0.017	0.587CysGly: 0.587 ± 0.022	0.19CysHis: 0.19 ± 0.012	0.476CysIle: 0.476 ± 0.019	0.347CysLys: 0.347 ± 0.019	0.608CysLeu: 0.608 ± 0.021	0.175CysMet: 0.175 ± 0.013	0.305CysAsn: 0.305 ± 0.018	0.297CysPro: 0.297 ± 0.018	0.231CysGln: 0.231 ± 0.014	0.26CysArg: 0.26 ± 0.017	0.467CysSer: 0.467 ± 0.018	0.325CysThr: 0.325 ± 0.015	0.348CysVal: 0.348 ± 0.019	0.068CysTrp: 0.068 ± 0.007	0.275CysTyr: 0.275 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.091AspAla: 3.091 ± 0.062	0.324AspCys: 0.324 ± 0.017	2.672AspAsp: 2.672 ± 0.056	4.492AspGlu: 4.492 ± 0.06	2.533AspPhe: 2.533 ± 0.046	3.669AspGly: 3.669 ± 0.063	1.24AspHis: 1.24 ± 0.037	4.467AspIle: 4.467 ± 0.065	3.485AspLys: 3.485 ± 0.057	4.9AspLeu: 4.9 ± 0.068	1.396AspMet: 1.396 ± 0.03	2.421AspAsn: 2.421 ± 0.052	2.144AspPro: 2.144 ± 0.053	2.637AspGln: 2.637 ± 0.055	2.313AspArg: 2.313 ± 0.045	2.852AspSer: 2.852 ± 0.055	2.72AspThr: 2.72 ± 0.058	3.52AspVal: 3.52 ± 0.056	0.779AspTrp: 0.779 ± 0.028	2.371AspTyr: 2.371 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.288GluAla: 5.288 ± 0.066	0.336GluCys: 0.336 ± 0.016	4.239GluAsp: 4.239 ± 0.06	7.978GluGlu: 7.978 ± 0.115	2.538GluPhe: 2.538 ± 0.054	4.289GluGly: 4.289 ± 0.066	1.423GluHis: 1.423 ± 0.031	6.097GluIle: 6.097 ± 0.076	6.716GluLys: 6.716 ± 0.082	7.072GluLeu: 7.072 ± 0.091	2.411GluMet: 2.411 ± 0.041	4.442GluAsn: 4.442 ± 0.064	2.008GluPro: 2.008 ± 0.041	3.735GluGln: 3.735 ± 0.065	3.257GluArg: 3.257 ± 0.054	3.823GluSer: 3.823 ± 0.061	4.13GluThr: 4.13 ± 0.058	5.18GluVal: 5.18 ± 0.075	0.971GluTrp: 0.971 ± 0.033	2.464GluTyr: 2.464 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.99PheAla: 2.99 ± 0.067	0.334PheCys: 0.334 ± 0.019	2.506PheAsp: 2.506 ± 0.046	2.844PheGlu: 2.844 ± 0.051	2.405PhePhe: 2.405 ± 0.061	3.086PheGly: 3.086 ± 0.057	1.149PheHis: 1.149 ± 0.033	4.113PheIle: 4.113 ± 0.071	2.175PheLys: 2.175 ± 0.044	4.692PheLeu: 4.692 ± 0.083	1.147PheMet: 1.147 ± 0.03	1.895PheAsn: 1.895 ± 0.043	1.648PhePro: 1.648 ± 0.041	1.822PheGln: 1.822 ± 0.04	1.689PheArg: 1.689 ± 0.044	3.311PheSer: 3.311 ± 0.057	2.745PheThr: 2.745 ± 0.054	3.047PheVal: 3.047 ± 0.053	0.541PheTrp: 0.541 ± 0.022	1.811PheTyr: 1.811 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.294GlyAla: 4.294 ± 0.073	0.535GlyCys: 0.535 ± 0.022	3.237GlyAsp: 3.237 ± 0.059	4.729GlyGlu: 4.729 ± 0.074	3.243GlyPhe: 3.243 ± 0.059	4.377GlyGly: 4.377 ± 0.077	1.23GlyHis: 1.23 ± 0.037	5.778GlyIle: 5.778 ± 0.083	4.636GlyLys: 4.636 ± 0.074	6.188GlyLeu: 6.188 ± 0.084	2.084GlyMet: 2.084 ± 0.049	2.952GlyAsn: 2.952 ± 0.059	1.589GlyPro: 1.589 ± 0.038	2.004GlyGln: 2.004 ± 0.043	2.322GlyArg: 2.322 ± 0.052	3.859GlySer: 3.859 ± 0.066	3.752GlyThr: 3.752 ± 0.06	4.514GlyVal: 4.514 ± 0.07	0.808GlyTrp: 0.808 ± 0.027	2.835GlyTyr: 2.835 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.295HisAla: 1.295 ± 0.034	0.195HisCys: 0.195 ± 0.013	1.005HisAsp: 1.005 ± 0.034	1.294HisGlu: 1.294 ± 0.035	1.161HisPhe: 1.161 ± 0.032	1.279HisGly: 1.279 ± 0.036	0.755HisHis: 0.755 ± 0.029	1.652HisIle: 1.652 ± 0.036	0.999HisLys: 0.999 ± 0.032	2.178HisLeu: 2.178 ± 0.047	0.518HisMet: 0.518 ± 0.023	0.881HisAsn: 0.881 ± 0.027	1.056HisPro: 1.056 ± 0.033	0.949HisGln: 0.949 ± 0.032	0.848HisArg: 0.848 ± 0.026	1.289HisSer: 1.289 ± 0.035	1.087HisThr: 1.087 ± 0.032	1.314HisVal: 1.314 ± 0.035	0.248HisTrp: 0.248 ± 0.015	0.971HisTyr: 0.971 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.171IleAla: 6.171 ± 0.081	0.602IleCys: 0.602 ± 0.022	4.813IleAsp: 4.813 ± 0.071	5.93IleGlu: 5.93 ± 0.07	3.822IlePhe: 3.822 ± 0.066	6.029IleGly: 6.029 ± 0.097	1.832IleHis: 1.832 ± 0.039	6.865IleIle: 6.865 ± 0.091	4.589IleLys: 4.589 ± 0.066	7.404IleLeu: 7.404 ± 0.108	1.844IleMet: 1.844 ± 0.037	3.796IleAsn: 3.796 ± 0.069	3.424IlePro: 3.424 ± 0.062	3.073IleGln: 3.073 ± 0.049	3.042IleArg: 3.042 ± 0.056	5.543IleSer: 5.543 ± 0.085	4.866IleThr: 4.866 ± 0.072	5.406IleVal: 5.406 ± 0.079	0.763IleTrp: 0.763 ± 0.024	2.768IleTyr: 2.768 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.205LysAla: 4.205 ± 0.065	0.292LysCys: 0.292 ± 0.018	3.819LysAsp: 3.819 ± 0.058	6.689LysGlu: 6.689 ± 0.091	1.922LysPhe: 1.922 ± 0.035	3.959LysGly: 3.959 ± 0.06	1.308LysHis: 1.308 ± 0.034	4.645LysIle: 4.645 ± 0.062	5.52LysLys: 5.52 ± 0.079	5.733LysLeu: 5.733 ± 0.076	2.081LysMet: 2.081 ± 0.043	3.217LysAsn: 3.217 ± 0.053	1.985LysPro: 1.985 ± 0.041	3.451LysGln: 3.451 ± 0.061	3.002LysArg: 3.002 ± 0.062	3.413LysSer: 3.413 ± 0.054	3.278LysThr: 3.278 ± 0.054	4.5LysVal: 4.5 ± 0.071	0.919LysTrp: 0.919 ± 0.029	2.389LysTyr: 2.389 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.885LeuAla: 6.885 ± 0.086	0.59LeuCys: 0.59 ± 0.023	4.959LeuAsp: 4.959 ± 0.074	6.874LeuGlu: 6.874 ± 0.079	4.874LeuPhe: 4.874 ± 0.079	5.547LeuGly: 5.547 ± 0.078	2.009LeuHis: 2.009 ± 0.044	7.859LeuIle: 7.859 ± 0.099	6.007LeuLys: 6.007 ± 0.065	10.141LeuLeu: 10.141 ± 0.124	2.432LeuMet: 2.432 ± 0.045	4.354LeuAsn: 4.354 ± 0.063	3.913LeuPro: 3.913 ± 0.059	3.587LeuGln: 3.587 ± 0.066	3.377LeuArg: 3.377 ± 0.057	6.624LeuSer: 6.624 ± 0.084	5.614LeuThr: 5.614 ± 0.071	5.865LeuVal: 5.865 ± 0.085	0.898LeuTrp: 0.898 ± 0.032	3.193LeuTyr: 3.193 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.885MetAla: 1.885 ± 0.045	0.118MetCys: 0.118 ± 0.011	1.563MetAsp: 1.563 ± 0.041	2.41MetGlu: 2.41 ± 0.048	1.08MetPhe: 1.08 ± 0.035	1.555MetGly: 1.555 ± 0.039	0.458MetHis: 0.458 ± 0.017	2.352MetIle: 2.352 ± 0.049	2.41MetLys: 2.41 ± 0.043	2.531MetLeu: 2.531 ± 0.046	0.837MetMet: 0.837 ± 0.03	1.549MetAsn: 1.549 ± 0.039	0.911MetPro: 0.911 ± 0.027	0.955MetGln: 0.955 ± 0.028	1.018MetArg: 1.018 ± 0.033	1.552MetSer: 1.552 ± 0.037	1.579MetThr: 1.579 ± 0.037	1.751MetVal: 1.751 ± 0.046	0.189MetTrp: 0.189 ± 0.013	0.781MetTyr: 0.781 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.788AsnAla: 2.788 ± 0.053	0.274AsnCys: 0.274 ± 0.019	2.583AsnAsp: 2.583 ± 0.055	4.041AsnGlu: 4.041 ± 0.061	1.863AsnPhe: 1.863 ± 0.042	3.588AsnGly: 3.588 ± 0.06	1.117AsnHis: 1.117 ± 0.035	3.869AsnIle: 3.869 ± 0.064	3.231AsnLys: 3.231 ± 0.056	3.811AsnLeu: 3.811 ± 0.049	1.339AsnMet: 1.339 ± 0.035	2.589AsnAsn: 2.589 ± 0.067	2.029AsnPro: 2.029 ± 0.04	2.407AsnGln: 2.407 ± 0.053	2.087AsnArg: 2.087 ± 0.041	2.537AsnSer: 2.537 ± 0.052	2.328AsnThr: 2.328 ± 0.045	3.098AsnVal: 3.098 ± 0.051	0.683AsnTrp: 0.683 ± 0.025	1.862AsnTyr: 1.862 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.347ProAla: 2.347 ± 0.05	0.205ProCys: 0.205 ± 0.014	2.317ProAsp: 2.317 ± 0.051	3.018ProGlu: 3.018 ± 0.055	1.904ProPhe: 1.904 ± 0.041	2.227ProGly: 2.227 ± 0.046	0.707ProHis: 0.707 ± 0.025	2.597ProIle: 2.597 ± 0.056	1.812ProLys: 1.812 ± 0.034	3.294ProLeu: 3.294 ± 0.057	0.792ProMet: 0.792 ± 0.029	1.651ProAsn: 1.651 ± 0.038	0.933ProPro: 0.933 ± 0.032	1.039ProGln: 1.039 ± 0.032	0.946ProArg: 0.946 ± 0.031	2.082ProSer: 2.082 ± 0.041	1.721ProThr: 1.721 ± 0.04	3.046ProVal: 3.046 ± 0.056	0.367ProTrp: 0.367 ± 0.016	1.447ProTyr: 1.447 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.627GlnAla: 2.627 ± 0.05	0.186GlnCys: 0.186 ± 0.012	1.714GlnAsp: 1.714 ± 0.038	2.935GlnGlu: 2.935 ± 0.059	1.819GlnPhe: 1.819 ± 0.04	2.072GlnGly: 2.072 ± 0.049	0.807GlnHis: 0.807 ± 0.023	3.043GlnIle: 3.043 ± 0.047	2.705GlnLys: 2.705 ± 0.056	4.749GlnLeu: 4.749 ± 0.073	1.227GlnMet: 1.227 ± 0.03	1.798GlnAsn: 1.798 ± 0.042	1.255GlnPro: 1.255 ± 0.042	2.133GlnGln: 2.133 ± 0.06	1.382GlnArg: 1.382 ± 0.038	2.467GlnSer: 2.467 ± 0.052	2.223GlnThr: 2.223 ± 0.041	2.467GlnVal: 2.467 ± 0.049	0.448GlnTrp: 0.448 ± 0.02	1.519GlnTyr: 1.519 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.178ArgAla: 2.178 ± 0.048	0.213ArgCys: 0.213 ± 0.015	1.984ArgAsp: 1.984 ± 0.043	3.124ArgGlu: 3.124 ± 0.054	1.798ArgPhe: 1.798 ± 0.038	2.054ArgGly: 2.054 ± 0.041	0.757ArgHis: 0.757 ± 0.026	3.092ArgIle: 3.092 ± 0.054	3.215ArgLys: 3.215 ± 0.059	3.724ArgLeu: 3.724 ± 0.059	1.202ArgMet: 1.202 ± 0.033	2.056ArgAsn: 2.056 ± 0.042	1.206ArgPro: 1.206 ± 0.038	1.465ArgGln: 1.465 ± 0.034	1.631ArgArg: 1.631 ± 0.039	2.109ArgSer: 2.109 ± 0.047	1.951ArgThr: 1.951 ± 0.044	2.376ArgVal: 2.376 ± 0.048	0.422ArgTrp: 0.422 ± 0.018	1.521ArgTyr: 1.521 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.696SerAla: 3.696 ± 0.061	0.43SerCys: 0.43 ± 0.025	3.218SerAsp: 3.218 ± 0.049	4.181SerGlu: 4.181 ± 0.067	3.338SerPhe: 3.338 ± 0.057	4.311SerGly: 4.311 ± 0.065	1.275SerHis: 1.275 ± 0.035	5.384SerIle: 5.384 ± 0.08	3.532SerLys: 3.532 ± 0.059	5.876SerLeu: 5.876 ± 0.085	1.654SerMet: 1.654 ± 0.035	3.009SerAsn: 3.009 ± 0.056	1.992SerPro: 1.992 ± 0.042	2.037SerGln: 2.037 ± 0.042	2.168SerArg: 2.168 ± 0.049	3.806SerSer: 3.806 ± 0.071	3.032SerThr: 3.032 ± 0.057	4.223SerVal: 4.223 ± 0.057	0.689SerTrp: 0.689 ± 0.023	2.387SerTyr: 2.387 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	3.785ThrAla: 3.785 ± 0.056	0.362ThrCys: 0.362 ± 0.017	3.186ThrAsp: 3.186 ± 0.057	4.055ThrGlu: 4.055 ± 0.052	2.62ThrPhe: 2.62 ± 0.053	4.105ThrGly: 4.105 ± 0.068	0.984ThrHis: 0.984 ± 0.03	4.759ThrIle: 4.759 ± 0.053	3.062ThrLys: 3.062 ± 0.049	5.049ThrLeu: 5.049 ± 0.072	1.347ThrMet: 1.347 ± 0.032	2.735ThrAsn: 2.735 ± 0.053	2.066ThrPro: 2.066 ± 0.048	1.371ThrGln: 1.371 ± 0.035	1.713ThrArg: 1.713 ± 0.038	3.378ThrSer: 3.378 ± 0.057	2.869ThrThr: 2.869 ± 0.057	4.25ThrVal: 4.25 ± 0.065	0.536ThrTrp: 0.536 ± 0.02	2.084ThrTyr: 2.084 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.48ValAla: 4.48 ± 0.071	0.518ValCys: 0.518 ± 0.022	3.673ValAsp: 3.673 ± 0.061	4.936ValGlu: 4.936 ± 0.069	3.132ValPhe: 3.132 ± 0.047	4.005ValGly: 4.005 ± 0.06	1.287ValHis: 1.287 ± 0.029	6.058ValIle: 6.058 ± 0.076	4.532ValLys: 4.532 ± 0.062	6.395ValLeu: 6.395 ± 0.095	1.872ValMet: 1.872 ± 0.041	3.27ValAsn: 3.27 ± 0.059	2.368ValPro: 2.368 ± 0.05	2.244ValGln: 2.244 ± 0.045	2.455ValArg: 2.455 ± 0.045	4.477ValSer: 4.477 ± 0.065	4.192ValThr: 4.192 ± 0.064	4.552ValVal: 4.552 ± 0.075	0.678ValTrp: 0.678 ± 0.026	2.365ValTyr: 2.365 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.598TrpAla: 0.598 ± 0.026	0.065TrpCys: 0.065 ± 0.007	0.606TrpAsp: 0.606 ± 0.026	0.786TrpGlu: 0.786 ± 0.024	0.547TrpPhe: 0.547 ± 0.023	0.684TrpGly: 0.684 ± 0.025	0.252TrpHis: 0.252 ± 0.015	0.91TrpIle: 0.91 ± 0.032	0.83TrpLys: 0.83 ± 0.027	1.236TrpLeu: 1.236 ± 0.036	0.366TrpMet: 0.366 ± 0.019	0.616TrpAsn: 0.616 ± 0.024	0.28TrpPro: 0.28 ± 0.018	0.506TrpGln: 0.506 ± 0.021	0.444TrpArg: 0.444 ± 0.022	0.66TrpSer: 0.66 ± 0.027	0.576TrpThr: 0.576 ± 0.02	0.654TrpVal: 0.654 ± 0.025	0.154TrpTrp: 0.154 ± 0.011	0.422TrpTyr: 0.422 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.133TyrAla: 2.133 ± 0.035	0.268TyrCys: 0.268 ± 0.014	2.065TyrAsp: 2.065 ± 0.043	2.71TyrGlu: 2.71 ± 0.055	2.025TyrPhe: 2.025 ± 0.042	2.493TyrGly: 2.493 ± 0.045	1.039TyrHis: 1.039 ± 0.033	2.785TyrIle: 2.785 ± 0.052	2.032TyrLys: 2.032 ± 0.042	3.664TyrLeu: 3.664 ± 0.062	0.885TyrMet: 0.885 ± 0.027	1.662TyrAsn: 1.662 ± 0.04	1.534TyrPro: 1.534 ± 0.037	1.922TyrGln: 1.922 ± 0.047	1.782TyrArg: 1.782 ± 0.041	2.144TyrSer: 2.144 ± 0.042	1.913TyrThr: 1.913 ± 0.045	2.26TyrVal: 2.26 ± 0.041	0.445TyrTrp: 0.445 ± 0.018	1.757TyrTyr: 1.757 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3985 proteins (1176553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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