Amino acid dipepetide frequency for Martelella sp. AD-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.116AlaAla: 16.116 ± 0.147	1.008AlaCys: 1.008 ± 0.028	6.97AlaAsp: 6.97 ± 0.079	8.306AlaGlu: 8.306 ± 0.098	5.14AlaPhe: 5.14 ± 0.063	10.87AlaGly: 10.87 ± 0.089	2.072AlaHis: 2.072 ± 0.041	6.883AlaIle: 6.883 ± 0.083	3.615AlaLys: 3.615 ± 0.054	13.551AlaLeu: 13.551 ± 0.133	3.65AlaMet: 3.65 ± 0.056	2.862AlaAsn: 2.862 ± 0.05	4.937AlaPro: 4.937 ± 0.069	3.03AlaGln: 3.03 ± 0.052	8.313AlaArg: 8.313 ± 0.109	5.961AlaSer: 5.961 ± 0.064	5.537AlaThr: 5.537 ± 0.07	8.837AlaVal: 8.837 ± 0.083	1.378AlaTrp: 1.378 ± 0.035	2.712AlaTyr: 2.712 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.896CysAla: 0.896 ± 0.024	0.123CysCys: 0.123 ± 0.01	0.51CysAsp: 0.51 ± 0.02	0.474CysGlu: 0.474 ± 0.016	0.339CysPhe: 0.339 ± 0.016	0.924CysGly: 0.924 ± 0.027	0.255CysHis: 0.255 ± 0.015	0.326CysIle: 0.326 ± 0.015	0.183CysLys: 0.183 ± 0.012	0.805CysLeu: 0.805 ± 0.029	0.155CysMet: 0.155 ± 0.009	0.229CysAsn: 0.229 ± 0.013	0.4CysPro: 0.4 ± 0.016	0.219CysGln: 0.219 ± 0.013	0.585CysArg: 0.585 ± 0.02	0.445CysSer: 0.445 ± 0.018	0.37CysThr: 0.37 ± 0.018	0.537CysVal: 0.537 ± 0.02	0.119CysTrp: 0.119 ± 0.009	0.206CysTyr: 0.206 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.741AspAla: 6.741 ± 0.068	0.535AspCys: 0.535 ± 0.019	3.62AspAsp: 3.62 ± 0.066	3.857AspGlu: 3.857 ± 0.058	2.465AspPhe: 2.465 ± 0.045	5.636AspGly: 5.636 ± 0.084	1.303AspHis: 1.303 ± 0.029	3.543AspIle: 3.543 ± 0.045	1.696AspLys: 1.696 ± 0.037	5.693AspLeu: 5.693 ± 0.069	1.613AspMet: 1.613 ± 0.033	1.655AspAsn: 1.655 ± 0.037	3.373AspPro: 3.373 ± 0.053	1.62AspGln: 1.62 ± 0.033	4.348AspArg: 4.348 ± 0.066	2.137AspSer: 2.137 ± 0.041	2.555AspThr: 2.555 ± 0.046	4.053AspVal: 4.053 ± 0.061	1.029AspTrp: 1.029 ± 0.027	1.69AspTyr: 1.69 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.205GluAla: 8.205 ± 0.099	0.345GluCys: 0.345 ± 0.015	3.483GluAsp: 3.483 ± 0.052	3.918GluGlu: 3.918 ± 0.066	1.747GluPhe: 1.747 ± 0.037	4.767GluGly: 4.767 ± 0.061	1.194GluHis: 1.194 ± 0.029	3.942GluIle: 3.942 ± 0.048	2.89GluLys: 2.89 ± 0.05	5.021GluLeu: 5.021 ± 0.066	1.721GluMet: 1.721 ± 0.035	2.325GluAsn: 2.325 ± 0.04	2.734GluPro: 2.734 ± 0.053	1.916GluGln: 1.916 ± 0.043	5.009GluArg: 5.009 ± 0.074	2.467GluSer: 2.467 ± 0.041	4.228GluThr: 4.228 ± 0.059	3.547GluVal: 3.547 ± 0.061	0.747GluTrp: 0.747 ± 0.025	1.111GluTyr: 1.111 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.829PheAla: 4.829 ± 0.068	0.403PheCys: 0.403 ± 0.018	2.888PheAsp: 2.888 ± 0.044	2.41PheGlu: 2.41 ± 0.038	1.769PhePhe: 1.769 ± 0.042	3.944PheGly: 3.944 ± 0.06	0.761PheHis: 0.761 ± 0.021	2.064PheIle: 2.064 ± 0.044	0.983PheLys: 0.983 ± 0.028	3.744PheLeu: 3.744 ± 0.062	1.017PheMet: 1.017 ± 0.028	1.202PheAsn: 1.202 ± 0.034	1.719PhePro: 1.719 ± 0.038	1.05PheGln: 1.05 ± 0.026	2.287PheArg: 2.287 ± 0.033	2.885PheSer: 2.885 ± 0.044	2.088PheThr: 2.088 ± 0.034	2.935PheVal: 2.935 ± 0.047	0.601PheTrp: 0.601 ± 0.019	1.004PheTyr: 1.004 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.121GlyAla: 9.121 ± 0.115	0.794GlyCys: 0.794 ± 0.024	4.67GlyAsp: 4.67 ± 0.079	5.268GlyGlu: 5.268 ± 0.068	3.912GlyPhe: 3.912 ± 0.06	7.498GlyGly: 7.498 ± 0.207	1.814GlyHis: 1.814 ± 0.039	4.988GlyIle: 4.988 ± 0.066	3.406GlyLys: 3.406 ± 0.052	9.073GlyLeu: 9.073 ± 0.099	2.521GlyMet: 2.521 ± 0.043	2.476GlyAsn: 2.476 ± 0.061	3.422GlyPro: 3.422 ± 0.052	2.594GlyGln: 2.594 ± 0.045	6.046GlyArg: 6.046 ± 0.065	4.563GlySer: 4.563 ± 0.079	4.462GlyThr: 4.462 ± 0.099	5.966GlyVal: 5.966 ± 0.079	1.298GlyTrp: 1.298 ± 0.03	2.403GlyTyr: 2.403 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.189HisAla: 2.189 ± 0.041	0.228HisCys: 0.228 ± 0.013	1.269HisAsp: 1.269 ± 0.031	1.1HisGlu: 1.1 ± 0.027	0.922HisPhe: 0.922 ± 0.028	1.805HisGly: 1.805 ± 0.036	0.533HisHis: 0.533 ± 0.024	0.996HisIle: 0.996 ± 0.023	0.54HisLys: 0.54 ± 0.018	1.896HisLeu: 1.896 ± 0.04	0.537HisMet: 0.537 ± 0.018	0.442HisAsn: 0.442 ± 0.019	1.212HisPro: 1.212 ± 0.029	0.553HisGln: 0.553 ± 0.016	1.289HisArg: 1.289 ± 0.037	0.825HisSer: 0.825 ± 0.021	0.767HisThr: 0.767 ± 0.025	1.461HisVal: 1.461 ± 0.031	0.302HisTrp: 0.302 ± 0.016	0.562HisTyr: 0.562 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.006IleAla: 8.006 ± 0.084	0.562IleCys: 0.562 ± 0.019	3.868IleAsp: 3.868 ± 0.057	3.655IleGlu: 3.655 ± 0.052	2.105IlePhe: 2.105 ± 0.047	5.407IleGly: 5.407 ± 0.071	0.921IleHis: 0.921 ± 0.024	2.784IleIle: 2.784 ± 0.055	1.351IleLys: 1.351 ± 0.035	4.74IleLeu: 4.74 ± 0.07	1.227IleMet: 1.227 ± 0.032	1.576IleAsn: 1.576 ± 0.032	2.46IlePro: 2.46 ± 0.044	1.091IleGln: 1.091 ± 0.027	3.246IleArg: 3.246 ± 0.048	3.24IleSer: 3.24 ± 0.049	2.806IleThr: 2.806 ± 0.048	4.357IleVal: 4.357 ± 0.06	0.654IleTrp: 0.654 ± 0.021	1.311IleTyr: 1.311 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.473LysAla: 4.473 ± 0.061	0.164LysCys: 0.164 ± 0.013	1.795LysAsp: 1.795 ± 0.038	1.66LysGlu: 1.66 ± 0.039	0.893LysPhe: 0.893 ± 0.023	2.778LysGly: 2.778 ± 0.046	0.561LysHis: 0.561 ± 0.018	1.798LysIle: 1.798 ± 0.041	1.38LysLys: 1.38 ± 0.036	3.112LysLeu: 3.112 ± 0.055	0.852LysMet: 0.852 ± 0.027	0.984LysAsn: 0.984 ± 0.025	2.07LysPro: 2.07 ± 0.041	0.917LysGln: 0.917 ± 0.025	2.503LysArg: 2.503 ± 0.043	1.903LysSer: 1.903 ± 0.038	2.258LysThr: 2.258 ± 0.038	2.368LysVal: 2.368 ± 0.045	0.384LysTrp: 0.384 ± 0.018	0.602LysTyr: 0.602 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.023LeuAla: 13.023 ± 0.12	0.853LeuCys: 0.853 ± 0.029	5.745LeuAsp: 5.745 ± 0.077	5.724LeuGlu: 5.724 ± 0.072	3.983LeuPhe: 3.983 ± 0.061	7.819LeuGly: 7.819 ± 0.088	1.682LeuHis: 1.682 ± 0.04	5.126LeuIle: 5.126 ± 0.071	3.953LeuLys: 3.953 ± 0.054	8.857LeuLeu: 8.857 ± 0.112	2.548LeuMet: 2.548 ± 0.047	2.679LeuAsn: 2.679 ± 0.047	5.252LeuPro: 5.252 ± 0.067	2.603LeuGln: 2.603 ± 0.046	5.753LeuArg: 5.753 ± 0.074	7.329LeuSer: 7.329 ± 0.069	5.454LeuThr: 5.454 ± 0.058	7.201LeuVal: 7.201 ± 0.082	1.055LeuTrp: 1.055 ± 0.026	2.218LeuTyr: 2.218 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.362MetAla: 3.362 ± 0.049	0.164MetCys: 0.164 ± 0.011	1.247MetAsp: 1.247 ± 0.034	1.373MetGlu: 1.373 ± 0.033	0.777MetPhe: 0.777 ± 0.027	1.903MetGly: 1.903 ± 0.045	0.485MetHis: 0.485 ± 0.018	1.674MetIle: 1.674 ± 0.038	1.119MetLys: 1.119 ± 0.03	2.725MetLeu: 2.725 ± 0.054	0.806MetMet: 0.806 ± 0.029	0.908MetAsn: 0.908 ± 0.027	1.571MetPro: 1.571 ± 0.033	0.823MetGln: 0.823 ± 0.022	1.918MetArg: 1.918 ± 0.04	1.729MetSer: 1.729 ± 0.039	2.056MetThr: 2.056 ± 0.038	1.827MetVal: 1.827 ± 0.036	0.223MetTrp: 0.223 ± 0.012	0.328MetTyr: 0.328 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.403AsnAla: 3.403 ± 0.056	0.227AsnCys: 0.227 ± 0.013	1.638AsnAsp: 1.638 ± 0.035	1.393AsnGlu: 1.393 ± 0.032	1.097AsnPhe: 1.097 ± 0.03	2.804AsnGly: 2.804 ± 0.06	0.556AsnHis: 0.556 ± 0.016	1.563AsnIle: 1.563 ± 0.033	0.708AsnLys: 0.708 ± 0.023	2.702AsnLeu: 2.702 ± 0.042	0.744AsnMet: 0.744 ± 0.023	0.792AsnAsn: 0.792 ± 0.026	1.966AsnPro: 1.966 ± 0.035	0.771AsnGln: 0.771 ± 0.025	1.972AsnArg: 1.972 ± 0.036	1.23AsnSer: 1.23 ± 0.033	1.322AsnThr: 1.322 ± 0.034	1.986AsnVal: 1.986 ± 0.047	0.506AsnTrp: 0.506 ± 0.02	0.766AsnTyr: 0.766 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.716ProAla: 5.716 ± 0.069	0.301ProCys: 0.301 ± 0.016	3.691ProAsp: 3.691 ± 0.049	4.313ProGlu: 4.313 ± 0.064	2.067ProPhe: 2.067 ± 0.042	4.272ProGly: 4.272 ± 0.063	0.96ProHis: 0.96 ± 0.027	2.181ProIle: 2.181 ± 0.042	1.655ProLys: 1.655 ± 0.04	4.597ProLeu: 4.597 ± 0.059	1.163ProMet: 1.163 ± 0.03	1.22ProAsn: 1.22 ± 0.03	2.23ProPro: 2.23 ± 0.056	1.502ProGln: 1.502 ± 0.032	2.483ProArg: 2.483 ± 0.044	2.548ProSer: 2.548 ± 0.047	2.136ProThr: 2.136 ± 0.045	4.249ProVal: 4.249 ± 0.06	0.661ProTrp: 0.661 ± 0.022	1.283ProTyr: 1.283 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.455GlnAla: 3.455 ± 0.054	0.17GlnCys: 0.17 ± 0.01	1.376GlnAsp: 1.376 ± 0.029	1.434GlnGlu: 1.434 ± 0.032	1.08GlnPhe: 1.08 ± 0.028	1.998GlnGly: 1.998 ± 0.04	0.525GlnHis: 0.525 ± 0.021	1.676GlnIle: 1.676 ± 0.036	1.185GlnLys: 1.185 ± 0.029	2.445GlnLeu: 2.445 ± 0.048	0.913GlnMet: 0.913 ± 0.024	0.882GlnAsn: 0.882 ± 0.029	1.453GlnPro: 1.453 ± 0.033	1.027GlnGln: 1.027 ± 0.03	1.967GlnArg: 1.967 ± 0.045	1.725GlnSer: 1.725 ± 0.037	1.651GlnThr: 1.651 ± 0.032	1.905GlnVal: 1.905 ± 0.038	0.366GlnTrp: 0.366 ± 0.016	0.646GlnTyr: 0.646 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.483ArgAla: 7.483 ± 0.102	0.414ArgCys: 0.414 ± 0.017	3.902ArgAsp: 3.902 ± 0.062	4.024ArgGlu: 4.024 ± 0.064	3.043ArgPhe: 3.043 ± 0.046	4.291ArgGly: 4.291 ± 0.059	1.608ArgHis: 1.608 ± 0.034	4.002ArgIle: 4.002 ± 0.055	2.514ArgLys: 2.514 ± 0.047	7.476ArgLeu: 7.476 ± 0.099	1.949ArgMet: 1.949 ± 0.039	1.912ArgAsn: 1.912 ± 0.041	3.301ArgPro: 3.301 ± 0.058	2.454ArgGln: 2.454 ± 0.048	5.299ArgArg: 5.299 ± 0.076	3.384ArgSer: 3.384 ± 0.054	3.045ArgThr: 3.045 ± 0.05	4.199ArgVal: 4.199 ± 0.058	0.876ArgTrp: 0.876 ± 0.026	1.758ArgTyr: 1.758 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.437SerAla: 6.437 ± 0.07	0.381SerCys: 0.381 ± 0.017	3.268SerAsp: 3.268 ± 0.056	3.207SerGlu: 3.207 ± 0.054	2.367SerPhe: 2.367 ± 0.04	5.941SerGly: 5.941 ± 0.091	1.071SerHis: 1.071 ± 0.026	2.823SerIle: 2.823 ± 0.052	1.58SerLys: 1.58 ± 0.035	5.456SerLeu: 5.456 ± 0.063	1.372SerMet: 1.372 ± 0.03	1.42SerAsn: 1.42 ± 0.037	2.606SerPro: 2.606 ± 0.041	1.473SerGln: 1.473 ± 0.037	3.521SerArg: 3.521 ± 0.055	2.899SerSer: 2.899 ± 0.053	2.563SerThr: 2.563 ± 0.046	4.262SerVal: 4.262 ± 0.06	0.757SerTrp: 0.757 ± 0.024	1.378SerTyr: 1.378 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.082ThrAla: 6.082 ± 0.069	0.41ThrCys: 0.41 ± 0.018	2.801ThrAsp: 2.801 ± 0.051	2.771ThrGlu: 2.771 ± 0.05	2.101ThrPhe: 2.101 ± 0.04	5.372ThrGly: 5.372 ± 0.076	1.004ThrHis: 1.004 ± 0.027	3.043ThrIle: 3.043 ± 0.048	1.382ThrLys: 1.382 ± 0.036	5.799ThrLeu: 5.799 ± 0.073	1.313ThrMet: 1.313 ± 0.031	1.254ThrAsn: 1.254 ± 0.031	3.072ThrPro: 3.072 ± 0.045	1.171ThrGln: 1.171 ± 0.03	3.109ThrArg: 3.109 ± 0.052	2.608ThrSer: 2.608 ± 0.047	2.743ThrThr: 2.743 ± 0.049	4.568ThrVal: 4.568 ± 0.063	0.66ThrTrp: 0.66 ± 0.026	1.242ThrTyr: 1.242 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	8.491ValAla: 8.491 ± 0.083	0.624ValCys: 0.624 ± 0.021	4.182ValAsp: 4.182 ± 0.057	4.512ValGlu: 4.512 ± 0.06	3.148ValPhe: 3.148 ± 0.052	5.171ValGly: 5.171 ± 0.069	1.261ValHis: 1.261 ± 0.035	4.329ValIle: 4.329 ± 0.057	2.214ValLys: 2.214 ± 0.043	7.214ValLeu: 7.214 ± 0.08	2.035ValMet: 2.035 ± 0.034	2.114ValAsn: 2.114 ± 0.05	3.504ValPro: 3.504 ± 0.047	1.689ValGln: 1.689 ± 0.032	4.36ValArg: 4.36 ± 0.056	4.774ValSer: 4.774 ± 0.051	4.537ValThr: 4.537 ± 0.061	5.388ValVal: 5.388 ± 0.074	0.944ValTrp: 0.944 ± 0.029	1.662ValTyr: 1.662 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.03	0.128TrpCys: 0.128 ± 0.01	0.629TrpAsp: 0.629 ± 0.019	0.567TrpGlu: 0.567 ± 0.019	0.579TrpPhe: 0.579 ± 0.024	0.875TrpGly: 0.875 ± 0.026	0.326TrpHis: 0.326 ± 0.013	0.621TrpIle: 0.621 ± 0.022	0.509TrpLys: 0.509 ± 0.021	1.56TrpLeu: 1.56 ± 0.035	0.37TrpMet: 0.37 ± 0.016	0.508TrpAsn: 0.508 ± 0.019	0.686TrpPro: 0.686 ± 0.023	0.604TrpGln: 0.604 ± 0.021	1.075TrpArg: 1.075 ± 0.029	0.846TrpSer: 0.846 ± 0.025	0.767TrpThr: 0.767 ± 0.027	0.8TrpVal: 0.8 ± 0.025	0.248TrpTrp: 0.248 ± 0.013	0.311TrpTyr: 0.311 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.553TyrAla: 2.553 ± 0.042	0.266TyrCys: 0.266 ± 0.014	1.613TyrAsp: 1.613 ± 0.037	1.349TyrGlu: 1.349 ± 0.028	1.049TyrPhe: 1.049 ± 0.027	2.221TyrGly: 2.221 ± 0.041	0.535TyrHis: 0.535 ± 0.019	1.005TyrIle: 1.005 ± 0.024	0.593TyrLys: 0.593 ± 0.022	2.391TyrLeu: 2.391 ± 0.041	0.513TyrMet: 0.513 ± 0.018	0.704TyrAsn: 0.704 ± 0.023	1.259TyrPro: 1.259 ± 0.027	0.771TyrGln: 0.771 ± 0.024	1.855TyrArg: 1.855 ± 0.041	1.284TyrSer: 1.284 ± 0.032	1.161TyrThr: 1.161 ± 0.033	1.705TyrVal: 1.705 ± 0.034	0.367TyrTrp: 0.367 ± 0.016	0.68TyrTyr: 0.68 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4480 proteins (1449651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---