Amino acid dipepetide frequency for Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.907AlaAla: 4.907 ± 1.618
2.181AlaCys: 2.181 ± 0.433
1.363AlaAsp: 1.363 ± 0.526
5.18AlaGlu: 5.18 ± 1.449
1.363AlaPhe: 1.363 ± 0.769
4.362AlaGly: 4.362 ± 1.108
1.091AlaHis: 1.091 ± 0.603
5.998AlaIle: 5.998 ± 1.178
1.908AlaLys: 1.908 ± 0.499
5.725AlaLeu: 5.725 ± 0.73
1.636AlaMet: 1.636 ± 0.392
2.181AlaAsn: 2.181 ± 0.433
2.726AlaPro: 2.726 ± 0.842
2.454AlaGln: 2.454 ± 0.523
4.089AlaArg: 4.089 ± 0.848
5.998AlaSer: 5.998 ± 1.018
3.544AlaThr: 3.544 ± 0.834
5.18AlaVal: 5.18 ± 0.529
1.908AlaTrp: 1.908 ± 0.619
0.818AlaTyr: 0.818 ± 0.355
0.0AlaXaa: 0.0 ± 0.0
Cys
1.636CysAla: 1.636 ± 0.97
0.818CysCys: 0.818 ± 1.089
0.0CysAsp: 0.0 ± 0.0
1.363CysGlu: 1.363 ± 0.602
1.363CysPhe: 1.363 ± 0.785
1.091CysGly: 1.091 ± 0.567
0.818CysHis: 0.818 ± 0.414
0.0CysIle: 0.0 ± 0.0
2.181CysLys: 2.181 ± 0.697
0.545CysLeu: 0.545 ± 0.237
0.273CysMet: 0.273 ± 0.24
2.181CysAsn: 2.181 ± 0.985
0.818CysPro: 0.818 ± 0.355
1.363CysGln: 1.363 ± 0.624
1.636CysArg: 1.636 ± 0.467
0.545CysSer: 0.545 ± 0.237
1.363CysThr: 1.363 ± 0.487
1.363CysVal: 1.363 ± 0.59
0.818CysTrp: 0.818 ± 0.367
1.908CysTyr: 1.908 ± 1.977
0.0CysXaa: 0.0 ± 0.0
Asp
1.908AspAla: 1.908 ± 0.467
1.636AspCys: 1.636 ± 0.735
1.363AspAsp: 1.363 ± 0.429
0.818AspGlu: 0.818 ± 0.311
0.818AspPhe: 0.818 ± 0.355
1.363AspGly: 1.363 ± 0.692
0.818AspHis: 0.818 ± 0.582
4.907AspIle: 4.907 ± 1.185
1.636AspLys: 1.636 ± 0.873
3.544AspLeu: 3.544 ± 0.996
0.545AspMet: 0.545 ± 0.457
1.908AspAsn: 1.908 ± 0.45
3.544AspPro: 3.544 ± 2.176
1.908AspGln: 1.908 ± 0.805
2.999AspArg: 2.999 ± 1.268
1.908AspSer: 1.908 ± 0.816
2.999AspThr: 2.999 ± 0.641
0.545AspVal: 0.545 ± 0.377
0.545AspTrp: 0.545 ± 0.467
1.091AspTyr: 1.091 ± 0.491
0.0AspXaa: 0.0 ± 0.0
Glu
3.817GluAla: 3.817 ± 1.091
0.273GluCys: 0.273 ± 0.24
2.454GluAsp: 2.454 ± 0.821
6.543GluGlu: 6.543 ± 2.47
1.908GluPhe: 1.908 ± 0.803
5.453GluGly: 5.453 ± 1.305
1.363GluHis: 1.363 ± 0.725
2.726GluIle: 2.726 ± 1.129
3.817GluLys: 3.817 ± 0.68
6.816GluLeu: 6.816 ± 1.353
1.363GluMet: 1.363 ± 0.395
1.908GluAsn: 1.908 ± 0.674
3.272GluPro: 3.272 ± 0.797
5.453GluGln: 5.453 ± 1.876
4.362GluArg: 4.362 ± 1.529
2.726GluSer: 2.726 ± 1.036
4.907GluThr: 4.907 ± 1.674
5.453GluVal: 5.453 ± 1.466
1.908GluTrp: 1.908 ± 0.453
1.091GluTyr: 1.091 ± 0.357
0.0GluXaa: 0.0 ± 0.0
Phe
1.091PheAla: 1.091 ± 0.567
0.273PheCys: 0.273 ± 0.24
0.818PheAsp: 0.818 ± 1.061
1.091PheGlu: 1.091 ± 1.054
1.091PhePhe: 1.091 ± 0.778
1.091PheGly: 1.091 ± 0.435
0.0PheHis: 0.0 ± 0.0
1.091PheIle: 1.091 ± 0.785
1.091PheLys: 1.091 ± 0.409
2.454PheLeu: 2.454 ± 0.753
1.091PheMet: 1.091 ± 0.567
3.272PheAsn: 3.272 ± 1.386
1.636PhePro: 1.636 ± 1.62
0.545PheGln: 0.545 ± 0.387
2.181PheArg: 2.181 ± 0.924
0.818PheSer: 0.818 ± 0.438
1.636PheThr: 1.636 ± 0.813
1.091PheVal: 1.091 ± 0.56
0.273PheTrp: 0.273 ± 0.189
1.091PheTyr: 1.091 ± 0.379
0.0PheXaa: 0.0 ± 0.0
Gly
4.089GlyAla: 4.089 ± 1.048
1.363GlyCys: 1.363 ± 0.452
2.726GlyAsp: 2.726 ± 0.737
2.454GlyGlu: 2.454 ± 0.708
2.454GlyPhe: 2.454 ± 1.516
8.179GlyGly: 8.179 ± 1.248
2.999GlyHis: 2.999 ± 1.262
5.453GlyIle: 5.453 ± 1.539
5.18GlyLys: 5.18 ± 1.289
3.817GlyLeu: 3.817 ± 0.85
0.818GlyMet: 0.818 ± 0.438
2.999GlyAsn: 2.999 ± 1.276
5.453GlyPro: 5.453 ± 1.494
5.18GlyGln: 5.18 ± 1.327
2.999GlyArg: 2.999 ± 1.957
5.453GlySer: 5.453 ± 1.612
6.27GlyThr: 6.27 ± 1.31
3.272GlyVal: 3.272 ± 0.61
0.818GlyTrp: 0.818 ± 0.781
2.181GlyTyr: 2.181 ± 0.487
0.0GlyXaa: 0.0 ± 0.0
His
0.273HisAla: 0.273 ± 0.483
0.818HisCys: 0.818 ± 1.089
0.0HisAsp: 0.0 ± 0.0
0.818HisGlu: 0.818 ± 0.566
0.545HisPhe: 0.545 ± 0.513
2.181HisGly: 2.181 ± 0.715
1.363HisHis: 1.363 ± 1.041
0.818HisIle: 0.818 ± 0.367
2.726HisLys: 2.726 ± 0.949
2.726HisLeu: 2.726 ± 0.842
0.545HisMet: 0.545 ± 0.331
1.363HisAsn: 1.363 ± 0.353
2.999HisPro: 2.999 ± 1.459
2.454HisGln: 2.454 ± 0.714
0.818HisArg: 0.818 ± 0.357
1.091HisSer: 1.091 ± 0.511
1.091HisThr: 1.091 ± 0.409
0.818HisVal: 0.818 ± 0.547
0.545HisTrp: 0.545 ± 0.284
1.091HisTyr: 1.091 ± 0.794
0.0HisXaa: 0.0 ± 0.0
Ile
2.726IleAla: 2.726 ± 0.706
0.818IleCys: 0.818 ± 0.355
1.636IleAsp: 1.636 ± 0.634
1.636IleGlu: 1.636 ± 0.898
0.818IlePhe: 0.818 ± 0.355
4.907IleGly: 4.907 ± 1.3
1.636IleHis: 1.636 ± 0.378
6.816IleIle: 6.816 ± 1.384
3.817IleLys: 3.817 ± 0.987
6.543IleLeu: 6.543 ± 1.076
0.545IleMet: 0.545 ± 0.237
2.181IleAsn: 2.181 ± 0.581
4.907IlePro: 4.907 ± 0.411
4.635IleGln: 4.635 ± 1.447
6.543IleArg: 6.543 ± 0.661
4.635IleSer: 4.635 ± 0.692
1.908IleThr: 1.908 ± 1.271
4.907IleVal: 4.907 ± 0.803
1.908IleTrp: 1.908 ± 1.1
1.908IleTyr: 1.908 ± 0.454
0.0IleXaa: 0.0 ± 0.0
Lys
5.18LysAla: 5.18 ± 1.159
2.181LysCys: 2.181 ± 0.43
3.272LysAsp: 3.272 ± 0.461
6.27LysGlu: 6.27 ± 1.704
1.091LysPhe: 1.091 ± 0.773
6.816LysGly: 6.816 ± 1.132
1.363LysHis: 1.363 ± 0.305
3.817LysIle: 3.817 ± 1.109
5.18LysLys: 5.18 ± 0.888
6.543LysLeu: 6.543 ± 1.851
1.908LysMet: 1.908 ± 0.467
1.908LysAsn: 1.908 ± 0.53
1.908LysPro: 1.908 ± 0.352
5.18LysGln: 5.18 ± 1.374
2.999LysArg: 2.999 ± 1.485
2.181LysSer: 2.181 ± 0.912
2.181LysThr: 2.181 ± 0.692
2.454LysVal: 2.454 ± 0.818
1.908LysTrp: 1.908 ± 0.547
2.999LysTyr: 2.999 ± 1.098
0.273LysXaa: 0.273 ± 0.189
Leu
5.18LeuAla: 5.18 ± 0.835
1.091LeuCys: 1.091 ± 0.517
3.544LeuAsp: 3.544 ± 0.763
7.361LeuGlu: 7.361 ± 0.836
2.726LeuPhe: 2.726 ± 1.16
5.453LeuGly: 5.453 ± 0.837
1.636LeuHis: 1.636 ± 0.678
1.908LeuIle: 1.908 ± 0.549
7.634LeuLys: 7.634 ± 1.941
7.906LeuLeu: 7.906 ± 1.466
1.636LeuMet: 1.636 ± 0.741
4.089LeuAsn: 4.089 ± 0.985
3.544LeuPro: 3.544 ± 1.044
4.362LeuGln: 4.362 ± 0.777
4.635LeuArg: 4.635 ± 1.706
4.362LeuSer: 4.362 ± 1.161
4.089LeuThr: 4.089 ± 0.84
3.544LeuVal: 3.544 ± 0.526
4.635LeuTrp: 4.635 ± 0.875
2.181LeuTyr: 2.181 ± 0.72
0.0LeuXaa: 0.0 ± 0.0
Met
3.544MetAla: 3.544 ± 0.813
0.0MetCys: 0.0 ± 0.0
1.636MetAsp: 1.636 ± 0.742
2.181MetGlu: 2.181 ± 0.557
1.091MetPhe: 1.091 ± 0.411
2.454MetGly: 2.454 ± 0.446
0.273MetHis: 0.273 ± 0.417
1.636MetIle: 1.636 ± 0.752
1.636MetLys: 1.636 ± 0.54
0.818MetLeu: 0.818 ± 0.234
0.818MetMet: 0.818 ± 0.234
0.545MetAsn: 0.545 ± 0.332
0.273MetPro: 0.273 ± 0.338
0.818MetGln: 0.818 ± 0.234
0.545MetArg: 0.545 ± 0.467
0.273MetSer: 0.273 ± 0.24
1.908MetThr: 1.908 ± 0.555
1.908MetVal: 1.908 ± 0.729
0.273MetTrp: 0.273 ± 0.417
0.818MetTyr: 0.818 ± 0.234
0.0MetXaa: 0.0 ± 0.0
Asn
3.817AsnAla: 3.817 ± 1.337
2.181AsnCys: 2.181 ± 0.72
0.545AsnAsp: 0.545 ± 0.377
3.272AsnGlu: 3.272 ± 0.743
1.091AsnPhe: 1.091 ± 0.51
2.726AsnGly: 2.726 ± 0.717
0.545AsnHis: 0.545 ± 0.479
4.635AsnIle: 4.635 ± 2.078
2.181AsnLys: 2.181 ± 0.456
1.908AsnLeu: 1.908 ± 1.157
0.818AsnMet: 0.818 ± 0.561
2.999AsnAsn: 2.999 ± 1.216
4.089AsnPro: 4.089 ± 1.417
1.636AsnGln: 1.636 ± 0.578
1.908AsnArg: 1.908 ± 0.459
2.181AsnSer: 2.181 ± 1.64
2.454AsnThr: 2.454 ± 1.176
2.181AsnVal: 2.181 ± 1.019
1.908AsnTrp: 1.908 ± 0.352
1.908AsnTyr: 1.908 ± 0.724
0.0AsnXaa: 0.0 ± 0.0
Pro
3.272ProAla: 3.272 ± 0.749
1.636ProCys: 1.636 ± 1.025
2.454ProAsp: 2.454 ± 0.699
4.362ProGlu: 4.362 ± 1.278
1.908ProPhe: 1.908 ± 0.583
5.18ProGly: 5.18 ± 1.795
0.273ProHis: 0.273 ± 0.189
4.907ProIle: 4.907 ± 1.482
2.454ProLys: 2.454 ± 0.627
4.089ProLeu: 4.089 ± 0.768
1.908ProMet: 1.908 ± 1.073
1.636ProAsn: 1.636 ± 0.499
4.362ProPro: 4.362 ± 1.435
2.999ProGln: 2.999 ± 1.163
3.544ProArg: 3.544 ± 1.593
1.908ProSer: 1.908 ± 0.906
3.544ProThr: 3.544 ± 0.573
6.27ProVal: 6.27 ± 0.903
0.818ProTrp: 0.818 ± 0.942
0.818ProTyr: 0.818 ± 0.355
0.0ProXaa: 0.0 ± 0.0
Gln
5.18GlnAla: 5.18 ± 1.301
0.0GlnCys: 0.0 ± 0.0
1.636GlnAsp: 1.636 ± 0.407
7.088GlnGlu: 7.088 ± 1.389
0.273GlnPhe: 0.273 ± 0.189
5.453GlnGly: 5.453 ± 0.989
0.545GlnHis: 0.545 ± 0.488
6.543GlnIle: 6.543 ± 1.026
5.18GlnLys: 5.18 ± 1.076
5.18GlnLeu: 5.18 ± 1.374
3.272GlnMet: 3.272 ± 0.776
3.272GlnAsn: 3.272 ± 0.866
2.454GlnPro: 2.454 ± 0.711
4.635GlnGln: 4.635 ± 1.021
1.363GlnArg: 1.363 ± 0.571
2.999GlnSer: 2.999 ± 0.707
1.091GlnThr: 1.091 ± 0.474
3.272GlnVal: 3.272 ± 0.938
0.818GlnTrp: 0.818 ± 0.566
1.363GlnTyr: 1.363 ± 0.615
0.0GlnXaa: 0.0 ± 0.0
Arg
3.544ArgAla: 3.544 ± 0.86
0.545ArgCys: 0.545 ± 0.659
2.999ArgAsp: 2.999 ± 1.218
4.907ArgGlu: 4.907 ± 1.592
1.363ArgPhe: 1.363 ± 0.614
2.999ArgGly: 2.999 ± 1.424
0.545ArgHis: 0.545 ± 0.581
3.544ArgIle: 3.544 ± 1.476
7.088ArgLys: 7.088 ± 2.982
2.999ArgLeu: 2.999 ± 0.51
0.818ArgMet: 0.818 ± 0.611
2.999ArgAsn: 2.999 ± 0.709
3.817ArgPro: 3.817 ± 1.262
4.089ArgGln: 4.089 ± 0.892
3.544ArgArg: 3.544 ± 2.36
1.908ArgSer: 1.908 ± 1.157
3.817ArgThr: 3.817 ± 0.879
2.999ArgVal: 2.999 ± 0.66
1.363ArgTrp: 1.363 ± 0.714
1.363ArgTyr: 1.363 ± 0.305
0.0ArgXaa: 0.0 ± 0.0
Ser
2.999SerAla: 2.999 ± 1.035
1.091SerCys: 1.091 ± 0.407
2.181SerAsp: 2.181 ± 0.467
3.272SerGlu: 3.272 ± 1.129
0.545SerPhe: 0.545 ± 0.467
1.908SerGly: 1.908 ± 0.803
1.908SerHis: 1.908 ± 1.601
2.726SerIle: 2.726 ± 0.457
2.454SerLys: 2.454 ± 0.657
4.907SerLeu: 4.907 ± 1.359
1.363SerMet: 1.363 ± 0.46
2.726SerAsn: 2.726 ± 0.855
3.544SerPro: 3.544 ± 0.916
2.999SerGln: 2.999 ± 0.731
4.089SerArg: 4.089 ± 1.418
2.999SerSer: 2.999 ± 1.132
3.817SerThr: 3.817 ± 1.835
2.726SerVal: 2.726 ± 0.608
0.273SerTrp: 0.273 ± 0.24
1.363SerTyr: 1.363 ± 0.65
0.273SerXaa: 0.273 ± 0.24
Thr
4.635ThrAla: 4.635 ± 1.054
1.908ThrCys: 1.908 ± 1.251
2.726ThrAsp: 2.726 ± 0.962
3.544ThrGlu: 3.544 ± 0.906
1.636ThrPhe: 1.636 ± 1.23
4.635ThrGly: 4.635 ± 0.923
3.544ThrHis: 3.544 ± 1.126
1.908ThrIle: 1.908 ± 0.594
2.181ThrLys: 2.181 ± 0.721
5.998ThrLeu: 5.998 ± 1.878
1.363ThrMet: 1.363 ± 0.353
1.908ThrAsn: 1.908 ± 1.1
3.272ThrPro: 3.272 ± 1.091
3.544ThrGln: 3.544 ± 0.559
2.726ThrArg: 2.726 ± 0.755
2.999ThrSer: 2.999 ± 0.675
3.817ThrThr: 3.817 ± 0.81
3.544ThrVal: 3.544 ± 1.199
2.181ThrTrp: 2.181 ± 0.817
1.636ThrTyr: 1.636 ± 0.582
0.0ThrXaa: 0.0 ± 0.0
Val
2.999ValAla: 2.999 ± 0.747
1.363ValCys: 1.363 ± 0.673
2.999ValAsp: 2.999 ± 1.537
2.181ValGlu: 2.181 ± 0.63
0.818ValPhe: 0.818 ± 0.367
4.907ValGly: 4.907 ± 0.743
2.181ValHis: 2.181 ± 0.889
3.272ValIle: 3.272 ± 0.782
4.635ValLys: 4.635 ± 1.072
6.27ValLeu: 6.27 ± 1.295
1.091ValMet: 1.091 ± 0.636
1.636ValAsn: 1.636 ± 0.873
3.272ValPro: 3.272 ± 1.173
3.817ValGln: 3.817 ± 0.81
2.726ValArg: 2.726 ± 0.953
4.089ValSer: 4.089 ± 0.754
4.089ValThr: 4.089 ± 1.672
3.817ValVal: 3.817 ± 0.878
1.636ValTrp: 1.636 ± 0.378
1.636ValTyr: 1.636 ± 0.535
0.0ValXaa: 0.0 ± 0.0
Trp
2.454TrpAla: 2.454 ± 0.461
0.545TrpCys: 0.545 ± 0.284
1.636TrpAsp: 1.636 ± 0.54
1.636TrpGlu: 1.636 ± 0.567
0.0TrpPhe: 0.0 ± 0.0
1.908TrpGly: 1.908 ± 0.624
0.545TrpHis: 0.545 ± 0.659
1.908TrpIle: 1.908 ± 0.757
2.454TrpLys: 2.454 ± 0.81
1.363TrpLeu: 1.363 ± 0.874
0.818TrpMet: 0.818 ± 0.367
1.908TrpAsn: 1.908 ± 0.747
0.818TrpPro: 0.818 ± 0.367
1.636TrpGln: 1.636 ± 0.741
1.091TrpArg: 1.091 ± 0.463
0.0TrpSer: 0.0 ± 0.0
2.454TrpThr: 2.454 ± 0.555
1.636TrpVal: 1.636 ± 0.588
0.818TrpTrp: 0.818 ± 0.422
1.091TrpTyr: 1.091 ± 0.445
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.363TyrAla: 1.363 ± 0.899
1.363TyrCys: 1.363 ± 0.943
0.818TyrAsp: 0.818 ± 0.367
1.636TyrGlu: 1.636 ± 0.652
0.818TyrPhe: 0.818 ± 0.422
1.091TyrGly: 1.091 ± 0.872
1.363TyrHis: 1.363 ± 0.658
0.818TyrIle: 0.818 ± 0.577
2.181TyrLys: 2.181 ± 0.845
1.363TyrLeu: 1.363 ± 0.648
0.545TyrMet: 0.545 ± 0.237
1.363TyrAsn: 1.363 ± 0.499
1.636TyrPro: 1.636 ± 0.807
2.181TyrGln: 2.181 ± 1.009
2.454TyrArg: 2.454 ± 0.91
1.091TyrSer: 1.091 ± 0.395
2.726TyrThr: 2.726 ± 0.697
2.454TyrVal: 2.454 ± 0.644
1.091TyrTrp: 1.091 ± 0.338
0.818TyrTyr: 0.818 ± 0.566
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.273XaaHis: 0.273 ± 0.189
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.273XaaTrp: 0.273 ± 0.24
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (3669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski