Amino acid dipepetide frequency for Alteromonas confluentis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.824AlaAla: 8.824 ± 0.105
0.995AlaCys: 0.995 ± 0.026
5.473AlaAsp: 5.473 ± 0.077
6.088AlaGlu: 6.088 ± 0.077
3.793AlaPhe: 3.793 ± 0.048
6.791AlaGly: 6.791 ± 0.092
1.735AlaHis: 1.735 ± 0.044
5.757AlaIle: 5.757 ± 0.068
4.338AlaLys: 4.338 ± 0.059
10.329AlaLeu: 10.329 ± 0.098
2.944AlaMet: 2.944 ± 0.05
3.526AlaAsn: 3.526 ± 0.049
3.308AlaPro: 3.308 ± 0.056
3.613AlaGln: 3.613 ± 0.055
4.201AlaArg: 4.201 ± 0.058
6.021AlaSer: 6.021 ± 0.072
4.937AlaThr: 4.937 ± 0.069
6.508AlaVal: 6.508 ± 0.077
1.06AlaTrp: 1.06 ± 0.028
2.561AlaTyr: 2.561 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.858CysAla: 0.858 ± 0.026
0.14CysCys: 0.14 ± 0.01
0.585CysAsp: 0.585 ± 0.023
0.605CysGlu: 0.605 ± 0.019
0.416CysPhe: 0.416 ± 0.018
0.782CysGly: 0.782 ± 0.025
0.301CysHis: 0.301 ± 0.015
0.497CysIle: 0.497 ± 0.018
0.374CysLys: 0.374 ± 0.015
0.897CysLeu: 0.897 ± 0.026
0.224CysMet: 0.224 ± 0.012
0.338CysAsn: 0.338 ± 0.017
0.396CysPro: 0.396 ± 0.018
0.401CysGln: 0.401 ± 0.018
0.468CysArg: 0.468 ± 0.017
0.626CysSer: 0.626 ± 0.022
0.456CysThr: 0.456 ± 0.018
0.624CysVal: 0.624 ± 0.02
0.128CysTrp: 0.128 ± 0.009
0.296CysTyr: 0.296 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.545AspAla: 5.545 ± 0.073
0.499AspCys: 0.499 ± 0.022
3.93AspAsp: 3.93 ± 0.07
4.261AspGlu: 4.261 ± 0.058
2.734AspPhe: 2.734 ± 0.049
4.457AspGly: 4.457 ± 0.111
1.054AspHis: 1.054 ± 0.026
4.25AspIle: 4.25 ± 0.063
3.179AspLys: 3.179 ± 0.051
4.867AspLeu: 4.867 ± 0.06
1.634AspMet: 1.634 ± 0.035
2.81AspAsn: 2.81 ± 0.059
2.161AspPro: 2.161 ± 0.045
1.629AspGln: 1.629 ± 0.036
2.319AspArg: 2.319 ± 0.045
3.579AspSer: 3.579 ± 0.071
3.242AspThr: 3.242 ± 0.049
4.508AspVal: 4.508 ± 0.064
0.92AspTrp: 0.92 ± 0.027
2.22AspTyr: 2.22 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.798GluAla: 5.798 ± 0.082
0.429GluCys: 0.429 ± 0.017
3.351GluAsp: 3.351 ± 0.052
3.88GluGlu: 3.88 ± 0.067
2.321GluPhe: 2.321 ± 0.04
3.856GluGly: 3.856 ± 0.055
1.488GluHis: 1.488 ± 0.033
3.551GluIle: 3.551 ± 0.054
3.693GluLys: 3.693 ± 0.062
6.291GluLeu: 6.291 ± 0.069
1.778GluMet: 1.778 ± 0.034
2.916GluAsn: 2.916 ± 0.047
2.14GluPro: 2.14 ± 0.041
3.626GluGln: 3.626 ± 0.055
3.188GluArg: 3.188 ± 0.056
3.788GluSer: 3.788 ± 0.053
3.394GluThr: 3.394 ± 0.058
4.192GluVal: 4.192 ± 0.059
0.778GluTrp: 0.778 ± 0.025
1.79GluTyr: 1.79 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.876PheAla: 3.876 ± 0.059
0.479PheCys: 0.479 ± 0.02
3.024PheAsp: 3.024 ± 0.047
2.466PheGlu: 2.466 ± 0.042
1.766PhePhe: 1.766 ± 0.037
3.236PheGly: 3.236 ± 0.058
0.813PheHis: 0.813 ± 0.024
2.703PheIle: 2.703 ± 0.049
1.692PheLys: 1.692 ± 0.033
3.38PheLeu: 3.38 ± 0.052
1.022PheMet: 1.022 ± 0.03
2.061PheAsn: 2.061 ± 0.041
1.553PhePro: 1.553 ± 0.035
1.228PheGln: 1.228 ± 0.026
1.841PheArg: 1.841 ± 0.036
3.528PheSer: 3.528 ± 0.054
2.673PheThr: 2.673 ± 0.05
2.874PheVal: 2.874 ± 0.046
0.569PheTrp: 0.569 ± 0.021
1.436PheTyr: 1.436 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.649GlyAla: 5.649 ± 0.073
0.837GlyCys: 0.837 ± 0.025
4.173GlyAsp: 4.173 ± 0.068
4.585GlyGlu: 4.585 ± 0.059
3.557GlyPhe: 3.557 ± 0.054
4.946GlyGly: 4.946 ± 0.082
1.443GlyHis: 1.443 ± 0.038
4.609GlyIle: 4.609 ± 0.063
4.019GlyLys: 4.019 ± 0.059
6.956GlyLeu: 6.956 ± 0.074
2.15GlyMet: 2.15 ± 0.044
2.897GlyAsn: 2.897 ± 0.054
1.817GlyPro: 1.817 ± 0.04
2.644GlyGln: 2.644 ± 0.048
3.109GlyArg: 3.109 ± 0.051
4.182GlySer: 4.182 ± 0.064
3.731GlyThr: 3.731 ± 0.065
5.405GlyVal: 5.405 ± 0.066
1.019GlyTrp: 1.019 ± 0.029
2.597GlyTyr: 2.597 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.687HisAla: 1.687 ± 0.036
0.317HisCys: 0.317 ± 0.016
1.14HisAsp: 1.14 ± 0.032
1.154HisGlu: 1.154 ± 0.029
1.083HisPhe: 1.083 ± 0.027
1.595HisGly: 1.595 ± 0.038
0.675HisHis: 0.675 ± 0.029
1.328HisIle: 1.328 ± 0.03
0.909HisLys: 0.909 ± 0.026
2.036HisLeu: 2.036 ± 0.041
0.504HisMet: 0.504 ± 0.019
0.822HisAsn: 0.822 ± 0.025
1.159HisPro: 1.159 ± 0.033
0.997HisGln: 0.997 ± 0.033
1.094HisArg: 1.094 ± 0.029
1.296HisSer: 1.296 ± 0.036
1.07HisThr: 1.07 ± 0.032
1.371HisVal: 1.371 ± 0.032
0.36HisTrp: 0.36 ± 0.017
0.854HisTyr: 0.854 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.076IleAla: 6.076 ± 0.069
0.595IleCys: 0.595 ± 0.021
4.063IleAsp: 4.063 ± 0.059
4.024IleGlu: 4.024 ± 0.061
2.084IlePhe: 2.084 ± 0.046
4.267IleGly: 4.267 ± 0.061
1.204IleHis: 1.204 ± 0.031
3.181IleIle: 3.181 ± 0.058
2.672IleLys: 2.672 ± 0.049
4.74IleLeu: 4.74 ± 0.066
1.234IleMet: 1.234 ± 0.03
2.895IleAsn: 2.895 ± 0.047
2.508IlePro: 2.508 ± 0.041
1.957IleGln: 1.957 ± 0.035
2.858IleArg: 2.858 ± 0.049
4.242IleSer: 4.242 ± 0.054
3.739IleThr: 3.739 ± 0.056
3.955IleVal: 3.955 ± 0.054
0.602IleTrp: 0.602 ± 0.019
1.598IleTyr: 1.598 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.838LysAla: 4.838 ± 0.068
0.288LysCys: 0.288 ± 0.017
2.569LysAsp: 2.569 ± 0.047
2.701LysGlu: 2.701 ± 0.05
1.441LysPhe: 1.441 ± 0.032
3.102LysGly: 3.102 ± 0.053
1.127LysHis: 1.127 ± 0.028
2.468LysIle: 2.468 ± 0.046
2.527LysLys: 2.527 ± 0.052
4.808LysLeu: 4.808 ± 0.063
1.258LysMet: 1.258 ± 0.03
1.918LysAsn: 1.918 ± 0.039
2.39LysPro: 2.39 ± 0.041
2.492LysGln: 2.492 ± 0.048
2.626LysArg: 2.626 ± 0.048
2.896LysSer: 2.896 ± 0.051
2.764LysThr: 2.764 ± 0.047
3.48LysVal: 3.48 ± 0.053
0.532LysTrp: 0.532 ± 0.022
1.256LysTyr: 1.256 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
9.826LeuAla: 9.826 ± 0.105
0.988LeuCys: 0.988 ± 0.029
5.5LeuAsp: 5.5 ± 0.069
5.555LeuGlu: 5.555 ± 0.073
4.182LeuPhe: 4.182 ± 0.072
6.432LeuGly: 6.432 ± 0.091
2.0LeuHis: 2.0 ± 0.043
5.653LeuIle: 5.653 ± 0.078
4.912LeuLys: 4.912 ± 0.063
9.877LeuLeu: 9.877 ± 0.131
2.516LeuMet: 2.516 ± 0.045
4.436LeuAsn: 4.436 ± 0.06
4.838LeuPro: 4.838 ± 0.073
3.761LeuGln: 3.761 ± 0.061
4.515LeuArg: 4.515 ± 0.063
7.858LeuSer: 7.858 ± 0.089
6.129LeuThr: 6.129 ± 0.07
6.646LeuVal: 6.646 ± 0.079
1.047LeuTrp: 1.047 ± 0.028
2.633LeuTyr: 2.633 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.663MetAla: 2.663 ± 0.045
0.173MetCys: 0.173 ± 0.01
1.335MetAsp: 1.335 ± 0.032
1.349MetGlu: 1.349 ± 0.034
0.942MetPhe: 0.942 ± 0.026
1.765MetGly: 1.765 ± 0.038
0.551MetHis: 0.551 ± 0.021
1.299MetIle: 1.299 ± 0.031
1.464MetLys: 1.464 ± 0.034
2.858MetLeu: 2.858 ± 0.049
0.808MetMet: 0.808 ± 0.027
1.093MetAsn: 1.093 ± 0.024
1.375MetPro: 1.375 ± 0.033
1.201MetGln: 1.201 ± 0.03
1.317MetArg: 1.317 ± 0.032
1.953MetSer: 1.953 ± 0.042
1.694MetThr: 1.694 ± 0.036
1.754MetVal: 1.754 ± 0.038
0.262MetTrp: 0.262 ± 0.012
0.539MetTyr: 0.539 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.019AsnAla: 4.019 ± 0.056
0.368AsnCys: 0.368 ± 0.016
2.667AsnAsp: 2.667 ± 0.054
2.375AsnGlu: 2.375 ± 0.046
1.55AsnPhe: 1.55 ± 0.036
3.219AsnGly: 3.219 ± 0.056
0.897AsnHis: 0.897 ± 0.025
2.537AsnIle: 2.537 ± 0.04
1.888AsnLys: 1.888 ± 0.036
3.824AsnLeu: 3.824 ± 0.053
1.017AsnMet: 1.017 ± 0.022
1.876AsnAsn: 1.876 ± 0.042
2.07AsnPro: 2.07 ± 0.041
1.821AsnGln: 1.821 ± 0.035
2.111AsnArg: 2.111 ± 0.038
2.408AsnSer: 2.408 ± 0.04
2.338AsnThr: 2.338 ± 0.044
2.966AsnVal: 2.966 ± 0.049
0.679AsnTrp: 0.679 ± 0.024
1.376AsnTyr: 1.376 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.88ProAla: 3.88 ± 0.053
0.265ProCys: 0.265 ± 0.014
2.942ProAsp: 2.942 ± 0.044
3.459ProGlu: 3.459 ± 0.053
1.865ProPhe: 1.865 ± 0.038
2.985ProGly: 2.985 ± 0.046
0.806ProHis: 0.806 ± 0.026
1.965ProIle: 1.965 ± 0.039
1.606ProLys: 1.606 ± 0.033
4.038ProLeu: 4.038 ± 0.059
1.002ProMet: 1.002 ± 0.028
1.426ProAsn: 1.426 ± 0.032
1.342ProPro: 1.342 ± 0.037
1.667ProGln: 1.667 ± 0.033
1.508ProArg: 1.508 ± 0.035
2.462ProSer: 2.462 ± 0.042
2.105ProThr: 2.105 ± 0.035
3.823ProVal: 3.823 ± 0.05
0.54ProTrp: 0.54 ± 0.019
1.233ProTyr: 1.233 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.143GlnAla: 4.143 ± 0.059
0.368GlnCys: 0.368 ± 0.018
1.912GlnAsp: 1.912 ± 0.037
2.172GlnGlu: 2.172 ± 0.043
1.817GlnPhe: 1.817 ± 0.034
2.574GlnGly: 2.574 ± 0.042
1.136GlnHis: 1.136 ± 0.03
2.348GlnIle: 2.348 ± 0.039
1.928GlnLys: 1.928 ± 0.037
4.318GlnLeu: 4.318 ± 0.061
1.024GlnMet: 1.024 ± 0.029
1.599GlnAsn: 1.599 ± 0.034
1.797GlnPro: 1.797 ± 0.038
2.815GlnGln: 2.815 ± 0.052
2.347GlnArg: 2.347 ± 0.046
2.793GlnSer: 2.793 ± 0.051
2.261GlnThr: 2.261 ± 0.04
2.784GlnVal: 2.784 ± 0.047
0.614GlnTrp: 0.614 ± 0.024
1.27GlnTyr: 1.27 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.694ArgAla: 3.694 ± 0.05
0.43ArgCys: 0.43 ± 0.016
2.71ArgAsp: 2.71 ± 0.048
3.207ArgGlu: 3.207 ± 0.055
2.393ArgPhe: 2.393 ± 0.045
2.831ArgGly: 2.831 ± 0.046
1.19ArgHis: 1.19 ± 0.028
3.047ArgIle: 3.047 ± 0.043
2.347ArgLys: 2.347 ± 0.046
4.946ArgLeu: 4.946 ± 0.068
1.278ArgMet: 1.278 ± 0.034
2.01ArgAsn: 2.01 ± 0.04
1.746ArgPro: 1.746 ± 0.035
2.366ArgGln: 2.366 ± 0.042
2.529ArgArg: 2.529 ± 0.052
2.615ArgSer: 2.615 ± 0.044
2.317ArgThr: 2.317 ± 0.04
3.249ArgVal: 3.249 ± 0.051
0.7ArgTrp: 0.7 ± 0.023
1.824ArgTyr: 1.824 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.261SerAla: 6.261 ± 0.06
0.558SerCys: 0.558 ± 0.022
4.017SerAsp: 4.017 ± 0.064
4.227SerGlu: 4.227 ± 0.064
2.832SerPhe: 2.832 ± 0.053
5.36SerGly: 5.36 ± 0.074
1.47SerHis: 1.47 ± 0.038
3.397SerIle: 3.397 ± 0.05
2.726SerLys: 2.726 ± 0.05
7.025SerLeu: 7.025 ± 0.074
1.741SerMet: 1.741 ± 0.04
2.434SerAsn: 2.434 ± 0.047
2.702SerPro: 2.702 ± 0.048
2.781SerGln: 2.781 ± 0.048
3.159SerArg: 3.159 ± 0.048
4.247SerSer: 4.247 ± 0.07
3.456SerThr: 3.456 ± 0.055
5.082SerVal: 5.082 ± 0.067
0.844SerTrp: 0.844 ± 0.025
1.982SerTyr: 1.982 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
5.109ThrAla: 5.109 ± 0.068
0.46ThrCys: 0.46 ± 0.02
3.516ThrAsp: 3.516 ± 0.06
3.328ThrGlu: 3.328 ± 0.044
2.382ThrPhe: 2.382 ± 0.044
4.526ThrGly: 4.526 ± 0.062
1.136ThrHis: 1.136 ± 0.031
3.239ThrIle: 3.239 ± 0.047
1.921ThrLys: 1.921 ± 0.042
6.462ThrLeu: 6.462 ± 0.076
1.256ThrMet: 1.256 ± 0.031
1.996ThrAsn: 1.996 ± 0.038
2.922ThrPro: 2.922 ± 0.05
2.188ThrGln: 2.188 ± 0.044
2.59ThrArg: 2.59 ± 0.044
3.521ThrSer: 3.521 ± 0.051
3.169ThrThr: 3.169 ± 0.061
4.222ThrVal: 4.222 ± 0.064
0.644ThrTrp: 0.644 ± 0.022
1.661ThrTyr: 1.661 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
6.76ValAla: 6.76 ± 0.083
0.76ValCys: 0.76 ± 0.024
4.342ValAsp: 4.342 ± 0.056
4.407ValGlu: 4.407 ± 0.059
2.961ValPhe: 2.961 ± 0.048
4.606ValGly: 4.606 ± 0.068
1.287ValHis: 1.287 ± 0.029
4.462ValIle: 4.462 ± 0.056
3.559ValLys: 3.559 ± 0.05
6.742ValLeu: 6.742 ± 0.081
1.976ValMet: 1.976 ± 0.04
3.306ValAsn: 3.306 ± 0.045
2.845ValPro: 2.845 ± 0.049
2.238ValGln: 2.238 ± 0.043
3.08ValArg: 3.08 ± 0.048
5.485ValSer: 5.485 ± 0.074
4.603ValThr: 4.603 ± 0.066
5.486ValVal: 5.486 ± 0.07
0.843ValTrp: 0.843 ± 0.026
2.015ValTyr: 2.015 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.811TrpAla: 0.811 ± 0.023
0.14TrpCys: 0.14 ± 0.01
0.688TrpAsp: 0.688 ± 0.025
0.639TrpGlu: 0.639 ± 0.022
0.612TrpPhe: 0.612 ± 0.019
0.802TrpGly: 0.802 ± 0.027
0.382TrpHis: 0.382 ± 0.016
0.676TrpIle: 0.676 ± 0.022
0.506TrpLys: 0.506 ± 0.018
1.698TrpLeu: 1.698 ± 0.033
0.406TrpMet: 0.406 ± 0.019
0.451TrpAsn: 0.451 ± 0.02
0.484TrpPro: 0.484 ± 0.019
0.947TrpGln: 0.947 ± 0.027
0.736TrpArg: 0.736 ± 0.026
0.751TrpSer: 0.751 ± 0.024
0.553TrpThr: 0.553 ± 0.022
0.882TrpVal: 0.882 ± 0.028
0.204TrpTrp: 0.204 ± 0.012
0.421TrpTyr: 0.421 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.485TyrAla: 2.485 ± 0.045
0.324TyrCys: 0.324 ± 0.016
1.858TyrAsp: 1.858 ± 0.039
1.771TyrGlu: 1.771 ± 0.033
1.491TyrPhe: 1.491 ± 0.033
2.194TyrGly: 2.194 ± 0.049
0.76TyrHis: 0.76 ± 0.023
1.523TyrIle: 1.523 ± 0.03
1.222TyrLys: 1.222 ± 0.028
3.21TyrLeu: 3.21 ± 0.053
0.624TyrMet: 0.624 ± 0.019
1.197TyrAsn: 1.197 ± 0.034
1.366TyrPro: 1.366 ± 0.035
1.647TyrGln: 1.647 ± 0.035
1.833TyrArg: 1.833 ± 0.035
2.051TyrSer: 2.051 ± 0.04
1.615TyrThr: 1.615 ± 0.039
1.948TyrVal: 1.948 ± 0.036
0.444TyrTrp: 0.444 ± 0.018
1.03TyrTyr: 1.03 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4086 proteins (1417638 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski