Amino acid dipepetide frequency for Aeromicrobium erythreum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.692AlaAla: 18.692 ± 0.207
0.978AlaCys: 0.978 ± 0.033
9.0AlaAsp: 9.0 ± 0.103
7.681AlaGlu: 7.681 ± 0.095
3.653AlaPhe: 3.653 ± 0.068
11.521AlaGly: 11.521 ± 0.128
2.63AlaHis: 2.63 ± 0.051
3.844AlaIle: 3.844 ± 0.079
2.365AlaLys: 2.365 ± 0.061
13.916AlaLeu: 13.916 ± 0.139
2.514AlaMet: 2.514 ± 0.051
1.718AlaAsn: 1.718 ± 0.047
6.106AlaPro: 6.106 ± 0.089
3.897AlaGln: 3.897 ± 0.069
9.77AlaArg: 9.77 ± 0.125
6.833AlaSer: 6.833 ± 0.079
7.57AlaThr: 7.57 ± 0.099
12.778AlaVal: 12.778 ± 0.142
2.109AlaTrp: 2.109 ± 0.051
2.397AlaTyr: 2.397 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.831CysAla: 0.831 ± 0.032
0.062CysCys: 0.062 ± 0.008
0.437CysAsp: 0.437 ± 0.019
0.341CysGlu: 0.341 ± 0.02
0.192CysPhe: 0.192 ± 0.015
0.764CysGly: 0.764 ± 0.028
0.158CysHis: 0.158 ± 0.015
0.163CysIle: 0.163 ± 0.012
0.09CysLys: 0.09 ± 0.011
0.608CysLeu: 0.608 ± 0.027
0.094CysMet: 0.094 ± 0.01
0.116CysAsn: 0.116 ± 0.012
0.366CysPro: 0.366 ± 0.019
0.16CysGln: 0.16 ± 0.013
0.512CysArg: 0.512 ± 0.023
0.437CysSer: 0.437 ± 0.022
0.452CysThr: 0.452 ± 0.023
0.612CysVal: 0.612 ± 0.027
0.092CysTrp: 0.092 ± 0.011
0.102CysTyr: 0.102 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
9.488AspAla: 9.488 ± 0.117
0.304AspCys: 0.304 ± 0.017
5.701AspAsp: 5.701 ± 0.083
4.368AspGlu: 4.368 ± 0.072
1.504AspPhe: 1.504 ± 0.041
6.93AspGly: 6.93 ± 0.082
1.603AspHis: 1.603 ± 0.043
1.509AspIle: 1.509 ± 0.047
0.897AspLys: 0.897 ± 0.04
7.6AspLeu: 7.6 ± 0.102
0.719AspMet: 0.719 ± 0.028
0.737AspAsn: 0.737 ± 0.03
4.728AspPro: 4.728 ± 0.068
1.66AspGln: 1.66 ± 0.039
5.021AspArg: 5.021 ± 0.073
2.163AspSer: 2.163 ± 0.051
3.108AspThr: 3.108 ± 0.062
8.364AspVal: 8.364 ± 0.103
0.926AspTrp: 0.926 ± 0.027
1.138AspTyr: 1.138 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.049GluAla: 7.049 ± 0.11
0.275GluCys: 0.275 ± 0.017
2.864GluAsp: 2.864 ± 0.061
3.251GluGlu: 3.251 ± 0.067
1.206GluPhe: 1.206 ± 0.035
4.37GluGly: 4.37 ± 0.075
1.739GluHis: 1.739 ± 0.046
2.081GluIle: 2.081 ± 0.048
1.338GluLys: 1.338 ± 0.043
6.277GluLeu: 6.277 ± 0.089
0.848GluMet: 0.848 ± 0.032
0.954GluAsn: 0.954 ± 0.035
3.296GluPro: 3.296 ± 0.073
2.436GluGln: 2.436 ± 0.059
5.815GluArg: 5.815 ± 0.083
2.591GluSer: 2.591 ± 0.052
2.927GluThr: 2.927 ± 0.058
5.544GluVal: 5.544 ± 0.087
0.648GluTrp: 0.648 ± 0.027
0.977GluTyr: 0.977 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.71PheAla: 3.71 ± 0.06
0.252PheCys: 0.252 ± 0.016
2.099PheAsp: 2.099 ± 0.046
1.523PheGlu: 1.523 ± 0.038
0.867PhePhe: 0.867 ± 0.032
2.993PheGly: 2.993 ± 0.055
0.58PheHis: 0.58 ± 0.024
0.696PheIle: 0.696 ± 0.028
0.474PheLys: 0.474 ± 0.025
2.532PheLeu: 2.532 ± 0.058
0.431PheMet: 0.431 ± 0.023
0.489PheAsn: 0.489 ± 0.021
1.202PhePro: 1.202 ± 0.038
0.611PheGln: 0.611 ± 0.026
1.643PheArg: 1.643 ± 0.04
1.474PheSer: 1.474 ± 0.034
1.813PheThr: 1.813 ± 0.043
2.855PheVal: 2.855 ± 0.056
0.405PheTrp: 0.405 ± 0.023
0.633PheTyr: 0.633 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
10.439GlyAla: 10.439 ± 0.111
0.731GlyCys: 0.731 ± 0.03
5.457GlyAsp: 5.457 ± 0.072
4.804GlyGlu: 4.804 ± 0.076
2.98GlyPhe: 2.98 ± 0.058
7.881GlyGly: 7.881 ± 0.124
2.065GlyHis: 2.065 ± 0.044
3.421GlyIle: 3.421 ± 0.067
1.904GlyLys: 1.904 ± 0.049
9.484GlyLeu: 9.484 ± 0.121
1.707GlyMet: 1.707 ± 0.046
1.388GlyAsn: 1.388 ± 0.049
4.568GlyPro: 4.568 ± 0.083
2.576GlyGln: 2.576 ± 0.054
7.553GlyArg: 7.553 ± 0.106
5.506GlySer: 5.506 ± 0.084
5.996GlyThr: 5.996 ± 0.094
8.714GlyVal: 8.714 ± 0.114
1.637GlyTrp: 1.637 ± 0.043
2.077GlyTyr: 2.077 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.701HisAla: 2.701 ± 0.056
0.151HisCys: 0.151 ± 0.013
1.733HisAsp: 1.733 ± 0.045
1.343HisGlu: 1.343 ± 0.035
0.507HisPhe: 0.507 ± 0.025
2.279HisGly: 2.279 ± 0.046
0.686HisHis: 0.686 ± 0.027
0.365HisIle: 0.365 ± 0.021
0.256HisLys: 0.256 ± 0.015
2.51HisLeu: 2.51 ± 0.05
0.239HisMet: 0.239 ± 0.015
0.278HisAsn: 0.278 ± 0.02
1.636HisPro: 1.636 ± 0.044
0.581HisGln: 0.581 ± 0.026
1.87HisArg: 1.87 ± 0.045
0.721HisSer: 0.721 ± 0.026
1.085HisThr: 1.085 ± 0.037
2.527HisVal: 2.527 ± 0.055
0.301HisTrp: 0.301 ± 0.017
0.43HisTyr: 0.43 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.289IleAla: 4.289 ± 0.078
0.222IleCys: 0.222 ± 0.016
2.494IleAsp: 2.494 ± 0.055
1.984IleGlu: 1.984 ± 0.054
0.682IlePhe: 0.682 ± 0.03
3.353IleGly: 3.353 ± 0.073
0.579IleHis: 0.579 ± 0.024
0.928IleIle: 0.928 ± 0.039
0.657IleLys: 0.657 ± 0.026
2.257IleLeu: 2.257 ± 0.051
0.441IleMet: 0.441 ± 0.025
0.624IleAsn: 0.624 ± 0.027
1.442IlePro: 1.442 ± 0.038
0.667IleGln: 0.667 ± 0.027
1.783IleArg: 1.783 ± 0.048
1.543IleSer: 1.543 ± 0.044
1.954IleThr: 1.954 ± 0.046
2.996IleVal: 2.996 ± 0.061
0.329IleTrp: 0.329 ± 0.021
0.507IleTyr: 0.507 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
2.466LysAla: 2.466 ± 0.064
0.074LysCys: 0.074 ± 0.009
1.268LysAsp: 1.268 ± 0.049
0.946LysGlu: 0.946 ± 0.037
0.369LysPhe: 0.369 ± 0.017
1.569LysGly: 1.569 ± 0.055
0.395LysHis: 0.395 ± 0.02
0.799LysIle: 0.799 ± 0.035
0.733LysLys: 0.733 ± 0.038
1.519LysLeu: 1.519 ± 0.047
0.288LysMet: 0.288 ± 0.021
0.474LysAsn: 0.474 ± 0.024
1.059LysPro: 1.059 ± 0.037
0.606LysGln: 0.606 ± 0.026
1.292LysArg: 1.292 ± 0.046
0.953LysSer: 0.953 ± 0.031
1.111LysThr: 1.111 ± 0.041
1.903LysVal: 1.903 ± 0.058
0.164LysTrp: 0.164 ± 0.013
0.349LysTyr: 0.349 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.902LeuAla: 14.902 ± 0.145
0.672LeuCys: 0.672 ± 0.027
7.984LeuAsp: 7.984 ± 0.103
5.892LeuGlu: 5.892 ± 0.094
2.438LeuPhe: 2.438 ± 0.052
9.725LeuGly: 9.725 ± 0.112
2.193LeuHis: 2.193 ± 0.052
2.188LeuIle: 2.188 ± 0.054
1.717LeuLys: 1.717 ± 0.053
11.309LeuLeu: 11.309 ± 0.175
1.484LeuMet: 1.484 ± 0.041
1.406LeuAsn: 1.406 ± 0.034
5.648LeuPro: 5.648 ± 0.071
2.706LeuGln: 2.706 ± 0.05
8.307LeuArg: 8.307 ± 0.113
5.155LeuSer: 5.155 ± 0.079
6.36LeuThr: 6.36 ± 0.089
11.769LeuVal: 11.769 ± 0.137
1.25LeuTrp: 1.25 ± 0.04
1.478LeuTyr: 1.478 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.056MetAla: 2.056 ± 0.046
0.104MetCys: 0.104 ± 0.01
0.832MetAsp: 0.832 ± 0.029
0.635MetGlu: 0.635 ± 0.026
0.449MetPhe: 0.449 ± 0.021
1.308MetGly: 1.308 ± 0.037
0.357MetHis: 0.357 ± 0.018
0.575MetIle: 0.575 ± 0.023
0.389MetLys: 0.389 ± 0.019
1.658MetLeu: 1.658 ± 0.04
0.27MetMet: 0.27 ± 0.016
0.363MetAsn: 0.363 ± 0.018
0.953MetPro: 0.953 ± 0.032
0.47MetGln: 0.47 ± 0.024
1.324MetArg: 1.324 ± 0.038
1.41MetSer: 1.41 ± 0.034
1.544MetThr: 1.544 ± 0.04
1.426MetVal: 1.426 ± 0.041
0.161MetTrp: 0.161 ± 0.012
0.232MetTyr: 0.232 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
1.926AsnAla: 1.926 ± 0.047
0.104AsnCys: 0.104 ± 0.01
0.92AsnAsp: 0.92 ± 0.034
0.757AsnGlu: 0.757 ± 0.026
0.439AsnPhe: 0.439 ± 0.023
1.461AsnGly: 1.461 ± 0.047
0.333AsnHis: 0.333 ± 0.018
0.602AsnIle: 0.602 ± 0.027
0.297AsnLys: 0.297 ± 0.021
1.687AsnLeu: 1.687 ± 0.043
0.22AsnMet: 0.22 ± 0.016
0.351AsnAsn: 0.351 ± 0.02
1.216AsnPro: 1.216 ± 0.035
0.475AsnGln: 0.475 ± 0.023
1.11AsnArg: 1.11 ± 0.036
0.608AsnSer: 0.608 ± 0.029
0.896AsnThr: 0.896 ± 0.03
1.476AsnVal: 1.476 ± 0.042
0.206AsnTrp: 0.206 ± 0.016
0.345AsnTyr: 0.345 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.664ProAla: 6.664 ± 0.093
0.266ProCys: 0.266 ± 0.016
4.759ProAsp: 4.759 ± 0.081
3.636ProGlu: 3.636 ± 0.065
1.661ProPhe: 1.661 ± 0.041
5.377ProGly: 5.377 ± 0.081
1.235ProHis: 1.235 ± 0.035
1.449ProIle: 1.449 ± 0.04
0.918ProLys: 0.918 ± 0.032
4.898ProLeu: 4.898 ± 0.062
0.912ProMet: 0.912 ± 0.031
0.768ProAsn: 0.768 ± 0.028
2.383ProPro: 2.383 ± 0.056
1.527ProGln: 1.527 ± 0.041
3.973ProArg: 3.973 ± 0.075
3.106ProSer: 3.106 ± 0.064
3.776ProThr: 3.776 ± 0.083
5.287ProVal: 5.287 ± 0.079
0.995ProTrp: 0.995 ± 0.036
1.036ProTyr: 1.036 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.694GlnAla: 3.694 ± 0.066
0.148GlnCys: 0.148 ± 0.014
1.448GlnAsp: 1.448 ± 0.041
1.4GlnGlu: 1.4 ± 0.038
0.648GlnPhe: 0.648 ± 0.026
2.332GlnGly: 2.332 ± 0.053
0.743GlnHis: 0.743 ± 0.026
0.912GlnIle: 0.912 ± 0.032
0.649GlnLys: 0.649 ± 0.028
3.075GlnLeu: 3.075 ± 0.058
0.485GlnMet: 0.485 ± 0.024
0.459GlnAsn: 0.459 ± 0.022
1.472GlnPro: 1.472 ± 0.036
1.234GlnGln: 1.234 ± 0.04
2.647GlnArg: 2.647 ± 0.054
1.196GlnSer: 1.196 ± 0.038
1.432GlnThr: 1.432 ± 0.045
3.174GlnVal: 3.174 ± 0.056
0.422GlnTrp: 0.422 ± 0.02
0.55GlnTyr: 0.55 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
9.247ArgAla: 9.247 ± 0.118
0.47ArgCys: 0.47 ± 0.025
5.021ArgAsp: 5.021 ± 0.072
4.556ArgGlu: 4.556 ± 0.075
2.41ArgPhe: 2.41 ± 0.056
5.887ArgGly: 5.887 ± 0.079
1.893ArgHis: 1.893 ± 0.046
2.656ArgIle: 2.656 ± 0.057
1.271ArgLys: 1.271 ± 0.039
8.71ArgLeu: 8.71 ± 0.116
1.611ArgMet: 1.611 ± 0.044
1.12ArgAsn: 1.12 ± 0.028
4.587ArgPro: 4.587 ± 0.081
2.201ArgGln: 2.201 ± 0.044
8.059ArgArg: 8.059 ± 0.121
4.446ArgSer: 4.446 ± 0.078
5.299ArgThr: 5.299 ± 0.087
6.814ArgVal: 6.814 ± 0.088
1.407ArgTrp: 1.407 ± 0.041
1.578ArgTyr: 1.578 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.413SerAla: 6.413 ± 0.08
0.355SerCys: 0.355 ± 0.021
3.091SerAsp: 3.091 ± 0.058
2.285SerGlu: 2.285 ± 0.05
1.594SerPhe: 1.594 ± 0.042
5.603SerGly: 5.603 ± 0.081
0.974SerHis: 0.974 ± 0.033
1.791SerIle: 1.791 ± 0.05
0.907SerLys: 0.907 ± 0.038
5.196SerLeu: 5.196 ± 0.076
1.197SerMet: 1.197 ± 0.033
0.909SerAsn: 0.909 ± 0.032
2.878SerPro: 2.878 ± 0.059
1.333SerGln: 1.333 ± 0.038
3.876SerArg: 3.876 ± 0.066
3.361SerSer: 3.361 ± 0.073
3.826SerThr: 3.826 ± 0.071
4.838SerVal: 4.838 ± 0.077
0.905SerTrp: 0.905 ± 0.032
1.079SerTyr: 1.079 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.386ThrAla: 7.386 ± 0.099
0.453ThrCys: 0.453 ± 0.024
3.574ThrAsp: 3.574 ± 0.062
2.811ThrGlu: 2.811 ± 0.064
2.115ThrPhe: 2.115 ± 0.056
5.736ThrGly: 5.736 ± 0.073
1.234ThrHis: 1.234 ± 0.034
2.246ThrIle: 2.246 ± 0.058
1.113ThrLys: 1.113 ± 0.034
6.297ThrLeu: 6.297 ± 0.069
0.991ThrMet: 0.991 ± 0.037
1.032ThrAsn: 1.032 ± 0.035
3.856ThrPro: 3.856 ± 0.088
1.527ThrGln: 1.527 ± 0.04
4.076ThrArg: 4.076 ± 0.068
4.077ThrSer: 4.077 ± 0.072
4.276ThrThr: 4.276 ± 0.085
6.431ThrVal: 6.431 ± 0.102
1.138ThrTrp: 1.138 ± 0.03
1.43ThrTyr: 1.43 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
14.087ValAla: 14.087 ± 0.156
0.701ValCys: 0.701 ± 0.026
7.405ValAsp: 7.405 ± 0.091
6.599ValGlu: 6.599 ± 0.086
2.429ValPhe: 2.429 ± 0.058
8.926ValGly: 8.926 ± 0.107
2.163ValHis: 2.163 ± 0.051
2.575ValIle: 2.575 ± 0.054
1.78ValLys: 1.78 ± 0.049
11.313ValLeu: 11.313 ± 0.137
1.567ValMet: 1.567 ± 0.041
1.603ValAsn: 1.603 ± 0.047
5.55ValPro: 5.55 ± 0.075
2.451ValGln: 2.451 ± 0.05
7.768ValArg: 7.768 ± 0.098
4.897ValSer: 4.897 ± 0.064
6.24ValThr: 6.24 ± 0.09
13.024ValVal: 13.024 ± 0.167
1.166ValTrp: 1.166 ± 0.036
1.529ValTyr: 1.529 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.547TrpAla: 1.547 ± 0.043
0.134TrpCys: 0.134 ± 0.011
0.914TrpAsp: 0.914 ± 0.03
0.644TrpGlu: 0.644 ± 0.026
0.54TrpPhe: 0.54 ± 0.021
1.04TrpGly: 1.04 ± 0.036
0.327TrpHis: 0.327 ± 0.02
0.547TrpIle: 0.547 ± 0.027
0.278TrpLys: 0.278 ± 0.017
1.712TrpLeu: 1.712 ± 0.044
0.285TrpMet: 0.285 ± 0.016
0.318TrpAsn: 0.318 ± 0.018
0.752TrpPro: 0.752 ± 0.032
0.5TrpGln: 0.5 ± 0.023
1.275TrpArg: 1.275 ± 0.037
1.051TrpSer: 1.051 ± 0.033
1.124TrpThr: 1.124 ± 0.033
1.291TrpVal: 1.291 ± 0.042
0.387TrpTrp: 0.387 ± 0.023
0.299TrpTyr: 0.299 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.387TyrAla: 2.387 ± 0.046
0.133TyrCys: 0.133 ± 0.013
1.464TyrAsp: 1.464 ± 0.054
1.031TyrGlu: 1.031 ± 0.032
0.597TyrPhe: 0.597 ± 0.027
1.833TyrGly: 1.833 ± 0.046
0.313TyrHis: 0.313 ± 0.02
0.385TyrIle: 0.385 ± 0.021
0.306TyrLys: 0.306 ± 0.018
2.026TyrLeu: 2.026 ± 0.042
0.211TyrMet: 0.211 ± 0.014
0.324TyrAsn: 0.324 ± 0.022
0.928TyrPro: 0.928 ± 0.032
0.5TyrGln: 0.5 ± 0.024
1.569TyrArg: 1.569 ± 0.044
0.883TyrSer: 0.883 ± 0.03
1.012TyrThr: 1.012 ± 0.038
1.947TyrVal: 1.947 ± 0.044
0.317TyrTrp: 0.317 ± 0.02
0.414TyrTyr: 0.414 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3120 proteins (981426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski