Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)

Taxonomy: Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus; Human immunodeficiency virus 1; HIV-1 group O

Average proteome isoelectric point is 7.84

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 10 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|Q77377|ENV_HV1AN Envelope glycoprotein gp160 OS=Human immunodeficiency virus type 1 group O (isolate ANT70) OX=327105 GN=env PE=3 SV=1
MM1 pKa = 7.35HH2 pKa = 7.24HH3 pKa = 7.42RR4 pKa = 11.84DD5 pKa = 3.5LLAIIIISALLFINVILWGFILRR28 pKa = 11.84KK29 pKa = 9.8YY30 pKa = 10.58LEE32 pKa = 4.13QKK34 pKa = 9.35EE35 pKa = 4.12QDD37 pKa = 3.2RR38 pKa = 11.84KK39 pKa = 9.99EE40 pKa = 4.16RR41 pKa = 11.84EE42 pKa = 3.4ILEE45 pKa = 3.82RR46 pKa = 11.84LRR48 pKa = 11.84RR49 pKa = 11.84IRR51 pKa = 11.84EE52 pKa = 3.67IRR54 pKa = 11.84DD55 pKa = 3.3DD56 pKa = 4.34SDD58 pKa = 4.02YY59 pKa = 11.34EE60 pKa = 4.71SNGEE64 pKa = 4.02EE65 pKa = 4.15EE66 pKa = 4.57QEE68 pKa = 4.43VMDD71 pKa = 4.83LVLSHH76 pKa = 6.6GFDD79 pKa = 3.18NPMFEE84 pKa = 4.41PP85 pKa = 4.38

Molecular weight: 10.33 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|Q77375|VPR_HV1AN Protein Vpr OS=Human immunodeficiency virus type 1 group O (isolate ANT70) OX=327105 GN=vpr PE=3 SV=1
MM1 pKa = 7.31EE2 pKa = 5.36NRR4 pKa = 11.84WQVLIVWQVDD14 pKa = 3.8RR15 pKa = 11.84QKK17 pKa = 11.24VKK19 pKa = 10.43AWNSLVKK26 pKa = 8.38YY27 pKa = 9.79HH28 pKa = 7.46KK29 pKa = 9.62YY30 pKa = 10.19RR31 pKa = 11.84SRR33 pKa = 11.84KK34 pKa = 7.2TEE36 pKa = 3.64NWWYY40 pKa = 8.21RR41 pKa = 11.84HH42 pKa = 5.94HH43 pKa = 6.9YY44 pKa = 9.16EE45 pKa = 3.97SRR47 pKa = 11.84NPRR50 pKa = 11.84VSSSVYY56 pKa = 9.07IPVGVAHH63 pKa = 6.11VVVTTYY69 pKa = 9.77WGLMPGEE76 pKa = 4.14RR77 pKa = 11.84DD78 pKa = 3.03EE79 pKa = 4.98HH80 pKa = 7.16LGHH83 pKa = 6.4GVSIEE88 pKa = 3.71WRR90 pKa = 11.84YY91 pKa = 10.68KK92 pKa = 10.23KK93 pKa = 10.7YY94 pKa = 9.23KK95 pKa = 8.43TQIDD99 pKa = 4.42PEE101 pKa = 4.31TADD104 pKa = 3.96RR105 pKa = 11.84MIHH108 pKa = 5.85LHH110 pKa = 6.13YY111 pKa = 7.85FTCFTASAVRR121 pKa = 11.84KK122 pKa = 9.6AILGQRR128 pKa = 11.84VLTKK132 pKa = 10.41CEE134 pKa = 4.07YY135 pKa = 8.11PTGHH139 pKa = 5.92SQVGTLQLLALRR151 pKa = 11.84AVVKK155 pKa = 10.5ARR157 pKa = 11.84SRR159 pKa = 11.84KK160 pKa = 8.55PPLPSVQKK168 pKa = 9.64LTEE171 pKa = 4.25DD172 pKa = 2.89RR173 pKa = 11.84WNKK176 pKa = 9.32HH177 pKa = 4.74LRR179 pKa = 11.84IRR181 pKa = 11.84DD182 pKa = 3.74QLKK185 pKa = 8.38SPSMNGHH192 pKa = 6.6

Molecular weight: 22.74 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

1

10

3669

70

1435

366.9

41.49

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.46 ± 0.387

2.208 ± 0.426

3.679 ± 0.37

6.759 ± 0.764

2.371 ± 0.381

7.413 ± 0.338

2.507 ± 0.511

6.541 ± 0.789

6.759 ± 0.713

8.149 ± 0.669

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.344 ± 0.241

4.497 ± 0.659

5.833 ± 0.786

6.187 ± 0.412

5.724 ± 0.906

5.015 ± 0.276

5.969 ± 0.895

5.942 ± 0.376

2.671 ± 0.218

2.916 ± 0.228
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski