Amino acid dipepetide frequency for Gordonia phage Yago84

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.232AlaAla: 16.232 ± 0.946
0.517AlaCys: 0.517 ± 0.172
8.788AlaAsp: 8.788 ± 0.842
9.098AlaGlu: 9.098 ± 0.814
3.205AlaPhe: 3.205 ± 0.467
8.788AlaGly: 8.788 ± 1.181
2.326AlaHis: 2.326 ± 0.356
4.704AlaIle: 4.704 ± 0.602
3.36AlaLys: 3.36 ± 0.371
11.166AlaLeu: 11.166 ± 0.782
3.67AlaMet: 3.67 ± 0.497
3.257AlaAsn: 3.257 ± 0.433
6.565AlaPro: 6.565 ± 0.597
4.756AlaGln: 4.756 ± 0.568
8.374AlaArg: 8.374 ± 0.828
6.979AlaSer: 6.979 ± 0.688
7.702AlaThr: 7.702 ± 0.65
10.494AlaVal: 10.494 ± 0.708
2.068AlaTrp: 2.068 ± 0.362
2.326AlaTyr: 2.326 ± 0.315
0.0AlaXaa: 0.0 ± 0.0
Cys
1.086CysAla: 1.086 ± 0.257
0.207CysCys: 0.207 ± 0.128
0.775CysAsp: 0.775 ± 0.278
0.517CysGlu: 0.517 ± 0.166
0.103CysPhe: 0.103 ± 0.061
1.137CysGly: 1.137 ± 0.281
0.258CysHis: 0.258 ± 0.113
0.103CysIle: 0.103 ± 0.079
0.207CysLys: 0.207 ± 0.118
0.31CysLeu: 0.31 ± 0.107
0.155CysMet: 0.155 ± 0.084
0.258CysAsn: 0.258 ± 0.115
0.672CysPro: 0.672 ± 0.202
0.258CysGln: 0.258 ± 0.128
0.672CysArg: 0.672 ± 0.209
0.724CysSer: 0.724 ± 0.178
0.517CysThr: 0.517 ± 0.18
0.827CysVal: 0.827 ± 0.216
0.103CysTrp: 0.103 ± 0.072
0.31CysTyr: 0.31 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
8.271AspAla: 8.271 ± 0.623
0.672AspCys: 0.672 ± 0.204
5.531AspAsp: 5.531 ± 0.706
5.118AspGlu: 5.118 ± 0.609
1.086AspPhe: 1.086 ± 0.235
6.048AspGly: 6.048 ± 0.549
1.396AspHis: 1.396 ± 0.316
2.688AspIle: 2.688 ± 0.395
1.396AspLys: 1.396 ± 0.352
6.772AspLeu: 6.772 ± 0.594
1.861AspMet: 1.861 ± 0.326
2.016AspAsn: 2.016 ± 0.355
4.394AspPro: 4.394 ± 0.509
1.602AspGln: 1.602 ± 0.291
4.807AspArg: 4.807 ± 0.499
4.084AspSer: 4.084 ± 0.549
4.084AspThr: 4.084 ± 0.404
5.014AspVal: 5.014 ± 0.462
1.396AspTrp: 1.396 ± 0.246
1.396AspTyr: 1.396 ± 0.288
0.0AspXaa: 0.0 ± 0.0
Glu
7.599GluAla: 7.599 ± 0.584
1.034GluCys: 1.034 ± 0.274
3.722GluAsp: 3.722 ± 0.497
2.171GluGlu: 2.171 ± 0.427
1.499GluPhe: 1.499 ± 0.274
4.652GluGly: 4.652 ± 0.513
1.809GluHis: 1.809 ± 0.352
2.946GluIle: 2.946 ± 0.46
0.982GluLys: 0.982 ± 0.279
6.41GluLeu: 6.41 ± 0.549
1.292GluMet: 1.292 ± 0.298
1.344GluAsn: 1.344 ± 0.264
3.825GluPro: 3.825 ± 0.56
2.946GluGln: 2.946 ± 0.385
4.135GluArg: 4.135 ± 0.507
2.326GluSer: 2.326 ± 0.316
3.515GluThr: 3.515 ± 0.525
5.014GluVal: 5.014 ± 0.532
1.292GluTrp: 1.292 ± 0.201
1.034GluTyr: 1.034 ± 0.208
0.0GluXaa: 0.0 ± 0.0
Phe
2.688PheAla: 2.688 ± 0.313
0.155PheCys: 0.155 ± 0.094
2.171PheAsp: 2.171 ± 0.375
1.137PheGlu: 1.137 ± 0.295
0.62PhePhe: 0.62 ± 0.254
2.636PheGly: 2.636 ± 0.376
0.258PheHis: 0.258 ± 0.171
1.189PheIle: 1.189 ± 0.263
0.517PheLys: 0.517 ± 0.172
1.344PheLeu: 1.344 ± 0.242
0.827PheMet: 0.827 ± 0.221
0.724PheAsn: 0.724 ± 0.175
0.879PhePro: 0.879 ± 0.2
1.086PheGln: 1.086 ± 0.201
1.706PheArg: 1.706 ± 0.312
1.396PheSer: 1.396 ± 0.263
1.913PheThr: 1.913 ± 0.269
2.068PheVal: 2.068 ± 0.276
0.155PheTrp: 0.155 ± 0.098
0.362PheTyr: 0.362 ± 0.13
0.0PheXaa: 0.0 ± 0.0
Gly
9.046GlyAla: 9.046 ± 0.908
0.93GlyCys: 0.93 ± 0.267
5.893GlyAsp: 5.893 ± 0.495
5.376GlyGlu: 5.376 ± 0.503
2.274GlyPhe: 2.274 ± 0.512
8.064GlyGly: 8.064 ± 0.952
1.964GlyHis: 1.964 ± 0.312
4.239GlyIle: 4.239 ± 0.682
3.102GlyLys: 3.102 ± 0.402
7.34GlyLeu: 7.34 ± 0.902
1.654GlyMet: 1.654 ± 0.292
2.223GlyAsn: 2.223 ± 0.408
4.135GlyPro: 4.135 ± 0.372
3.153GlyGln: 3.153 ± 0.529
6.203GlyArg: 6.203 ± 0.63
5.273GlySer: 5.273 ± 0.512
5.376GlyThr: 5.376 ± 0.522
6.668GlyVal: 6.668 ± 0.538
2.326GlyTrp: 2.326 ± 0.386
2.068GlyTyr: 2.068 ± 0.402
0.0GlyXaa: 0.0 ± 0.0
His
2.274HisAla: 2.274 ± 0.354
0.052HisCys: 0.052 ± 0.048
1.499HisAsp: 1.499 ± 0.328
0.879HisGlu: 0.879 ± 0.199
0.569HisPhe: 0.569 ± 0.179
1.034HisGly: 1.034 ± 0.313
0.827HisHis: 0.827 ± 0.173
0.982HisIle: 0.982 ± 0.24
0.414HisLys: 0.414 ± 0.184
2.016HisLeu: 2.016 ± 0.322
0.31HisMet: 0.31 ± 0.127
0.465HisAsn: 0.465 ± 0.13
1.189HisPro: 1.189 ± 0.288
0.672HisGln: 0.672 ± 0.16
1.758HisArg: 1.758 ± 0.339
0.879HisSer: 0.879 ± 0.269
1.241HisThr: 1.241 ± 0.249
0.827HisVal: 0.827 ± 0.244
0.569HisTrp: 0.569 ± 0.155
0.517HisTyr: 0.517 ± 0.167
0.0HisXaa: 0.0 ± 0.0
Ile
6.307IleAla: 6.307 ± 0.629
0.258IleCys: 0.258 ± 0.114
4.135IleAsp: 4.135 ± 0.432
4.084IleGlu: 4.084 ± 0.581
0.827IlePhe: 0.827 ± 0.184
4.342IleGly: 4.342 ± 0.897
0.93IleHis: 0.93 ± 0.189
1.602IleIle: 1.602 ± 0.333
1.086IleLys: 1.086 ± 0.292
2.068IleLeu: 2.068 ± 0.344
0.93IleMet: 0.93 ± 0.259
1.396IleAsn: 1.396 ± 0.267
1.758IlePro: 1.758 ± 0.329
0.775IleGln: 0.775 ± 0.183
2.585IleArg: 2.585 ± 0.354
1.758IleSer: 1.758 ± 0.315
3.515IleThr: 3.515 ± 0.528
3.567IleVal: 3.567 ± 0.344
0.672IleTrp: 0.672 ± 0.194
0.93IleTyr: 0.93 ± 0.226
0.0IleXaa: 0.0 ± 0.0
Lys
3.102LysAla: 3.102 ± 0.387
0.155LysCys: 0.155 ± 0.083
0.982LysAsp: 0.982 ± 0.171
0.672LysGlu: 0.672 ± 0.151
0.62LysPhe: 0.62 ± 0.165
2.068LysGly: 2.068 ± 0.32
0.362LysHis: 0.362 ± 0.138
0.93LysIle: 0.93 ± 0.254
0.31LysLys: 0.31 ± 0.113
1.758LysLeu: 1.758 ± 0.292
0.465LysMet: 0.465 ± 0.171
0.569LysAsn: 0.569 ± 0.167
1.861LysPro: 1.861 ± 0.359
0.414LysGln: 0.414 ± 0.142
1.861LysArg: 1.861 ± 0.336
1.344LysSer: 1.344 ± 0.258
1.913LysThr: 1.913 ± 0.259
2.378LysVal: 2.378 ± 0.299
0.465LysTrp: 0.465 ± 0.131
0.31LysTyr: 0.31 ± 0.123
0.0LysXaa: 0.0 ± 0.0
Leu
11.114LeuAla: 11.114 ± 0.753
0.724LeuCys: 0.724 ± 0.228
6.513LeuAsp: 6.513 ± 0.616
2.946LeuGlu: 2.946 ± 0.304
2.016LeuPhe: 2.016 ± 0.372
8.323LeuGly: 8.323 ± 0.714
1.292LeuHis: 1.292 ± 0.29
3.929LeuIle: 3.929 ± 0.49
1.706LeuLys: 1.706 ± 0.28
6.1LeuLeu: 6.1 ± 0.577
1.861LeuMet: 1.861 ± 0.283
1.964LeuAsn: 1.964 ± 0.332
4.807LeuPro: 4.807 ± 0.514
3.205LeuGln: 3.205 ± 0.377
6.1LeuArg: 6.1 ± 0.638
4.652LeuSer: 4.652 ± 0.42
5.79LeuThr: 5.79 ± 0.507
5.738LeuVal: 5.738 ± 0.558
1.654LeuTrp: 1.654 ± 0.275
1.602LeuTyr: 1.602 ± 0.288
0.0LeuXaa: 0.0 ± 0.0
Met
3.05MetAla: 3.05 ± 0.358
0.207MetCys: 0.207 ± 0.12
1.499MetAsp: 1.499 ± 0.335
1.086MetGlu: 1.086 ± 0.228
0.62MetPhe: 0.62 ± 0.155
2.016MetGly: 2.016 ± 0.275
0.517MetHis: 0.517 ± 0.191
1.189MetIle: 1.189 ± 0.246
0.362MetLys: 0.362 ± 0.147
1.447MetLeu: 1.447 ± 0.26
0.258MetMet: 0.258 ± 0.108
0.775MetAsn: 0.775 ± 0.188
1.602MetPro: 1.602 ± 0.221
0.724MetGln: 0.724 ± 0.168
1.809MetArg: 1.809 ± 0.266
2.274MetSer: 2.274 ± 0.303
2.585MetThr: 2.585 ± 0.392
1.654MetVal: 1.654 ± 0.268
0.258MetTrp: 0.258 ± 0.13
0.517MetTyr: 0.517 ± 0.15
0.0MetXaa: 0.0 ± 0.0
Asn
3.412AsnAla: 3.412 ± 0.465
0.362AsnCys: 0.362 ± 0.134
1.964AsnAsp: 1.964 ± 0.342
0.775AsnGlu: 0.775 ± 0.164
0.724AsnPhe: 0.724 ± 0.242
2.843AsnGly: 2.843 ± 0.444
0.569AsnHis: 0.569 ± 0.186
0.724AsnIle: 0.724 ± 0.195
0.517AsnLys: 0.517 ± 0.203
2.119AsnLeu: 2.119 ± 0.346
0.31AsnMet: 0.31 ± 0.121
0.879AsnAsn: 0.879 ± 0.234
1.809AsnPro: 1.809 ± 0.298
0.672AsnGln: 0.672 ± 0.189
1.241AsnArg: 1.241 ± 0.211
2.119AsnSer: 2.119 ± 0.28
2.326AsnThr: 2.326 ± 0.246
2.533AsnVal: 2.533 ± 0.578
0.62AsnTrp: 0.62 ± 0.174
0.465AsnTyr: 0.465 ± 0.157
0.0AsnXaa: 0.0 ± 0.0
Pro
6.203ProAla: 6.203 ± 0.518
0.465ProCys: 0.465 ± 0.122
4.446ProAsp: 4.446 ± 0.608
5.066ProGlu: 5.066 ± 0.417
1.654ProPhe: 1.654 ± 0.277
5.324ProGly: 5.324 ± 0.523
0.879ProHis: 0.879 ± 0.271
2.326ProIle: 2.326 ± 0.36
0.827ProLys: 0.827 ± 0.256
3.877ProLeu: 3.877 ± 0.394
1.654ProMet: 1.654 ± 0.236
0.982ProAsn: 0.982 ± 0.29
3.877ProPro: 3.877 ± 0.573
1.913ProGln: 1.913 ± 0.329
3.05ProArg: 3.05 ± 0.474
3.257ProSer: 3.257 ± 0.271
4.187ProThr: 4.187 ± 0.568
4.963ProVal: 4.963 ± 0.498
0.93ProTrp: 0.93 ± 0.185
1.189ProTyr: 1.189 ± 0.261
0.0ProXaa: 0.0 ± 0.0
Gln
4.911GlnAla: 4.911 ± 0.501
0.207GlnCys: 0.207 ± 0.116
1.292GlnAsp: 1.292 ± 0.289
1.396GlnGlu: 1.396 ± 0.252
1.137GlnPhe: 1.137 ± 0.188
2.533GlnGly: 2.533 ± 0.411
0.569GlnHis: 0.569 ± 0.157
1.499GlnIle: 1.499 ± 0.249
0.517GlnLys: 0.517 ± 0.175
3.98GlnLeu: 3.98 ± 0.435
1.292GlnMet: 1.292 ± 0.344
1.086GlnAsn: 1.086 ± 0.27
1.292GlnPro: 1.292 ± 0.311
1.861GlnGln: 1.861 ± 0.539
2.895GlnArg: 2.895 ± 0.43
1.499GlnSer: 1.499 ± 0.274
2.481GlnThr: 2.481 ± 0.321
3.205GlnVal: 3.205 ± 0.381
0.517GlnTrp: 0.517 ± 0.158
0.362GlnTyr: 0.362 ± 0.111
0.0GlnXaa: 0.0 ± 0.0
Arg
8.684ArgAla: 8.684 ± 0.611
0.827ArgCys: 0.827 ± 0.196
4.601ArgAsp: 4.601 ± 0.576
4.394ArgGlu: 4.394 ± 0.518
1.499ArgPhe: 1.499 ± 0.27
4.911ArgGly: 4.911 ± 0.441
1.499ArgHis: 1.499 ± 0.269
2.843ArgIle: 2.843 ± 0.36
1.809ArgLys: 1.809 ± 0.309
5.996ArgLeu: 5.996 ± 0.658
1.809ArgMet: 1.809 ± 0.339
1.758ArgAsn: 1.758 ± 0.283
3.825ArgPro: 3.825 ± 0.491
3.05ArgGln: 3.05 ± 0.37
6.255ArgArg: 6.255 ± 0.91
3.463ArgSer: 3.463 ± 0.481
4.342ArgThr: 4.342 ± 0.469
4.652ArgVal: 4.652 ± 0.469
1.602ArgTrp: 1.602 ± 0.328
2.74ArgTyr: 2.74 ± 0.423
0.0ArgXaa: 0.0 ± 0.0
Ser
6.307SerAla: 6.307 ± 0.536
0.517SerCys: 0.517 ± 0.234
3.153SerAsp: 3.153 ± 0.417
2.378SerGlu: 2.378 ± 0.372
1.137SerPhe: 1.137 ± 0.321
5.893SerGly: 5.893 ± 0.613
0.775SerHis: 0.775 ± 0.201
3.257SerIle: 3.257 ± 0.4
1.551SerLys: 1.551 ± 0.315
4.342SerLeu: 4.342 ± 0.597
1.551SerMet: 1.551 ± 0.248
1.344SerAsn: 1.344 ± 0.289
3.257SerPro: 3.257 ± 0.423
2.43SerGln: 2.43 ± 0.348
3.412SerArg: 3.412 ± 0.511
3.67SerSer: 3.67 ± 0.452
3.825SerThr: 3.825 ± 0.444
4.342SerVal: 4.342 ± 0.421
1.551SerTrp: 1.551 ± 0.284
1.499SerTyr: 1.499 ± 0.3
0.0SerXaa: 0.0 ± 0.0
Thr
9.925ThrAla: 9.925 ± 0.828
0.775ThrCys: 0.775 ± 0.207
4.446ThrAsp: 4.446 ± 0.47
4.187ThrGlu: 4.187 ± 0.435
1.447ThrPhe: 1.447 ± 0.315
6.513ThrGly: 6.513 ± 0.458
0.775ThrHis: 0.775 ± 0.209
3.619ThrIle: 3.619 ± 0.404
1.758ThrLys: 1.758 ± 0.319
4.704ThrLeu: 4.704 ± 0.427
1.602ThrMet: 1.602 ± 0.281
1.758ThrAsn: 1.758 ± 0.377
4.601ThrPro: 4.601 ± 0.581
1.499ThrGln: 1.499 ± 0.292
4.807ThrArg: 4.807 ± 0.567
3.774ThrSer: 3.774 ± 0.483
5.221ThrThr: 5.221 ± 0.605
4.911ThrVal: 4.911 ± 0.503
1.396ThrTrp: 1.396 ± 0.285
1.551ThrTyr: 1.551 ± 0.28
0.0ThrXaa: 0.0 ± 0.0
Val
9.46ValAla: 9.46 ± 0.668
0.672ValCys: 0.672 ± 0.211
5.066ValAsp: 5.066 ± 0.441
5.583ValGlu: 5.583 ± 0.589
1.447ValPhe: 1.447 ± 0.262
7.289ValGly: 7.289 ± 0.486
1.034ValHis: 1.034 ± 0.256
3.825ValIle: 3.825 ± 0.625
1.447ValLys: 1.447 ± 0.265
6.772ValLeu: 6.772 ± 0.673
1.861ValMet: 1.861 ± 0.304
2.585ValAsn: 2.585 ± 0.358
4.394ValPro: 4.394 ± 0.412
1.861ValGln: 1.861 ± 0.304
5.841ValArg: 5.841 ± 0.637
3.98ValSer: 3.98 ± 0.547
5.893ValThr: 5.893 ± 0.483
6.1ValVal: 6.1 ± 0.564
1.706ValTrp: 1.706 ± 0.382
1.551ValTyr: 1.551 ± 0.278
0.0ValXaa: 0.0 ± 0.0
Trp
2.274TrpAla: 2.274 ± 0.41
0.258TrpCys: 0.258 ± 0.133
1.602TrpAsp: 1.602 ± 0.234
1.344TrpGlu: 1.344 ± 0.266
0.672TrpPhe: 0.672 ± 0.186
0.827TrpGly: 0.827 ± 0.196
0.414TrpHis: 0.414 ± 0.142
0.465TrpIle: 0.465 ± 0.151
0.362TrpLys: 0.362 ± 0.129
1.396TrpLeu: 1.396 ± 0.3
0.672TrpMet: 0.672 ± 0.214
1.086TrpAsn: 1.086 ± 0.414
1.189TrpPro: 1.189 ± 0.309
1.086TrpGln: 1.086 ± 0.249
1.292TrpArg: 1.292 ± 0.255
1.189TrpSer: 1.189 ± 0.233
1.447TrpThr: 1.447 ± 0.268
1.861TrpVal: 1.861 ± 0.268
0.414TrpTrp: 0.414 ± 0.196
0.362TrpTyr: 0.362 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.43TyrAla: 2.43 ± 0.327
0.207TyrCys: 0.207 ± 0.092
1.551TyrAsp: 1.551 ± 0.297
1.396TyrGlu: 1.396 ± 0.333
0.672TyrPhe: 0.672 ± 0.178
2.068TyrGly: 2.068 ± 0.373
0.517TyrHis: 0.517 ± 0.2
0.465TyrIle: 0.465 ± 0.187
0.31TyrLys: 0.31 ± 0.129
2.119TyrLeu: 2.119 ± 0.32
0.362TyrMet: 0.362 ± 0.123
0.517TyrAsn: 0.517 ± 0.148
1.137TyrPro: 1.137 ± 0.288
0.569TyrGln: 0.569 ± 0.147
1.758TyrArg: 1.758 ± 0.29
1.551TyrSer: 1.551 ± 0.311
1.396TyrThr: 1.396 ± 0.254
1.551TyrVal: 1.551 ± 0.292
0.517TyrTrp: 0.517 ± 0.177
0.31TyrTyr: 0.31 ± 0.112
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (19346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski