Amino acid dipepetide frequency for Mesobacillus foraminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.834AlaAla: 6.834 ± 0.085	0.574AlaCys: 0.574 ± 0.022	3.619AlaAsp: 3.619 ± 0.051	5.238AlaGlu: 5.238 ± 0.069	3.353AlaPhe: 3.353 ± 0.05	6.307AlaGly: 6.307 ± 0.072	1.273AlaHis: 1.273 ± 0.03	5.496AlaIle: 5.496 ± 0.059	4.516AlaLys: 4.516 ± 0.056	7.079AlaLeu: 7.079 ± 0.076	2.037AlaMet: 2.037 ± 0.038	2.753AlaAsn: 2.753 ± 0.044	2.378AlaPro: 2.378 ± 0.115	2.123AlaGln: 2.123 ± 0.038	2.903AlaArg: 2.903 ± 0.046	4.362AlaSer: 4.362 ± 0.06	3.173AlaThr: 3.173 ± 0.073	5.738AlaVal: 5.738 ± 0.073	0.712AlaTrp: 0.712 ± 0.023	2.396AlaTyr: 2.396 ± 0.043	0.001AlaXaa: 0.001 ± 0.001
Cys	0.451CysAla: 0.451 ± 0.019	0.094CysCys: 0.094 ± 0.008	0.378CysAsp: 0.378 ± 0.016	0.464CysGlu: 0.464 ± 0.019	0.315CysPhe: 0.315 ± 0.016	0.666CysGly: 0.666 ± 0.022	0.212CysHis: 0.212 ± 0.012	0.517CysIle: 0.517 ± 0.018	0.35CysLys: 0.35 ± 0.016	0.713CysLeu: 0.713 ± 0.026	0.194CysMet: 0.194 ± 0.01	0.285CysAsn: 0.285 ± 0.014	0.364CysPro: 0.364 ± 0.017	0.264CysGln: 0.264 ± 0.014	0.353CysArg: 0.353 ± 0.015	0.548CysSer: 0.548 ± 0.02	0.393CysThr: 0.393 ± 0.018	0.373CysVal: 0.373 ± 0.014	0.07CysTrp: 0.07 ± 0.006	0.255CysTyr: 0.255 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.19AspAla: 3.19 ± 0.043	0.387AspCys: 0.387 ± 0.018	2.194AspAsp: 2.194 ± 0.045	3.972AspGlu: 3.972 ± 0.062	2.567AspPhe: 2.567 ± 0.045	3.822AspGly: 3.822 ± 0.063	1.277AspHis: 1.277 ± 0.033	3.883AspIle: 3.883 ± 0.05	3.055AspLys: 3.055 ± 0.048	5.112AspLeu: 5.112 ± 0.061	1.269AspMet: 1.269 ± 0.03	1.744AspAsn: 1.744 ± 0.04	2.214AspPro: 2.214 ± 0.041	2.014AspGln: 2.014 ± 0.035	2.408AspArg: 2.408 ± 0.037	2.916AspSer: 2.916 ± 0.047	2.34AspThr: 2.34 ± 0.042	3.342AspVal: 3.342 ± 0.047	0.7AspTrp: 0.7 ± 0.026	2.206AspTyr: 2.206 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.647GluAla: 5.647 ± 0.073	0.428GluCys: 0.428 ± 0.018	3.897GluAsp: 3.897 ± 0.056	6.96GluGlu: 6.96 ± 0.088	2.773GluPhe: 2.773 ± 0.043	4.752GluGly: 4.752 ± 0.062	1.511GluHis: 1.511 ± 0.03	5.522GluIle: 5.522 ± 0.061	6.348GluLys: 6.348 ± 0.071	7.231GluLeu: 7.231 ± 0.079	2.289GluMet: 2.289 ± 0.04	3.676GluAsn: 3.676 ± 0.054	2.015GluPro: 2.015 ± 0.039	3.032GluGln: 3.032 ± 0.05	3.434GluArg: 3.434 ± 0.061	3.551GluSer: 3.551 ± 0.051	3.956GluThr: 3.956 ± 0.05	4.769GluVal: 4.769 ± 0.069	0.85GluTrp: 0.85 ± 0.026	2.362GluTyr: 2.362 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.103PheAla: 3.103 ± 0.044	0.357PheCys: 0.357 ± 0.016	2.33PheAsp: 2.33 ± 0.038	2.826PheGlu: 2.826 ± 0.044	2.324PhePhe: 2.324 ± 0.052	3.506PheGly: 3.506 ± 0.054	1.018PheHis: 1.018 ± 0.027	3.74PheIle: 3.74 ± 0.057	2.57PheLys: 2.57 ± 0.046	4.709PheLeu: 4.709 ± 0.071	1.229PheMet: 1.229 ± 0.03	1.994PheAsn: 1.994 ± 0.041	1.745PhePro: 1.745 ± 0.04	1.53PheGln: 1.53 ± 0.03	1.669PheArg: 1.669 ± 0.034	3.276PheSer: 3.276 ± 0.045	2.554PheThr: 2.554 ± 0.046	2.898PheVal: 2.898 ± 0.05	0.543PheTrp: 0.543 ± 0.019	1.813PheTyr: 1.813 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.274GlyAla: 5.274 ± 0.09	0.653GlyCys: 0.653 ± 0.022	3.412GlyAsp: 3.412 ± 0.052	4.865GlyGlu: 4.865 ± 0.062	3.499GlyPhe: 3.499 ± 0.048	5.19GlyGly: 5.19 ± 0.074	1.469GlyHis: 1.469 ± 0.029	6.217GlyIle: 6.217 ± 0.077	5.361GlyLys: 5.361 ± 0.065	6.987GlyLeu: 6.987 ± 0.075	2.276GlyMet: 2.276 ± 0.042	3.07GlyAsn: 3.07 ± 0.05	2.04GlyPro: 2.04 ± 0.069	2.302GlyGln: 2.302 ± 0.044	3.067GlyArg: 3.067 ± 0.051	4.39GlySer: 4.39 ± 0.06	4.29GlyThr: 4.29 ± 0.067	5.127GlyVal: 5.127 ± 0.057	0.936GlyTrp: 0.936 ± 0.026	2.916GlyTyr: 2.916 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.288HisAla: 1.288 ± 0.033	0.225HisCys: 0.225 ± 0.013	1.004HisAsp: 1.004 ± 0.027	1.343HisGlu: 1.343 ± 0.029	1.136HisPhe: 1.136 ± 0.028	1.504HisGly: 1.504 ± 0.036	0.671HisHis: 0.671 ± 0.025	1.409HisIle: 1.409 ± 0.029	0.996HisLys: 0.996 ± 0.027	2.102HisLeu: 2.102 ± 0.036	0.498HisMet: 0.498 ± 0.018	0.778HisAsn: 0.778 ± 0.02	1.194HisPro: 1.194 ± 0.031	0.838HisGln: 0.838 ± 0.026	0.926HisArg: 0.926 ± 0.027	1.315HisSer: 1.315 ± 0.034	1.041HisThr: 1.041 ± 0.027	1.278HisVal: 1.278 ± 0.033	0.259HisTrp: 0.259 ± 0.014	0.895HisTyr: 0.895 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.519IleAla: 5.519 ± 0.066	0.594IleCys: 0.594 ± 0.022	4.015IleAsp: 4.015 ± 0.055	5.344IleGlu: 5.344 ± 0.075	3.192IlePhe: 3.192 ± 0.052	5.774IleGly: 5.774 ± 0.071	1.609IleHis: 1.609 ± 0.034	5.274IleIle: 5.274 ± 0.079	4.528IleLys: 4.528 ± 0.052	7.299IleLeu: 7.299 ± 0.08	1.781IleMet: 1.781 ± 0.036	3.209IleAsn: 3.209 ± 0.053	3.336IlePro: 3.336 ± 0.051	2.709IleGln: 2.709 ± 0.045	3.111IleArg: 3.111 ± 0.047	5.069IleSer: 5.069 ± 0.056	3.98IleThr: 3.98 ± 0.051	4.961IleVal: 4.961 ± 0.06	0.664IleTrp: 0.664 ± 0.023	2.37IleTyr: 2.37 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	5.049LysAla: 5.049 ± 0.065	0.299LysCys: 0.299 ± 0.015	3.828LysAsp: 3.828 ± 0.056	6.634LysGlu: 6.634 ± 0.076	1.923LysPhe: 1.923 ± 0.035	4.791LysGly: 4.791 ± 0.061	1.187LysHis: 1.187 ± 0.027	4.539LysIle: 4.539 ± 0.053	5.504LysLys: 5.504 ± 0.066	5.599LysLeu: 5.599 ± 0.066	2.056LysMet: 2.056 ± 0.034	3.331LysAsn: 3.331 ± 0.044	2.292LysPro: 2.292 ± 0.046	2.725LysGln: 2.725 ± 0.036	3.091LysArg: 3.091 ± 0.042	3.397LysSer: 3.397 ± 0.054	3.577LysThr: 3.577 ± 0.052	4.642LysVal: 4.642 ± 0.06	0.864LysTrp: 0.864 ± 0.026	2.145LysTyr: 2.145 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	7.733LeuAla: 7.733 ± 0.084	0.709LeuCys: 0.709 ± 0.021	4.906LeuAsp: 4.906 ± 0.052	6.835LeuGlu: 6.835 ± 0.081	4.892LeuPhe: 4.892 ± 0.066	6.727LeuGly: 6.727 ± 0.07	1.849LeuHis: 1.849 ± 0.037	6.946LeuIle: 6.946 ± 0.085	6.839LeuLys: 6.839 ± 0.077	10.109LeuLeu: 10.109 ± 0.112	2.591LeuMet: 2.591 ± 0.045	4.384LeuAsn: 4.384 ± 0.063	4.181LeuPro: 4.181 ± 0.058	3.401LeuGln: 3.401 ± 0.051	3.709LeuArg: 3.709 ± 0.055	6.8LeuSer: 6.8 ± 0.075	5.493LeuThr: 5.493 ± 0.07	6.216LeuVal: 6.216 ± 0.064	0.92LeuTrp: 0.92 ± 0.026	3.209LeuTyr: 3.209 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.215MetAla: 2.215 ± 0.042	0.146MetCys: 0.146 ± 0.011	1.473MetAsp: 1.473 ± 0.032	2.096MetGlu: 2.096 ± 0.039	1.119MetPhe: 1.119 ± 0.027	1.943MetGly: 1.943 ± 0.04	0.425MetHis: 0.425 ± 0.016	2.074MetIle: 2.074 ± 0.039	2.367MetLys: 2.367 ± 0.041	2.581MetLeu: 2.581 ± 0.048	0.841MetMet: 0.841 ± 0.023	1.468MetAsn: 1.468 ± 0.031	1.076MetPro: 1.076 ± 0.023	0.805MetGln: 0.805 ± 0.024	0.981MetArg: 0.981 ± 0.027	1.595MetSer: 1.595 ± 0.031	1.469MetThr: 1.469 ± 0.029	1.892MetVal: 1.892 ± 0.042	0.217MetTrp: 0.217 ± 0.011	0.697MetTyr: 0.697 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.727AsnAla: 2.727 ± 0.048	0.31AsnCys: 0.31 ± 0.018	2.173AsnAsp: 2.173 ± 0.036	3.291AsnGlu: 3.291 ± 0.048	1.638AsnPhe: 1.638 ± 0.034	3.6AsnGly: 3.6 ± 0.049	1.039AsnHis: 1.039 ± 0.03	3.156AsnIle: 3.156 ± 0.049	2.771AsnLys: 2.771 ± 0.043	4.026AsnLeu: 4.026 ± 0.056	1.134AsnMet: 1.134 ± 0.031	1.809AsnAsn: 1.809 ± 0.041	2.29AsnPro: 2.29 ± 0.045	1.917AsnGln: 1.917 ± 0.041	2.046AsnArg: 2.046 ± 0.038	2.546AsnSer: 2.546 ± 0.045	2.1AsnThr: 2.1 ± 0.037	2.77AsnVal: 2.77 ± 0.048	0.609AsnTrp: 0.609 ± 0.022	1.518AsnTyr: 1.518 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	2.907ProAla: 2.907 ± 0.046	0.238ProCys: 0.238 ± 0.012	2.249ProAsp: 2.249 ± 0.039	3.443ProGlu: 3.443 ± 0.053	2.079ProPhe: 2.079 ± 0.038	2.782ProGly: 2.782 ± 0.047	0.798ProHis: 0.798 ± 0.022	2.519ProIle: 2.519 ± 0.041	2.111ProLys: 2.111 ± 0.043	3.655ProLeu: 3.655 ± 0.054	0.859ProMet: 0.859 ± 0.023	1.602ProAsn: 1.602 ± 0.034	1.067ProPro: 1.067 ± 0.033	1.122ProGln: 1.122 ± 0.023	1.236ProArg: 1.236 ± 0.035	2.315ProSer: 2.315 ± 0.041	1.717ProThr: 1.717 ± 0.032	3.454ProVal: 3.454 ± 0.221	0.428ProTrp: 0.428 ± 0.018	1.475ProTyr: 1.475 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.624GlnAla: 2.624 ± 0.044	0.203GlnCys: 0.203 ± 0.012	1.675GlnAsp: 1.675 ± 0.03	2.875GlnGlu: 2.875 ± 0.046	1.576GlnPhe: 1.576 ± 0.036	2.308GlnGly: 2.308 ± 0.037	0.746GlnHis: 0.746 ± 0.02	2.4GlnIle: 2.4 ± 0.04	2.526GlnLys: 2.526 ± 0.042	3.757GlnLeu: 3.757 ± 0.056	1.051GlnMet: 1.051 ± 0.025	1.61GlnAsn: 1.61 ± 0.03	1.226GlnPro: 1.226 ± 0.029	1.592GlnGln: 1.592 ± 0.038	1.441GlnArg: 1.441 ± 0.031	2.072GlnSer: 2.072 ± 0.038	1.871GlnThr: 1.871 ± 0.039	2.278GlnVal: 2.278 ± 0.043	0.407GlnTrp: 0.407 ± 0.016	1.368GlnTyr: 1.368 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.473ArgAla: 2.473 ± 0.039	0.256ArgCys: 0.256 ± 0.012	2.154ArgAsp: 2.154 ± 0.035	3.481ArgGlu: 3.481 ± 0.045	1.97ArgPhe: 1.97 ± 0.037	2.503ArgGly: 2.503 ± 0.044	0.857ArgHis: 0.857 ± 0.025	3.072ArgIle: 3.072 ± 0.048	3.216ArgLys: 3.216 ± 0.043	4.171ArgLeu: 4.171 ± 0.054	1.337ArgMet: 1.337 ± 0.031	2.033ArgAsn: 2.033 ± 0.033	1.414ArgPro: 1.414 ± 0.032	1.65ArgGln: 1.65 ± 0.034	1.896ArgArg: 1.896 ± 0.041	2.337ArgSer: 2.337 ± 0.041	2.176ArgThr: 2.176 ± 0.035	2.545ArgVal: 2.545 ± 0.043	0.466ArgTrp: 0.466 ± 0.016	1.597ArgTyr: 1.597 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.1SerAla: 4.1 ± 0.06	0.472SerCys: 0.472 ± 0.019	2.864SerAsp: 2.864 ± 0.047	4.042SerGlu: 4.042 ± 0.054	3.309SerPhe: 3.309 ± 0.048	4.845SerGly: 4.845 ± 0.062	1.259SerHis: 1.259 ± 0.029	4.87SerIle: 4.87 ± 0.07	3.765SerLys: 3.765 ± 0.058	6.536SerLeu: 6.536 ± 0.074	1.704SerMet: 1.704 ± 0.033	2.428SerAsn: 2.428 ± 0.045	2.344SerPro: 2.344 ± 0.059	2.045SerGln: 2.045 ± 0.044	2.593SerArg: 2.593 ± 0.039	4.16SerSer: 4.16 ± 0.054	2.995SerThr: 2.995 ± 0.045	4.174SerVal: 4.174 ± 0.052	0.746SerTrp: 0.746 ± 0.026	2.257SerTyr: 2.257 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.074ThrAla: 4.074 ± 0.048	0.348ThrCys: 0.348 ± 0.015	2.602ThrAsp: 2.602 ± 0.048	3.483ThrGlu: 3.483 ± 0.05	2.487ThrPhe: 2.487 ± 0.04	4.564ThrGly: 4.564 ± 0.082	0.963ThrHis: 0.963 ± 0.025	4.114ThrIle: 4.114 ± 0.052	2.984ThrLys: 2.984 ± 0.046	5.111ThrLeu: 5.111 ± 0.059	1.272ThrMet: 1.272 ± 0.028	2.197ThrAsn: 2.197 ± 0.044	2.195ThrPro: 2.195 ± 0.034	1.388ThrGln: 1.388 ± 0.032	1.933ThrArg: 1.933 ± 0.036	3.221ThrSer: 3.221 ± 0.049	2.489ThrThr: 2.489 ± 0.042	4.158ThrVal: 4.158 ± 0.047	0.521ThrTrp: 0.521 ± 0.02	1.845ThrTyr: 1.845 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	4.796ValAla: 4.796 ± 0.116	0.573ValCys: 0.573 ± 0.02	3.377ValAsp: 3.377 ± 0.043	4.545ValGlu: 4.545 ± 0.052	3.2ValPhe: 3.2 ± 0.049	4.373ValGly: 4.373 ± 0.077	1.404ValHis: 1.404 ± 0.031	5.351ValIle: 5.351 ± 0.072	4.683ValLys: 4.683 ± 0.059	6.753ValLeu: 6.753 ± 0.063	1.835ValMet: 1.835 ± 0.037	3.051ValAsn: 3.051 ± 0.046	2.891ValPro: 2.891 ± 0.044	2.271ValGln: 2.271 ± 0.037	2.625ValArg: 2.625 ± 0.044	4.675ValSer: 4.675 ± 0.073	3.991ValThr: 3.991 ± 0.058	4.462ValVal: 4.462 ± 0.058	0.68ValTrp: 0.68 ± 0.019	2.329ValTyr: 2.329 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.742TrpAla: 0.742 ± 0.024	0.09TrpCys: 0.09 ± 0.007	0.591TrpAsp: 0.591 ± 0.021	0.806TrpGlu: 0.806 ± 0.026	0.529TrpPhe: 0.529 ± 0.02	0.796TrpGly: 0.796 ± 0.026	0.243TrpHis: 0.243 ± 0.012	0.798TrpIle: 0.798 ± 0.023	0.812TrpLys: 0.812 ± 0.024	1.2TrpLeu: 1.2 ± 0.034	0.366TrpMet: 0.366 ± 0.017	0.584TrpAsn: 0.584 ± 0.019	0.293TrpPro: 0.293 ± 0.015	0.369TrpGln: 0.369 ± 0.018	0.455TrpArg: 0.455 ± 0.017	0.675TrpSer: 0.675 ± 0.019	0.563TrpThr: 0.563 ± 0.021	0.714TrpVal: 0.714 ± 0.021	0.154TrpTrp: 0.154 ± 0.011	0.41TrpTyr: 0.41 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.116TyrAla: 2.116 ± 0.043	0.302TyrCys: 0.302 ± 0.014	1.867TyrAsp: 1.867 ± 0.042	2.459TyrGlu: 2.459 ± 0.039	1.853TyrPhe: 1.853 ± 0.038	2.587TyrGly: 2.587 ± 0.045	0.891TyrHis: 0.891 ± 0.022	2.442TyrIle: 2.442 ± 0.044	2.167TyrLys: 2.167 ± 0.041	3.717TyrLeu: 3.717 ± 0.057	0.862TyrMet: 0.862 ± 0.026	1.463TyrAsn: 1.463 ± 0.032	1.503TyrPro: 1.503 ± 0.034	1.508TyrGln: 1.508 ± 0.035	1.729TyrArg: 1.729 ± 0.034	2.292TyrSer: 2.292 ± 0.042	1.781TyrThr: 1.781 ± 0.036	2.078TyrVal: 2.078 ± 0.043	0.446TyrTrp: 0.446 ± 0.017	1.44TyrTyr: 1.44 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 5324 proteins (1559474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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