Amino acid dipepetide frequency for Enterobacter phage Arya

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.177AlaAla: 14.177 ± 1.503
0.925AlaCys: 0.925 ± 0.226
7.705AlaAsp: 7.705 ± 0.891
6.78AlaGlu: 6.78 ± 0.759
4.084AlaPhe: 4.084 ± 0.523
9.169AlaGly: 9.169 ± 1.058
1.464AlaHis: 1.464 ± 0.435
5.624AlaIle: 5.624 ± 0.793
5.779AlaLys: 5.779 ± 0.763
7.088AlaLeu: 7.088 ± 0.524
2.388AlaMet: 2.388 ± 0.526
6.164AlaAsn: 6.164 ± 0.659
4.931AlaPro: 4.931 ± 0.72
4.006AlaGln: 4.006 ± 0.494
6.164AlaArg: 6.164 ± 0.639
4.931AlaSer: 4.931 ± 0.501
7.011AlaThr: 7.011 ± 0.826
7.551AlaVal: 7.551 ± 0.696
1.464AlaTrp: 1.464 ± 0.333
3.005AlaTyr: 3.005 ± 0.527
0.0AlaXaa: 0.0 ± 0.0
Cys
0.925CysAla: 0.925 ± 0.243
0.539CysCys: 0.539 ± 0.188
0.693CysAsp: 0.693 ± 0.267
0.77CysGlu: 0.77 ± 0.296
0.385CysPhe: 0.385 ± 0.157
1.002CysGly: 1.002 ± 0.316
0.231CysHis: 0.231 ± 0.126
0.462CysIle: 0.462 ± 0.225
0.385CysLys: 0.385 ± 0.175
1.156CysLeu: 1.156 ± 0.329
0.0CysMet: 0.0 ± 0.0
0.077CysAsn: 0.077 ± 0.071
1.079CysPro: 1.079 ± 0.264
0.154CysGln: 0.154 ± 0.111
0.462CysArg: 0.462 ± 0.209
1.156CysSer: 1.156 ± 0.288
0.616CysThr: 0.616 ± 0.219
0.848CysVal: 0.848 ± 0.272
0.231CysTrp: 0.231 ± 0.143
0.154CysTyr: 0.154 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
6.01AspAla: 6.01 ± 0.613
0.925AspCys: 0.925 ± 0.255
4.469AspAsp: 4.469 ± 0.507
4.7AspGlu: 4.7 ± 0.628
2.774AspPhe: 2.774 ± 0.472
6.857AspGly: 6.857 ± 0.601
1.233AspHis: 1.233 ± 0.382
3.544AspIle: 3.544 ± 0.538
2.697AspLys: 2.697 ± 0.457
4.546AspLeu: 4.546 ± 0.5
1.849AspMet: 1.849 ± 0.397
3.082AspAsn: 3.082 ± 0.407
2.851AspPro: 2.851 ± 0.469
2.311AspGln: 2.311 ± 0.365
2.851AspArg: 2.851 ± 0.546
2.003AspSer: 2.003 ± 0.41
3.005AspThr: 3.005 ± 0.564
4.392AspVal: 4.392 ± 0.743
1.156AspTrp: 1.156 ± 0.339
2.08AspTyr: 2.08 ± 0.425
0.0AspXaa: 0.0 ± 0.0
Glu
5.085GluAla: 5.085 ± 0.612
0.925GluCys: 0.925 ± 0.294
1.387GluAsp: 1.387 ± 0.402
3.698GluGlu: 3.698 ± 0.751
1.849GluPhe: 1.849 ± 0.455
3.621GluGly: 3.621 ± 0.463
1.233GluHis: 1.233 ± 0.352
3.621GluIle: 3.621 ± 0.629
3.236GluLys: 3.236 ± 0.77
5.316GluLeu: 5.316 ± 0.633
1.695GluMet: 1.695 ± 0.307
1.618GluAsn: 1.618 ± 0.303
2.928GluPro: 2.928 ± 0.616
3.082GluGln: 3.082 ± 0.469
3.775GluArg: 3.775 ± 0.607
3.852GluSer: 3.852 ± 0.412
3.39GluThr: 3.39 ± 0.531
3.852GluVal: 3.852 ± 0.54
2.003GluTrp: 2.003 ± 0.402
1.541GluTyr: 1.541 ± 0.299
0.0GluXaa: 0.0 ± 0.0
Phe
3.544PheAla: 3.544 ± 0.454
0.385PheCys: 0.385 ± 0.154
2.62PheAsp: 2.62 ± 0.522
2.157PheGlu: 2.157 ± 0.426
0.925PhePhe: 0.925 ± 0.249
3.467PheGly: 3.467 ± 0.384
0.462PheHis: 0.462 ± 0.17
2.388PheIle: 2.388 ± 0.429
1.541PheLys: 1.541 ± 0.436
1.618PheLeu: 1.618 ± 0.375
1.233PheMet: 1.233 ± 0.316
2.157PheAsn: 2.157 ± 0.57
1.156PhePro: 1.156 ± 0.26
1.156PheGln: 1.156 ± 0.349
2.234PheArg: 2.234 ± 0.446
2.003PheSer: 2.003 ± 0.357
2.08PheThr: 2.08 ± 0.395
2.003PheVal: 2.003 ± 0.388
0.539PheTrp: 0.539 ± 0.222
0.848PheTyr: 0.848 ± 0.35
0.0PheXaa: 0.0 ± 0.0
Gly
8.706GlyAla: 8.706 ± 0.904
0.693GlyCys: 0.693 ± 0.244
3.929GlyAsp: 3.929 ± 0.473
5.008GlyGlu: 5.008 ± 0.611
3.852GlyPhe: 3.852 ± 0.627
8.398GlyGly: 8.398 ± 1.694
1.233GlyHis: 1.233 ± 0.268
4.854GlyIle: 4.854 ± 0.633
5.393GlyLys: 5.393 ± 0.708
4.931GlyLeu: 4.931 ± 0.575
2.466GlyMet: 2.466 ± 0.469
3.775GlyAsn: 3.775 ± 0.612
2.543GlyPro: 2.543 ± 0.456
3.621GlyGln: 3.621 ± 0.545
4.315GlyArg: 4.315 ± 0.686
5.316GlySer: 5.316 ± 0.801
5.547GlyThr: 5.547 ± 0.724
5.856GlyVal: 5.856 ± 0.655
1.926GlyTrp: 1.926 ± 0.405
3.082GlyTyr: 3.082 ± 0.377
0.0GlyXaa: 0.0 ± 0.0
His
2.003HisAla: 2.003 ± 0.478
0.693HisCys: 0.693 ± 0.23
1.156HisAsp: 1.156 ± 0.307
0.77HisGlu: 0.77 ± 0.276
0.616HisPhe: 0.616 ± 0.183
1.464HisGly: 1.464 ± 0.266
0.539HisHis: 0.539 ± 0.234
0.693HisIle: 0.693 ± 0.25
0.462HisLys: 0.462 ± 0.173
1.464HisLeu: 1.464 ± 0.274
0.385HisMet: 0.385 ± 0.163
0.462HisAsn: 0.462 ± 0.209
0.539HisPro: 0.539 ± 0.214
1.002HisGln: 1.002 ± 0.277
1.156HisArg: 1.156 ± 0.364
0.77HisSer: 0.77 ± 0.221
0.308HisThr: 0.308 ± 0.135
0.616HisVal: 0.616 ± 0.169
0.308HisTrp: 0.308 ± 0.154
0.385HisTyr: 0.385 ± 0.168
0.0HisXaa: 0.0 ± 0.0
Ile
6.395IleAla: 6.395 ± 0.797
0.693IleCys: 0.693 ± 0.294
4.777IleAsp: 4.777 ± 0.771
3.159IleGlu: 3.159 ± 0.55
1.618IlePhe: 1.618 ± 0.366
5.008IleGly: 5.008 ± 0.747
0.848IleHis: 0.848 ± 0.228
2.388IleIle: 2.388 ± 0.471
2.157IleLys: 2.157 ± 0.408
3.005IleLeu: 3.005 ± 0.454
1.079IleMet: 1.079 ± 0.257
2.466IleAsn: 2.466 ± 0.429
1.926IlePro: 1.926 ± 0.362
1.926IleGln: 1.926 ± 0.489
3.467IleArg: 3.467 ± 0.468
2.543IleSer: 2.543 ± 0.53
4.854IleThr: 4.854 ± 0.621
2.62IleVal: 2.62 ± 0.378
0.848IleTrp: 0.848 ± 0.236
0.925IleTyr: 0.925 ± 0.343
0.0IleXaa: 0.0 ± 0.0
Lys
4.931LysAla: 4.931 ± 0.85
0.539LysCys: 0.539 ± 0.236
2.311LysAsp: 2.311 ± 0.398
2.62LysGlu: 2.62 ± 0.625
1.464LysPhe: 1.464 ± 0.325
4.006LysGly: 4.006 ± 0.579
0.385LysHis: 0.385 ± 0.167
2.466LysIle: 2.466 ± 0.4
2.157LysLys: 2.157 ± 0.513
4.392LysLeu: 4.392 ± 0.508
1.387LysMet: 1.387 ± 0.359
2.388LysAsn: 2.388 ± 0.338
3.39LysPro: 3.39 ± 0.628
2.774LysGln: 2.774 ± 0.536
3.621LysArg: 3.621 ± 0.579
3.159LysSer: 3.159 ± 0.529
2.543LysThr: 2.543 ± 0.56
2.543LysVal: 2.543 ± 0.392
0.848LysTrp: 0.848 ± 0.275
1.618LysTyr: 1.618 ± 0.299
0.0LysXaa: 0.0 ± 0.0
Leu
9.169LeuAla: 9.169 ± 0.676
0.848LeuCys: 0.848 ± 0.246
4.777LeuAsp: 4.777 ± 0.53
4.238LeuGlu: 4.238 ± 0.689
2.234LeuPhe: 2.234 ± 0.373
4.623LeuGly: 4.623 ± 0.577
1.618LeuHis: 1.618 ± 0.302
4.238LeuIle: 4.238 ± 0.733
3.621LeuLys: 3.621 ± 0.589
5.624LeuLeu: 5.624 ± 0.752
1.31LeuMet: 1.31 ± 0.261
3.775LeuAsn: 3.775 ± 0.506
4.315LeuPro: 4.315 ± 0.477
3.313LeuGln: 3.313 ± 0.595
4.469LeuArg: 4.469 ± 0.511
3.852LeuSer: 3.852 ± 0.802
5.162LeuThr: 5.162 ± 0.58
5.933LeuVal: 5.933 ± 0.65
1.618LeuTrp: 1.618 ± 0.359
1.387LeuTyr: 1.387 ± 0.397
0.0LeuXaa: 0.0 ± 0.0
Met
3.005MetAla: 3.005 ± 0.426
0.077MetCys: 0.077 ± 0.071
1.31MetAsp: 1.31 ± 0.342
1.002MetGlu: 1.002 ± 0.257
0.539MetPhe: 0.539 ± 0.168
2.388MetGly: 2.388 ± 0.473
0.231MetHis: 0.231 ± 0.147
1.002MetIle: 1.002 ± 0.27
2.003MetLys: 2.003 ± 0.431
1.772MetLeu: 1.772 ± 0.3
0.848MetMet: 0.848 ± 0.28
1.926MetAsn: 1.926 ± 0.359
1.002MetPro: 1.002 ± 0.277
1.002MetGln: 1.002 ± 0.294
1.464MetArg: 1.464 ± 0.386
1.233MetSer: 1.233 ± 0.247
2.003MetThr: 2.003 ± 0.491
0.925MetVal: 0.925 ± 0.251
0.231MetTrp: 0.231 ± 0.108
0.308MetTyr: 0.308 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
5.47AsnAla: 5.47 ± 0.597
0.616AsnCys: 0.616 ± 0.191
3.852AsnAsp: 3.852 ± 0.596
2.08AsnGlu: 2.08 ± 0.293
1.464AsnPhe: 1.464 ± 0.405
3.929AsnGly: 3.929 ± 0.543
0.616AsnHis: 0.616 ± 0.177
2.234AsnIle: 2.234 ± 0.428
1.772AsnLys: 1.772 ± 0.35
4.623AsnLeu: 4.623 ± 0.653
0.77AsnMet: 0.77 ± 0.233
1.079AsnAsn: 1.079 ± 0.276
2.466AsnPro: 2.466 ± 0.362
1.541AsnGln: 1.541 ± 0.286
2.08AsnArg: 2.08 ± 0.314
1.695AsnSer: 1.695 ± 0.374
2.774AsnThr: 2.774 ± 0.429
3.313AsnVal: 3.313 ± 0.475
0.616AsnTrp: 0.616 ± 0.327
1.464AsnTyr: 1.464 ± 0.269
0.0AsnXaa: 0.0 ± 0.0
Pro
6.01ProAla: 6.01 ± 0.702
0.077ProCys: 0.077 ± 0.077
4.238ProAsp: 4.238 ± 0.545
2.466ProGlu: 2.466 ± 0.473
1.695ProPhe: 1.695 ± 0.36
4.315ProGly: 4.315 ± 0.558
0.77ProHis: 0.77 ± 0.273
1.464ProIle: 1.464 ± 0.322
2.697ProLys: 2.697 ± 0.551
3.005ProLeu: 3.005 ± 0.335
1.002ProMet: 1.002 ± 0.291
1.618ProAsn: 1.618 ± 0.418
1.695ProPro: 1.695 ± 0.482
2.003ProGln: 2.003 ± 0.492
2.157ProArg: 2.157 ± 0.359
2.62ProSer: 2.62 ± 0.463
2.928ProThr: 2.928 ± 0.486
3.313ProVal: 3.313 ± 0.435
0.539ProTrp: 0.539 ± 0.184
1.002ProTyr: 1.002 ± 0.278
0.0ProXaa: 0.0 ± 0.0
Gln
3.929GlnAla: 3.929 ± 0.583
0.231GlnCys: 0.231 ± 0.146
2.157GlnAsp: 2.157 ± 0.353
2.851GlnGlu: 2.851 ± 0.541
1.31GlnPhe: 1.31 ± 0.308
2.388GlnGly: 2.388 ± 0.412
0.77GlnHis: 0.77 ± 0.244
1.31GlnIle: 1.31 ± 0.349
2.003GlnLys: 2.003 ± 0.375
3.313GlnLeu: 3.313 ± 0.543
1.618GlnMet: 1.618 ± 0.252
0.848GlnAsn: 0.848 ± 0.255
2.928GlnPro: 2.928 ± 0.513
2.543GlnGln: 2.543 ± 0.601
3.313GlnArg: 3.313 ± 0.616
2.697GlnSer: 2.697 ± 0.422
2.466GlnThr: 2.466 ± 0.331
3.082GlnVal: 3.082 ± 0.458
0.539GlnTrp: 0.539 ± 0.163
0.693GlnTyr: 0.693 ± 0.247
0.0GlnXaa: 0.0 ± 0.0
Arg
6.395ArgAla: 6.395 ± 0.893
0.385ArgCys: 0.385 ± 0.178
3.236ArgAsp: 3.236 ± 0.48
3.775ArgGlu: 3.775 ± 0.447
1.618ArgPhe: 1.618 ± 0.353
3.852ArgGly: 3.852 ± 0.59
1.387ArgHis: 1.387 ± 0.347
2.774ArgIle: 2.774 ± 0.444
3.082ArgLys: 3.082 ± 0.508
5.316ArgLeu: 5.316 ± 0.565
1.618ArgMet: 1.618 ± 0.464
2.774ArgAsn: 2.774 ± 0.424
2.08ArgPro: 2.08 ± 0.384
2.311ArgGln: 2.311 ± 0.374
4.006ArgArg: 4.006 ± 0.578
3.082ArgSer: 3.082 ± 0.487
3.005ArgThr: 3.005 ± 0.482
3.852ArgVal: 3.852 ± 0.475
1.31ArgTrp: 1.31 ± 0.333
1.772ArgTyr: 1.772 ± 0.28
0.0ArgXaa: 0.0 ± 0.0
Ser
5.47SerAla: 5.47 ± 0.61
0.462SerCys: 0.462 ± 0.191
3.39SerAsp: 3.39 ± 0.506
2.388SerGlu: 2.388 ± 0.391
1.695SerPhe: 1.695 ± 0.334
5.779SerGly: 5.779 ± 0.905
0.693SerHis: 0.693 ± 0.216
3.313SerIle: 3.313 ± 0.563
3.313SerLys: 3.313 ± 0.464
4.777SerLeu: 4.777 ± 0.62
1.233SerMet: 1.233 ± 0.376
3.005SerAsn: 3.005 ± 0.477
2.466SerPro: 2.466 ± 0.468
1.926SerGln: 1.926 ± 0.397
2.774SerArg: 2.774 ± 0.484
3.544SerSer: 3.544 ± 0.799
3.39SerThr: 3.39 ± 0.537
3.313SerVal: 3.313 ± 0.572
1.079SerTrp: 1.079 ± 0.342
1.233SerTyr: 1.233 ± 0.308
0.0SerXaa: 0.0 ± 0.0
Thr
8.321ThrAla: 8.321 ± 0.869
0.539ThrCys: 0.539 ± 0.205
3.775ThrAsp: 3.775 ± 0.451
3.005ThrGlu: 3.005 ± 0.494
2.157ThrPhe: 2.157 ± 0.371
6.857ThrGly: 6.857 ± 0.829
0.231ThrHis: 0.231 ± 0.123
4.546ThrIle: 4.546 ± 0.674
2.774ThrLys: 2.774 ± 0.566
4.238ThrLeu: 4.238 ± 0.565
1.156ThrMet: 1.156 ± 0.325
2.157ThrAsn: 2.157 ± 0.363
3.544ThrPro: 3.544 ± 0.458
1.926ThrGln: 1.926 ± 0.367
2.003ThrArg: 2.003 ± 0.415
4.392ThrSer: 4.392 ± 0.453
4.238ThrThr: 4.238 ± 0.598
5.624ThrVal: 5.624 ± 0.721
1.233ThrTrp: 1.233 ± 0.348
1.541ThrTyr: 1.541 ± 0.359
0.0ThrXaa: 0.0 ± 0.0
Val
6.472ValAla: 6.472 ± 0.777
0.925ValCys: 0.925 ± 0.25
4.854ValAsp: 4.854 ± 0.691
3.698ValGlu: 3.698 ± 0.544
2.234ValPhe: 2.234 ± 0.387
5.085ValGly: 5.085 ± 0.701
0.693ValHis: 0.693 ± 0.208
4.392ValIle: 4.392 ± 0.797
2.851ValLys: 2.851 ± 0.479
5.856ValLeu: 5.856 ± 0.948
1.464ValMet: 1.464 ± 0.408
3.082ValAsn: 3.082 ± 0.439
2.08ValPro: 2.08 ± 0.367
2.08ValGln: 2.08 ± 0.35
4.161ValArg: 4.161 ± 0.711
4.161ValSer: 4.161 ± 0.779
5.624ValThr: 5.624 ± 0.691
4.469ValVal: 4.469 ± 0.744
0.848ValTrp: 0.848 ± 0.208
1.695ValTyr: 1.695 ± 0.409
0.0ValXaa: 0.0 ± 0.0
Trp
1.464TrpAla: 1.464 ± 0.353
0.231TrpCys: 0.231 ± 0.132
0.693TrpAsp: 0.693 ± 0.217
1.31TrpGlu: 1.31 ± 0.318
1.156TrpPhe: 1.156 ± 0.245
1.387TrpGly: 1.387 ± 0.328
0.462TrpHis: 0.462 ± 0.201
0.539TrpIle: 0.539 ± 0.215
0.693TrpLys: 0.693 ± 0.241
1.849TrpLeu: 1.849 ± 0.371
0.462TrpMet: 0.462 ± 0.192
1.079TrpAsn: 1.079 ± 0.215
0.539TrpPro: 0.539 ± 0.191
1.002TrpGln: 1.002 ± 0.257
1.387TrpArg: 1.387 ± 0.318
1.079TrpSer: 1.079 ± 0.329
1.233TrpThr: 1.233 ± 0.332
0.77TrpVal: 0.77 ± 0.197
0.385TrpTrp: 0.385 ± 0.194
0.385TrpTyr: 0.385 ± 0.159
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.005TyrAla: 3.005 ± 0.375
0.616TyrCys: 0.616 ± 0.281
2.003TyrAsp: 2.003 ± 0.41
1.233TyrGlu: 1.233 ± 0.315
0.848TyrPhe: 0.848 ± 0.208
1.849TyrGly: 1.849 ± 0.411
0.693TyrHis: 0.693 ± 0.225
0.848TyrIle: 0.848 ± 0.279
0.925TyrLys: 0.925 ± 0.243
2.234TyrLeu: 2.234 ± 0.445
0.231TyrMet: 0.231 ± 0.13
0.925TyrAsn: 0.925 ± 0.254
1.156TyrPro: 1.156 ± 0.26
1.31TyrGln: 1.31 ± 0.275
1.772TyrArg: 1.772 ± 0.388
1.156TyrSer: 1.156 ± 0.223
2.08TyrThr: 2.08 ± 0.341
1.849TyrVal: 1.849 ± 0.441
0.385TyrTrp: 0.385 ± 0.169
0.693TyrTyr: 0.693 ± 0.279
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (12980 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski