Amino acid dipepetide frequency for Trichoderma harzianum CBS 226.95

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.434AlaAla: 9.434 ± 0.064	1.15AlaCys: 1.15 ± 0.017	4.243AlaAsp: 4.243 ± 0.027	5.027AlaGlu: 5.027 ± 0.038	3.2AlaPhe: 3.2 ± 0.026	5.6AlaGly: 5.6 ± 0.039	1.754AlaHis: 1.754 ± 0.019	4.655AlaIle: 4.655 ± 0.031	4.211AlaLys: 4.211 ± 0.031	7.717AlaLeu: 7.717 ± 0.046	2.032AlaMet: 2.032 ± 0.019	3.077AlaAsn: 3.077 ± 0.024	4.53AlaPro: 4.53 ± 0.04	3.389AlaGln: 3.389 ± 0.029	4.68AlaArg: 4.68 ± 0.032	7.466AlaSer: 7.466 ± 0.048	5.261AlaThr: 5.261 ± 0.031	5.43AlaVal: 5.43 ± 0.032	1.219AlaTrp: 1.219 ± 0.017	2.178AlaTyr: 2.178 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.973CysAla: 0.973 ± 0.014	0.307CysCys: 0.307 ± 0.009	0.738CysAsp: 0.738 ± 0.014	0.614CysGlu: 0.614 ± 0.011	0.624CysPhe: 0.624 ± 0.012	1.003CysGly: 1.003 ± 0.018	0.37CysHis: 0.37 ± 0.008	0.814CysIle: 0.814 ± 0.012	0.559CysLys: 0.559 ± 0.011	1.379CysLeu: 1.379 ± 0.017	0.289CysMet: 0.289 ± 0.008	0.486CysAsn: 0.486 ± 0.01	0.7CysPro: 0.7 ± 0.014	0.514CysGln: 0.514 ± 0.01	0.824CysArg: 0.824 ± 0.013	1.055CysSer: 1.055 ± 0.015	0.747CysThr: 0.747 ± 0.012	0.83CysVal: 0.83 ± 0.016	0.231CysTrp: 0.231 ± 0.007	0.396CysTyr: 0.396 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.864AspAla: 4.864 ± 0.032	0.672AspCys: 0.672 ± 0.012	4.345AspAsp: 4.345 ± 0.04	4.54AspGlu: 4.54 ± 0.04	2.234AspPhe: 2.234 ± 0.019	4.199AspGly: 4.199 ± 0.028	1.213AspHis: 1.213 ± 0.015	3.277AspIle: 3.277 ± 0.026	2.552AspLys: 2.552 ± 0.023	4.902AspLeu: 4.902 ± 0.033	1.299AspMet: 1.299 ± 0.015	1.969AspAsn: 1.969 ± 0.021	3.065AspPro: 3.065 ± 0.025	1.848AspGln: 1.848 ± 0.016	2.876AspArg: 2.876 ± 0.026	4.12AspSer: 4.12 ± 0.034	2.853AspThr: 2.853 ± 0.022	3.751AspVal: 3.751 ± 0.028	0.897AspTrp: 0.897 ± 0.012	1.616AspTyr: 1.616 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.528GluAla: 5.528 ± 0.041	0.657GluCys: 0.657 ± 0.013	4.076GluAsp: 4.076 ± 0.035	5.274GluGlu: 5.274 ± 0.053	1.985GluPhe: 1.985 ± 0.019	3.462GluGly: 3.462 ± 0.024	1.365GluHis: 1.365 ± 0.016	3.12GluIle: 3.12 ± 0.028	3.621GluLys: 3.621 ± 0.031	5.193GluLeu: 5.193 ± 0.036	1.507GluMet: 1.507 ± 0.017	2.224GluAsn: 2.224 ± 0.018	2.689GluPro: 2.689 ± 0.026	2.422GluGln: 2.422 ± 0.022	3.643GluArg: 3.643 ± 0.03	4.185GluSer: 4.185 ± 0.03	3.448GluThr: 3.448 ± 0.028	3.369GluVal: 3.369 ± 0.029	0.906GluTrp: 0.906 ± 0.015	1.674GluTyr: 1.674 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.121PheAla: 3.121 ± 0.025	0.633PheCys: 0.633 ± 0.011	2.334PheAsp: 2.334 ± 0.022	2.109PheGlu: 2.109 ± 0.018	1.831PhePhe: 1.831 ± 0.022	2.884PheGly: 2.884 ± 0.026	0.941PheHis: 0.941 ± 0.013	2.036PheIle: 2.036 ± 0.022	1.557PheLys: 1.557 ± 0.018	3.55PheLeu: 3.55 ± 0.029	0.819PheMet: 0.819 ± 0.013	1.521PheAsn: 1.521 ± 0.018	1.986PhePro: 1.986 ± 0.02	1.457PheGln: 1.457 ± 0.014	1.958PheArg: 1.958 ± 0.017	3.158PheSer: 3.158 ± 0.025	2.194PheThr: 2.194 ± 0.021	2.446PheVal: 2.446 ± 0.023	0.681PheTrp: 0.681 ± 0.011	1.163PheTyr: 1.163 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.199GlyAla: 5.199 ± 0.037	0.93GlyCys: 0.93 ± 0.014	3.664GlyAsp: 3.664 ± 0.027	3.56GlyGlu: 3.56 ± 0.031	2.817GlyPhe: 2.817 ± 0.026	5.519GlyGly: 5.519 ± 0.053	1.705GlyHis: 1.705 ± 0.02	3.725GlyIle: 3.725 ± 0.028	3.458GlyLys: 3.458 ± 0.028	6.039GlyLeu: 6.039 ± 0.034	1.552GlyMet: 1.552 ± 0.016	2.589GlyAsn: 2.589 ± 0.025	3.23GlyPro: 3.23 ± 0.026	2.55GlyGln: 2.55 ± 0.024	3.992GlyArg: 3.992 ± 0.027	5.691GlySer: 5.691 ± 0.035	3.849GlyThr: 3.849 ± 0.028	4.223GlyVal: 4.223 ± 0.032	1.181GlyTrp: 1.181 ± 0.015	2.13GlyTyr: 2.13 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.751HisAla: 1.751 ± 0.015	0.36HisCys: 0.36 ± 0.009	1.371HisAsp: 1.371 ± 0.013	1.304HisGlu: 1.304 ± 0.015	0.958HisPhe: 0.958 ± 0.013	1.729HisGly: 1.729 ± 0.02	0.904HisHis: 0.904 ± 0.017	1.293HisIle: 1.293 ± 0.015	0.97HisLys: 0.97 ± 0.013	2.304HisLeu: 2.304 ± 0.021	0.542HisMet: 0.542 ± 0.01	0.865HisAsn: 0.865 ± 0.011	1.554HisPro: 1.554 ± 0.017	1.058HisGln: 1.058 ± 0.015	1.503HisArg: 1.503 ± 0.016	1.814HisSer: 1.814 ± 0.021	1.225HisThr: 1.225 ± 0.016	1.454HisVal: 1.454 ± 0.016	0.374HisTrp: 0.374 ± 0.008	0.703HisTyr: 0.703 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.392IleAla: 4.392 ± 0.03	0.84IleCys: 0.84 ± 0.013	3.023IleAsp: 3.023 ± 0.025	2.984IleGlu: 2.984 ± 0.025	2.172IlePhe: 2.172 ± 0.021	3.37IleGly: 3.37 ± 0.026	1.326IleHis: 1.326 ± 0.016	2.844IleIle: 2.844 ± 0.025	2.379IleLys: 2.379 ± 0.024	4.812IleLeu: 4.812 ± 0.034	1.101IleMet: 1.101 ± 0.014	2.011IleAsn: 2.011 ± 0.018	3.13IlePro: 3.13 ± 0.026	2.07IleGln: 2.07 ± 0.021	2.931IleArg: 2.931 ± 0.027	4.179IleSer: 4.179 ± 0.03	2.984IleThr: 2.984 ± 0.022	3.277IleVal: 3.277 ± 0.026	0.804IleTrp: 0.804 ± 0.013	1.513IleTyr: 1.513 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.365LysAla: 4.365 ± 0.032	0.533LysCys: 0.533 ± 0.012	2.829LysAsp: 2.829 ± 0.025	3.323LysGlu: 3.323 ± 0.031	1.538LysPhe: 1.538 ± 0.016	2.944LysGly: 2.944 ± 0.026	1.127LysHis: 1.127 ± 0.013	2.418LysIle: 2.418 ± 0.02	3.349LysLys: 3.349 ± 0.036	4.269LysLeu: 4.269 ± 0.031	1.066LysMet: 1.066 ± 0.015	1.761LysAsn: 1.761 ± 0.018	2.684LysPro: 2.684 ± 0.024	1.898LysGln: 1.898 ± 0.021	3.291LysArg: 3.291 ± 0.029	3.554LysSer: 3.554 ± 0.023	2.924LysThr: 2.924 ± 0.023	2.781LysVal: 2.781 ± 0.023	0.7LysTrp: 0.7 ± 0.011	1.423LysTyr: 1.423 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.958LeuAla: 7.958 ± 0.043	1.323LeuCys: 1.323 ± 0.016	5.294LeuAsp: 5.294 ± 0.029	5.408LeuGlu: 5.408 ± 0.033	3.493LeuPhe: 3.493 ± 0.031	5.981LeuGly: 5.981 ± 0.035	2.249LeuHis: 2.249 ± 0.022	4.232LeuIle: 4.232 ± 0.028	4.251LeuLys: 4.251 ± 0.027	8.648LeuLeu: 8.648 ± 0.052	1.847LeuMet: 1.847 ± 0.018	3.217LeuAsn: 3.217 ± 0.024	5.402LeuPro: 5.402 ± 0.033	3.938LeuGln: 3.938 ± 0.031	5.62LeuArg: 5.62 ± 0.033	7.479LeuSer: 7.479 ± 0.041	4.752LeuThr: 4.752 ± 0.029	5.559LeuVal: 5.559 ± 0.036	1.283LeuTrp: 1.283 ± 0.017	2.436LeuTyr: 2.436 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.376MetAla: 2.376 ± 0.021	0.272MetCys: 0.272 ± 0.007	1.299MetAsp: 1.299 ± 0.016	1.308MetGlu: 1.308 ± 0.015	0.742MetPhe: 0.742 ± 0.012	1.47MetGly: 1.47 ± 0.019	0.485MetHis: 0.485 ± 0.009	1.055MetIle: 1.055 ± 0.013	1.036MetLys: 1.036 ± 0.013	1.919MetLeu: 1.919 ± 0.018	0.627MetMet: 0.627 ± 0.011	0.822MetAsn: 0.822 ± 0.013	1.32MetPro: 1.32 ± 0.015	0.877MetGln: 0.877 ± 0.013	1.292MetArg: 1.292 ± 0.016	1.87MetSer: 1.87 ± 0.018	1.303MetThr: 1.303 ± 0.015	1.314MetVal: 1.314 ± 0.015	0.273MetTrp: 0.273 ± 0.006	0.549MetTyr: 0.549 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.12AsnAla: 3.12 ± 0.023	0.493AsnCys: 0.493 ± 0.009	2.025AsnAsp: 2.025 ± 0.018	2.012AsnGlu: 2.012 ± 0.016	1.431AsnPhe: 1.431 ± 0.016	3.033AsnGly: 3.033 ± 0.027	0.881AsnHis: 0.881 ± 0.012	2.201AsnIle: 2.201 ± 0.018	1.658AsnLys: 1.658 ± 0.016	3.334AsnLeu: 3.334 ± 0.023	0.902AsnMet: 0.902 ± 0.012	1.603AsnAsn: 1.603 ± 0.022	2.363AsnPro: 2.363 ± 0.022	1.368AsnGln: 1.368 ± 0.016	1.951AsnArg: 1.951 ± 0.018	2.818AsnSer: 2.818 ± 0.025	2.182AsnThr: 2.182 ± 0.021	2.313AsnVal: 2.313 ± 0.019	0.594AsnTrp: 0.594 ± 0.009	1.108AsnTyr: 1.108 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.839ProAla: 4.839 ± 0.038	0.617ProCys: 0.617 ± 0.012	3.127ProAsp: 3.127 ± 0.024	3.654ProGlu: 3.654 ± 0.025	2.103ProPhe: 2.103 ± 0.018	3.727ProGly: 3.727 ± 0.029	1.268ProHis: 1.268 ± 0.015	2.589ProIle: 2.589 ± 0.022	2.642ProLys: 2.642 ± 0.023	4.806ProLeu: 4.806 ± 0.034	1.105ProMet: 1.105 ± 0.014	2.217ProAsn: 2.217 ± 0.02	4.756ProPro: 4.756 ± 0.066	2.38ProGln: 2.38 ± 0.028	3.215ProArg: 3.215 ± 0.027	5.65ProSer: 5.65 ± 0.043	3.692ProThr: 3.692 ± 0.032	3.429ProVal: 3.429 ± 0.029	0.776ProTrp: 0.776 ± 0.012	1.463ProTyr: 1.463 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.51GlnAla: 3.51 ± 0.031	0.491GlnCys: 0.491 ± 0.01	2.122GlnAsp: 2.122 ± 0.02	2.37GlnGlu: 2.37 ± 0.023	1.374GlnPhe: 1.374 ± 0.017	2.464GlnGly: 2.464 ± 0.025	1.082GlnHis: 1.082 ± 0.016	1.933GlnIle: 1.933 ± 0.018	1.971GlnLys: 1.971 ± 0.019	3.644GlnLeu: 3.644 ± 0.028	0.907GlnMet: 0.907 ± 0.014	1.545GlnAsn: 1.545 ± 0.016	2.506GlnPro: 2.506 ± 0.029	2.544GlnGln: 2.544 ± 0.053	2.594GlnArg: 2.594 ± 0.021	3.096GlnSer: 3.096 ± 0.023	2.268GlnThr: 2.268 ± 0.019	2.194GlnVal: 2.194 ± 0.019	0.619GlnTrp: 0.619 ± 0.009	1.172GlnTyr: 1.172 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.471ArgAla: 4.471 ± 0.031	0.792ArgCys: 0.792 ± 0.013	3.328ArgAsp: 3.328 ± 0.029	3.616ArgGlu: 3.616 ± 0.031	2.151ArgPhe: 2.151 ± 0.019	3.638ArgGly: 3.638 ± 0.031	1.587ArgHis: 1.587 ± 0.017	2.99ArgIle: 2.99 ± 0.021	3.21ArgLys: 3.21 ± 0.026	5.544ArgLeu: 5.544 ± 0.039	1.283ArgMet: 1.283 ± 0.013	2.208ArgAsn: 2.208 ± 0.021	3.376ArgPro: 3.376 ± 0.031	2.598ArgGln: 2.598 ± 0.02	4.877ArgArg: 4.877 ± 0.041	4.536ArgSer: 4.536 ± 0.042	3.033ArgThr: 3.033 ± 0.022	3.28ArgVal: 3.28 ± 0.022	0.931ArgTrp: 0.931 ± 0.013	1.655ArgTyr: 1.655 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.507SerAla: 6.507 ± 0.04	1.023SerCys: 1.023 ± 0.015	4.152SerAsp: 4.152 ± 0.03	4.037SerGlu: 4.037 ± 0.031	3.19SerPhe: 3.19 ± 0.025	5.518SerGly: 5.518 ± 0.039	2.011SerHis: 2.011 ± 0.02	4.278SerIle: 4.278 ± 0.031	3.776SerLys: 3.776 ± 0.031	7.449SerLeu: 7.449 ± 0.04	1.759SerMet: 1.759 ± 0.019	3.046SerAsn: 3.046 ± 0.023	5.193SerPro: 5.193 ± 0.038	3.367SerGln: 3.367 ± 0.028	4.983SerArg: 4.983 ± 0.04	8.661SerSer: 8.661 ± 0.068	5.309SerThr: 5.309 ± 0.038	4.588SerVal: 4.588 ± 0.032	1.234SerTrp: 1.234 ± 0.016	2.135SerTyr: 2.135 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.15ThrAla: 5.15 ± 0.03	0.807ThrCys: 0.807 ± 0.014	2.788ThrAsp: 2.788 ± 0.022	3.053ThrGlu: 3.053 ± 0.026	2.253ThrPhe: 2.253 ± 0.02	4.086ThrGly: 4.086 ± 0.032	1.233ThrHis: 1.233 ± 0.015	3.242ThrIle: 3.242 ± 0.031	2.649ThrLys: 2.649 ± 0.022	5.194ThrLeu: 5.194 ± 0.034	1.201ThrMet: 1.201 ± 0.014	2.142ThrAsn: 2.142 ± 0.02	3.947ThrPro: 3.947 ± 0.032	2.039ThrGln: 2.039 ± 0.02	3.023ThrArg: 3.023 ± 0.023	5.077ThrSer: 5.077 ± 0.037	4.056ThrThr: 4.056 ± 0.039	3.648ThrVal: 3.648 ± 0.027	0.893ThrTrp: 0.893 ± 0.012	1.635ThrTyr: 1.635 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.298ValAla: 5.298 ± 0.03	0.889ValCys: 0.889 ± 0.016	3.681ValAsp: 3.681 ± 0.027	3.715ValGlu: 3.715 ± 0.025	2.471ValPhe: 2.471 ± 0.02	3.908ValGly: 3.908 ± 0.031	1.374ValHis: 1.374 ± 0.015	3.111ValIle: 3.111 ± 0.023	2.929ValLys: 2.929 ± 0.024	5.546ValLeu: 5.546 ± 0.035	1.333ValMet: 1.333 ± 0.015	2.26ValAsn: 2.26 ± 0.02	3.473ValPro: 3.473 ± 0.027	2.378ValGln: 2.378 ± 0.02	3.273ValArg: 3.273 ± 0.021	4.645ValSer: 4.645 ± 0.03	3.513ValThr: 3.513 ± 0.027	4.297ValVal: 4.297 ± 0.034	0.888ValTrp: 0.888 ± 0.014	1.724ValTyr: 1.724 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.229TrpAla: 1.229 ± 0.018	0.208TrpCys: 0.208 ± 0.006	0.981TrpAsp: 0.981 ± 0.017	0.869TrpGlu: 0.869 ± 0.012	0.57TrpPhe: 0.57 ± 0.011	0.968TrpGly: 0.968 ± 0.014	0.385TrpHis: 0.385 ± 0.009	0.839TrpIle: 0.839 ± 0.014	0.819TrpLys: 0.819 ± 0.012	1.424TrpLeu: 1.424 ± 0.017	0.383TrpMet: 0.383 ± 0.008	0.68TrpAsn: 0.68 ± 0.014	0.655TrpPro: 0.655 ± 0.012	0.597TrpGln: 0.597 ± 0.011	0.98TrpArg: 0.98 ± 0.012	1.081TrpSer: 1.081 ± 0.015	0.953TrpThr: 0.953 ± 0.012	0.899TrpVal: 0.899 ± 0.012	0.296TrpTrp: 0.296 ± 0.008	0.431TrpTyr: 0.431 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.167TyrAla: 2.167 ± 0.023	0.457TyrCys: 0.457 ± 0.009	1.672TyrAsp: 1.672 ± 0.019	1.57TyrGlu: 1.57 ± 0.016	1.242TyrPhe: 1.242 ± 0.014	2.101TyrGly: 2.101 ± 0.021	0.777TyrHis: 0.777 ± 0.012	1.491TyrIle: 1.491 ± 0.018	1.179TyrLys: 1.179 ± 0.017	2.697TyrLeu: 2.697 ± 0.023	0.652TyrMet: 0.652 ± 0.011	1.147TyrAsn: 1.147 ± 0.014	1.495TyrPro: 1.495 ± 0.016	1.118TyrGln: 1.118 ± 0.014	1.599TyrArg: 1.599 ± 0.016	2.079TyrSer: 2.079 ± 0.021	1.569TyrThr: 1.569 ± 0.016	1.626TyrVal: 1.626 ± 0.018	0.468TyrTrp: 0.468 ± 0.009	0.96TyrTyr: 0.96 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.024XaaXaa: 0.024 ± 0.013

Statistics based on 14049 proteins (6187755 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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