Amino acid dipepetide frequency for Streptococcus phage Javan549

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.832AlaAla: 2.832 ± 0.966
0.442AlaCys: 0.442 ± 0.217
5.044AlaAsp: 5.044 ± 0.65
5.575AlaGlu: 5.575 ± 0.64
1.858AlaPhe: 1.858 ± 0.43
4.513AlaGly: 4.513 ± 0.655
0.708AlaHis: 0.708 ± 0.292
5.398AlaIle: 5.398 ± 0.516
6.725AlaLys: 6.725 ± 0.865
6.46AlaLeu: 6.46 ± 0.866
2.478AlaMet: 2.478 ± 0.543
3.982AlaAsn: 3.982 ± 0.635
1.15AlaPro: 1.15 ± 0.334
3.716AlaGln: 3.716 ± 0.799
3.628AlaArg: 3.628 ± 0.515
4.247AlaSer: 4.247 ± 0.842
6.283AlaThr: 6.283 ± 1.32
6.017AlaVal: 6.017 ± 0.892
0.796AlaTrp: 0.796 ± 0.284
2.212AlaTyr: 2.212 ± 0.558
0.0AlaXaa: 0.0 ± 0.0
Cys
0.177CysAla: 0.177 ± 0.122
0.177CysCys: 0.177 ± 0.126
0.265CysAsp: 0.265 ± 0.165
0.619CysGlu: 0.619 ± 0.231
0.442CysPhe: 0.442 ± 0.214
0.354CysGly: 0.354 ± 0.195
0.177CysHis: 0.177 ± 0.114
0.0CysIle: 0.0 ± 0.0
0.265CysLys: 0.265 ± 0.193
0.708CysLeu: 0.708 ± 0.255
0.088CysMet: 0.088 ± 0.11
0.088CysAsn: 0.088 ± 0.114
0.354CysPro: 0.354 ± 0.251
0.177CysGln: 0.177 ± 0.15
0.442CysArg: 0.442 ± 0.243
0.354CysSer: 0.354 ± 0.207
0.442CysThr: 0.442 ± 0.173
0.088CysVal: 0.088 ± 0.093
0.088CysTrp: 0.088 ± 0.076
0.265CysTyr: 0.265 ± 0.178
0.0CysXaa: 0.0 ± 0.0
Asp
3.982AspAla: 3.982 ± 0.569
0.265AspCys: 0.265 ± 0.18
3.363AspAsp: 3.363 ± 0.67
6.017AspGlu: 6.017 ± 0.997
2.743AspPhe: 2.743 ± 0.367
4.247AspGly: 4.247 ± 0.752
0.531AspHis: 0.531 ± 0.209
3.628AspIle: 3.628 ± 0.58
5.575AspLys: 5.575 ± 0.606
5.575AspLeu: 5.575 ± 0.584
1.681AspMet: 1.681 ± 0.505
4.247AspAsn: 4.247 ± 0.645
1.593AspPro: 1.593 ± 0.413
1.416AspGln: 1.416 ± 0.316
1.416AspArg: 1.416 ± 0.273
3.451AspSer: 3.451 ± 0.626
3.186AspThr: 3.186 ± 0.615
3.54AspVal: 3.54 ± 0.564
1.15AspTrp: 1.15 ± 0.47
3.186AspTyr: 3.186 ± 0.52
0.0AspXaa: 0.0 ± 0.0
Glu
5.486GluAla: 5.486 ± 0.61
0.265GluCys: 0.265 ± 0.168
3.451GluAsp: 3.451 ± 0.683
6.725GluGlu: 6.725 ± 0.761
2.743GluPhe: 2.743 ± 0.548
3.009GluGly: 3.009 ± 0.487
1.416GluHis: 1.416 ± 0.406
6.814GluIle: 6.814 ± 0.806
5.752GluLys: 5.752 ± 1.108
8.849GluLeu: 8.849 ± 1.34
2.124GluMet: 2.124 ± 0.581
3.716GluAsn: 3.716 ± 0.711
1.416GluPro: 1.416 ± 0.427
3.274GluGln: 3.274 ± 0.665
3.186GluArg: 3.186 ± 0.549
5.309GluSer: 5.309 ± 0.855
5.044GluThr: 5.044 ± 0.51
6.991GluVal: 6.991 ± 0.992
1.062GluTrp: 1.062 ± 0.292
2.478GluTyr: 2.478 ± 0.616
0.0GluXaa: 0.0 ± 0.0
Phe
2.389PheAla: 2.389 ± 0.383
0.265PheCys: 0.265 ± 0.181
2.832PheAsp: 2.832 ± 0.62
3.274PheGlu: 3.274 ± 0.514
0.796PhePhe: 0.796 ± 0.369
2.566PheGly: 2.566 ± 0.517
0.177PheHis: 0.177 ± 0.125
2.566PheIle: 2.566 ± 0.396
3.451PheLys: 3.451 ± 0.482
2.212PheLeu: 2.212 ± 0.555
1.15PheMet: 1.15 ± 0.384
2.301PheAsn: 2.301 ± 0.648
1.15PhePro: 1.15 ± 0.37
0.708PheGln: 0.708 ± 0.262
1.416PheArg: 1.416 ± 0.372
2.035PheSer: 2.035 ± 0.439
2.124PheThr: 2.124 ± 0.349
1.947PheVal: 1.947 ± 0.436
0.177PheTrp: 0.177 ± 0.131
2.035PheTyr: 2.035 ± 0.44
0.0PheXaa: 0.0 ± 0.0
Gly
2.743GlyAla: 2.743 ± 0.778
0.088GlyCys: 0.088 ± 0.076
2.389GlyAsp: 2.389 ± 0.429
3.805GlyGlu: 3.805 ± 0.494
2.035GlyPhe: 2.035 ± 0.43
3.274GlyGly: 3.274 ± 0.576
1.15GlyHis: 1.15 ± 0.338
4.07GlyIle: 4.07 ± 0.51
6.371GlyLys: 6.371 ± 0.831
5.752GlyLeu: 5.752 ± 0.908
2.301GlyMet: 2.301 ± 0.684
3.186GlyAsn: 3.186 ± 0.587
1.062GlyPro: 1.062 ± 0.343
2.92GlyGln: 2.92 ± 0.516
2.655GlyArg: 2.655 ± 0.441
2.655GlySer: 2.655 ± 0.523
3.009GlyThr: 3.009 ± 0.594
4.424GlyVal: 4.424 ± 0.555
0.973GlyTrp: 0.973 ± 0.233
2.389GlyTyr: 2.389 ± 0.422
0.0GlyXaa: 0.0 ± 0.0
His
0.531HisAla: 0.531 ± 0.213
0.0HisCys: 0.0 ± 0.0
0.885HisAsp: 0.885 ± 0.289
1.15HisGlu: 1.15 ± 0.285
0.531HisPhe: 0.531 ± 0.243
0.973HisGly: 0.973 ± 0.341
0.442HisHis: 0.442 ± 0.267
1.062HisIle: 1.062 ± 0.383
0.885HisLys: 0.885 ± 0.327
0.796HisLeu: 0.796 ± 0.278
0.265HisMet: 0.265 ± 0.152
0.619HisAsn: 0.619 ± 0.246
0.708HisPro: 0.708 ± 0.189
0.265HisGln: 0.265 ± 0.167
0.885HisArg: 0.885 ± 0.301
0.973HisSer: 0.973 ± 0.286
1.062HisThr: 1.062 ± 0.317
0.531HisVal: 0.531 ± 0.304
0.265HisTrp: 0.265 ± 0.16
0.531HisTyr: 0.531 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
5.84IleAla: 5.84 ± 0.553
0.619IleCys: 0.619 ± 0.319
4.159IleAsp: 4.159 ± 0.595
5.575IleGlu: 5.575 ± 0.569
1.504IlePhe: 1.504 ± 0.426
3.54IleGly: 3.54 ± 0.536
0.796IleHis: 0.796 ± 0.244
3.893IleIle: 3.893 ± 0.622
4.955IleLys: 4.955 ± 0.796
5.575IleLeu: 5.575 ± 0.671
1.416IleMet: 1.416 ± 0.463
4.955IleAsn: 4.955 ± 0.914
1.858IlePro: 1.858 ± 0.403
1.239IleGln: 1.239 ± 0.332
2.301IleArg: 2.301 ± 0.608
4.336IleSer: 4.336 ± 0.456
4.867IleThr: 4.867 ± 0.752
3.451IleVal: 3.451 ± 0.536
0.619IleTrp: 0.619 ± 0.26
2.212IleTyr: 2.212 ± 0.462
0.0IleXaa: 0.0 ± 0.0
Lys
6.814LysAla: 6.814 ± 0.877
0.619LysCys: 0.619 ± 0.302
4.513LysAsp: 4.513 ± 0.548
7.433LysGlu: 7.433 ± 1.412
3.274LysPhe: 3.274 ± 0.551
4.247LysGly: 4.247 ± 0.643
1.593LysHis: 1.593 ± 0.359
4.601LysIle: 4.601 ± 0.823
6.283LysLys: 6.283 ± 0.937
6.283LysLeu: 6.283 ± 0.933
2.212LysMet: 2.212 ± 0.387
4.159LysAsn: 4.159 ± 0.587
2.389LysPro: 2.389 ± 0.444
4.247LysGln: 4.247 ± 0.548
3.451LysArg: 3.451 ± 0.811
3.982LysSer: 3.982 ± 0.746
7.61LysThr: 7.61 ± 0.958
5.663LysVal: 5.663 ± 0.626
1.062LysTrp: 1.062 ± 0.31
3.097LysTyr: 3.097 ± 0.634
0.0LysXaa: 0.0 ± 0.0
Leu
7.344LeuAla: 7.344 ± 1.127
0.088LeuCys: 0.088 ± 0.096
6.902LeuAsp: 6.902 ± 0.641
7.521LeuGlu: 7.521 ± 1.177
2.92LeuPhe: 2.92 ± 0.578
4.601LeuGly: 4.601 ± 1.148
0.973LeuHis: 0.973 ± 0.312
4.247LeuIle: 4.247 ± 0.442
7.964LeuLys: 7.964 ± 1.222
7.964LeuLeu: 7.964 ± 0.91
1.504LeuMet: 1.504 ± 0.401
5.132LeuAsn: 5.132 ± 0.744
1.593LeuPro: 1.593 ± 0.442
3.363LeuGln: 3.363 ± 0.48
3.716LeuArg: 3.716 ± 0.513
7.079LeuSer: 7.079 ± 0.547
6.548LeuThr: 6.548 ± 0.755
4.601LeuVal: 4.601 ± 0.725
0.619LeuTrp: 0.619 ± 0.246
3.097LeuTyr: 3.097 ± 0.497
0.0LeuXaa: 0.0 ± 0.0
Met
1.593MetAla: 1.593 ± 0.398
0.265MetCys: 0.265 ± 0.189
1.062MetAsp: 1.062 ± 0.328
1.593MetGlu: 1.593 ± 0.487
0.885MetPhe: 0.885 ± 0.301
0.973MetGly: 0.973 ± 0.326
0.354MetHis: 0.354 ± 0.174
1.327MetIle: 1.327 ± 0.381
2.301MetLys: 2.301 ± 0.661
2.478MetLeu: 2.478 ± 0.558
0.442MetMet: 0.442 ± 0.233
1.593MetAsn: 1.593 ± 0.387
0.442MetPro: 0.442 ± 0.194
1.327MetGln: 1.327 ± 0.307
0.708MetArg: 0.708 ± 0.253
1.858MetSer: 1.858 ± 0.501
2.832MetThr: 2.832 ± 0.687
1.77MetVal: 1.77 ± 0.379
0.265MetTrp: 0.265 ± 0.145
0.619MetTyr: 0.619 ± 0.265
0.0MetXaa: 0.0 ± 0.0
Asn
5.132AsnAla: 5.132 ± 0.906
0.0AsnCys: 0.0 ± 0.0
2.92AsnAsp: 2.92 ± 0.499
4.159AsnGlu: 4.159 ± 0.686
2.566AsnPhe: 2.566 ± 0.63
3.893AsnGly: 3.893 ± 0.522
0.619AsnHis: 0.619 ± 0.201
3.186AsnIle: 3.186 ± 0.543
4.159AsnLys: 4.159 ± 0.674
4.955AsnLeu: 4.955 ± 0.614
1.327AsnMet: 1.327 ± 0.298
3.363AsnAsn: 3.363 ± 0.589
2.655AsnPro: 2.655 ± 0.614
2.389AsnGln: 2.389 ± 0.562
1.504AsnArg: 1.504 ± 0.421
3.805AsnSer: 3.805 ± 0.673
3.186AsnThr: 3.186 ± 0.728
3.451AsnVal: 3.451 ± 0.517
0.708AsnTrp: 0.708 ± 0.249
2.655AsnTyr: 2.655 ± 0.464
0.0AsnXaa: 0.0 ± 0.0
Pro
1.77ProAla: 1.77 ± 0.369
0.0ProCys: 0.0 ± 0.0
2.212ProAsp: 2.212 ± 0.529
1.77ProGlu: 1.77 ± 0.348
1.593ProPhe: 1.593 ± 0.445
0.885ProGly: 0.885 ± 0.306
0.177ProHis: 0.177 ± 0.116
1.327ProIle: 1.327 ± 0.301
1.77ProLys: 1.77 ± 0.385
2.566ProLeu: 2.566 ± 0.529
0.531ProMet: 0.531 ± 0.222
1.15ProAsn: 1.15 ± 0.396
0.973ProPro: 0.973 ± 0.43
0.973ProGln: 0.973 ± 0.32
1.681ProArg: 1.681 ± 0.515
1.593ProSer: 1.593 ± 0.478
2.212ProThr: 2.212 ± 0.494
2.035ProVal: 2.035 ± 0.426
0.354ProTrp: 0.354 ± 0.158
1.416ProTyr: 1.416 ± 0.403
0.0ProXaa: 0.0 ± 0.0
Gln
3.363GlnAla: 3.363 ± 0.563
0.177GlnCys: 0.177 ± 0.124
0.973GlnAsp: 0.973 ± 0.297
3.186GlnGlu: 3.186 ± 0.631
1.947GlnPhe: 1.947 ± 0.45
1.947GlnGly: 1.947 ± 0.359
0.442GlnHis: 0.442 ± 0.313
2.92GlnIle: 2.92 ± 0.556
2.832GlnLys: 2.832 ± 0.776
4.601GlnLeu: 4.601 ± 0.752
0.885GlnMet: 0.885 ± 0.258
2.478GlnAsn: 2.478 ± 0.601
0.531GlnPro: 0.531 ± 0.228
1.416GlnGln: 1.416 ± 0.46
2.124GlnArg: 2.124 ± 0.454
3.186GlnSer: 3.186 ± 0.723
3.009GlnThr: 3.009 ± 0.697
2.655GlnVal: 2.655 ± 0.623
0.265GlnTrp: 0.265 ± 0.154
1.239GlnTyr: 1.239 ± 0.3
0.0GlnXaa: 0.0 ± 0.0
Arg
2.389ArgAla: 2.389 ± 0.477
0.354ArgCys: 0.354 ± 0.22
2.655ArgAsp: 2.655 ± 0.601
2.655ArgGlu: 2.655 ± 0.672
0.973ArgPhe: 0.973 ± 0.3
2.743ArgGly: 2.743 ± 0.438
0.442ArgHis: 0.442 ± 0.221
3.54ArgIle: 3.54 ± 0.654
4.69ArgLys: 4.69 ± 0.936
2.92ArgLeu: 2.92 ± 0.479
1.15ArgMet: 1.15 ± 0.337
2.832ArgAsn: 2.832 ± 0.362
1.416ArgPro: 1.416 ± 0.379
1.77ArgGln: 1.77 ± 0.351
2.212ArgArg: 2.212 ± 0.477
1.947ArgSer: 1.947 ± 0.433
2.655ArgThr: 2.655 ± 0.876
2.389ArgVal: 2.389 ± 0.513
0.885ArgTrp: 0.885 ± 0.294
2.035ArgTyr: 2.035 ± 0.427
0.0ArgXaa: 0.0 ± 0.0
Ser
5.929SerAla: 5.929 ± 1.075
0.265SerCys: 0.265 ± 0.147
4.778SerAsp: 4.778 ± 0.79
5.132SerGlu: 5.132 ± 0.757
2.478SerPhe: 2.478 ± 0.589
3.893SerGly: 3.893 ± 0.726
0.708SerHis: 0.708 ± 0.249
3.893SerIle: 3.893 ± 0.617
4.424SerLys: 4.424 ± 0.635
4.867SerLeu: 4.867 ± 0.523
0.885SerMet: 0.885 ± 0.247
3.097SerAsn: 3.097 ± 0.495
2.212SerPro: 2.212 ± 0.523
2.301SerGln: 2.301 ± 0.416
2.92SerArg: 2.92 ± 0.578
3.716SerSer: 3.716 ± 0.582
3.54SerThr: 3.54 ± 0.767
3.805SerVal: 3.805 ± 0.553
0.531SerTrp: 0.531 ± 0.195
2.832SerTyr: 2.832 ± 0.466
0.0SerXaa: 0.0 ± 0.0
Thr
6.46ThrAla: 6.46 ± 1.023
0.177ThrCys: 0.177 ± 0.133
3.716ThrAsp: 3.716 ± 0.686
4.513ThrGlu: 4.513 ± 0.74
2.92ThrPhe: 2.92 ± 0.558
4.69ThrGly: 4.69 ± 0.593
1.062ThrHis: 1.062 ± 0.299
4.778ThrIle: 4.778 ± 0.689
5.221ThrLys: 5.221 ± 0.521
4.955ThrLeu: 4.955 ± 0.671
1.593ThrMet: 1.593 ± 0.482
3.451ThrAsn: 3.451 ± 0.534
2.389ThrPro: 2.389 ± 0.574
3.451ThrGln: 3.451 ± 0.562
2.743ThrArg: 2.743 ± 0.464
3.982ThrSer: 3.982 ± 0.662
4.69ThrThr: 4.69 ± 0.977
5.929ThrVal: 5.929 ± 1.204
0.619ThrTrp: 0.619 ± 0.184
2.035ThrTyr: 2.035 ± 0.371
0.0ThrXaa: 0.0 ± 0.0
Val
5.575ValAla: 5.575 ± 0.748
0.442ValCys: 0.442 ± 0.271
5.398ValAsp: 5.398 ± 0.653
5.132ValGlu: 5.132 ± 0.775
1.593ValPhe: 1.593 ± 0.36
4.513ValGly: 4.513 ± 0.542
0.796ValHis: 0.796 ± 0.237
3.274ValIle: 3.274 ± 0.73
5.575ValLys: 5.575 ± 0.704
5.752ValLeu: 5.752 ± 1.042
0.973ValMet: 0.973 ± 0.34
3.451ValAsn: 3.451 ± 0.585
1.593ValPro: 1.593 ± 0.499
2.743ValGln: 2.743 ± 0.448
3.097ValArg: 3.097 ± 0.404
5.221ValSer: 5.221 ± 0.785
4.424ValThr: 4.424 ± 0.638
4.424ValVal: 4.424 ± 0.692
0.619ValTrp: 0.619 ± 0.27
2.035ValTyr: 2.035 ± 0.623
0.0ValXaa: 0.0 ± 0.0
Trp
0.973TrpAla: 0.973 ± 0.273
0.442TrpCys: 0.442 ± 0.233
0.354TrpAsp: 0.354 ± 0.184
0.885TrpGlu: 0.885 ± 0.276
0.354TrpPhe: 0.354 ± 0.159
0.619TrpGly: 0.619 ± 0.289
0.088TrpHis: 0.088 ± 0.076
0.885TrpIle: 0.885 ± 0.265
1.15TrpLys: 1.15 ± 0.396
1.239TrpLeu: 1.239 ± 0.39
0.265TrpMet: 0.265 ± 0.147
0.796TrpAsn: 0.796 ± 0.303
0.088TrpPro: 0.088 ± 0.085
0.265TrpGln: 0.265 ± 0.136
0.708TrpArg: 0.708 ± 0.376
0.531TrpSer: 0.531 ± 0.218
0.531TrpThr: 0.531 ± 0.225
0.796TrpVal: 0.796 ± 0.238
0.0TrpTrp: 0.0 ± 0.0
0.796TrpTyr: 0.796 ± 0.251
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.743TyrAla: 2.743 ± 0.52
0.619TyrCys: 0.619 ± 0.199
2.92TyrAsp: 2.92 ± 0.659
2.389TyrGlu: 2.389 ± 0.497
1.504TyrPhe: 1.504 ± 0.334
1.77TyrGly: 1.77 ± 0.449
0.708TyrHis: 0.708 ± 0.318
2.301TyrIle: 2.301 ± 0.613
3.186TyrLys: 3.186 ± 0.494
3.274TyrLeu: 3.274 ± 0.494
1.327TyrMet: 1.327 ± 0.537
2.035TyrAsn: 2.035 ± 0.493
1.416TyrPro: 1.416 ± 0.336
2.212TyrGln: 2.212 ± 0.41
1.858TyrArg: 1.858 ± 0.476
1.947TyrSer: 1.947 ± 0.426
2.124TyrThr: 2.124 ± 0.364
2.124TyrVal: 2.124 ± 0.483
0.708TyrTrp: 0.708 ± 0.252
0.973TyrTyr: 0.973 ± 0.244
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (11302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski