Amino acid dipepetide frequency for Ornithinimicrobium cerasi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.156AlaAla: 19.156 ± 0.212	0.848AlaCys: 0.848 ± 0.029	8.238AlaAsp: 8.238 ± 0.095	7.98AlaGlu: 7.98 ± 0.102	3.072AlaPhe: 3.072 ± 0.054	12.793AlaGly: 12.793 ± 0.13	2.61AlaHis: 2.61 ± 0.053	3.253AlaIle: 3.253 ± 0.063	1.649AlaLys: 1.649 ± 0.052	14.247AlaLeu: 14.247 ± 0.159	2.567AlaMet: 2.567 ± 0.045	1.611AlaAsn: 1.611 ± 0.049	6.538AlaPro: 6.538 ± 0.085	3.821AlaGln: 3.821 ± 0.063	10.658AlaArg: 10.658 ± 0.113	6.066AlaSer: 6.066 ± 0.079	7.361AlaThr: 7.361 ± 0.096	12.486AlaVal: 12.486 ± 0.147	2.148AlaTrp: 2.148 ± 0.049	2.437AlaTyr: 2.437 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.75CysAla: 0.75 ± 0.03	0.074CysCys: 0.074 ± 0.01	0.415CysAsp: 0.415 ± 0.02	0.366CysGlu: 0.366 ± 0.018	0.185CysPhe: 0.185 ± 0.013	0.766CysGly: 0.766 ± 0.028	0.18CysHis: 0.18 ± 0.013	0.169CysIle: 0.169 ± 0.014	0.059CysLys: 0.059 ± 0.007	0.573CysLeu: 0.573 ± 0.023	0.083CysMet: 0.083 ± 0.007	0.107CysAsn: 0.107 ± 0.011	0.456CysPro: 0.456 ± 0.025	0.162CysGln: 0.162 ± 0.014	0.496CysArg: 0.496 ± 0.022	0.353CysSer: 0.353 ± 0.015	0.412CysThr: 0.412 ± 0.021	0.547CysVal: 0.547 ± 0.022	0.107CysTrp: 0.107 ± 0.012	0.12CysTyr: 0.12 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.866AspAla: 7.866 ± 0.081	0.305AspCys: 0.305 ± 0.017	4.233AspAsp: 4.233 ± 0.085	4.414AspGlu: 4.414 ± 0.069	1.379AspPhe: 1.379 ± 0.037	6.838AspGly: 6.838 ± 0.107	1.579AspHis: 1.579 ± 0.045	1.572AspIle: 1.572 ± 0.044	0.793AspLys: 0.793 ± 0.029	7.664AspLeu: 7.664 ± 0.083	0.773AspMet: 0.773 ± 0.027	0.807AspAsn: 0.807 ± 0.028	5.034AspPro: 5.034 ± 0.073	1.732AspGln: 1.732 ± 0.035	5.208AspArg: 5.208 ± 0.073	2.157AspSer: 2.157 ± 0.043	2.899AspThr: 2.899 ± 0.05	6.319AspVal: 6.319 ± 0.079	0.973AspTrp: 0.973 ± 0.032	1.195AspTyr: 1.195 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.659GluAla: 7.659 ± 0.1	0.282GluCys: 0.282 ± 0.016	3.835GluAsp: 3.835 ± 0.066	4.363GluGlu: 4.363 ± 0.071	1.174GluPhe: 1.174 ± 0.036	5.335GluGly: 5.335 ± 0.069	1.828GluHis: 1.828 ± 0.046	2.023GluIle: 2.023 ± 0.048	0.929GluLys: 0.929 ± 0.035	6.69GluLeu: 6.69 ± 0.084	0.945GluMet: 0.945 ± 0.028	0.786GluAsn: 0.786 ± 0.029	3.359GluPro: 3.359 ± 0.065	2.493GluGln: 2.493 ± 0.05	5.654GluArg: 5.654 ± 0.082	2.342GluSer: 2.342 ± 0.049	2.76GluThr: 2.76 ± 0.057	6.288GluVal: 6.288 ± 0.085	0.793GluTrp: 0.793 ± 0.025	0.803GluTyr: 0.803 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.052PheAla: 3.052 ± 0.052	0.219PheCys: 0.219 ± 0.015	1.754PheAsp: 1.754 ± 0.044	1.364PheGlu: 1.364 ± 0.035	0.849PhePhe: 0.849 ± 0.03	2.69PheGly: 2.69 ± 0.052	0.509PheHis: 0.509 ± 0.024	0.627PheIle: 0.627 ± 0.026	0.32PheLys: 0.32 ± 0.018	2.413PheLeu: 2.413 ± 0.047	0.363PheMet: 0.363 ± 0.018	0.458PheAsn: 0.458 ± 0.021	1.246PhePro: 1.246 ± 0.033	0.518PheGln: 0.518 ± 0.02	1.596PheArg: 1.596 ± 0.033	1.36PheSer: 1.36 ± 0.039	1.65PheThr: 1.65 ± 0.035	2.516PheVal: 2.516 ± 0.051	0.411PheTrp: 0.411 ± 0.02	0.519PheTyr: 0.519 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.19GlyAla: 11.19 ± 0.144	0.728GlyCys: 0.728 ± 0.028	5.448GlyAsp: 5.448 ± 0.076	5.825GlyGlu: 5.825 ± 0.08	2.565GlyPhe: 2.565 ± 0.053	8.924GlyGly: 8.924 ± 0.122	2.21GlyHis: 2.21 ± 0.046	3.187GlyIle: 3.187 ± 0.061	1.584GlyLys: 1.584 ± 0.044	10.017GlyLeu: 10.017 ± 0.131	2.319GlyMet: 2.319 ± 0.051	1.412GlyAsn: 1.412 ± 0.044	5.307GlyPro: 5.307 ± 0.081	2.929GlyGln: 2.929 ± 0.046	8.223GlyArg: 8.223 ± 0.096	5.63GlySer: 5.63 ± 0.058	6.292GlyThr: 6.292 ± 0.087	8.596GlyVal: 8.596 ± 0.095	1.944GlyTrp: 1.944 ± 0.041	2.171GlyTyr: 2.171 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.686HisAla: 2.686 ± 0.05	0.163HisCys: 0.163 ± 0.012	1.595HisAsp: 1.595 ± 0.043	1.398HisGlu: 1.398 ± 0.034	0.471HisPhe: 0.471 ± 0.021	2.363HisGly: 2.363 ± 0.05	0.727HisHis: 0.727 ± 0.029	0.464HisIle: 0.464 ± 0.021	0.273HisLys: 0.273 ± 0.016	2.695HisLeu: 2.695 ± 0.049	0.268HisMet: 0.268 ± 0.014	0.332HisAsn: 0.332 ± 0.017	1.795HisPro: 1.795 ± 0.045	0.685HisGln: 0.685 ± 0.024	2.055HisArg: 2.055 ± 0.046	0.856HisSer: 0.856 ± 0.029	1.176HisThr: 1.176 ± 0.034	2.155HisVal: 2.155 ± 0.05	0.33HisTrp: 0.33 ± 0.015	0.424HisTyr: 0.424 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.684IleAla: 3.684 ± 0.068	0.239IleCys: 0.239 ± 0.013	1.99IleAsp: 1.99 ± 0.048	1.791IleGlu: 1.791 ± 0.049	0.769IlePhe: 0.769 ± 0.028	2.847IleGly: 2.847 ± 0.057	0.501IleHis: 0.501 ± 0.023	0.858IleIle: 0.858 ± 0.03	0.439IleLys: 0.439 ± 0.022	2.479IleLeu: 2.479 ± 0.056	0.426IleMet: 0.426 ± 0.021	0.575IleAsn: 0.575 ± 0.024	1.655IlePro: 1.655 ± 0.036	0.635IleGln: 0.635 ± 0.026	1.77IleArg: 1.77 ± 0.041	1.549IleSer: 1.549 ± 0.039	1.957IleThr: 1.957 ± 0.042	2.709IleVal: 2.709 ± 0.059	0.35IleTrp: 0.35 ± 0.018	0.578IleTyr: 0.578 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	1.651LysAla: 1.651 ± 0.051	0.066LysCys: 0.066 ± 0.008	0.949LysAsp: 0.949 ± 0.037	0.819LysGlu: 0.819 ± 0.034	0.327LysPhe: 0.327 ± 0.019	1.206LysGly: 1.206 ± 0.036	0.344LysHis: 0.344 ± 0.018	0.547LysIle: 0.547 ± 0.023	0.461LysLys: 0.461 ± 0.029	1.161LysLeu: 1.161 ± 0.039	0.268LysMet: 0.268 ± 0.017	0.32LysAsn: 0.32 ± 0.02	0.706LysPro: 0.706 ± 0.029	0.437LysGln: 0.437 ± 0.022	0.909LysArg: 0.909 ± 0.039	0.689LysSer: 0.689 ± 0.029	0.828LysThr: 0.828 ± 0.033	1.436LysVal: 1.436 ± 0.046	0.139LysTrp: 0.139 ± 0.013	0.297LysTyr: 0.297 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.546LeuAla: 15.546 ± 0.187	0.612LeuCys: 0.612 ± 0.022	7.145LeuAsp: 7.145 ± 0.088	5.805LeuGlu: 5.805 ± 0.071	2.204LeuPhe: 2.204 ± 0.057	10.431LeuGly: 10.431 ± 0.122	2.254LeuHis: 2.254 ± 0.05	2.467LeuIle: 2.467 ± 0.053	1.235LeuLys: 1.235 ± 0.044	11.643LeuLeu: 11.643 ± 0.161	1.718LeuMet: 1.718 ± 0.042	1.417LeuAsn: 1.417 ± 0.037	6.399LeuPro: 6.399 ± 0.087	2.519LeuGln: 2.519 ± 0.053	8.936LeuArg: 8.936 ± 0.106	5.349LeuSer: 5.349 ± 0.06	6.902LeuThr: 6.902 ± 0.095	11.256LeuVal: 11.256 ± 0.146	1.454LeuTrp: 1.454 ± 0.039	1.429LeuTyr: 1.429 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.24MetAla: 2.24 ± 0.043	0.104MetCys: 0.104 ± 0.011	0.946MetAsp: 0.946 ± 0.032	0.798MetGlu: 0.798 ± 0.027	0.442MetPhe: 0.442 ± 0.022	1.447MetGly: 1.447 ± 0.04	0.361MetHis: 0.361 ± 0.018	0.653MetIle: 0.653 ± 0.024	0.317MetLys: 0.317 ± 0.015	1.776MetLeu: 1.776 ± 0.041	0.301MetMet: 0.301 ± 0.015	0.35MetAsn: 0.35 ± 0.019	1.168MetPro: 1.168 ± 0.037	0.488MetGln: 0.488 ± 0.022	1.424MetArg: 1.424 ± 0.037	1.414MetSer: 1.414 ± 0.035	1.776MetThr: 1.776 ± 0.039	1.584MetVal: 1.584 ± 0.038	0.212MetTrp: 0.212 ± 0.013	0.245MetTyr: 0.245 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	1.805AsnAla: 1.805 ± 0.042	0.102AsnCys: 0.102 ± 0.009	0.895AsnAsp: 0.895 ± 0.031	0.697AsnGlu: 0.697 ± 0.027	0.44AsnPhe: 0.44 ± 0.023	1.369AsnGly: 1.369 ± 0.042	0.339AsnHis: 0.339 ± 0.02	0.48AsnIle: 0.48 ± 0.021	0.238AsnLys: 0.238 ± 0.017	1.586AsnLeu: 1.586 ± 0.042	0.235AsnMet: 0.235 ± 0.016	0.333AsnAsn: 0.333 ± 0.018	1.225AsnPro: 1.225 ± 0.039	0.43AsnGln: 0.43 ± 0.019	1.016AsnArg: 1.016 ± 0.029	0.635AsnSer: 0.635 ± 0.027	0.821AsnThr: 0.821 ± 0.03	1.309AsnVal: 1.309 ± 0.035	0.195AsnTrp: 0.195 ± 0.014	0.351AsnTyr: 0.351 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.689ProAla: 7.689 ± 0.103	0.26ProCys: 0.26 ± 0.015	4.577ProAsp: 4.577 ± 0.073	4.302ProGlu: 4.302 ± 0.069	1.493ProPhe: 1.493 ± 0.036	6.804ProGly: 6.804 ± 0.085	1.375ProHis: 1.375 ± 0.038	1.171ProIle: 1.171 ± 0.032	0.646ProLys: 0.646 ± 0.025	5.109ProLeu: 5.109 ± 0.076	1.074ProMet: 1.074 ± 0.033	0.688ProAsn: 0.688 ± 0.024	3.389ProPro: 3.389 ± 0.071	1.761ProGln: 1.761 ± 0.039	4.092ProArg: 4.092 ± 0.072	3.086ProSer: 3.086 ± 0.061	3.872ProThr: 3.872 ± 0.062	6.08ProVal: 6.08 ± 0.071	1.096ProTrp: 1.096 ± 0.036	1.049ProTyr: 1.049 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.638GlnAla: 3.638 ± 0.061	0.148GlnCys: 0.148 ± 0.013	1.653GlnAsp: 1.653 ± 0.045	1.733GlnGlu: 1.733 ± 0.039	0.644GlnPhe: 0.644 ± 0.026	2.44GlnGly: 2.44 ± 0.046	0.711GlnHis: 0.711 ± 0.025	1.035GlnIle: 1.035 ± 0.028	0.378GlnLys: 0.378 ± 0.02	3.258GlnLeu: 3.258 ± 0.06	0.552GlnMet: 0.552 ± 0.024	0.426GlnAsn: 0.426 ± 0.021	1.682GlnPro: 1.682 ± 0.041	1.19GlnGln: 1.19 ± 0.043	2.431GlnArg: 2.431 ± 0.053	1.091GlnSer: 1.091 ± 0.038	1.484GlnThr: 1.484 ± 0.041	3.358GlnVal: 3.358 ± 0.056	0.419GlnTrp: 0.419 ± 0.018	0.413GlnTyr: 0.413 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.082ArgAla: 10.082 ± 0.12	0.52ArgCys: 0.52 ± 0.019	4.744ArgAsp: 4.744 ± 0.072	5.03ArgGlu: 5.03 ± 0.081	2.061ArgPhe: 2.061 ± 0.04	6.432ArgGly: 6.432 ± 0.07	2.173ArgHis: 2.173 ± 0.043	2.501ArgIle: 2.501 ± 0.059	1.094ArgLys: 1.094 ± 0.039	8.577ArgLeu: 8.577 ± 0.101	1.821ArgMet: 1.821 ± 0.041	1.062ArgAsn: 1.062 ± 0.033	4.878ArgPro: 4.878 ± 0.07	2.416ArgGln: 2.416 ± 0.059	7.961ArgArg: 7.961 ± 0.104	4.543ArgSer: 4.543 ± 0.069	5.252ArgThr: 5.252 ± 0.075	7.163ArgVal: 7.163 ± 0.097	1.648ArgTrp: 1.648 ± 0.037	1.61ArgTyr: 1.61 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.061SerAla: 6.061 ± 0.074	0.347SerCys: 0.347 ± 0.021	2.735SerAsp: 2.735 ± 0.049	2.535SerGlu: 2.535 ± 0.05	1.515SerPhe: 1.515 ± 0.04	5.537SerGly: 5.537 ± 0.073	0.951SerHis: 0.951 ± 0.03	1.437SerIle: 1.437 ± 0.046	0.671SerLys: 0.671 ± 0.03	4.991SerLeu: 4.991 ± 0.07	1.143SerMet: 1.143 ± 0.035	0.715SerAsn: 0.715 ± 0.029	3.098SerPro: 3.098 ± 0.057	1.265SerGln: 1.265 ± 0.032	3.988SerArg: 3.988 ± 0.06	3.012SerSer: 3.012 ± 0.061	3.487SerThr: 3.487 ± 0.051	4.593SerVal: 4.593 ± 0.06	0.965SerTrp: 0.965 ± 0.033	1.107SerTyr: 1.107 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.638ThrAla: 7.638 ± 0.092	0.433ThrCys: 0.433 ± 0.019	3.757ThrAsp: 3.757 ± 0.066	3.134ThrGlu: 3.134 ± 0.058	1.761ThrPhe: 1.761 ± 0.041	6.441ThrGly: 6.441 ± 0.072	1.252ThrHis: 1.252 ± 0.034	1.79ThrIle: 1.79 ± 0.042	0.803ThrLys: 0.803 ± 0.027	6.192ThrLeu: 6.192 ± 0.078	1.05ThrMet: 1.05 ± 0.024	0.98ThrAsn: 0.98 ± 0.034	4.049ThrPro: 4.049 ± 0.066	1.507ThrGln: 1.507 ± 0.035	4.231ThrArg: 4.231 ± 0.058	3.416ThrSer: 3.416 ± 0.064	4.29ThrThr: 4.29 ± 0.088	6.232ThrVal: 6.232 ± 0.079	1.081ThrTrp: 1.081 ± 0.034	1.316ThrTyr: 1.316 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	12.752ValAla: 12.752 ± 0.122	0.646ValCys: 0.646 ± 0.026	6.579ValAsp: 6.579 ± 0.077	6.13ValGlu: 6.13 ± 0.086	2.062ValPhe: 2.062 ± 0.049	8.788ValGly: 8.788 ± 0.097	2.246ValHis: 2.246 ± 0.047	2.733ValIle: 2.733 ± 0.053	1.21ValLys: 1.21 ± 0.038	11.553ValLeu: 11.553 ± 0.143	1.667ValMet: 1.667 ± 0.04	1.519ValAsn: 1.519 ± 0.04	5.727ValPro: 5.727 ± 0.068	2.529ValGln: 2.529 ± 0.046	7.94ValArg: 7.94 ± 0.095	4.799ValSer: 4.799 ± 0.079	6.191ValThr: 6.191 ± 0.087	11.541ValVal: 11.541 ± 0.136	1.367ValTrp: 1.367 ± 0.037	1.496ValTyr: 1.496 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.835TrpAla: 1.835 ± 0.043	0.152TrpCys: 0.152 ± 0.012	0.936TrpAsp: 0.936 ± 0.035	0.839TrpGlu: 0.839 ± 0.026	0.52TrpPhe: 0.52 ± 0.019	1.256TrpGly: 1.256 ± 0.033	0.388TrpHis: 0.388 ± 0.02	0.445TrpIle: 0.445 ± 0.02	0.213TrpLys: 0.213 ± 0.014	1.97TrpLeu: 1.97 ± 0.042	0.299TrpMet: 0.299 ± 0.018	0.3TrpAsn: 0.3 ± 0.016	0.854TrpPro: 0.854 ± 0.03	0.602TrpGln: 0.602 ± 0.024	1.468TrpArg: 1.468 ± 0.043	0.982TrpSer: 0.982 ± 0.026	0.975TrpThr: 0.975 ± 0.03	1.567TrpVal: 1.567 ± 0.039	0.48TrpTrp: 0.48 ± 0.022	0.317TrpTyr: 0.317 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.56TyrAla: 2.56 ± 0.056	0.132TyrCys: 0.132 ± 0.012	1.315TyrAsp: 1.315 ± 0.042	1.02TyrGlu: 1.02 ± 0.029	0.506TyrPhe: 0.506 ± 0.023	1.793TyrGly: 1.793 ± 0.041	0.373TyrHis: 0.373 ± 0.018	0.392TyrIle: 0.392 ± 0.019	0.251TyrLys: 0.251 ± 0.017	2.128TyrLeu: 2.128 ± 0.046	0.172TyrMet: 0.172 ± 0.012	0.303TyrAsn: 0.303 ± 0.019	1.048TyrPro: 1.048 ± 0.034	0.562TyrGln: 0.562 ± 0.026	1.509TyrArg: 1.509 ± 0.037	0.826TyrSer: 0.826 ± 0.028	0.966TyrThr: 0.966 ± 0.031	1.737TyrVal: 1.737 ± 0.04	0.285TyrTrp: 0.285 ± 0.013	0.404TyrTyr: 0.404 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3368 proteins (1132626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---