Amino acid dipepetide frequency for Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.995AlaAla: 8.995 ± 0.111
0.875AlaCys: 0.875 ± 0.027
4.632AlaAsp: 4.632 ± 0.069
5.936AlaGlu: 5.936 ± 0.098
3.073AlaPhe: 3.073 ± 0.054
6.029AlaGly: 6.029 ± 0.091
1.553AlaHis: 1.553 ± 0.043
7.92AlaIle: 7.92 ± 0.089
3.977AlaLys: 3.977 ± 0.067
9.697AlaLeu: 9.697 ± 0.112
2.048AlaMet: 2.048 ± 0.044
3.111AlaAsn: 3.111 ± 0.068
3.822AlaPro: 3.822 ± 0.08
5.477AlaGln: 5.477 ± 0.088
3.76AlaArg: 3.76 ± 0.067
4.238AlaSer: 4.238 ± 0.064
5.307AlaThr: 5.307 ± 0.082
5.743AlaVal: 5.743 ± 0.077
1.276AlaTrp: 1.276 ± 0.032
2.352AlaTyr: 2.352 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.727CysAla: 0.727 ± 0.029
0.166CysCys: 0.166 ± 0.013
0.608CysAsp: 0.608 ± 0.026
0.534CysGlu: 0.534 ± 0.024
0.452CysPhe: 0.452 ± 0.021
0.928CysGly: 0.928 ± 0.033
0.329CysHis: 0.329 ± 0.018
0.513CysIle: 0.513 ± 0.025
0.243CysLys: 0.243 ± 0.016
1.227CysLeu: 1.227 ± 0.041
0.127CysMet: 0.127 ± 0.011
0.331CysAsn: 0.331 ± 0.017
0.677CysPro: 0.677 ± 0.029
0.658CysGln: 0.658 ± 0.023
0.606CysArg: 0.606 ± 0.028
0.528CysSer: 0.528 ± 0.024
0.491CysThr: 0.491 ± 0.022
0.577CysVal: 0.577 ± 0.023
0.139CysTrp: 0.139 ± 0.012
0.333CysTyr: 0.333 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.832AspAla: 3.832 ± 0.056
0.564AspCys: 0.564 ± 0.026
2.378AspAsp: 2.378 ± 0.061
2.841AspGlu: 2.841 ± 0.068
2.663AspPhe: 2.663 ± 0.063
3.297AspGly: 3.297 ± 0.071
1.137AspHis: 1.137 ± 0.039
3.115AspIle: 3.115 ± 0.058
1.659AspLys: 1.659 ± 0.043
6.926AspLeu: 6.926 ± 0.111
0.773AspMet: 0.773 ± 0.029
1.809AspAsn: 1.809 ± 0.046
3.189AspPro: 3.189 ± 0.054
2.899AspGln: 2.899 ± 0.061
3.935AspArg: 3.935 ± 0.066
2.447AspSer: 2.447 ± 0.058
2.228AspThr: 2.228 ± 0.048
3.082AspVal: 3.082 ± 0.062
0.932AspTrp: 0.932 ± 0.031
2.088AspTyr: 2.088 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.526GluAla: 6.526 ± 0.096
0.388GluCys: 0.388 ± 0.021
2.7GluAsp: 2.7 ± 0.057
3.568GluGlu: 3.568 ± 0.078
2.378GluPhe: 2.378 ± 0.054
3.328GluGly: 3.328 ± 0.058
1.004GluHis: 1.004 ± 0.031
4.748GluIle: 4.748 ± 0.069
3.494GluLys: 3.494 ± 0.071
6.39GluLeu: 6.39 ± 0.106
1.493GluMet: 1.493 ± 0.04
2.669GluAsn: 2.669 ± 0.06
2.538GluPro: 2.538 ± 0.05
3.492GluGln: 3.492 ± 0.076
3.214GluArg: 3.214 ± 0.062
2.901GluSer: 2.901 ± 0.059
4.374GluThr: 4.374 ± 0.073
3.885GluVal: 3.885 ± 0.063
0.681GluTrp: 0.681 ± 0.027
1.631GluTyr: 1.631 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.399PheAla: 3.399 ± 0.063
0.568PheCys: 0.568 ± 0.026
2.346PheAsp: 2.346 ± 0.054
2.229PheGlu: 2.229 ± 0.054
1.956PhePhe: 1.956 ± 0.051
3.182PheGly: 3.182 ± 0.065
0.75PheHis: 0.75 ± 0.026
2.238PheIle: 2.238 ± 0.047
1.417PheLys: 1.417 ± 0.042
4.318PheLeu: 4.318 ± 0.071
0.747PheMet: 0.747 ± 0.026
1.606PheAsn: 1.606 ± 0.045
2.082PhePro: 2.082 ± 0.047
2.143PheGln: 2.143 ± 0.044
1.914PheArg: 1.914 ± 0.043
2.811PheSer: 2.811 ± 0.056
2.295PheThr: 2.295 ± 0.044
2.53PheVal: 2.53 ± 0.057
0.753PheTrp: 0.753 ± 0.031
1.36PheTyr: 1.36 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.73GlyAla: 5.73 ± 0.093
0.897GlyCys: 0.897 ± 0.03
4.405GlyAsp: 4.405 ± 0.072
4.452GlyGlu: 4.452 ± 0.071
3.258GlyPhe: 3.258 ± 0.059
4.982GlyGly: 4.982 ± 0.097
1.322GlyHis: 1.322 ± 0.041
5.019GlyIle: 5.019 ± 0.072
3.495GlyLys: 3.495 ± 0.075
7.778GlyLeu: 7.778 ± 0.109
1.564GlyMet: 1.564 ± 0.044
2.636GlyAsn: 2.636 ± 0.06
1.585GlyPro: 1.585 ± 0.044
3.48GlyGln: 3.48 ± 0.063
3.395GlyArg: 3.395 ± 0.058
3.906GlySer: 3.906 ± 0.067
4.056GlyThr: 4.056 ± 0.072
4.77GlyVal: 4.77 ± 0.079
1.126GlyTrp: 1.126 ± 0.041
2.366GlyTyr: 2.366 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.14HisAla: 1.14 ± 0.034
0.373HisCys: 0.373 ± 0.02
0.863HisAsp: 0.863 ± 0.029
0.817HisGlu: 0.817 ± 0.029
0.913HisPhe: 0.913 ± 0.033
1.331HisGly: 1.331 ± 0.043
0.808HisHis: 0.808 ± 0.036
1.015HisIle: 1.015 ± 0.034
0.631HisLys: 0.631 ± 0.024
2.511HisLeu: 2.511 ± 0.056
0.292HisMet: 0.292 ± 0.019
0.714HisAsn: 0.714 ± 0.028
1.477HisPro: 1.477 ± 0.041
1.388HisGln: 1.388 ± 0.039
1.245HisArg: 1.245 ± 0.033
1.108HisSer: 1.108 ± 0.034
0.91HisThr: 0.91 ± 0.031
0.896HisVal: 0.896 ± 0.033
0.471HisTrp: 0.471 ± 0.024
0.78HisTyr: 0.78 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
7.971IleAla: 7.971 ± 0.1
0.713IleCys: 0.713 ± 0.025
3.325IleAsp: 3.325 ± 0.074
3.847IleGlu: 3.847 ± 0.072
2.688IlePhe: 2.688 ± 0.059
4.154IleGly: 4.154 ± 0.076
1.296IleHis: 1.296 ± 0.043
3.365IleIle: 3.365 ± 0.064
2.258IleLys: 2.258 ± 0.05
6.786IleLeu: 6.786 ± 0.09
0.847IleMet: 0.847 ± 0.031
2.294IleAsn: 2.294 ± 0.056
3.528IlePro: 3.528 ± 0.054
3.168IleGln: 3.168 ± 0.058
3.104IleArg: 3.104 ± 0.056
3.454IleSer: 3.454 ± 0.057
3.575IleThr: 3.575 ± 0.073
3.839IleVal: 3.839 ± 0.067
0.789IleTrp: 0.789 ± 0.03
1.833IleTyr: 1.833 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
3.735LysAla: 3.735 ± 0.058
0.249LysCys: 0.249 ± 0.016
1.966LysAsp: 1.966 ± 0.049
2.474LysGlu: 2.474 ± 0.06
1.561LysPhe: 1.561 ± 0.042
2.463LysGly: 2.463 ± 0.053
0.709LysHis: 0.709 ± 0.028
3.157LysIle: 3.157 ± 0.061
2.266LysLys: 2.266 ± 0.059
4.403LysLeu: 4.403 ± 0.077
0.882LysMet: 0.882 ± 0.027
1.861LysAsn: 1.861 ± 0.055
2.157LysPro: 2.157 ± 0.05
2.211LysGln: 2.211 ± 0.047
2.185LysArg: 2.185 ± 0.049
2.236LysSer: 2.236 ± 0.054
2.887LysThr: 2.887 ± 0.053
2.721LysVal: 2.721 ± 0.058
0.372LysTrp: 0.372 ± 0.022
1.201LysTyr: 1.201 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
10.251LeuAla: 10.251 ± 0.116
1.113LeuCys: 1.113 ± 0.033
6.17LeuAsp: 6.17 ± 0.096
7.675LeuGlu: 7.675 ± 0.106
3.982LeuPhe: 3.982 ± 0.078
8.86LeuGly: 8.86 ± 0.13
1.959LeuHis: 1.959 ± 0.042
6.332LeuIle: 6.332 ± 0.097
5.297LeuLys: 5.297 ± 0.09
11.314LeuLeu: 11.314 ± 0.135
2.273LeuMet: 2.273 ± 0.05
4.339LeuAsn: 4.339 ± 0.068
6.071LeuPro: 6.071 ± 0.083
6.11LeuGln: 6.11 ± 0.094
5.74LeuArg: 5.74 ± 0.078
7.097LeuSer: 7.097 ± 0.092
6.685LeuThr: 6.685 ± 0.09
7.145LeuVal: 7.145 ± 0.091
1.634LeuTrp: 1.634 ± 0.049
2.712LeuTyr: 2.712 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.306MetAla: 2.306 ± 0.054
0.133MetCys: 0.133 ± 0.012
0.861MetAsp: 0.861 ± 0.03
0.989MetGlu: 0.989 ± 0.032
0.579MetPhe: 0.579 ± 0.025
1.647MetGly: 1.647 ± 0.043
0.298MetHis: 0.298 ± 0.018
1.207MetIle: 1.207 ± 0.033
0.847MetLys: 0.847 ± 0.032
1.925MetLeu: 1.925 ± 0.052
0.454MetMet: 0.454 ± 0.021
0.738MetAsn: 0.738 ± 0.024
1.033MetPro: 1.033 ± 0.031
0.831MetGln: 0.831 ± 0.029
0.919MetArg: 0.919 ± 0.031
1.155MetSer: 1.155 ± 0.036
1.413MetThr: 1.413 ± 0.042
1.521MetVal: 1.521 ± 0.047
0.168MetTrp: 0.168 ± 0.014
0.366MetTyr: 0.366 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.867AsnAla: 2.867 ± 0.061
0.387AsnCys: 0.387 ± 0.021
1.601AsnAsp: 1.601 ± 0.045
1.609AsnGlu: 1.609 ± 0.044
1.796AsnPhe: 1.796 ± 0.048
2.545AsnGly: 2.545 ± 0.058
0.897AsnHis: 0.897 ± 0.026
2.275AsnIle: 2.275 ± 0.044
1.184AsnLys: 1.184 ± 0.038
5.001AsnLeu: 5.001 ± 0.092
0.589AsnMet: 0.589 ± 0.027
1.518AsnAsn: 1.518 ± 0.059
2.906AsnPro: 2.906 ± 0.06
2.32AsnGln: 2.32 ± 0.056
2.114AsnArg: 2.114 ± 0.046
2.0AsnSer: 2.0 ± 0.047
1.893AsnThr: 1.893 ± 0.046
2.086AsnVal: 2.086 ± 0.052
0.58AsnTrp: 0.58 ± 0.023
1.22AsnTyr: 1.22 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
3.87ProAla: 3.87 ± 0.076
0.427ProCys: 0.427 ± 0.023
3.333ProAsp: 3.333 ± 0.054
4.606ProGlu: 4.606 ± 0.077
1.89ProPhe: 1.89 ± 0.044
3.175ProGly: 3.175 ± 0.065
1.041ProHis: 1.041 ± 0.031
2.838ProIle: 2.838 ± 0.049
2.219ProLys: 2.219 ± 0.054
5.383ProLeu: 5.383 ± 0.08
0.986ProMet: 0.986 ± 0.026
2.052ProAsn: 2.052 ± 0.047
2.622ProPro: 2.622 ± 0.069
3.219ProGln: 3.219 ± 0.068
2.087ProArg: 2.087 ± 0.052
2.715ProSer: 2.715 ± 0.056
3.151ProThr: 3.151 ± 0.067
3.375ProVal: 3.375 ± 0.061
0.851ProTrp: 0.851 ± 0.032
1.396ProTyr: 1.396 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.968GlnAla: 5.968 ± 0.098
0.367GlnCys: 0.367 ± 0.022
2.634GlnAsp: 2.634 ± 0.053
3.431GlnGlu: 3.431 ± 0.067
1.913GlnPhe: 1.913 ± 0.044
4.177GlnGly: 4.177 ± 0.074
0.973GlnHis: 0.973 ± 0.03
3.442GlnIle: 3.442 ± 0.058
2.636GlnLys: 2.636 ± 0.061
6.157GlnLeu: 6.157 ± 0.097
1.094GlnMet: 1.094 ± 0.032
1.989GlnAsn: 1.989 ± 0.05
2.838GlnPro: 2.838 ± 0.058
3.843GlnGln: 3.843 ± 0.09
3.572GlnArg: 3.572 ± 0.063
2.751GlnSer: 2.751 ± 0.055
3.681GlnThr: 3.681 ± 0.068
3.689GlnVal: 3.689 ± 0.064
0.979GlnTrp: 0.979 ± 0.03
1.397GlnTyr: 1.397 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
3.628ArgAla: 3.628 ± 0.069
0.54ArgCys: 0.54 ± 0.022
2.613ArgAsp: 2.613 ± 0.056
3.12ArgGlu: 3.12 ± 0.059
2.27ArgPhe: 2.27 ± 0.05
3.036ArgGly: 3.036 ± 0.056
1.284ArgHis: 1.284 ± 0.039
2.968ArgIle: 2.968 ± 0.056
2.044ArgLys: 2.044 ± 0.05
6.721ArgLeu: 6.721 ± 0.097
0.946ArgMet: 0.946 ± 0.029
1.892ArgAsn: 1.892 ± 0.048
2.573ArgPro: 2.573 ± 0.06
3.769ArgGln: 3.769 ± 0.067
3.507ArgArg: 3.507 ± 0.072
3.08ArgSer: 3.08 ± 0.061
2.585ArgThr: 2.585 ± 0.053
3.148ArgVal: 3.148 ± 0.061
0.939ArgTrp: 0.939 ± 0.036
1.893ArgTyr: 1.893 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.092SerAla: 4.092 ± 0.068
0.572SerCys: 0.572 ± 0.024
2.599SerAsp: 2.599 ± 0.053
3.108SerGlu: 3.108 ± 0.06
2.403SerPhe: 2.403 ± 0.054
4.234SerGly: 4.234 ± 0.065
1.23SerHis: 1.23 ± 0.039
2.986SerIle: 2.986 ± 0.055
1.852SerLys: 1.852 ± 0.048
7.06SerLeu: 7.06 ± 0.099
1.107SerMet: 1.107 ± 0.031
1.926SerAsn: 1.926 ± 0.054
3.574SerPro: 3.574 ± 0.066
3.21SerGln: 3.21 ± 0.06
2.899SerArg: 2.899 ± 0.058
3.241SerSer: 3.241 ± 0.069
3.049SerThr: 3.049 ± 0.065
3.251SerVal: 3.251 ± 0.059
0.791SerTrp: 0.791 ± 0.028
1.558SerTyr: 1.558 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.565ThrAla: 5.565 ± 0.075
0.541ThrCys: 0.541 ± 0.023
2.892ThrAsp: 2.892 ± 0.053
3.652ThrGlu: 3.652 ± 0.058
2.247ThrPhe: 2.247 ± 0.047
4.364ThrGly: 4.364 ± 0.075
1.032ThrHis: 1.032 ± 0.033
3.518ThrIle: 3.518 ± 0.058
2.091ThrLys: 2.091 ± 0.046
6.864ThrLeu: 6.864 ± 0.096
1.023ThrMet: 1.023 ± 0.034
2.006ThrAsn: 2.006 ± 0.049
3.633ThrPro: 3.633 ± 0.074
2.991ThrGln: 2.991 ± 0.056
2.193ThrArg: 2.193 ± 0.05
2.908ThrSer: 2.908 ± 0.052
3.608ThrThr: 3.608 ± 0.078
4.43ThrVal: 4.43 ± 0.075
0.806ThrTrp: 0.806 ± 0.03
1.676ThrTyr: 1.676 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
6.036ValAla: 6.036 ± 0.092
0.733ValCys: 0.733 ± 0.028
3.507ValAsp: 3.507 ± 0.064
3.961ValGlu: 3.961 ± 0.064
2.551ValPhe: 2.551 ± 0.052
4.842ValGly: 4.842 ± 0.078
0.999ValHis: 0.999 ± 0.033
4.09ValIle: 4.09 ± 0.06
2.683ValLys: 2.683 ± 0.048
6.529ValLeu: 6.529 ± 0.085
1.488ValMet: 1.488 ± 0.038
2.516ValAsn: 2.516 ± 0.047
3.004ValPro: 3.004 ± 0.052
2.849ValGln: 2.849 ± 0.058
3.115ValArg: 3.115 ± 0.056
3.728ValSer: 3.728 ± 0.06
3.981ValThr: 3.981 ± 0.073
4.601ValVal: 4.601 ± 0.077
0.821ValTrp: 0.821 ± 0.029
1.79ValTyr: 1.79 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.073TrpAla: 1.073 ± 0.038
0.153TrpCys: 0.153 ± 0.013
0.718TrpAsp: 0.718 ± 0.028
0.911TrpGlu: 0.911 ± 0.028
0.683TrpPhe: 0.683 ± 0.029
1.17TrpGly: 1.17 ± 0.037
0.392TrpHis: 0.392 ± 0.021
0.728TrpIle: 0.728 ± 0.028
0.429TrpLys: 0.429 ± 0.02
2.199TrpLeu: 2.199 ± 0.052
0.265TrpMet: 0.265 ± 0.017
0.442TrpAsn: 0.442 ± 0.022
0.332TrpPro: 0.332 ± 0.02
1.452TrpGln: 1.452 ± 0.05
0.971TrpArg: 0.971 ± 0.034
0.809TrpSer: 0.809 ± 0.031
0.559TrpThr: 0.559 ± 0.029
0.897TrpVal: 0.897 ± 0.029
0.278TrpTrp: 0.278 ± 0.02
0.431TrpTyr: 0.431 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.107TyrAla: 2.107 ± 0.049
0.432TyrCys: 0.432 ± 0.024
1.641TyrAsp: 1.641 ± 0.042
1.641TyrGlu: 1.641 ± 0.045
1.388TyrPhe: 1.388 ± 0.038
2.478TyrGly: 2.478 ± 0.05
0.672TyrHis: 0.672 ± 0.024
1.361TyrIle: 1.361 ± 0.042
0.975TyrLys: 0.975 ± 0.035
3.567TyrLeu: 3.567 ± 0.063
0.391TyrMet: 0.391 ± 0.021
0.94TyrAsn: 0.94 ± 0.031
1.596TyrPro: 1.596 ± 0.044
2.023TyrGln: 2.023 ± 0.051
2.081TyrArg: 2.081 ± 0.048
1.628TyrSer: 1.628 ± 0.04
1.312TyrThr: 1.312 ± 0.037
1.639TyrVal: 1.639 ± 0.041
0.51TyrTrp: 0.51 ± 0.026
0.976TyrTyr: 0.976 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3180 proteins (988541 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski