Amino acid dipepetide frequency for Duganella sp. CF517

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.133AlaAla: 19.133 ± 0.177
1.111AlaCys: 1.111 ± 0.024
7.127AlaAsp: 7.127 ± 0.06
6.089AlaGlu: 6.089 ± 0.061
3.832AlaPhe: 3.832 ± 0.043
11.467AlaGly: 11.467 ± 0.133
2.423AlaHis: 2.423 ± 0.035
5.733AlaIle: 5.733 ± 0.054
4.198AlaLys: 4.198 ± 0.063
14.044AlaLeu: 14.044 ± 0.177
3.434AlaMet: 3.434 ± 0.045
3.6AlaAsn: 3.6 ± 0.044
6.62AlaPro: 6.62 ± 0.078
5.22AlaGln: 5.22 ± 0.097
8.249AlaArg: 8.249 ± 0.084
6.846AlaSer: 6.846 ± 0.068
6.393AlaThr: 6.393 ± 0.058
8.671AlaVal: 8.671 ± 0.079
1.721AlaTrp: 1.721 ± 0.03
2.82AlaTyr: 2.82 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.129CysAla: 1.129 ± 0.028
0.107CysCys: 0.107 ± 0.008
0.466CysAsp: 0.466 ± 0.017
0.396CysGlu: 0.396 ± 0.015
0.273CysPhe: 0.273 ± 0.012
0.869CysGly: 0.869 ± 0.025
0.209CysHis: 0.209 ± 0.01
0.355CysIle: 0.355 ± 0.014
0.238CysLys: 0.238 ± 0.011
0.715CysLeu: 0.715 ± 0.018
0.188CysMet: 0.188 ± 0.01
0.208CysAsn: 0.208 ± 0.009
0.349CysPro: 0.349 ± 0.012
0.214CysGln: 0.214 ± 0.011
0.461CysArg: 0.461 ± 0.017
0.44CysSer: 0.44 ± 0.015
0.413CysThr: 0.413 ± 0.015
0.617CysVal: 0.617 ± 0.016
0.115CysTrp: 0.115 ± 0.007
0.232CysTyr: 0.232 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.055AspAla: 7.055 ± 0.069
0.439AspCys: 0.439 ± 0.015
3.185AspAsp: 3.185 ± 0.047
2.943AspGlu: 2.943 ± 0.041
2.159AspPhe: 2.159 ± 0.034
5.539AspGly: 5.539 ± 0.068
1.109AspHis: 1.109 ± 0.025
2.835AspIle: 2.835 ± 0.043
2.179AspLys: 2.179 ± 0.039
5.228AspLeu: 5.228 ± 0.053
1.345AspMet: 1.345 ± 0.028
1.695AspAsn: 1.695 ± 0.033
2.801AspPro: 2.801 ± 0.039
2.029AspGln: 2.029 ± 0.061
2.996AspArg: 2.996 ± 0.042
2.632AspSer: 2.632 ± 0.035
2.771AspThr: 2.771 ± 0.049
4.017AspVal: 4.017 ± 0.051
0.934AspTrp: 0.934 ± 0.022
1.673AspTyr: 1.673 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
5.901GluAla: 5.901 ± 0.063
0.336GluCys: 0.336 ± 0.013
2.03GluAsp: 2.03 ± 0.035
2.365GluGlu: 2.365 ± 0.044
1.764GluPhe: 1.764 ± 0.029
3.298GluGly: 3.298 ± 0.048
1.231GluHis: 1.231 ± 0.028
2.614GluIle: 2.614 ± 0.035
2.008GluLys: 2.008 ± 0.038
5.616GluLeu: 5.616 ± 0.066
1.285GluMet: 1.285 ± 0.026
1.452GluAsn: 1.452 ± 0.027
2.176GluPro: 2.176 ± 0.036
2.739GluGln: 2.739 ± 0.042
4.175GluArg: 4.175 ± 0.053
2.37GluSer: 2.37 ± 0.039
2.5GluThr: 2.5 ± 0.037
3.432GluVal: 3.432 ± 0.044
0.724GluTrp: 0.724 ± 0.018
1.172GluTyr: 1.172 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
4.035PheAla: 4.035 ± 0.05
0.351PheCys: 0.351 ± 0.013
2.561PheAsp: 2.561 ± 0.036
1.824PheGlu: 1.824 ± 0.031
1.364PhePhe: 1.364 ± 0.029
3.414PheGly: 3.414 ± 0.047
0.743PheHis: 0.743 ± 0.02
1.623PheIle: 1.623 ± 0.029
1.349PheLys: 1.349 ± 0.026
2.904PheLeu: 2.904 ± 0.04
0.841PheMet: 0.841 ± 0.021
1.385PheAsn: 1.385 ± 0.027
1.46PhePro: 1.46 ± 0.028
1.079PheGln: 1.079 ± 0.024
1.804PheArg: 1.804 ± 0.031
2.377PheSer: 2.377 ± 0.034
2.02PheThr: 2.02 ± 0.033
2.503PheVal: 2.503 ± 0.037
0.481PheTrp: 0.481 ± 0.015
1.029PheTyr: 1.029 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
10.589GlyAla: 10.589 ± 0.13
0.715GlyCys: 0.715 ± 0.018
4.506GlyAsp: 4.506 ± 0.063
4.062GlyGlu: 4.062 ± 0.046
3.244GlyPhe: 3.244 ± 0.04
7.98GlyGly: 7.98 ± 0.287
1.808GlyHis: 1.808 ± 0.035
4.042GlyIle: 4.042 ± 0.05
4.043GlyLys: 4.043 ± 0.051
8.11GlyLeu: 8.11 ± 0.072
2.373GlyMet: 2.373 ± 0.03
2.713GlyAsn: 2.713 ± 0.064
2.871GlyPro: 2.871 ± 0.04
3.167GlyGln: 3.167 ± 0.042
5.033GlyArg: 5.033 ± 0.054
4.475GlySer: 4.475 ± 0.059
4.419GlyThr: 4.419 ± 0.06
6.648GlyVal: 6.648 ± 0.068
1.36GlyTrp: 1.36 ± 0.03
2.624GlyTyr: 2.624 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.628HisAla: 2.628 ± 0.04
0.219HisCys: 0.219 ± 0.01
1.191HisAsp: 1.191 ± 0.027
1.041HisGlu: 1.041 ± 0.025
0.879HisPhe: 0.879 ± 0.021
2.059HisGly: 2.059 ± 0.034
0.616HisHis: 0.616 ± 0.02
0.96HisIle: 0.96 ± 0.021
0.618HisLys: 0.618 ± 0.018
2.076HisLeu: 2.076 ± 0.034
0.475HisMet: 0.475 ± 0.014
0.566HisAsn: 0.566 ± 0.017
1.277HisPro: 1.277 ± 0.026
0.798HisGln: 0.798 ± 0.02
1.249HisArg: 1.249 ± 0.026
1.021HisSer: 1.021 ± 0.02
1.061HisThr: 1.061 ± 0.023
1.41HisVal: 1.41 ± 0.03
0.338HisTrp: 0.338 ± 0.012
0.663HisTyr: 0.663 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.449IleAla: 6.449 ± 0.07
0.406IleCys: 0.406 ± 0.012
3.539IleAsp: 3.539 ± 0.04
2.95IleGlu: 2.95 ± 0.037
1.406IlePhe: 1.406 ± 0.031
4.579IleGly: 4.579 ± 0.054
0.849IleHis: 0.849 ± 0.023
1.859IleIle: 1.859 ± 0.036
1.846IleLys: 1.846 ± 0.036
3.601IleLeu: 3.601 ± 0.05
0.901IleMet: 0.901 ± 0.02
1.728IleAsn: 1.728 ± 0.031
2.02IlePro: 2.02 ± 0.032
1.224IleGln: 1.224 ± 0.025
2.492IleArg: 2.492 ± 0.036
2.713IleSer: 2.713 ± 0.038
2.557IleThr: 2.557 ± 0.04
3.699IleVal: 3.699 ± 0.047
0.501IleTrp: 0.501 ± 0.016
1.109IleTyr: 1.109 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
4.134LysAla: 4.134 ± 0.053
0.168LysCys: 0.168 ± 0.009
1.891LysAsp: 1.891 ± 0.034
1.733LysGlu: 1.733 ± 0.031
1.142LysPhe: 1.142 ± 0.024
2.532LysGly: 2.532 ± 0.04
0.722LysHis: 0.722 ± 0.019
1.89LysIle: 1.89 ± 0.038
1.634LysLys: 1.634 ± 0.034
4.121LysLeu: 4.121 ± 0.056
1.033LysMet: 1.033 ± 0.022
1.262LysAsn: 1.262 ± 0.028
2.321LysPro: 2.321 ± 0.041
1.562LysGln: 1.562 ± 0.031
2.282LysArg: 2.282 ± 0.031
2.069LysSer: 2.069 ± 0.034
2.166LysThr: 2.166 ± 0.037
2.827LysVal: 2.827 ± 0.041
0.398LysTrp: 0.398 ± 0.014
0.859LysTyr: 0.859 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.091LeuAla: 14.091 ± 0.111
0.909LeuCys: 0.909 ± 0.024
5.792LeuAsp: 5.792 ± 0.057
4.991LeuGlu: 4.991 ± 0.057
3.403LeuPhe: 3.403 ± 0.047
7.874LeuGly: 7.874 ± 0.073
2.178LeuHis: 2.178 ± 0.035
4.368LeuIle: 4.368 ± 0.047
3.87LeuLys: 3.87 ± 0.049
10.647LeuLeu: 10.647 ± 0.11
2.416LeuMet: 2.416 ± 0.039
3.213LeuAsn: 3.213 ± 0.044
5.754LeuPro: 5.754 ± 0.061
3.69LeuGln: 3.69 ± 0.043
7.222LeuArg: 7.222 ± 0.074
6.511LeuSer: 6.511 ± 0.074
5.869LeuThr: 5.869 ± 0.097
6.955LeuVal: 6.955 ± 0.071
1.19LeuTrp: 1.19 ± 0.029
2.305LeuTyr: 2.305 ± 0.031
0.0LeuXaa: 0.0 ± 0.0
Met
3.006MetAla: 3.006 ± 0.039
0.161MetCys: 0.161 ± 0.009
1.183MetAsp: 1.183 ± 0.026
1.118MetGlu: 1.118 ± 0.022
0.762MetPhe: 0.762 ± 0.02
1.687MetGly: 1.687 ± 0.028
0.552MetHis: 0.552 ± 0.017
1.09MetIle: 1.09 ± 0.022
1.069MetLys: 1.069 ± 0.023
2.905MetLeu: 2.905 ± 0.047
0.693MetMet: 0.693 ± 0.02
0.964MetAsn: 0.964 ± 0.022
1.446MetPro: 1.446 ± 0.025
1.04MetGln: 1.04 ± 0.021
1.727MetArg: 1.727 ± 0.033
1.62MetSer: 1.62 ± 0.03
1.693MetThr: 1.693 ± 0.027
1.699MetVal: 1.699 ± 0.025
0.236MetTrp: 0.236 ± 0.01
0.47MetTyr: 0.47 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.811AsnAla: 3.811 ± 0.047
0.245AsnCys: 0.245 ± 0.01
1.699AsnAsp: 1.699 ± 0.033
1.334AsnGlu: 1.334 ± 0.027
1.205AsnPhe: 1.205 ± 0.025
2.941AsnGly: 2.941 ± 0.046
0.609AsnHis: 0.609 ± 0.015
1.583AsnIle: 1.583 ± 0.027
1.112AsnLys: 1.112 ± 0.025
3.134AsnLeu: 3.134 ± 0.041
0.718AsnMet: 0.718 ± 0.019
1.139AsnAsn: 1.139 ± 0.03
1.894AsnPro: 1.894 ± 0.034
1.189AsnGln: 1.189 ± 0.027
1.772AsnArg: 1.772 ± 0.032
1.644AsnSer: 1.644 ± 0.031
1.71AsnThr: 1.71 ± 0.032
2.331AsnVal: 2.331 ± 0.04
0.476AsnTrp: 0.476 ± 0.016
0.95AsnTyr: 0.95 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.392ProAla: 7.392 ± 0.076
0.296ProCys: 0.296 ± 0.013
3.053ProAsp: 3.053 ± 0.043
2.933ProGlu: 2.933 ± 0.039
1.697ProPhe: 1.697 ± 0.032
4.357ProGly: 4.357 ± 0.049
1.04ProHis: 1.04 ± 0.023
1.807ProIle: 1.807 ± 0.036
1.548ProLys: 1.548 ± 0.03
5.035ProLeu: 5.035 ± 0.055
1.196ProMet: 1.196 ± 0.023
1.401ProAsn: 1.401 ± 0.029
2.554ProPro: 2.554 ± 0.046
1.946ProGln: 1.946 ± 0.033
2.666ProArg: 2.666 ± 0.038
2.755ProSer: 2.755 ± 0.039
2.434ProThr: 2.434 ± 0.049
3.998ProVal: 3.998 ± 0.048
0.641ProTrp: 0.641 ± 0.02
1.189ProTyr: 1.189 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
5.04GlnAla: 5.04 ± 0.066
0.264GlnCys: 0.264 ± 0.011
1.545GlnAsp: 1.545 ± 0.031
1.527GlnGlu: 1.527 ± 0.028
1.418GlnPhe: 1.418 ± 0.029
2.756GlnGly: 2.756 ± 0.039
0.886GlnHis: 0.886 ± 0.021
2.003GlnIle: 2.003 ± 0.078
1.265GlnLys: 1.265 ± 0.023
4.293GlnLeu: 4.293 ± 0.082
1.014GlnMet: 1.014 ± 0.022
1.042GlnAsn: 1.042 ± 0.023
2.049GlnPro: 2.049 ± 0.034
2.05GlnGln: 2.05 ± 0.038
2.964GlnArg: 2.964 ± 0.041
2.114GlnSer: 2.114 ± 0.047
2.014GlnThr: 2.014 ± 0.034
2.92GlnVal: 2.92 ± 0.059
0.593GlnTrp: 0.593 ± 0.016
0.953GlnTyr: 0.953 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.478ArgAla: 7.478 ± 0.067
0.472ArgCys: 0.472 ± 0.016
3.7ArgAsp: 3.7 ± 0.045
3.467ArgGlu: 3.467 ± 0.046
2.532ArgPhe: 2.532 ± 0.035
4.354ArgGly: 4.354 ± 0.051
1.769ArgHis: 1.769 ± 0.03
3.301ArgIle: 3.301 ± 0.036
2.181ArgLys: 2.181 ± 0.033
6.976ArgLeu: 6.976 ± 0.071
1.779ArgMet: 1.779 ± 0.032
1.977ArgAsn: 1.977 ± 0.034
2.757ArgPro: 2.757 ± 0.04
2.861ArgGln: 2.861 ± 0.038
4.512ArgArg: 4.512 ± 0.06
3.184ArgSer: 3.184 ± 0.045
2.943ArgThr: 2.943 ± 0.046
4.45ArgVal: 4.45 ± 0.053
0.994ArgTrp: 0.994 ± 0.022
2.032ArgTyr: 2.032 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
7.024SerAla: 7.024 ± 0.069
0.422SerCys: 0.422 ± 0.019
2.871SerAsp: 2.871 ± 0.042
2.471SerGlu: 2.471 ± 0.037
2.079SerPhe: 2.079 ± 0.033
5.49SerGly: 5.49 ± 0.072
1.145SerHis: 1.145 ± 0.024
2.651SerIle: 2.651 ± 0.04
1.901SerLys: 1.901 ± 0.034
5.75SerLeu: 5.75 ± 0.054
1.393SerMet: 1.393 ± 0.026
1.765SerAsn: 1.765 ± 0.031
2.73SerPro: 2.73 ± 0.039
1.909SerGln: 1.909 ± 0.034
3.151SerArg: 3.151 ± 0.04
3.231SerSer: 3.231 ± 0.045
3.167SerThr: 3.167 ± 0.061
4.018SerVal: 4.018 ± 0.048
0.78SerTrp: 0.78 ± 0.02
1.612SerTyr: 1.612 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
6.387ThrAla: 6.387 ± 0.094
0.346ThrCys: 0.346 ± 0.014
2.812ThrAsp: 2.812 ± 0.055
2.332ThrGlu: 2.332 ± 0.036
1.79ThrPhe: 1.79 ± 0.028
4.846ThrGly: 4.846 ± 0.061
1.028ThrHis: 1.028 ± 0.021
2.645ThrIle: 2.645 ± 0.036
1.522ThrLys: 1.522 ± 0.029
6.144ThrLeu: 6.144 ± 0.059
1.243ThrMet: 1.243 ± 0.024
1.534ThrAsn: 1.534 ± 0.03
3.553ThrPro: 3.553 ± 0.053
1.825ThrGln: 1.825 ± 0.038
3.152ThrArg: 3.152 ± 0.045
2.958ThrSer: 2.958 ± 0.049
3.188ThrThr: 3.188 ± 0.089
4.444ThrVal: 4.444 ± 0.058
0.683ThrTrp: 0.683 ± 0.02
1.377ThrTyr: 1.377 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
9.391ValAla: 9.391 ± 0.089
0.64ValCys: 0.64 ± 0.018
4.227ValAsp: 4.227 ± 0.045
3.833ValGlu: 3.833 ± 0.05
2.559ValPhe: 2.559 ± 0.036
5.596ValGly: 5.596 ± 0.074
1.345ValHis: 1.345 ± 0.025
3.432ValIle: 3.432 ± 0.044
2.709ValLys: 2.709 ± 0.043
7.571ValLeu: 7.571 ± 0.072
1.842ValMet: 1.842 ± 0.03
2.453ValAsn: 2.453 ± 0.037
3.443ValPro: 3.443 ± 0.036
2.397ValGln: 2.397 ± 0.036
4.726ValArg: 4.726 ± 0.047
4.229ValSer: 4.229 ± 0.043
4.249ValThr: 4.249 ± 0.051
5.788ValVal: 5.788 ± 0.057
0.894ValTrp: 0.894 ± 0.021
1.726ValTyr: 1.726 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.151TrpAla: 1.151 ± 0.027
0.138TrpCys: 0.138 ± 0.008
0.677TrpAsp: 0.677 ± 0.017
0.569TrpGlu: 0.569 ± 0.018
0.543TrpPhe: 0.543 ± 0.018
0.896TrpGly: 0.896 ± 0.023
0.354TrpHis: 0.354 ± 0.014
0.657TrpIle: 0.657 ± 0.02
0.519TrpLys: 0.519 ± 0.018
1.723TrpLeu: 1.723 ± 0.032
0.406TrpMet: 0.406 ± 0.013
0.53TrpAsn: 0.53 ± 0.014
0.601TrpPro: 0.601 ± 0.016
0.698TrpGln: 0.698 ± 0.019
1.186TrpArg: 1.186 ± 0.027
0.859TrpSer: 0.859 ± 0.02
0.761TrpThr: 0.761 ± 0.019
0.822TrpVal: 0.822 ± 0.021
0.24TrpTrp: 0.24 ± 0.011
0.353TrpTyr: 0.353 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.908TyrAla: 2.908 ± 0.037
0.249TyrCys: 0.249 ± 0.011
1.507TyrAsp: 1.507 ± 0.029
1.212TyrGlu: 1.212 ± 0.025
1.096TyrPhe: 1.096 ± 0.023
2.245TyrGly: 2.245 ± 0.031
0.53TyrHis: 0.53 ± 0.015
0.977TyrIle: 0.977 ± 0.022
0.938TyrLys: 0.938 ± 0.025
2.655TyrLeu: 2.655 ± 0.035
0.545TyrMet: 0.545 ± 0.018
0.872TyrAsn: 0.872 ± 0.023
1.26TyrPro: 1.26 ± 0.026
1.073TyrGln: 1.073 ± 0.025
1.899TyrArg: 1.899 ± 0.032
1.514TyrSer: 1.514 ± 0.029
1.482TyrThr: 1.482 ± 0.028
1.801TyrVal: 1.801 ± 0.032
0.385TyrTrp: 0.385 ± 0.012
0.787TyrTyr: 0.787 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5879 proteins (2143361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski