Amino acid dipepetide frequency for Saccharomonospora xinjiangensis XJ-54

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.663AlaAla: 18.663 ± 0.177	1.082AlaCys: 1.082 ± 0.03	8.722AlaAsp: 8.722 ± 0.098	9.787AlaGlu: 9.787 ± 0.105	3.508AlaPhe: 3.508 ± 0.054	12.382AlaGly: 12.382 ± 0.128	2.644AlaHis: 2.644 ± 0.047	3.607AlaIle: 3.607 ± 0.058	2.636AlaLys: 2.636 ± 0.054	14.15AlaLeu: 14.15 ± 0.132	2.5AlaMet: 2.5 ± 0.041	1.957AlaAsn: 1.957 ± 0.038	5.836AlaPro: 5.836 ± 0.088	3.385AlaGln: 3.385 ± 0.051	9.776AlaArg: 9.776 ± 0.095	6.259AlaSer: 6.259 ± 0.065	7.375AlaThr: 7.375 ± 0.076	12.846AlaVal: 12.846 ± 0.139	1.719AlaTrp: 1.719 ± 0.039	2.213AlaTyr: 2.213 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.99CysAla: 0.99 ± 0.029	0.084CysCys: 0.084 ± 0.008	0.505CysAsp: 0.505 ± 0.021	0.444CysGlu: 0.444 ± 0.017	0.204CysPhe: 0.204 ± 0.012	0.944CysGly: 0.944 ± 0.028	0.193CysHis: 0.193 ± 0.011	0.135CysIle: 0.135 ± 0.01	0.098CysLys: 0.098 ± 0.008	0.728CysLeu: 0.728 ± 0.021	0.083CysMet: 0.083 ± 0.008	0.109CysAsn: 0.109 ± 0.009	0.455CysPro: 0.455 ± 0.018	0.159CysGln: 0.159 ± 0.01	0.605CysArg: 0.605 ± 0.02	0.482CysSer: 0.482 ± 0.019	0.422CysThr: 0.422 ± 0.018	0.699CysVal: 0.699 ± 0.022	0.122CysTrp: 0.122 ± 0.009	0.163CysTyr: 0.163 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.783AspAla: 7.783 ± 0.093	0.403AspCys: 0.403 ± 0.018	4.294AspAsp: 4.294 ± 0.059	4.333AspGlu: 4.333 ± 0.06	1.522AspPhe: 1.522 ± 0.041	6.15AspGly: 6.15 ± 0.075	1.441AspHis: 1.441 ± 0.033	2.021AspIle: 2.021 ± 0.043	0.986AspLys: 0.986 ± 0.032	6.309AspLeu: 6.309 ± 0.077	0.755AspMet: 0.755 ± 0.022	1.009AspAsn: 1.009 ± 0.028	4.392AspPro: 4.392 ± 0.068	1.312AspGln: 1.312 ± 0.031	4.816AspArg: 4.816 ± 0.066	2.897AspSer: 2.897 ± 0.046	3.511AspThr: 3.511 ± 0.054	5.917AspVal: 5.917 ± 0.078	0.847AspTrp: 0.847 ± 0.03	1.29AspTyr: 1.29 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.372GluAla: 7.372 ± 0.083	0.417GluCys: 0.417 ± 0.017	2.761GluAsp: 2.761 ± 0.053	3.416GluGlu: 3.416 ± 0.061	1.814GluPhe: 1.814 ± 0.039	4.713GluGly: 4.713 ± 0.063	1.897GluHis: 1.897 ± 0.041	2.483GluIle: 2.483 ± 0.04	1.331GluLys: 1.331 ± 0.036	7.431GluLeu: 7.431 ± 0.088	0.807GluMet: 0.807 ± 0.024	1.195GluAsn: 1.195 ± 0.034	3.771GluPro: 3.771 ± 0.061	2.48GluGln: 2.48 ± 0.047	5.939GluArg: 5.939 ± 0.073	2.988GluSer: 2.988 ± 0.049	2.958GluThr: 2.958 ± 0.047	5.235GluVal: 5.235 ± 0.066	0.881GluTrp: 0.881 ± 0.025	1.12GluTyr: 1.12 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.974PheAla: 3.974 ± 0.061	0.262PheCys: 0.262 ± 0.014	2.206PheAsp: 2.206 ± 0.045	1.422PheGlu: 1.422 ± 0.037	0.858PhePhe: 0.858 ± 0.027	3.253PheGly: 3.253 ± 0.049	0.589PheHis: 0.589 ± 0.02	0.587PheIle: 0.587 ± 0.025	0.359PheLys: 0.359 ± 0.017	2.563PheLeu: 2.563 ± 0.043	0.322PheMet: 0.322 ± 0.015	0.479PheAsn: 0.479 ± 0.021	1.336PhePro: 1.336 ± 0.028	0.554PheGln: 0.554 ± 0.023	1.844PheArg: 1.844 ± 0.037	1.577PheSer: 1.577 ± 0.034	1.999PheThr: 1.999 ± 0.039	2.641PheVal: 2.641 ± 0.051	0.389PheTrp: 0.389 ± 0.018	0.551PheTyr: 0.551 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.53GlyAla: 10.53 ± 0.108	0.771GlyCys: 0.771 ± 0.025	5.416GlyAsp: 5.416 ± 0.063	5.959GlyGlu: 5.959 ± 0.075	2.883GlyPhe: 2.883 ± 0.05	8.518GlyGly: 8.518 ± 0.127	2.212GlyHis: 2.212 ± 0.041	3.461GlyIle: 3.461 ± 0.055	2.205GlyLys: 2.205 ± 0.045	9.096GlyLeu: 9.096 ± 0.114	2.049GlyMet: 2.049 ± 0.041	1.757GlyAsn: 1.757 ± 0.045	4.397GlyPro: 4.397 ± 0.064	2.62GlyGln: 2.62 ± 0.056	7.262GlyArg: 7.262 ± 0.075	5.282GlySer: 5.282 ± 0.059	6.071GlyThr: 6.071 ± 0.069	8.393GlyVal: 8.393 ± 0.086	1.567GlyTrp: 1.567 ± 0.034	2.183GlyTyr: 2.183 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.742HisAla: 2.742 ± 0.048	0.22HisCys: 0.22 ± 0.013	1.475HisAsp: 1.475 ± 0.034	1.233HisGlu: 1.233 ± 0.031	0.598HisPhe: 0.598 ± 0.024	2.407HisGly: 2.407 ± 0.041	0.64HisHis: 0.64 ± 0.023	0.619HisIle: 0.619 ± 0.023	0.307HisLys: 0.307 ± 0.015	2.26HisLeu: 2.26 ± 0.039	0.281HisMet: 0.281 ± 0.015	0.392HisAsn: 0.392 ± 0.013	1.675HisPro: 1.675 ± 0.034	0.566HisGln: 0.566 ± 0.02	2.098HisArg: 2.098 ± 0.039	1.095HisSer: 1.095 ± 0.034	1.308HisThr: 1.308 ± 0.034	1.905HisVal: 1.905 ± 0.038	0.349HisTrp: 0.349 ± 0.016	0.48HisTyr: 0.48 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.906IleAla: 4.906 ± 0.066	0.224IleCys: 0.224 ± 0.012	2.702IleAsp: 2.702 ± 0.048	2.208IleGlu: 2.208 ± 0.048	0.669IlePhe: 0.669 ± 0.026	3.499IleGly: 3.499 ± 0.06	0.553IleHis: 0.553 ± 0.019	0.883IleIle: 0.883 ± 0.025	0.594IleLys: 0.594 ± 0.024	2.251IleLeu: 2.251 ± 0.047	0.415IleMet: 0.415 ± 0.021	0.629IleAsn: 0.629 ± 0.024	1.743IlePro: 1.743 ± 0.041	0.602IleGln: 0.602 ± 0.024	2.075IleArg: 2.075 ± 0.041	1.644IleSer: 1.644 ± 0.034	2.347IleThr: 2.347 ± 0.051	3.069IleVal: 3.069 ± 0.056	0.297IleTrp: 0.297 ± 0.015	0.492IleTyr: 0.492 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.642LysAla: 2.642 ± 0.055	0.104LysCys: 0.104 ± 0.009	1.042LysAsp: 1.042 ± 0.03	1.023LysGlu: 1.023 ± 0.036	0.415LysPhe: 0.415 ± 0.017	1.568LysGly: 1.568 ± 0.037	0.426LysHis: 0.426 ± 0.018	0.78LysIle: 0.78 ± 0.023	0.584LysLys: 0.584 ± 0.025	1.91LysLeu: 1.91 ± 0.044	0.309LysMet: 0.309 ± 0.015	0.396LysAsn: 0.396 ± 0.017	1.309LysPro: 1.309 ± 0.032	0.639LysGln: 0.639 ± 0.022	1.488LysArg: 1.488 ± 0.036	0.946LysSer: 0.946 ± 0.027	1.08LysThr: 1.08 ± 0.033	1.717LysVal: 1.717 ± 0.038	0.21LysTrp: 0.21 ± 0.012	0.353LysTyr: 0.353 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.756LeuAla: 15.756 ± 0.145	0.787LeuCys: 0.787 ± 0.023	7.414LeuAsp: 7.414 ± 0.082	4.411LeuGlu: 4.411 ± 0.067	2.653LeuPhe: 2.653 ± 0.051	9.396LeuGly: 9.396 ± 0.089	2.258LeuHis: 2.258 ± 0.04	2.904LeuIle: 2.904 ± 0.05	1.513LeuLys: 1.513 ± 0.042	11.199LeuLeu: 11.199 ± 0.128	1.302LeuMet: 1.302 ± 0.028	1.522LeuAsn: 1.522 ± 0.034	6.324LeuPro: 6.324 ± 0.071	1.68LeuGln: 1.68 ± 0.036	9.559LeuArg: 9.559 ± 0.095	5.891LeuSer: 5.891 ± 0.059	6.616LeuThr: 6.616 ± 0.075	9.801LeuVal: 9.801 ± 0.104	1.255LeuTrp: 1.255 ± 0.036	1.571LeuTyr: 1.571 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.103MetAla: 2.103 ± 0.038	0.112MetCys: 0.112 ± 0.009	0.781MetAsp: 0.781 ± 0.025	0.678MetGlu: 0.678 ± 0.022	0.461MetPhe: 0.461 ± 0.021	1.181MetGly: 1.181 ± 0.031	0.276MetHis: 0.276 ± 0.015	0.662MetIle: 0.662 ± 0.021	0.333MetLys: 0.333 ± 0.016	1.708MetLeu: 1.708 ± 0.037	0.265MetMet: 0.265 ± 0.018	0.409MetAsn: 0.409 ± 0.019	1.1MetPro: 1.1 ± 0.029	0.384MetGln: 0.384 ± 0.017	1.473MetArg: 1.473 ± 0.034	1.329MetSer: 1.329 ± 0.031	1.464MetThr: 1.464 ± 0.034	1.341MetVal: 1.341 ± 0.032	0.213MetTrp: 0.213 ± 0.011	0.246MetTyr: 0.246 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.228AsnAla: 2.228 ± 0.04	0.15AsnCys: 0.15 ± 0.011	0.972AsnAsp: 0.972 ± 0.03	0.801AsnGlu: 0.801 ± 0.027	0.449AsnPhe: 0.449 ± 0.018	1.76AsnGly: 1.76 ± 0.042	0.382AsnHis: 0.382 ± 0.017	0.65AsnIle: 0.65 ± 0.02	0.344AsnLys: 0.344 ± 0.018	1.786AsnLeu: 1.786 ± 0.036	0.274AsnMet: 0.274 ± 0.014	0.365AsnAsn: 0.365 ± 0.019	1.393AsnPro: 1.393 ± 0.03	0.48AsnGln: 0.48 ± 0.019	1.327AsnArg: 1.327 ± 0.029	0.883AsnSer: 0.883 ± 0.028	1.12AsnThr: 1.12 ± 0.032	1.39AsnVal: 1.39 ± 0.035	0.26AsnTrp: 0.26 ± 0.014	0.394AsnTyr: 0.394 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.157ProAla: 7.157 ± 0.091	0.349ProCys: 0.349 ± 0.016	4.162ProAsp: 4.162 ± 0.059	4.43ProGlu: 4.43 ± 0.059	1.527ProPhe: 1.527 ± 0.035	6.299ProGly: 6.299 ± 0.075	1.318ProHis: 1.318 ± 0.035	1.531ProIle: 1.531 ± 0.034	1.151ProLys: 1.151 ± 0.033	5.017ProLeu: 5.017 ± 0.064	1.028ProMet: 1.028 ± 0.026	0.941ProAsn: 0.941 ± 0.031	3.366ProPro: 3.366 ± 0.071	1.614ProGln: 1.614 ± 0.041	3.955ProArg: 3.955 ± 0.058	3.579ProSer: 3.579 ± 0.053	3.106ProThr: 3.106 ± 0.049	5.364ProVal: 5.364 ± 0.073	0.914ProTrp: 0.914 ± 0.026	1.081ProTyr: 1.081 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.398GlnAla: 3.398 ± 0.05	0.154GlnCys: 0.154 ± 0.01	1.121GlnAsp: 1.121 ± 0.032	1.257GlnGlu: 1.257 ± 0.03	0.641GlnPhe: 0.641 ± 0.026	2.112GlnGly: 2.112 ± 0.043	0.629GlnHis: 0.629 ± 0.024	0.945GlnIle: 0.945 ± 0.03	0.452GlnLys: 0.452 ± 0.018	2.848GlnLeu: 2.848 ± 0.053	0.368GlnMet: 0.368 ± 0.019	0.47GlnAsn: 0.47 ± 0.018	1.732GlnPro: 1.732 ± 0.048	1.164GlnGln: 1.164 ± 0.037	2.733GlnArg: 2.733 ± 0.048	1.125GlnSer: 1.125 ± 0.031	1.108GlnThr: 1.108 ± 0.031	2.207GlnVal: 2.207 ± 0.041	0.416GlnTrp: 0.416 ± 0.019	0.507GlnTyr: 0.507 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.495ArgAla: 9.495 ± 0.091	0.635ArgCys: 0.635 ± 0.023	4.635ArgAsp: 4.635 ± 0.061	5.054ArgGlu: 5.054 ± 0.066	2.425ArgPhe: 2.425 ± 0.049	5.98ArgGly: 5.98 ± 0.067	2.133ArgHis: 2.133 ± 0.04	3.137ArgIle: 3.137 ± 0.045	1.871ArgLys: 1.871 ± 0.043	8.922ArgLeu: 8.922 ± 0.102	1.896ArgMet: 1.896 ± 0.037	1.444ArgAsn: 1.444 ± 0.033	4.683ArgPro: 4.683 ± 0.061	2.495ArgGln: 2.495 ± 0.043	8.4ArgArg: 8.4 ± 0.1	4.373ArgSer: 4.373 ± 0.058	4.971ArgThr: 4.971 ± 0.067	6.528ArgVal: 6.528 ± 0.071	1.454ArgTrp: 1.454 ± 0.036	1.886ArgTyr: 1.886 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.265SerAla: 7.265 ± 0.082	0.413SerCys: 0.413 ± 0.018	3.151SerAsp: 3.151 ± 0.053	3.085SerGlu: 3.085 ± 0.056	1.611SerPhe: 1.611 ± 0.032	6.188SerGly: 6.188 ± 0.082	0.996SerHis: 0.996 ± 0.025	1.551SerIle: 1.551 ± 0.029	0.924SerLys: 0.924 ± 0.025	4.98SerLeu: 4.98 ± 0.064	1.181SerMet: 1.181 ± 0.03	0.871SerAsn: 0.871 ± 0.028	3.327SerPro: 3.327 ± 0.052	1.241SerGln: 1.241 ± 0.029	4.093SerArg: 4.093 ± 0.057	3.229SerSer: 3.229 ± 0.063	3.177SerThr: 3.177 ± 0.044	4.816SerVal: 4.816 ± 0.063	0.882SerTrp: 0.882 ± 0.023	1.056SerTyr: 1.056 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	7.979ThrAla: 7.979 ± 0.081	0.405ThrCys: 0.405 ± 0.016	3.515ThrAsp: 3.515 ± 0.05	3.666ThrGlu: 3.666 ± 0.054	1.659ThrPhe: 1.659 ± 0.036	6.255ThrGly: 6.255 ± 0.072	1.152ThrHis: 1.152 ± 0.026	1.875ThrIle: 1.875 ± 0.039	1.099ThrLys: 1.099 ± 0.03	5.767ThrLeu: 5.767 ± 0.071	1.009ThrMet: 1.009 ± 0.03	0.972ThrAsn: 0.972 ± 0.028	3.801ThrPro: 3.801 ± 0.059	1.222ThrGln: 1.222 ± 0.028	4.043ThrArg: 4.043 ± 0.052	3.498ThrSer: 3.498 ± 0.058	4.054ThrThr: 4.054 ± 0.061	6.51ThrVal: 6.51 ± 0.076	0.831ThrTrp: 0.831 ± 0.023	1.18ThrTyr: 1.18 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	12.314ValAla: 12.314 ± 0.12	0.758ValCys: 0.758 ± 0.026	5.034ValAsp: 5.034 ± 0.07	5.952ValGlu: 5.952 ± 0.065	2.763ValPhe: 2.763 ± 0.053	7.155ValGly: 7.155 ± 0.081	2.066ValHis: 2.066 ± 0.036	3.022ValIle: 3.022 ± 0.046	1.617ValLys: 1.617 ± 0.031	10.831ValLeu: 10.831 ± 0.115	1.261ValMet: 1.261 ± 0.03	1.792ValAsn: 1.792 ± 0.036	5.321ValPro: 5.321 ± 0.062	1.769ValGln: 1.769 ± 0.039	7.783ValArg: 7.783 ± 0.081	5.118ValSer: 5.118 ± 0.062	5.821ValThr: 5.821 ± 0.066	10.02ValVal: 10.02 ± 0.117	1.191ValTrp: 1.191 ± 0.033	1.513ValTyr: 1.513 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.49TrpAla: 1.49 ± 0.034	0.149TrpCys: 0.149 ± 0.009	0.731TrpAsp: 0.731 ± 0.021	0.722TrpGlu: 0.722 ± 0.023	0.512TrpPhe: 0.512 ± 0.02	0.972TrpGly: 0.972 ± 0.026	0.378TrpHis: 0.378 ± 0.016	0.528TrpIle: 0.528 ± 0.019	0.283TrpLys: 0.283 ± 0.015	1.913TrpLeu: 1.913 ± 0.041	0.247TrpMet: 0.247 ± 0.012	0.34TrpAsn: 0.34 ± 0.015	0.84TrpPro: 0.84 ± 0.026	0.536TrpGln: 0.536 ± 0.019	1.38TrpArg: 1.38 ± 0.036	0.845TrpSer: 0.845 ± 0.025	0.908TrpThr: 0.908 ± 0.023	1.068TrpVal: 1.068 ± 0.028	0.37TrpTrp: 0.37 ± 0.019	0.293TrpTyr: 0.293 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.259TyrAla: 2.259 ± 0.038	0.145TyrCys: 0.145 ± 0.009	1.348TyrAsp: 1.348 ± 0.045	1.127TyrGlu: 1.127 ± 0.032	0.594TyrPhe: 0.594 ± 0.023	1.899TyrGly: 1.899 ± 0.04	0.467TyrHis: 0.467 ± 0.024	0.421TyrIle: 0.421 ± 0.017	0.253TyrLys: 0.253 ± 0.014	2.145TyrLeu: 2.145 ± 0.042	0.165TyrMet: 0.165 ± 0.011	0.36TyrAsn: 0.36 ± 0.017	1.087TyrPro: 1.087 ± 0.028	0.483TyrGln: 0.483 ± 0.021	1.77TyrArg: 1.77 ± 0.038	0.999TyrSer: 0.999 ± 0.029	1.077TyrThr: 1.077 ± 0.024	1.633TyrVal: 1.633 ± 0.04	0.34TyrTrp: 0.34 ± 0.015	0.41TyrTyr: 0.41 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4307 proteins (1425417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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