Amino acid dipepetide frequency for Actinoplanes derwentensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.621AlaAla: 21.621 ± 0.142	0.896AlaCys: 0.896 ± 0.018	8.522AlaAsp: 8.522 ± 0.057	8.017AlaGlu: 8.017 ± 0.065	3.416AlaPhe: 3.416 ± 0.04	14.2AlaGly: 14.2 ± 0.092	2.375AlaHis: 2.375 ± 0.032	4.538AlaIle: 4.538 ± 0.037	2.501AlaLys: 2.501 ± 0.041	13.573AlaLeu: 13.573 ± 0.103	2.46AlaMet: 2.46 ± 0.03	2.245AlaAsn: 2.245 ± 0.032	6.395AlaPro: 6.395 ± 0.059	3.438AlaGln: 3.438 ± 0.036	9.315AlaArg: 9.315 ± 0.066	5.833AlaSer: 5.833 ± 0.056	8.002AlaThr: 8.002 ± 0.065	12.42AlaVal: 12.42 ± 0.085	1.904AlaTrp: 1.904 ± 0.03	2.526AlaTyr: 2.526 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.848CysAla: 0.848 ± 0.018	0.079CysCys: 0.079 ± 0.006	0.45CysAsp: 0.45 ± 0.014	0.324CysGlu: 0.324 ± 0.012	0.204CysPhe: 0.204 ± 0.009	0.819CysGly: 0.819 ± 0.017	0.172CysHis: 0.172 ± 0.008	0.152CysIle: 0.152 ± 0.008	0.107CysLys: 0.107 ± 0.007	0.651CysLeu: 0.651 ± 0.016	0.108CysMet: 0.108 ± 0.006	0.134CysAsn: 0.134 ± 0.006	0.427CysPro: 0.427 ± 0.013	0.162CysGln: 0.162 ± 0.007	0.582CysArg: 0.582 ± 0.013	0.423CysSer: 0.423 ± 0.014	0.463CysThr: 0.463 ± 0.014	0.552CysVal: 0.552 ± 0.016	0.118CysTrp: 0.118 ± 0.007	0.144CysTyr: 0.144 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	6.865AspAla: 6.865 ± 0.051	0.381AspCys: 0.381 ± 0.013	3.997AspAsp: 3.997 ± 0.046	3.733AspGlu: 3.733 ± 0.035	1.709AspPhe: 1.709 ± 0.026	6.415AspGly: 6.415 ± 0.054	1.386AspHis: 1.386 ± 0.02	1.885AspIle: 1.885 ± 0.027	1.073AspLys: 1.073 ± 0.024	6.821AspLeu: 6.821 ± 0.044	0.819AspMet: 0.819 ± 0.015	1.113AspAsn: 1.113 ± 0.023	4.591AspPro: 4.591 ± 0.038	1.914AspGln: 1.914 ± 0.028	5.198AspArg: 5.198 ± 0.05	2.732AspSer: 2.732 ± 0.035	3.232AspThr: 3.232 ± 0.037	4.866AspVal: 4.866 ± 0.046	1.035AspTrp: 1.035 ± 0.017	1.179AspTyr: 1.179 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.202GluAla: 6.202 ± 0.053	0.311GluCys: 0.311 ± 0.01	2.252GluAsp: 2.252 ± 0.033	2.317GluGlu: 2.317 ± 0.037	1.562GluPhe: 1.562 ± 0.024	2.983GluGly: 2.983 ± 0.035	1.339GluHis: 1.339 ± 0.021	2.535GluIle: 2.535 ± 0.034	1.225GluLys: 1.225 ± 0.027	6.031GluLeu: 6.031 ± 0.053	0.946GluMet: 0.946 ± 0.021	1.052GluAsn: 1.052 ± 0.018	3.34GluPro: 3.34 ± 0.04	2.246GluGln: 2.246 ± 0.033	4.428GluArg: 4.428 ± 0.045	2.606GluSer: 2.606 ± 0.03	3.021GluThr: 3.021 ± 0.033	4.252GluVal: 4.252 ± 0.046	0.735GluTrp: 0.735 ± 0.017	1.007GluTyr: 1.007 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.897PheAla: 3.897 ± 0.038	0.248PheCys: 0.248 ± 0.009	2.092PheAsp: 2.092 ± 0.029	1.32PheGlu: 1.32 ± 0.021	0.844PhePhe: 0.844 ± 0.02	3.173PheGly: 3.173 ± 0.04	0.62PheHis: 0.62 ± 0.013	0.794PheIle: 0.794 ± 0.015	0.505PheLys: 0.505 ± 0.012	2.602PheLeu: 2.602 ± 0.033	0.379PheMet: 0.379 ± 0.01	0.613PheAsn: 0.613 ± 0.016	1.468PhePro: 1.468 ± 0.021	0.78PheGln: 0.78 ± 0.018	1.95PheArg: 1.95 ± 0.027	1.481PheSer: 1.481 ± 0.022	2.237PheThr: 2.237 ± 0.024	2.331PheVal: 2.331 ± 0.029	0.464PheTrp: 0.464 ± 0.011	0.637PheTyr: 0.637 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.062GlyAla: 10.062 ± 0.079	0.748GlyCys: 0.748 ± 0.017	5.561GlyAsp: 5.561 ± 0.055	4.464GlyGlu: 4.464 ± 0.039	3.017GlyPhe: 3.017 ± 0.036	8.174GlyGly: 8.174 ± 0.073	2.224GlyHis: 2.224 ± 0.034	3.579GlyIle: 3.579 ± 0.039	2.198GlyLys: 2.198 ± 0.037	9.418GlyLeu: 9.418 ± 0.069	1.803GlyMet: 1.803 ± 0.021	1.964GlyAsn: 1.964 ± 0.039	5.087GlyPro: 5.087 ± 0.054	2.717GlyGln: 2.717 ± 0.031	7.255GlyArg: 7.255 ± 0.06	5.401GlySer: 5.401 ± 0.054	6.426GlyThr: 6.426 ± 0.066	7.573GlyVal: 7.573 ± 0.054	1.854GlyTrp: 1.854 ± 0.031	2.382GlyTyr: 2.382 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.371HisAla: 2.371 ± 0.035	0.175HisCys: 0.175 ± 0.007	1.378HisAsp: 1.378 ± 0.022	1.071HisGlu: 1.071 ± 0.019	0.589HisPhe: 0.589 ± 0.013	2.086HisGly: 2.086 ± 0.031	0.674HisHis: 0.674 ± 0.017	0.621HisIle: 0.621 ± 0.013	0.276HisLys: 0.276 ± 0.009	2.531HisLeu: 2.531 ± 0.033	0.292HisMet: 0.292 ± 0.009	0.376HisAsn: 0.376 ± 0.011	1.658HisPro: 1.658 ± 0.027	0.697HisGln: 0.697 ± 0.016	2.07HisArg: 2.07 ± 0.032	0.939HisSer: 0.939 ± 0.016	1.232HisThr: 1.232 ± 0.027	1.612HisVal: 1.612 ± 0.023	0.344HisTrp: 0.344 ± 0.011	0.453HisTyr: 0.453 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.577IleAla: 5.577 ± 0.05	0.318IleCys: 0.318 ± 0.012	2.793IleAsp: 2.793 ± 0.032	2.185IleGlu: 2.185 ± 0.027	0.906IlePhe: 0.906 ± 0.017	4.103IleGly: 4.103 ± 0.044	0.647IleHis: 0.647 ± 0.014	1.21IleIle: 1.21 ± 0.019	0.796IleLys: 0.796 ± 0.018	3.055IleLeu: 3.055 ± 0.035	0.514IleMet: 0.514 ± 0.013	0.903IleAsn: 0.903 ± 0.018	2.007IlePro: 2.007 ± 0.025	0.863IleGln: 0.863 ± 0.018	2.811IleArg: 2.811 ± 0.032	2.103IleSer: 2.103 ± 0.026	2.819IleThr: 2.819 ± 0.033	3.289IleVal: 3.289 ± 0.037	0.505IleTrp: 0.505 ± 0.015	0.635IleTyr: 0.635 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.51LysAla: 2.51 ± 0.036	0.107LysCys: 0.107 ± 0.007	1.005LysAsp: 1.005 ± 0.024	0.815LysGlu: 0.815 ± 0.02	0.47LysPhe: 0.47 ± 0.013	1.384LysGly: 1.384 ± 0.027	0.381LysHis: 0.381 ± 0.013	0.984LysIle: 0.984 ± 0.021	0.655LysLys: 0.655 ± 0.021	1.883LysLeu: 1.883 ± 0.03	0.355LysMet: 0.355 ± 0.012	0.502LysAsn: 0.502 ± 0.015	1.346LysPro: 1.346 ± 0.026	0.666LysGln: 0.666 ± 0.016	1.367LysArg: 1.367 ± 0.025	1.148LysSer: 1.148 ± 0.024	1.354LysThr: 1.354 ± 0.025	1.726LysVal: 1.726 ± 0.032	0.255LysTrp: 0.255 ± 0.01	0.432LysTyr: 0.432 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.156LeuAla: 15.156 ± 0.081	0.666LeuCys: 0.666 ± 0.015	6.608LeuAsp: 6.608 ± 0.051	4.107LeuGlu: 4.107 ± 0.038	2.764LeuPhe: 2.764 ± 0.034	8.821LeuGly: 8.821 ± 0.061	2.254LeuHis: 2.254 ± 0.031	4.343LeuIle: 4.343 ± 0.035	1.76LeuLys: 1.76 ± 0.03	11.289LeuLeu: 11.289 ± 0.077	1.579LeuMet: 1.579 ± 0.026	1.947LeuAsn: 1.947 ± 0.028	6.407LeuPro: 6.407 ± 0.05	2.236LeuGln: 2.236 ± 0.028	8.497LeuArg: 8.497 ± 0.068	5.565LeuSer: 5.565 ± 0.049	7.58LeuThr: 7.58 ± 0.057	8.55LeuVal: 8.55 ± 0.065	1.326LeuTrp: 1.326 ± 0.024	1.736LeuTyr: 1.736 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.166MetAla: 2.166 ± 0.026	0.114MetCys: 0.114 ± 0.006	0.784MetAsp: 0.784 ± 0.013	0.621MetGlu: 0.621 ± 0.015	0.484MetPhe: 0.484 ± 0.012	1.093MetGly: 1.093 ± 0.022	0.325MetHis: 0.325 ± 0.011	0.884MetIle: 0.884 ± 0.018	0.375MetLys: 0.375 ± 0.011	1.881MetLeu: 1.881 ± 0.021	0.307MetMet: 0.307 ± 0.011	0.431MetAsn: 0.431 ± 0.012	1.15MetPro: 1.15 ± 0.023	0.439MetGln: 0.439 ± 0.012	1.444MetArg: 1.444 ± 0.02	1.277MetSer: 1.277 ± 0.024	1.651MetThr: 1.651 ± 0.02	1.293MetVal: 1.293 ± 0.022	0.212MetTrp: 0.212 ± 0.008	0.285MetTyr: 0.285 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.337AsnAla: 2.337 ± 0.033	0.169AsnCys: 0.169 ± 0.007	1.156AsnAsp: 1.156 ± 0.028	0.861AsnGlu: 0.861 ± 0.018	0.539AsnPhe: 0.539 ± 0.014	2.144AsnGly: 2.144 ± 0.04	0.413AsnHis: 0.413 ± 0.011	0.665AsnIle: 0.665 ± 0.015	0.398AsnLys: 0.398 ± 0.013	1.991AsnLeu: 1.991 ± 0.03	0.32AsnMet: 0.32 ± 0.011	0.524AsnAsn: 0.524 ± 0.018	1.559AsnPro: 1.559 ± 0.025	0.635AsnGln: 0.635 ± 0.017	1.583AsnArg: 1.583 ± 0.023	1.049AsnSer: 1.049 ± 0.021	1.284AsnThr: 1.284 ± 0.028	1.531AsnVal: 1.531 ± 0.025	0.356AsnTrp: 0.356 ± 0.01	0.451AsnTyr: 0.451 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.393ProAla: 9.393 ± 0.084	0.285ProCys: 0.285 ± 0.011	4.505ProAsp: 4.505 ± 0.046	3.785ProGlu: 3.785 ± 0.04	1.56ProPhe: 1.56 ± 0.023	6.579ProGly: 6.579 ± 0.062	1.179ProHis: 1.179 ± 0.024	1.919ProIle: 1.919 ± 0.025	1.044ProLys: 1.044 ± 0.024	4.977ProLeu: 4.977 ± 0.043	1.023ProMet: 1.023 ± 0.019	1.039ProAsn: 1.039 ± 0.02	3.574ProPro: 3.574 ± 0.061	1.543ProGln: 1.543 ± 0.023	3.602ProArg: 3.602 ± 0.042	3.41ProSer: 3.41 ± 0.036	3.209ProThr: 3.209 ± 0.037	5.765ProVal: 5.765 ± 0.05	0.933ProTrp: 0.933 ± 0.017	1.201ProTyr: 1.201 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.815GlnAla: 3.815 ± 0.044	0.146GlnCys: 0.146 ± 0.007	1.243GlnAsp: 1.243 ± 0.023	1.233GlnGlu: 1.233 ± 0.019	0.802GlnPhe: 0.802 ± 0.016	1.927GlnGly: 1.927 ± 0.025	0.674GlnHis: 0.674 ± 0.017	1.349GlnIle: 1.349 ± 0.023	0.573GlnLys: 0.573 ± 0.015	2.992GlnLeu: 2.992 ± 0.035	0.504GlnMet: 0.504 ± 0.016	0.62GlnAsn: 0.62 ± 0.017	1.895GlnPro: 1.895 ± 0.031	1.295GlnGln: 1.295 ± 0.027	2.644GlnArg: 2.644 ± 0.033	1.386GlnSer: 1.386 ± 0.026	1.545GlnThr: 1.545 ± 0.025	2.599GlnVal: 2.599 ± 0.032	0.528GlnTrp: 0.528 ± 0.014	0.568GlnTyr: 0.568 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	9.099ArgAla: 9.099 ± 0.072	0.546ArgCys: 0.546 ± 0.015	4.616ArgAsp: 4.616 ± 0.044	3.993ArgGlu: 3.993 ± 0.036	2.534ArgPhe: 2.534 ± 0.03	5.155ArgGly: 5.155 ± 0.049	2.057ArgHis: 2.057 ± 0.031	3.553ArgIle: 3.553 ± 0.039	1.476ArgLys: 1.476 ± 0.024	8.924ArgLeu: 8.924 ± 0.07	1.767ArgMet: 1.767 ± 0.024	1.558ArgAsn: 1.558 ± 0.024	4.723ArgPro: 4.723 ± 0.049	2.507ArgGln: 2.507 ± 0.034	7.394ArgArg: 7.394 ± 0.074	4.178ArgSer: 4.178 ± 0.038	4.95ArgThr: 4.95 ± 0.041	5.807ArgVal: 5.807 ± 0.047	1.455ArgTrp: 1.455 ± 0.021	1.861ArgTyr: 1.861 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	7.054SerAla: 7.054 ± 0.061	0.364SerCys: 0.364 ± 0.011	2.766SerAsp: 2.766 ± 0.034	2.321SerGlu: 2.321 ± 0.029	1.562SerPhe: 1.562 ± 0.023	6.173SerGly: 6.173 ± 0.062	0.984SerHis: 0.984 ± 0.016	1.866SerIle: 1.866 ± 0.026	0.908SerLys: 0.908 ± 0.019	4.786SerLeu: 4.786 ± 0.039	1.11SerMet: 1.11 ± 0.019	0.998SerAsn: 0.998 ± 0.022	3.447SerPro: 3.447 ± 0.04	1.275SerGln: 1.275 ± 0.024	4.022SerArg: 4.022 ± 0.047	3.193SerSer: 3.193 ± 0.049	3.514SerThr: 3.514 ± 0.043	4.325SerVal: 4.325 ± 0.04	1.014SerTrp: 1.014 ± 0.02	1.23SerTyr: 1.23 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	9.542ThrAla: 9.542 ± 0.083	0.448ThrCys: 0.448 ± 0.016	3.8ThrAsp: 3.8 ± 0.037	3.237ThrGlu: 3.237 ± 0.035	1.873ThrPhe: 1.873 ± 0.026	7.433ThrGly: 7.433 ± 0.067	1.078ThrHis: 1.078 ± 0.022	2.493ThrIle: 2.493 ± 0.033	1.154ThrLys: 1.154 ± 0.025	6.034ThrLeu: 6.034 ± 0.053	1.068ThrMet: 1.068 ± 0.018	1.19ThrAsn: 1.19 ± 0.025	4.182ThrPro: 4.182 ± 0.043	1.306ThrGln: 1.306 ± 0.023	4.103ThrArg: 4.103 ± 0.039	3.468ThrSer: 3.468 ± 0.041	4.434ThrThr: 4.434 ± 0.064	6.773ThrVal: 6.773 ± 0.064	1.024ThrTrp: 1.024 ± 0.017	1.32ThrTyr: 1.32 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.392ValAla: 11.392 ± 0.078	0.621ValCys: 0.621 ± 0.016	5.197ValAsp: 5.197 ± 0.045	4.3ValGlu: 4.3 ± 0.04	2.418ValPhe: 2.418 ± 0.028	6.262ValGly: 6.262 ± 0.054	1.793ValHis: 1.793 ± 0.026	3.514ValIle: 3.514 ± 0.036	1.659ValLys: 1.659 ± 0.029	9.58ValLeu: 9.58 ± 0.07	1.313ValMet: 1.313 ± 0.02	1.856ValAsn: 1.856 ± 0.027	5.271ValPro: 5.271 ± 0.051	2.147ValGln: 2.147 ± 0.028	6.576ValArg: 6.576 ± 0.051	4.613ValSer: 4.613 ± 0.039	6.631ValThr: 6.631 ± 0.06	7.905ValVal: 7.905 ± 0.068	1.156ValTrp: 1.156 ± 0.022	1.543ValTyr: 1.543 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.776TrpAla: 1.776 ± 0.031	0.138TrpCys: 0.138 ± 0.007	0.836TrpAsp: 0.836 ± 0.018	0.651TrpGlu: 0.651 ± 0.015	0.53TrpPhe: 0.53 ± 0.015	1.003TrpGly: 1.003 ± 0.02	0.428TrpHis: 0.428 ± 0.013	0.666TrpIle: 0.666 ± 0.016	0.331TrpLys: 0.331 ± 0.011	1.864TrpLeu: 1.864 ± 0.03	0.321TrpMet: 0.321 ± 0.01	0.473TrpAsn: 0.473 ± 0.014	0.86TrpPro: 0.86 ± 0.019	0.687TrpGln: 0.687 ± 0.014	1.443TrpArg: 1.443 ± 0.023	1.064TrpSer: 1.064 ± 0.022	1.131TrpThr: 1.131 ± 0.024	1.009TrpVal: 1.009 ± 0.019	0.389TrpTrp: 0.389 ± 0.012	0.363TrpTyr: 0.363 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.514TyrAla: 2.514 ± 0.029	0.16TyrCys: 0.16 ± 0.008	1.383TyrAsp: 1.383 ± 0.031	1.035TyrGlu: 1.035 ± 0.019	0.653TyrPhe: 0.653 ± 0.016	1.979TyrGly: 1.979 ± 0.028	0.442TyrHis: 0.442 ± 0.013	0.489TyrIle: 0.489 ± 0.014	0.332TyrLys: 0.332 ± 0.012	2.308TyrLeu: 2.308 ± 0.033	0.226TyrMet: 0.226 ± 0.01	0.428TyrAsn: 0.428 ± 0.014	1.138TyrPro: 1.138 ± 0.021	0.787TyrGln: 0.787 ± 0.018	1.865TyrArg: 1.865 ± 0.03	1.043TyrSer: 1.043 ± 0.019	1.244TyrThr: 1.244 ± 0.023	1.567TyrVal: 1.567 ± 0.024	0.36TyrTrp: 0.36 ± 0.011	0.455TyrTyr: 0.455 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9207 proteins (3147326 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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